JPS63145235A - External drug for skin - Google Patents
External drug for skinInfo
- Publication number
- JPS63145235A JPS63145235A JP61294423A JP29442386A JPS63145235A JP S63145235 A JPS63145235 A JP S63145235A JP 61294423 A JP61294423 A JP 61294423A JP 29442386 A JP29442386 A JP 29442386A JP S63145235 A JPS63145235 A JP S63145235A
- Authority
- JP
- Japan
- Prior art keywords
- water
- blueberry
- soluble
- skin
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940079593 drug Drugs 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 title abstract description 5
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 10
- 239000003381 stabilizer Substances 0.000 claims abstract 3
- 235000019216 blueberry extract Nutrition 0.000 claims description 17
- 229940055416 blueberry extract Drugs 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract description 9
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 abstract description 6
- 240000000851 Vaccinium corymbosum Species 0.000 abstract description 5
- 235000003095 Vaccinium corymbosum Nutrition 0.000 abstract description 5
- 235000017537 Vaccinium myrtillus Nutrition 0.000 abstract description 5
- 235000021014 blueberries Nutrition 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000600 sorbitol Substances 0.000 abstract description 4
- 235000010356 sorbitol Nutrition 0.000 abstract description 4
- 239000000284 extract Substances 0.000 abstract description 3
- 239000000843 powder Substances 0.000 abstract description 3
- 235000010265 sodium sulphite Nutrition 0.000 abstract description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract description 2
- 229930195725 Mannitol Natural products 0.000 abstract description 2
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 239000004310 lactic acid Substances 0.000 abstract description 2
- 235000014655 lactic acid Nutrition 0.000 abstract description 2
- 239000000594 mannitol Substances 0.000 abstract description 2
- 235000010355 mannitol Nutrition 0.000 abstract description 2
- 150000007524 organic acids Chemical class 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract description 2
- 239000003021 water soluble solvent Substances 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000845 maltitol Substances 0.000 abstract 1
- 235000010449 maltitol Nutrition 0.000 abstract 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 abstract 1
- 229940035436 maltitol Drugs 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- -1 anthocyanin glycosides Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000001593 sorbitan monooleate Substances 0.000 description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 description 2
- 229940035049 sorbitan monooleate Drugs 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、水溶性ブルーベリー抽出物を安定に含有する
皮膚外用剤に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external preparation for skin stably containing a water-soluble blueberry extract.
水溶性ブルーベリー抽出物はアントシアン配糖体を含ん
でいるため、きれいな紫色であり、色素として、また視
力の回復剤、毛細血管の抵抗力の増強剤などとしてヨー
ロッパ等で広く使用されている。Water-soluble blueberry extract has a beautiful purple color because it contains anthocyanin glycosides, and is widely used in Europe and other countries as a pigment, a vision restorer, and a capillary resistance enhancer.
しかし、水溶性ブルーベリー抽出物は非常に不安定であ
るため、通常の皮膚外用剤に安定に使用することができ
ない。これまで安定化のために数々の試みがなされてき
たが、いずれもうまくいかず、色が退色してしまい、効
果が無くなってしまう。However, water-soluble blueberry extract is extremely unstable and cannot be stably used in general skin preparations. Numerous attempts have been made to stabilize it, but all have failed, causing the color to fade and become ineffective.
本発明は、水溶性ブルーベリー抽出物を処方中で安定に
保つ目的でなされたものである。The present invention was made for the purpose of keeping water-soluble blueberry extracts stable in formulations.
即ち、本発明は、水溶性ブルーベリー抽出物を処方中で
安定に保つために、糖アルコールを含有することを特徴
とするものである。That is, the present invention is characterized by containing a sugar alcohol in order to keep the water-soluble blueberry extract stable in the formulation.
本発明の水溶性ブルーベリー抽出物は、野性あるいは栽
培のブルーベリーの果実を破砕して、水あるいは水溶性
溶剤で抽出した抽出液を濃縮乾燥した暗赤紫色の粉末で
ある。The water-soluble blueberry extract of the present invention is a dark reddish-purple powder obtained by crushing wild or cultivated blueberry fruit, extracting it with water or a water-soluble solvent, and concentrating and drying the extract.
本発明の糖アルコールとは、ｔａｇの分子のカルボニル
基を還元して得られる多価アルコールで、ソルビット、
マンニット、マルチソトなどがあげられる。The sugar alcohol of the present invention is a polyhydric alcohol obtained by reducing the carbonyl group of the tag molecule, and includes sorbitol,
Examples include mannitol and multi-soto.
本発明の皮膚外用剤は、水溶性ブルーベリー抽出物を含
む全組成物中に５重量％以上の量の糖アルコールを配合
することにより十分安定化することができるが、さらに
クエン酸、乳酸、コハク酸などの有機酸とそれらの塩な
どを使用してｐＨを３〜６の酸性に調節したり、亜硫酸
ナトリウム、ｄｌ−α−トコフェロールなどの抗酸化剤
を使用することによりさらに安定化することができる。The skin external preparation of the present invention can be sufficiently stabilized by incorporating sugar alcohol in an amount of 5% by weight or more into the entire composition containing the water-soluble blueberry extract, but it can also be stabilized by adding sugar alcohol in an amount of 5% by weight or more to the entire composition containing the water-soluble blueberry extract. Further stabilization can be achieved by adjusting the pH to an acidic level of 3 to 6 using organic acids such as acids and their salts, or by using antioxidants such as sodium sulfite and dl-α-tocopherol. can.
さらに本発明の皮膚外用剤は、通常化粧品、医薬品の外
用剤に使用される油相成分、界面活性剤、色素、香料、
防腐剤、ビタミン類、ホルモン類、動植物抽出物・酵素
などの生理活性物質、ヒアルロン酸などの保湿剤、その
他種々の薬剤と併用することができる。Furthermore, the skin external preparation of the present invention includes oil phase components, surfactants, pigments, fragrances, and the like, which are usually used in cosmetics and pharmaceutical external preparations.
It can be used in combination with preservatives, vitamins, hormones, physiologically active substances such as animal and plant extracts and enzymes, humectants such as hyaluronic acid, and various other drugs.
以下、本発明を実施例によりさらに具体的に説明するが
、本発明はこれら実施例に限定されない。尚実施例中の
％は重量％である。EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited to these Examples. Note that % in the examples is % by weight.
実施例１ クリームの調製
（Ａ）ブルーベリー抽出物 ０．６％セ
タノール １２ミリスチン酸イ
ソプロピル ２中鎖脂肪酸トリグリセリド
２ＰＯε（２０）ソルビタンモノオレエート７
．５水素添加レシチン １０（Ｂ）防腐
剤 ０．１亜硫酸ソーダ
０．３ソルビトール水溶液（７０％
）２５
乳酸 ｌ精製水で
１００（Ａ） 、 （Ｂ）を７０〜８
０°Ｃに加温溶解後、（Ｂ）を（Ａ）に加入乳化し、４
５〜４５°Ｃまで撹拌し、放置した。Example 1 Preparation of cream (A) Blueberry extract 0.6% cetanol 12 Isopropyl myristate 2 Medium chain fatty acid triglycerides
2POε(20) Sorbitan monooleate 7
．． 5 Hydrogenated lecithin 10 (B) Preservative 0.1 Sodium sulfite
0.3 sorbitol aqueous solution (70%
)25 lactic acid l with purified water
100 (A), (B) 70-8
After heating and dissolving at 0°C, (B) was added to (A) and emulsified.
Stir to 5-45°C and let stand.
本発明の糖アルコールを含まない従来のクリームでは、
１０日前後で水溶性ブルーベリー抽出物の退色が始まり
、約１ケ月経過後には黄褐色に変色してしまったが、実
施例１のクリームは３年以上安定であった。In the conventional cream that does not contain the sugar alcohol of the present invention,
The color of the water-soluble blueberry extract started to fade around 10 days, and the color changed to yellowish brown after about 1 month, but the cream of Example 1 was stable for more than 3 years.
実施例２ 乳液の調製
（Ａ）ブルーベリー抽出物 １．５％ＰＯ
Ｅ （２０）ステアリルエーテル １．０モノス
テアリン酸グリセリン １．０セタノール
０．５ステアリン酸
０．５ミツロウ ０．
５レシチン末 １．０スクワラ
ン １Ｏ００オクチルドデカノー
ル １０．０防腐剤
０．２（Ｂ）ソルビトール水溶液（７０％”）
２０．０カラギーナン ０．１
クエン酸 １精製水で
１００実施例１と同様の方法で製造
した。結果は実施例１と同様であった。Example 2 Preparation of emulsion (A) Blueberry extract 1.5% PO
E (20) Stearyl ether 1.0 Glyceryl monostearate 1.0 Cetanol
0.5 stearic acid
0.5 Beeswax 0.
5 Lecithin powder 1.0 Squalane 1000 Octyldodecanol 10.0 Preservative
0.2(B) Sorbitol aqueous solution (70%")
20.0 carrageenan 0.1
Citric acid 1 with purified water
100 Produced in the same manner as in Example 1. The results were similar to Example 1.
実施例３ スキンローションのＳＲＷ
（Ａ） ＰＯＨ（２０）ソルビタンモノオレエート１．
０％防腐剤 ０．１（Ｂ）
ブルーベリー抽出物 ０．５エタノール
１０マンニツト
１Ｏ６０グリセリン ３．
０クエン酸 １．０精製水で
１００（Ａ）を常温で混合し
、（Ｂ）も常温で混合する。Example 3 SRW of skin lotion (A) POH (20) Sorbitan monooleate 1.
0% preservative 0.1(B)
Blueberry extract 0.5 ethanol
10 mannits
1O60 glycerin 3.
0 citric acid 1.0 100 with purified water (A) is mixed at room temperature, and (B) is also mixed at room temperature.
（Ａ）と（Ｂ）を混合して均一にした。結果は実施例１
と同様であった。(A) and (B) were mixed and made uniform. The results are in Example 1
It was the same.
本発明は、水溶性ブルーベリー抽出物を安定に皮膚外用
剤に配合するもので、ブルーベリー抽出物の色の退色お
よび皮膚に対する効果の減少を防止することができる。The present invention stably incorporates a water-soluble blueberry extract into a skin external preparation, thereby preventing the blueberry extract from fading in color and reducing its effect on the skin.
すなわち、本発明によると、水溶性ブルーベリー抽出物
を３年以上安定に皮膚外用剤に配合することができる。That is, according to the present invention, a water-soluble blueberry extract can be stably incorporated into an external skin preparation for three years or more.
Claims (1)
膚外用剤において、ブルーベリー抽出物の安定化剤とし
て糖アルコールを配合してなることを特徴とする皮膚外
用剤。A skin external preparation containing a water-soluble blueberry extract as an active ingredient, characterized in that it contains a sugar alcohol as a stabilizer for the blueberry extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61294423A JPS63145235A (en) | 1986-12-10 | 1986-12-10 | External drug for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61294423A JPS63145235A (en) | 1986-12-10 | 1986-12-10 | External drug for skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63145235A true JPS63145235A (en) | 1988-06-17 |
Family
ID=17807567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61294423A Pending JPS63145235A (en) | 1986-12-10 | 1986-12-10 | External drug for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63145235A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006117700A (en) * | 1999-12-21 | 2006-05-11 | L'oreal Sa | Use of extract of at least one vaccinium-type plant as anti-glycation agent |
-
1986
- 1986-12-10 JP JP61294423A patent/JPS63145235A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006117700A (en) * | 1999-12-21 | 2006-05-11 | L'oreal Sa | Use of extract of at least one vaccinium-type plant as anti-glycation agent |
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