JPS6244919B2 - - Google Patents
Info
- Publication number
- JPS6244919B2 JPS6244919B2 JP60184995A JP18499585A JPS6244919B2 JP S6244919 B2 JPS6244919 B2 JP S6244919B2 JP 60184995 A JP60184995 A JP 60184995A JP 18499585 A JP18499585 A JP 18499585A JP S6244919 B2 JPS6244919 B2 JP S6244919B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- culture medium
- capsule
- membrane
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 102000014150 Interferons Human genes 0.000 claims description 20
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- 230000000813 microbial effect Effects 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 108010055896 polyornithine Proteins 0.000 description 1
- 229920002714 polyornithine Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 239000000007 protein synthesis inhibitor Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 210000002325 somatostatin-secreting cell Anatomy 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/32—Polylysine, polyornithine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/74—Alginate
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24358381A | 1981-03-13 | 1981-03-13 | |
| US243583 | 1981-03-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6188893A JPS6188893A (ja) | 1986-05-07 |
| JPS6244919B2 true JPS6244919B2 (de) | 1987-09-24 |
Family
ID=22919321
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57038238A Granted JPS5816693A (ja) | 1981-03-13 | 1982-03-12 | 細胞により産生される物質の製造方法 |
| JP60184995A Granted JPS6188893A (ja) | 1981-03-13 | 1985-08-22 | 細胞により産生される物質の製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57038238A Granted JPS5816693A (ja) | 1981-03-13 | 1982-03-12 | 細胞により産生される物質の製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| JP (2) | JPS5816693A (de) |
| BE (1) | BE892479A (de) |
| CA (1) | CA1172961A (de) |
| CH (1) | CH654328A5 (de) |
| DE (1) | DE3209127A1 (de) |
| DK (1) | DK112282A (de) |
| FR (1) | FR2503183B1 (de) |
| GB (1) | GB2094833B (de) |
| IT (1) | IT1150682B (de) |
| NO (1) | NO163060C (de) |
| SE (1) | SE454780B (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6414225U (de) * | 1987-07-15 | 1989-01-25 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
| US4582799A (en) * | 1983-04-15 | 1986-04-15 | Damon Biotech, Inc. | Process for recovering nonsecreted substances produced by cells |
| CA1196862A (en) * | 1983-06-01 | 1985-11-19 | Anthony M.F. Sun | Microencapsulation of living tissue and cells |
| JPS6025929A (ja) * | 1983-07-20 | 1985-02-08 | ザ・スト−ル・リサ−チ・アンド・デイベロツプメント・コ−ポレ−シヨン | カプセル化細胞、その製造方法および用途 |
| JPS60141281A (ja) * | 1983-12-28 | 1985-07-26 | Meiji Milk Prod Co Ltd | 菌体顆粒の製造方法及び装置 |
| EP0152898B1 (de) * | 1984-02-15 | 1990-01-17 | Massachusetts Institute Of Technology | Verfahren zur Verkapselung und Systeme mit verkapseltem Aktivmaterial |
| JPS60175539A (ja) * | 1984-02-23 | 1985-09-09 | Snow Brand Milk Prod Co Ltd | カプセル体およびその製造法 |
| GR851626B (de) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US6686455B1 (en) | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
| CA1241598A (en) * | 1984-07-11 | 1988-09-06 | Connaught Laboratories Limited | Droplet generation |
| EP0199362A3 (de) * | 1985-04-26 | 1987-10-07 | Massachusetts Institute Of Technology | System und Vorrichtung zur verzögerten und stossweisen Freisetzung biologisch aktiver Substanzen |
| CA1265443A (en) * | 1985-09-18 | 1990-02-06 | Elieser Gorelik | Assays for chemotherapeutic agents |
| DE3534983A1 (de) * | 1985-10-01 | 1987-04-02 | Sturge John & E Ltd | Komplexe immobilisierte biokatalysatoren sowie ihre herstellung und anwendung |
| JPS62166891A (ja) * | 1986-01-20 | 1987-07-23 | Snow Brand Milk Prod Co Ltd | 細胞培養による有用物質の製造方法 |
| AU6940087A (en) * | 1986-01-23 | 1987-08-14 | Ltl Associates | Covalent membranes |
| DE3615043A1 (de) * | 1986-05-03 | 1987-11-05 | Hoechst Ag | Verfahren zur verkapselung von biologisch aktivem material |
| IL79052A0 (en) * | 1986-06-06 | 1986-11-30 | Univ Ramot | Device and process for production of alginate-shell beads containing biologically active material |
| JP2530690Y2 (ja) * | 1986-08-28 | 1997-03-26 | カシオ計算機株式会社 | 電子楽器 |
| US5010010A (en) * | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
| US5420242A (en) * | 1986-10-22 | 1995-05-30 | Kaare M. Gautvik | Production of human parathyroid hormone from microorganisms |
| EP0383751B1 (de) | 1986-10-22 | 1994-03-09 | GAUTVIK, Kaare M., Dr. | Herstellung von human-parathyroidhormon |
| EP0355112A1 (de) * | 1987-04-22 | 1990-02-28 | Michael Bay | Zellkulturverfahren, -materialien und -produkte |
| JPH025797U (de) * | 1988-06-23 | 1990-01-16 | ||
| WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
| JP4215273B2 (ja) * | 1991-04-25 | 2009-01-28 | ブラウン ユニヴァーシティ リサーチ ファンデーション | 選択された治療物質放出用の移植可能で生体適合性の免疫遮断性ビークル |
| US5800829A (en) * | 1991-04-25 | 1998-09-01 | Brown University Research Foundation | Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
| DE4229526B4 (de) * | 1992-09-07 | 2006-02-16 | Schrezenmeir, Jürgen, Dr. | Vorrichtung zur Aufnahme und zum Einbringen von biologisch aktiven Geweben oder Zellen in den menschlichen Körper |
| US5908623A (en) * | 1993-08-12 | 1999-06-01 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| AU7568094A (en) * | 1993-08-12 | 1995-03-14 | Cytotherapeutics, Inc. | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| DE4426396A1 (de) * | 1994-07-26 | 1996-02-01 | Ulrich Prof Dr Zimmermann | Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form |
| US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
| SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| EP2673357A2 (de) * | 2011-02-07 | 2013-12-18 | Life Technologies Corporation | Zusammensetzungen und verfahren zur stabilisierung von empfindlichen verbindungen |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55157502A (en) * | 1979-03-28 | 1980-12-08 | Damon Corp | Live tissue encapsulation and tissue transplantation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4324683A (en) * | 1975-08-20 | 1982-04-13 | Damon Corporation | Encapsulation of labile biological material |
| NO158284C (no) * | 1981-03-13 | 1988-08-17 | Damon Biotech Inc | Fremgangsmaate for selektiv oppbrytning av en permeabel membran. |
| NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
-
1982
- 1982-03-11 NO NO820794A patent/NO163060C/no unknown
- 1982-03-12 GB GB8207309A patent/GB2094833B/en not_active Expired
- 1982-03-12 IT IT20140/82A patent/IT1150682B/it active
- 1982-03-12 DE DE19823209127 patent/DE3209127A1/de active Granted
- 1982-03-12 FR FR8204242A patent/FR2503183B1/fr not_active Expired
- 1982-03-12 CA CA000398218A patent/CA1172961A/en not_active Expired
- 1982-03-12 SE SE8201554A patent/SE454780B/sv not_active IP Right Cessation
- 1982-03-12 DK DK112282A patent/DK112282A/da not_active Application Discontinuation
- 1982-03-12 CH CH1575/82A patent/CH654328A5/de not_active IP Right Cessation
- 1982-03-12 JP JP57038238A patent/JPS5816693A/ja active Granted
- 1982-03-12 BE BE0/207559A patent/BE892479A/fr not_active IP Right Cessation
-
1985
- 1985-08-22 JP JP60184995A patent/JPS6188893A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55157502A (en) * | 1979-03-28 | 1980-12-08 | Damon Corp | Live tissue encapsulation and tissue transplantation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6414225U (de) * | 1987-07-15 | 1989-01-25 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3209127C2 (de) | 1988-02-04 |
| BE892479A (fr) | 1982-07-01 |
| NO163060B (no) | 1989-12-18 |
| CH654328A5 (de) | 1986-02-14 |
| CA1172961A (en) | 1984-08-21 |
| DK112282A (da) | 1982-09-14 |
| IT8220140A0 (it) | 1982-03-12 |
| GB2094833A (en) | 1982-09-22 |
| SE454780B (sv) | 1988-05-30 |
| NO163060C (no) | 1990-03-28 |
| GB2094833B (en) | 1984-06-20 |
| IT1150682B (it) | 1986-12-17 |
| NO820794L (no) | 1982-09-14 |
| SE8201554L (sv) | 1982-09-14 |
| JPS6188893A (ja) | 1986-05-07 |
| FR2503183B1 (fr) | 1985-11-08 |
| FR2503183A1 (fr) | 1982-10-08 |
| JPS6157288B2 (de) | 1986-12-06 |
| JPS5816693A (ja) | 1983-01-31 |
| DE3209127A1 (de) | 1982-12-09 |
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