JPS6244555B2 - - Google Patents

Info

Publication number
JPS6244555B2
JPS6244555B2 JP54019929A JP1992979A JPS6244555B2 JP S6244555 B2 JPS6244555 B2 JP S6244555B2 JP 54019929 A JP54019929 A JP 54019929A JP 1992979 A JP1992979 A JP 1992979A JP S6244555 B2 JPS6244555 B2 JP S6244555B2
Authority
JP
Japan
Prior art keywords
benzyl
ester
isoglutamine
solvent
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54019929A
Other languages
English (en)
Japanese (ja)
Other versions
JPS55111499A (en
Inventor
Juichi Yamamura
Ichiro Azuma
Sakae Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP1992979A priority Critical patent/JPS55111499A/ja
Priority to DE8080100811T priority patent/DE3061175D1/de
Priority to AT80100811T priority patent/ATE1906T1/de
Priority to EP80100811A priority patent/EP0014984B1/en
Priority to US06/123,401 priority patent/US4369178A/en
Priority to CA000346133A priority patent/CA1239636A/en
Publication of JPS55111499A publication Critical patent/JPS55111499A/ja
Publication of JPS6244555B2 publication Critical patent/JPS6244555B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP1992979A 1979-02-21 1979-02-21 Glucosamine derivative and its preparation Granted JPS55111499A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP1992979A JPS55111499A (en) 1979-02-21 1979-02-21 Glucosamine derivative and its preparation
DE8080100811T DE3061175D1 (en) 1979-02-21 1980-02-18 Glucosamine-peptide derivatives, their production and use
AT80100811T ATE1906T1 (de) 1979-02-21 1980-02-18 Glucosamin-peptid-derivate, ihre herstellung und verwendung.
EP80100811A EP0014984B1 (en) 1979-02-21 1980-02-18 Glucosamine-peptide derivatives, their production and use
US06/123,401 US4369178A (en) 1979-02-21 1980-02-21 Glucosamine peptide derivatives, their production and use
CA000346133A CA1239636A (en) 1979-02-21 1980-02-21 Glucosamine-peptide derivatives, their production and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1992979A JPS55111499A (en) 1979-02-21 1979-02-21 Glucosamine derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS55111499A JPS55111499A (en) 1980-08-28
JPS6244555B2 true JPS6244555B2 (enExample) 1987-09-21

Family

ID=12012904

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1992979A Granted JPS55111499A (en) 1979-02-21 1979-02-21 Glucosamine derivative and its preparation

Country Status (6)

Country Link
US (1) US4369178A (enExample)
EP (1) EP0014984B1 (enExample)
JP (1) JPS55111499A (enExample)
AT (1) ATE1906T1 (enExample)
CA (1) CA1239636A (enExample)
DE (1) DE3061175D1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2862107D1 (en) 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
US4406889A (en) * 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4368190A (en) * 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
JPS57144225A (en) * 1981-03-04 1982-09-06 Tadao Kokubu Antigenetic preparation for treating nonspecific allergic diseases and its preparation
JPS6042398A (ja) * 1983-08-18 1985-03-06 Toshiyuki Hamaoka ムラミルジペプチド活性エステル誘導体
US4933179A (en) * 1983-08-22 1990-06-12 Syntex (U.S.A.) Inc. Feline leukemia virus antigen vaccines
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4772466A (en) * 1983-08-22 1988-09-20 Syntex (U.S.A.) Inc. Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4770874A (en) * 1983-08-22 1988-09-13 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
FR2564096B1 (fr) * 1984-05-11 1988-02-19 Anvar Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir
GR851293B (enExample) * 1984-05-29 1985-11-25 Ciba Geigy Ag
JPS6157597A (ja) * 1984-08-29 1986-03-24 Toshiyuki Hamaoka ムラミルペプチド活性エステル誘導体
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
JPH0625067B2 (ja) * 1986-05-13 1994-04-06 全国農業協同組合連合会 子豚の離乳後下痢の感染防止法
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US5256646A (en) * 1990-07-27 1993-10-26 Bristol-Myers Squibb Company Antiviral antibiotic BU-4224V
JP2008528639A (ja) * 2005-02-04 2008-07-31 アルケミア リミティッド インテグリンと相互作用する化合物の複数のクラス
KR101203401B1 (ko) * 2005-06-08 2012-11-22 이쉥 바이오파마(싱가포르)피티이 리미티드 폴리이노신산-폴리시티딜산-기초 보조제
US20070166800A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
US20070166239A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant
FR2900150B1 (fr) * 2006-04-25 2012-07-06 Fluofarma Composes de type 1,4-naphtoquinones, compositions les comprenant et utilisation de ces composes en tant qu'agent anti-cancereux
GB2458473A (en) * 2008-03-17 2009-09-23 Imuthes Ltd 3'-O-allyl- and 3'-O-carboxymethyl- 2'-aminosaccharide derivatives, & amides thereof with peptides, as adjuvants
WO2014043792A1 (en) * 2012-09-19 2014-03-27 Fahkreddin Jamali Glucosamine pro-drugs
WO2016105274A1 (en) 2014-12-23 2016-06-30 Yisheng Biopharma (Singapore) Pte Ltd A rabies composition comprising pika adjuvant
CA3072735A1 (en) 2017-08-21 2019-02-28 Celgene Corporation Processes for the preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
GB1563561A (en) * 1976-06-23 1980-03-26 Daiichi Seiyaku Co Muramyldipeptide derivatives and process for the preparation thereof
DE2862107D1 (en) * 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes

Also Published As

Publication number Publication date
EP0014984A1 (en) 1980-09-03
DE3061175D1 (en) 1983-01-05
JPS55111499A (en) 1980-08-28
EP0014984B1 (en) 1982-12-01
CA1239636A (en) 1988-07-26
ATE1906T1 (de) 1982-12-15
US4369178A (en) 1983-01-18

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