JPS6241664A - Production of artificial dialyser - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (1) Background of the Invention (Technical Field) The present invention relates to a method for manufacturing an artificial dialysis device. Specifically, the present invention relates to a method for manufacturing an artificial dialysis device using regenerated cellulose hollow fibers, which has high dialysis ability and low water removal ability.

(Prior Art) Artificial dialysis machines used for hemodialysis of patients suffering from poisonous substance poisoning, etc., remove toxic metabolites or toxic substances contained in body fluids, such as urea, uric acid, and creatinine, from the blood. It is passed through the dialysis membrane of an artificial dialysis machine and transferred into the dialysate based on the difference in concentration, and one of the important functions of an artificial dialysis machine is to remove part of the water from body fluids.

Conventionally, such an artificial dialysis device (with two sets of dialysis membranes), a regenerating dialysis membrane, and four full acetic acid units.
1 of Su etc! There are some known materials, such as polysulfone, polyacrylic 1]-1, polymethylmethacryl, etc., but those that are currently in practical use are mainly derived from 1? With ruulose film C, special IC, copper nonon ■--71''! Regenerated cell []-lose film from ruulose (
There is. In addition, person 1 - dialysis machine (41, hollow fiber type, 211111 type, A Hυl'7 f
';: I don't know who it is, but the hollow fiber type () is the type that is most widely used at present. I'm here.

1. In the following, (as in 2) I-The dialysis machine must be selected to meet the patient's symptoms 15, [, b (゛, suitable water removal ability, and dialysis ability f2). Yes, for example, remembering the initial introduction of artificial dialysis (, 2 to 1.), 'C is an artificial dialysis machine with relatively low water removal capacity or suitable -' (・5゜This artificial dialysis machine with low water removal capacity Dialysis machines are conventionally used in 11
Increasing the film thickness of the 1-1-s hollow fiber, or adding c to the previous process of recycled 1"
f51. r'"" C1 [11 During plasticization [J Adjustment of glycerin suspension, smoothing concentration r = '/:) Adjustment b
Change in drying process 1 4 [How is JS?
Ll,,'s' will be C atl::=. However, such a method (, 'controlling water removal M by t,' requires unstable -C, and -t-''1:, for spinning hollow fibers with various performances. [,= means that there must be multiple production lines that correspond to each one.Extreme 1.: Unreasonable'(゛).

II. OBJECTS OF THE INVENTION Accordingly, it is an object of the present invention to provide a novel method for manufacturing a human 7F dialysis device. The object of the present invention is to provide a method for manufacturing an artificial dialysis machine that maintains high dialysis capacity and reduces water removal capacity.

An object of the present invention is to provide a method for manufacturing an artificial dialysis device 6 suitable for use in artificial dialysis patients.

After loading these regenerated cell [course hollow fiber bundles] into the cylindrical body and fixing both ends to the cylindrical body, the regenerated cellulose hollow fibers were heated at 60 to 150°C.
This is achieved by a process for manufacturing an artificial dialysis device, which is characterized by contacting with heated air.

The present invention is J2, hot air is passed for 10-120 seconds 4\4
].

11) '(,-'Manufacture of an artificial dialysis device)) method must be small. 7 The present invention l is further characterized in that the hot air is brought into contact with the hollow surface, inside the fibers, and the two hot air are passed through i11 and (J'). )
15j method” (“3, present invention 1.-1,
In addition, the contact with the hot air is made on the outside of the hollow fiber box.
= mature fever 1fdξ (, 2, II Umono C ゛ some people r dialysis M ”) J alliance) ? A method for manufacturing an artificial dialysis device is shown in which hollow fibers are made from a copper-based spinning solution. - From Hayashi's explanation - 1. The present invention is described in detail in the drawings.

Fig. 14, 1 Method of manufacturing an artificial dialysis device of the present invention.
Example 1. 2;(-J Diagram H-Q showing hot air treatment rod
be. 1Figure 11.゛As shown, the artificial dialysis device of the present invention: 4 construction methods 1, JL, regeneration 1' bill loss hollow fiber M
The end '1 is loaded into the cylindrical body 2 of the artificial dialysis machine (, = loaded,
When assembled by fixing both ends thereof, one of the blood vessels 1-4. Connect the circuit chip 1-7e to the air supply source (
The air pumped through 5 is heated to 60...150°C, preferably 100 to 140°C, at a temperature of 1 to 150°C.
, the blood flow, 11, or dialysis) 1
The regeneration cell of the artificial dialysis device 3 is then fed from the bow into the artificial dialysis device 3. At the stage when the hollow fiber bundle 1 has been fixed by tightening the two ends of the hollow fiber bundle 1, the circuit 1]-
・P7 (suitable 4 connected to this): Whichever holds the gripping tool on one end ('-J' S-J hot air treatment)
After that, assemble the artificial dialysis machine (c7.,,,,,,
L" is also possible.

Present invention 14': Regeneration cell of the artificial dialysis device 3 used [
Course hollow fiber 1. Yes, as long as it has a high dialysis capacity, you can use it (preferably a regenerated cell that can be prepared from 1-coat of copper ammonia).
-S hollow fiber ℃ available, for example $14 nonon 1 nini S, a L? /Relose) 8 liquid (7) Mix the permeation performance control agent according to
Discharge from the annular spinning hole 1], simultaneous N (-inner center & J
Introducing and filling the ul-coagulating and homogeneous liquid (ノ, ′) τ″ Passing through the coagulating liquid (′8-C) Pseudo-solidification regeneration (・, Washing the hollow fibers obtained in this way) If necessary, the beef tortoise can be treated with glycerin, and then "dried" by an appropriate method. []-S hollow fiber has a film thickness of 5-
・30μ〃・x,,tlf or 10-25μm
It's only to a certain extent.

<T,,,, (7) J, -)1Jlj 1111
E-t, y and reulose hollow fiber t1, j, predetermined length)
5. Cutting 1. ＼After 11, the required membrane area has been achieved. G, W
Apply bojing agent ε such as Boliu 1 Nokun to both ends of the middle part.
By sealing both ends of the cylindrical main body 2 at 3 and 9 (-14), blood inflow balls 1- 4 again (Yo discharge board 1-
10 respectively equipped λl, - header '11.12 are respectively abutted, and the header i1 is abutted by a cap 13.14.
．． 12 and the cylindrical main body 2 are each firmly shielded. Note that both end portions 1 of the cylindrical main body 2. − is dialysis Shibukawa inflow port 1.
15 ('j3 and ↑ノ1 output port 1 (5 are respectively set).

In this way, after assembling the artificial dialysis machine J3,
The blood inflow boat 1"-10 (or discharge boat 1"-10) of the artificial dialysis machine 33 is connected to the dialysate inflow boat 15 (or outflow boat 1...16), with a heater 5 on the way. 7 is connected to the air supply source 6 via an air heating device such as a Artificial dialysis machine: 30 blood baud t-=1
1. Send hot air. The hot air is heated to (30 to 150'C)
1, preferably at a temperature of 100-140'C.

(The higher the temperature of the hot air, the lower the water removal ability of the artificial dialysis machine.
Considering the deterioration due to J, 100=140°C is optimal. The appropriate time for this hot air treatment is 10 to 120 seconds, preferably 30 to 60 seconds, and the blowing pressure of the hot air per $15 of the hollow area is 0.5 to 2゜Okq/cm2.
, preferably 1.0 to 1.5 kg/cm2. The hot air 1 that entered from Blood Bo 1-4 is each regeneration 11? le [1
-・After passing through the inside of the hollow fiber, the other blood bowl 1-
10 and dialysate boat 15. From 16, artificial dialysis device 3
leaks to the outside. In addition, hot air treatment may be performed by i-1 or 10 before installing the header 11.12 on the human]-7 dialysis machine. In this case, the end 1. of the circuit Ch], -17. ·two,
A knee octave (not shown) may be provided at the end of the cylindrical body 2 in a substantially airtight manner.

Surprisingly [1-1] By performing a simple hot air treatment like this for 4f, the regenerated cell 1-course hollow fiber has no effect on the dialysis capacity of the hollow fiber (,71,;t: However, it has become clear that the water removal ability can be reduced by 1.

I don't know the exact reason, but from the hot air treatment eaves mentioned above,
After the shape of the hollow fibers is almost determined (regenerated cellulose (・
(If any, after solidification) manufacturing history
':? It is thought that a change has occurred.

As described above, the dialysis machine ()-C1, which has been assembled and then subjected to hot air treatment, is then sterilized by, for example, the T-tyrene A-killed gas sterilization method, and the dry type dialysis machine is
It is provided as a dialysis machine.

In the above explanation, hot air is mainly brought into contact with the inside of the hollow fibers, but the invention is not limited to this, but heat 1@ is introduced from any of the dialysate tubes and the hot air is brought into contact with the outside of the hollow fibers. 1. In addition, from the viewpoint of the configuration of the dialysis apparatus, it is considered more reliable to introduce hot air into each hollow fiber from a blood boat. In addition, the artificial dialysis machine is filled with an aqueous solution that is harmless to the living body, such as physiological saline or distilled water (after 7 days,
High-pressure steam sterilization 1Σ1 may be performed. Any known sterilization method (for example, radiation sterilization method) may be used.

Next, the present invention will be further explained in detail by giving two practical examples.

Example 1 Human knee dialysis with an inner diameter of approximately 200 μm, a membrane h' of 120 m, a copper ammonia with an h-efficiency of 2235 mn+, and approximately 6,800 cellulose hollow fibers with an effective membrane surface of approximately 1.0 m. Assembled the device. L for the semi-finished product of this artificial dialysis machine
After passing hot air at 140'C for 60 seconds from the ffxi liquid po I on the 'l side, ]-tyrene A'A4 noid gas sterilization was performed. ./i, the water removal ability, the removal of urea, crej7dinine and ditamin [312], and the permeability of 1. inulin were measured.

d3, water removal ability is T”MP (Note 1 ”) 1 (,)
0...mouth'i Hq 17. Under the conditions, city water was circulated at 37°C and a flow rate of 200 d/min.
) is measured (Note): (P i +Po)/
2=-200mn+Hq) Removal ability of mamu, urea, Claire J, Ni and vitamin mouth 12) For 4 parts, each ingredient is 2m! If/dl-containing solution was added to the blood side of the artificial dialysis machine at 37°C (-flow m2c',',',
',) C',) mρ/ Ill in the flow't
-”-10,000, dialysate side (, 0, jl, 37°C water flow, 500 d/n1in ′i: S, tl:.

At this time, the pressure force Δ- on the blood side is 0 and 1), and water removal is 43:
The state of 1j is the state of ;,'! ! CL,,,ii
>The person on the white liquor side (1 side solution out [-1 side solution 1.-1
j combination L), concentration ii difference of each component (;-J, extracted lζ: 1. Regarding the transmittance of inulin -<7 is 20 towns/'dl, ゛0. 01M phosphate buffer) volume) (([)t]6, ε3) A7 Warm to 37°C, artificial)6 (c) Blood side of the apparatus (, J) volume 'r)0'
(',',) Circulation at mρ/mi mouth [,・,T' M
P 20 On+mt1g 1. , knee (, limit syndrome) (
ritototo ``'' side solution worinburi] / gushi konomi ratio 4゛ found (
-Transmittance 7j.

Example 2 Assembled in the same manner as in Example 1 (-1. Half-finished dialysis machine for two people 1. = )! + side blood port,], 125'G
The heat is passed for 50 seconds. After the hot air treatment, row f5: -] - Blend 1st: is passed for gas sterilization. Water removal performance of the artificial dialysis machine, I)): Measurement of removal ability of base, taleabunin + 3, and terminus 1312, as well as permeability of inulin. The results are shown in Table 1.

Example Knee 3 Same as actual ff1D Example 1 except that the hot air hijin * = J-'l side J Ur '$ Tabor 1゛.

Comparative Example Same as Example 1 (J' group S''7 t: 9 I11 Artificial transparent 'tR semi-finished product directly from the machine was heated with hot air treatment)
也1"km Ii 'J'-1 non-i-=x=perform side gas sterilization] C product (↓?1. 1 Removal ability of noatinine A3 and vitamin [312] Transmittance of nage (z) imerin was measured and compared with Example 3, Results 4, Table ')
J, shown.

I'm sorry for the inconvenience. Specific details of the invention As mentioned above, the present invention provides a regeneration cell r'l
- Insert the bundle of ``intermediate fibers'' into the cylindrical body [JT, and fix both ends of the cylindrical body 11 and the regenerated cell l.
11-・Su hollow fiber navy blue-M',, 60...150'C
(The cap of the artificial dialysis machine) 1 (There is a 7-buf method, so the regeneration cell []-
Production of Hollow Fibers - 1. II 5 - U, ii 3. During plasticization (includes 1.0% of phosphorus in 1.0%; adjustment of bottled concentration is also 1.) < is a change in drying conditions If you want to control the water removal ability from % etc. (1), you can control the water removal ability with a more stable IC and simple operation (2) It is a dry type artificial with a relatively low water removal ability, which is required for patients with dialysis who are initially introduced to artificial dialysis. According to the manufacturing method of the present invention, it is possible to assemble an artificial dialysis device.
7; After T, the regenerated cell [60-150
It is possible to treat the regenerated hollow fibers prepared under the same conditions by treating them with hot air through the hot air of -(,'), which has different water removal abilities. This makes it unnecessary to set up production lines for regenerated cellulose hollow fibers for each water removal capacity.

In addition, the obtained artificial dialysis device has a hot air treatment time of 10 to 1
The regenerated cellulose hollow fiber is obtained from a copper ammonia cellulose spinning dope, which is better.

[Brief explanation of drawings]

FIG. 1 is a diagram showing a hot air treatment process in an embodiment of the manufacturing method of the present invention. DESCRIPTION OF SYMBOLS 1... Regenerated cellulose hollow fiber bundle, 2... Cylindrical main body, 3... Artificial dialysis device, 4, 10... Blood boat, 5... Heater, 6... Air supply source.

Claims (5)

[Claims] (1) A regenerated cellulose hollow fiber bundle is inserted into a cylindrical body, both ends of which are fixed to the cylindrical body, and then the regenerated cellulose hollow fibers are brought into contact with hot air at 60 to 150°C. A method for manufacturing a dialysis device. (2) The method for manufacturing an artificial dialysis device according to claim 1, wherein the hot air is passed for 10 to 120 seconds. (3) The method for manufacturing an artificial dialysis device according to claim 1 or 2, wherein the contact with hot air is performed by passing hot air through the hollow fibers. (4) The method for manufacturing an artificial dialysis device according to claim 1 or 2, wherein the contact with hot air is performed by passing hot air through the outside of the hollow fiber. (5) Claim 1, wherein the regenerated cellulose hollow fibers are obtained from a copper ammonia cellulose spinning dope.
4. A method for manufacturing an artificial dialysis device according to any one of items 4 to 4.