JPS6246908A - 水酸アパタイトの製造方法 - Google Patents
水酸アパタイトの製造方法Info
- Publication number
- JPS6246908A JPS6246908A JP18515085A JP18515085A JPS6246908A JP S6246908 A JPS6246908 A JP S6246908A JP 18515085 A JP18515085 A JP 18515085A JP 18515085 A JP18515085 A JP 18515085A JP S6246908 A JPS6246908 A JP S6246908A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyapatite
- reaction
- added
- molar ratio
- soluble calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims description 26
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims description 25
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 239000011575 calcium Substances 0.000 claims description 23
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 9
- 239000001506 calcium phosphate Substances 0.000 claims description 7
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 7
- 235000011010 calcium phosphates Nutrition 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 229910001424 calcium ion Inorganic materials 0.000 claims description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 2
- 230000003301 hydrolyzing effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 15
- 238000006460 hydrolysis reaction Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000007062 hydrolysis Effects 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 4
- 230000035484 reaction time Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 238000003746 solid phase reaction Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- -1 (CH Chemical compound 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001027 hydrothermal synthesis Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229910017974 NH40H Inorganic materials 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 235000011116 calcium hydroxide Nutrition 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18515085A JPS6246908A (ja) | 1985-08-23 | 1985-08-23 | 水酸アパタイトの製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18515085A JPS6246908A (ja) | 1985-08-23 | 1985-08-23 | 水酸アパタイトの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6246908A true JPS6246908A (ja) | 1987-02-28 |
| JPH0313162B2 JPH0313162B2 (enrdf_load_stackoverflow) | 1991-02-21 |
Family
ID=16165733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18515085A Granted JPS6246908A (ja) | 1985-08-23 | 1985-08-23 | 水酸アパタイトの製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6246908A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03146409A (ja) * | 1989-10-31 | 1991-06-21 | Sekisui Plastics Co Ltd | 水酸アパタイトの製造方法及び変成リン酸三カルシウムの製造方法 |
| GB2433257A (en) * | 2005-12-19 | 2007-06-20 | Accentus Plc | Preparation of hydroxyapatite |
| JP2007528833A (ja) * | 2003-07-16 | 2007-10-18 | イノフォス インコーポレーテッド | ヒドロキシアパタイトリン酸カルシウムの顆粒、それらの調製方法および使用 |
| JP2009136632A (ja) * | 2007-12-11 | 2009-06-25 | Yamahachi Shizai Kogyo Kk | インプラントの製造方法及び人工歯根の製造方法 |
| JP2021070619A (ja) * | 2019-11-01 | 2021-05-06 | ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 | 生産方法およびハイドロキシアパタイトの粒子 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS605009A (ja) * | 1983-06-22 | 1985-01-11 | Central Glass Co Ltd | ヒドロキシアパタイトの製造法 |
-
1985
- 1985-08-23 JP JP18515085A patent/JPS6246908A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS605009A (ja) * | 1983-06-22 | 1985-01-11 | Central Glass Co Ltd | ヒドロキシアパタイトの製造法 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03146409A (ja) * | 1989-10-31 | 1991-06-21 | Sekisui Plastics Co Ltd | 水酸アパタイトの製造方法及び変成リン酸三カルシウムの製造方法 |
| JP2007528833A (ja) * | 2003-07-16 | 2007-10-18 | イノフォス インコーポレーテッド | ヒドロキシアパタイトリン酸カルシウムの顆粒、それらの調製方法および使用 |
| JP4854507B2 (ja) * | 2003-07-16 | 2012-01-18 | イノフォス インコーポレーテッド | 顆粒形状のリン酸カルシウムの調製方法 |
| GB2433257A (en) * | 2005-12-19 | 2007-06-20 | Accentus Plc | Preparation of hydroxyapatite |
| JP2009136632A (ja) * | 2007-12-11 | 2009-06-25 | Yamahachi Shizai Kogyo Kk | インプラントの製造方法及び人工歯根の製造方法 |
| JP2021070619A (ja) * | 2019-11-01 | 2021-05-06 | ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 | 生産方法およびハイドロキシアパタイトの粒子 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0313162B2 (enrdf_load_stackoverflow) | 1991-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |