JPS63146809A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a composition for the oral cavity, capable of preventing dental calculus from forming and gingivitis or puyrrhoea alveolaris, simultaneously adsorbing and removing substances causing halitosis to prevent the halitosis, by blending specific acid-treated zeolite. CONSTITUTION:A composition for the oral cavity, obtained by blending acid- treated zeolite, prepared by treating zeolite, preferably selected from A-type zeolite, 4A-type zeolite, X-type zeolite, Y-type zeolite and mordenite with an acid so as to provide a pH of <=9, particularly 8-6 and having 1-10mum average particle size in an amount of 1-99wt% based on the total composition and useful as dentifrice, chewing gum, troche tablet, crunching tablet, etc., capable of exhibiting excellent halitosis preventing effects in addition to dental calculus preventing effects. Furthermore, since the zeolite preferentially adsorbs water, halitosis preventing effects are hardly produced in a system in which a large amount of water exist, e.g. interior of the oral cavity. The acid-treated zeolite, however, shows excellent action of adsorbing halitosis causative substances even in the coexistence of water and produces the above-mentioned effects.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention prevents gingivitis and alveolar pyorrhea by preventing the formation of tartar, and at the same time prevents bad breath by adsorbing and removing substances that cause bad breath. The present invention relates to an oral composition.

[Conventional technology and its problems]

It is known that gingivitis and alveolar pyorrhea are directly caused by dental plaque and tartar.

Dental plaque is a sticky substance formed by various oral bacteria adsorbed to teeth and multiplied, and dental tartar is the plaque that is further calcified by calcium and Jell in saliva. Plaque can be easily removed with a toothbrush, but tartar cannot be removed unless it is ground down by scaling. Therefore, brushing your teeth with a toothpaste that prevents tartar formation is thought to be effective in preventing gingivitis and alveolar pyorrhea, and various oral drugs and their compositions that claim to prevent tartar have been developed. Proposed.

Zeolite itself has already been incorporated into toothpaste and other products, and its tartar prevention effect has been proven. A patent application has been filed for a particularly fine zeolite used for i-brushing as being effective in preventing tartar (Public Patent Publication, 1972-24112).
).

[Problem that the invention seeks to solve]

On the other hand, patients with gingivitis and alveolar pyorrhea often have strong bad breath, which is said to be mainly due to the presence of volatile sulfides such as methyl mercaptan and hydrogen sulfide produced in the oral cavity in their breath. If zeolite adsorbs and removes these substances that cause bad breath, it is thought to be effective in preventing not only tartar but also bad breath. However, although zeolite shows excellent adsorption effects on hydrogen sulfide and ammonia in a dry system, In systems where a large amount of water coexists, such as in the oral cavity, the problem is that water is adsorbed with the highest priority, making it difficult to see any effects [Akio Oyamada;・Sharnal” Black 72
(1985) P79-82).

[Means for solving problems]

Under such circumstances, the present inventor conducted intensive research and found that zeolite treated with acid has an excellent adsorption effect on substances that cause bad breath even in the coexistence of water, and completed the present invention.

That is, the present invention provides an oral composition containing an acid-treated zeolite, which is obtained by treating the zeolite with an acid so that the pH thereof becomes lower than the pH level.

In the present invention, both synthetic zeolite and natural zeolite can be used as the zeolite. The zeolite is preferably a fine one with a particle size of about 1 to 10 μm from the viewpoint of preventing tartar. Natural zeolite requires a sophisticated pulverization technique to form such fine particles, but synthetic zeolite is advantageous because it can adjust the particle size t during its synthesis process. Preferred synthetic zeolites include, for example, A
Examples include zeolite, mordenite, 4A type, X type, and Y type.

Such acid treatment of zeolite is carried out by bringing the zeolite into contact with an acid.

Examples of acids include mineral acids such as sulfuric acid, hydrochloric acid, and nitric acid; organic acids such as citric acid, succinic acid, malic acid, and tartaric acid. Some zeolites, such as A-type zeolite, have their structures destroyed by acid, so it is generally best to make the acid into a solution of around 1M and add this to the slurry of zeolite under stirring. preferable.

Although the untreated zeolite has a pH of 10 or more, the acid treatment is performed until the pH of the acid-treated zeolite becomes 9 or less. In particular, since it is applied to the oral cavity, it is preferable to treat it to a pH of 13 to 6. The pH of zeolite was determined by sampling over time, and the solid content was approximately 5＠＠To
Measure the pH using a pH meter, and when the pH reaches a predetermined value, the treatment is terminated and thoroughly washed.

The acid-treated zeolite thus obtained may be blended into the oral composition as a slurry, or may be blended in a dried form. The amount of acid-treated zeolite to be blended can be selected within a wide range of 1 to 99% by weight of the total composition depending on the type of composition.

Examples of the oral composition of the present invention include dentifrice, chewing gum, troche tablets, and chewable tablets, and the components other than the acid-treated zeolite can be those normally used in these preparations. For example, as an abrasive for toothpaste, calcium hydrogen phosphate, calcium carbonate, aluminum hydroxide, alumina, hydrated silicic acid, anhydrous silicic acid, zolconicum silicate, insoluble sodium metaphosphate, calcium birophosphate, etc.; as a foaming agent, , sodium lauryl sulfate, sodium myristyl sulfate, sucrose long chain fatty acid ester, various amino acid long chain fatty acid amides, long chain fatty acid ethanolamide, ? Lioxyethylene alkyl ether,? Lioxyethylene? Ryzolovilenko? Rimmer? Lioxyethylene long chain fatty acid ester, sorbitol long chain fatty acid ester, ? Rioxyethylene Solpit long chain fatty acid esters, long chain fatty acid salts, Su? Ens,
Wetting agents include glycerin, Norbit solution, Zorobire 7 f IJ Cole, gyrolidone carboxylic acid salts, etc.; binders include carboxymethyl cellulose sodium, ? Sodium lyacrylate, carrageenan, xanthan gum, guar gum, gum gum, gum arabic, sodium alginate, gelatin, etc.; sweeteners include sodium saccharin, zopotassium glycyrrhizinate, licorice extract, NoQ latinose, as, Q luteme, stevioside, Active ingredients for preventing cavities and alveolar pyorrhea include ascorbic acid and its esters, azulene, dextranase, mutanase, amylase, protease, Su/Q-4, lytic enzyme, allantoin and its salts, 1-amitucazolonic acid, tranexamic acid, Irgasan DP-300, dihydrocholesterol, evidihydrocholesterol, cetylpyrizonium chloride, dequalinium chloride, sodium chloride, benzalkonium chloride, benzethonium chloride, lysozyme chloride, hydrochloride toxin, salts of chlorhexicine , di-α-me α-tocopherol dl-α-tocopherol acetate, nicotinic acid alkyl ester, sodium steel chlorophyllin, trichlorocarbanilide, halocarpan, hinokitiol, i-tin fluoride, sodium fluoride, ? Rie T Rengelicol, Sodium Monofluorophosphate, Glo? Squirrel, dew bee bunch, bow, toki, safflower,
etc.: Gum bases for chewing gum include natural chicle and vinyl acetate; excipients for troches and chewable tablets include lactose, crystalline cellulose, sucrose, and the like. Further, for the purpose of improving the feeling of use, a suitable flavoring agent such as peppermint, spearmint, anethole, etc. may be added.

[Action and effect]

Next, an experimental example will be shown to prove that acid-treated zeolite has an excellent adsorption effect on 4 substances that cause bad breath in the coexistence of water. In this experiment, we used methyl mercaptan, a major substance that causes bad breath, and synthetic zeolite, which has an average particle size of 3.63.
μ 4A type zeolite was used. That is, 10 to 100 zeolite samples were accurately weighed into a 10-sized glass test tube with a stopper, 129 m aqueous methyl mercaptan solution was added thereto, the stopper was sealed, the tube was shaken thoroughly, and the zeolite sample was heated to 20°C for 15 minutes.
After standing for a minute, free methyl mercaptan was determined by the DBC-Conway method. DBC-Conway method is BD
C-OH (4,4-pisuzomethylaminozophenylcargonylcarpinol) is acidic and carpinol? Immonium ion also exhibits a very strong blue color, but SH
This method takes advantage of the fact that this blue color disappears quickly when a compound is reacted. Specifically, the Conwaydis is a sealed container with two internally separated reservoirs.
BDC solution (0.1% BDC-OH acetone solution 50 pi, p
50 mM Tris-MaleateB of H6,5
After adding 10 ml of buffer and 100 µl of 10% sodium lauryl sulfate aqueous solution to the other reservoir, place 3 samples into the other reservoir, seal, and incubate at 37°C for 2 hours.
Incubated for hours.

After that, the HDC solution was cooled to room temperature and the 610! The absorbance at (3) was measured. Separately, a calibration curve was prepared in the same manner, and the amount of free methyl mercaptan was calculated. Figure 1 shows the results.

The vertical axis shows the amount of free methyl mercaptan remaining without being adsorbed on the zeolite, and the horizontal axis shows the amount of added zeolite. From this figure, it can be seen that the IOQ of the acid-treated zeolite has the same effect as the untreated zeolite 5089, that is, the acid-treated zeolite is superior to the untreated zeolite in adsorbing substances that cause bad breath.

〔Example〕

Next, the present invention will be explained in more detail by showing examples.
The invention is not limited to these examples.

Example 1 The following components were degassed and mixed to form a paste-like toothpaste.

Calcium hydrogen phosphate for toothpaste 35.0 Silicic anhydride zOcal? Sodium oxymethylcellulose 20 Sodium lauryl sulfate 1.7 Sodium saccharin 0.2 Glycerin
10.070% sorbitol liquid
15.0 Methyl Q Laben
0.1 fragrance
0.9 total 100.0W flea * Treated with 11M sulfuric acid aqueous solution to pH 7.0.

Example 2 Toothpaste The following ingredients were degassed and mixed to form a toothpaste with a translucent appearance.

Acid-treated zeolite *2 (4Afi, Hei 14 grain f4 Z Op)
5°OW% silicic anhydride
25.0 Cal? Sodium oxymethylcellulose
1.5 Sodium lauryl sulfate
1.5 Sodium
0.2 Glycerin 20.07
0% Sorbitol liquid 35.0 Butylno Q Lapen 0.1 Fragrance 0.9 Coloring agent Slight
Refining water balance meter
100.0W% *Treated with 21M hydrochloric acid aqueous solution and converted to p)(s, o).

Example 3 The following components were mixed to form a powdered dentifrice.

Precipitated calcium carbonate 70.0 Sodium lauroyl glutamate 0.5 Sucrose fatty acid ester Z5 Sodium saccharin 0.1 Flavor
Fine needle too, o
w% *SIM treated with citric acid aqueous solution to pH 7.5.

Example 4 The following components were mixed and a small amount of purified water was added to form a paste, which was then molded into a disk shape and dried to obtain a lozenge.

Citric acid 0.1 Stevioside 0.05 Dextrin
10.0 Gum Arabic 4
．． 0 flavors, trace lactose
Balance meter 100.0W Yuhon Treated with 41M tartaric acid aqueous solution and adjusted to pH 8.0.

Example 5 The following components were mixed and dry-compressed to obtain crushed tablets.

Dry aluminum hydroxide gel 45.0 Magnesium stearate 1, O Asno 9 Luteme 0.1 Fragrance Trace amount Magnesium aluminate metasilicate Balance meter 100.0 W% * Treated with SIM co-phosphoric acid aqueous solution, pH 7.2 What was said.

Example 6 The following ingredients were heat-coated and molded into chewing gum.

Gum base 20.0 Corn syrup 20.0 Flavor
Small amount of powdered sucrose
Balance meter 100.0Wi
6 *s IM Treated with malic acid aqueous solution to pH 6.5.

[Brief explanation of the drawing]

Figure 1 shows the adsorption and removal effect of methylmercazotane by zeolite in a water-coexisting system. that's all

Claims (1)

[Scope of Claims] 1. An oral composition characterized by containing acid-treated zeolite, which is obtained by treating zeolite with an acid to have a pH of 9 or less. 2. The oral composition according to claim 1, wherein the acid-treated zeolite content is 1 to 99% by weight of the total composition. 3. Zeolite is type A zeolite, type 4A zeolite,
The oral composition according to claim 1, which is selected from the group consisting of X-type zeolite, Y-type zeolite, and mordenite. 4. The oral composition according to claim 1 or 2, wherein the acid-treated zeolite has an average particle size of 1 to 10 μm.