JPH029418A - Manufacture of non-exothermic solution - Google Patents
Manufacture of non-exothermic solutionInfo
- Publication number
- JPH029418A JPH029418A JP1095083A JP9508389A JPH029418A JP H029418 A JPH029418 A JP H029418A JP 1095083 A JP1095083 A JP 1095083A JP 9508389 A JP9508389 A JP 9508389A JP H029418 A JPH029418 A JP H029418A
- Authority
- JP
- Japan
- Prior art keywords
- compartment
- pressure
- dialysis membrane
- distilled water
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 238000000502 dialysis Methods 0.000 claims abstract description 17
- 239000012528 membrane Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 230000001698 pyrogenic effect Effects 0.000 claims abstract description 5
- 230000002706 hydrostatic effect Effects 0.000 abstract description 4
- 150000003839 salts Chemical class 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1672—Apparatus for preparing dialysates using membrane filters, e.g. for sterilising the dialysate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F21/00—Dissolving
- B01F21/30—Workflow diagrams or layout of plants, e.g. flow charts; Details of workflow diagrams or layout of plants, e.g. controlling means
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は１１色者に注入するだめの無菌の非発熱性溶液
を製造する方法に関する。DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a method for producing a sterile, non-pyrogenic solution for injection into eleven patients.
（従来の技術）
溶液をバッグ（袋）に入れてからその内容物を滅菌する
ことにより、上述したような溶液を得ることは知られて
いる。また、フィルタを使用することも知られている。BACKGROUND OF THE INVENTION It is known to obtain solutions such as those described above by placing the solution in a bag and then sterilizing the contents. It is also known to use filters.
蒸留法も利用されている。Distillation methods are also used.
（発明の概要）
本発明の発明者は、上述したような無菌の非発熱性溶液
を得る手段として、透析膜の蒸留水側の圧力を溶質溶液
側の圧力より高く維持するようにしながら、この透析膜
を通して所望の溶質を蒸留水中に取り入れるようにする
のが有効であると考え ！二 。(Summary of the Invention) As a means for obtaining a sterile, non-pyrogenic solution as described above, the inventor of the present invention has developed a system in which the pressure on the distilled water side of the dialysis membrane is maintained higher than the pressure on the solute solution side. We believe that it is effective to introduce the desired solute into distilled water through a dialysis membrane! Two.
（実施例）
添付図面に基づいて本発明の望ましい実施例について説
明する。(Example) A preferred example of the present invention will be described based on the accompanying drawings.
水道水を蒸留器１０４こ入れて蒸留水をつくり、それを
透析装置１４の区画室１２に入れる。区画室１２と区画
室１６との間には溶質透析膜１８が設けられている。Tap water is introduced into the distiller 104 to produce distilled water, which is then introduced into the compartment 12 of the dialysis machine 14. A solute dialysis membrane 18 is provided between compartment 12 and compartment 16.
区画室１６内に導入される塩溶液は、区画室１２から出
てゆく蒸留水に導入されるべき所望の濃度の塩類を含ん
でいる。成分を例示すれば、次のようである。The salt solution introduced into compartment 16 contains the desired concentration of salts to be introduced into the distilled water exiting compartment 12. Examples of the components are as follows.
溶 質 ミ リ当量Ｎｓ
１２４．８７Ｋ
１．９７ＭＥ
Ｏ，７４
Ｃｓ ２．９５
ＣＩ １０３．９９
Ｃ，Ｈ，０，１，９７
ＣｚＯｓ ２４．５６区画室１２の入
口における静水圧は、区画室１６の入口における静水圧
よりも７５＋＊ｍＨ！たけ高くされており、透析膜１８
の両側（区画室１２側および区画室１６側）で該透析膜
１８に沿って圧力降下が生じても、区画室１２ｇ１の圧
力が透析膜１８の領域の全範囲にわたって区画室１６側
の圧力よりも高くなるようになされている。Solute milliequivalent Ns
124.87K
1.97ME
O,74 Cs 2.95 CI 103.99 C,H,0,1,97 CzOs 24.56 The hydrostatic pressure at the inlet of compartment 12 is 75+*mH higher than the hydrostatic pressure at the inlet of compartment 16! The dialysis membrane 18
Even if a pressure drop occurs along the dialysis membrane 18 on both sides (the compartment 12 side and the compartment 16 side), the pressure in the compartment 12g1 is lower than the pressure on the compartment 16 side over the entire area of the dialysis membrane 18. It is also becoming more expensive.
流れは並流であり、流量速度は蒸留水の区画室１２で５
０１／分、溶液の区画室１６で５００１／分である。The flow is co-current and the flow rate is 5 in the distilled water compartment 12.
01/min, and 5001/min in solution compartment 16.
【図面の簡単な説明】
第１図は本発明による方法を実施する行程を模式的に示
した図である。
１０ ：
ｌ ４ ：
１８ ：
蒸留器
透析装置
透析膜
１２ ：
ｌ ６ ：
第１の区画室
第２の区画室
図面の浄書（内容に変更なし）
ノリ
手
続
捕
Ｆ
書
′ノ
゛う。
田′１の表小
゛１′成１年特ｒ「願第９５０８３号
発明の名称
非発熱性溶液の製造ｈｔ１：
１山ＩＦをする乙
Ｊ＃件との関係 特許出願人
住所
名 １ｊト コープ・ラボラトリーズ・インコーホ
レーテッド新人−ｆ町ビル
２０６区
５゜
浦１「の対象
１［１願大の代表古名を記載した願古BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram schematically showing steps for implementing the method according to the present invention. 10: 14: 18: Distiller dialysis equipment dialysis membrane 12: 16: Reproduction of drawings of the first compartment and second compartment (no changes to the contents). Name of the invention No. 95083 Manufacture of non-pyrogenic solution・Laboratories Incorporated Newcomer - F Town Building 206 Ward 5゜ura 1 Target 1 [1 Ganko with the representative ancient name of Gandai
Claims (1)
つの区画室を有する透析装置の第１の区画室へと第１の
圧力で蒸留水を供給し、該透析装置の第２の区画室へと
第２の圧力で前記溶液を供給し、前記第１の圧力は、前
記第１の区画室内の圧力が、前記透析膜の領域の全体に
わたつて、前記第２の区画室内の圧力よりも高い状態を
維持できる程度に、前記第２の圧力よりも高くされてい
ることを特徴とする、非発熱性溶液の製造方法。supplying distilled water at a first pressure to a first compartment of a dialysis machine having two compartments separated by a dialysis membrane permeable to solutes in the solution; the solution at a second pressure, the first pressure being such that the pressure in the first compartment is lower than the pressure in the second compartment over the entire area of the dialysis membrane. A method for producing a non-pyrogenic solution, characterized in that the pressure is set higher than the second pressure to such an extent that the pressure is maintained at a high level.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18192488A | 1988-04-15 | 1988-04-15 | |
| US181924 | 1988-04-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH029418A true JPH029418A (en) | 1990-01-12 |
| JP2901638B2 JP2901638B2 (en) | 1999-06-07 |
Family
ID=22666376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1095083A Expired - Lifetime JP2901638B2 (en) | 1988-04-15 | 1989-04-14 | Method for producing non-pyrogenic solution |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2901638B2 (en) |
| CA (1) | CA1327756C (en) |
| DE (1) | DE3912221A1 (en) |
| FR (1) | FR2630021B1 (en) |
| GB (1) | GB2217230B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9025506B2 (en) | 2012-08-30 | 2015-05-05 | Kabushiki Kaisha Toshiba | Wireless communication device, wireless communication system and wireless communication method |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE29616876U1 (en) * | 1996-06-10 | 1997-01-23 | Eichenauer Johannes Dipl Agr I | Device for disinfecting and / or sterilizing medical instruments or materials |
| US6582385B2 (en) * | 1998-02-19 | 2003-06-24 | Nstage Medical, Inc. | Hemofiltration system including ultrafiltrate purification and re-infusion system |
| RU2457894C1 (en) * | 2010-12-27 | 2012-08-10 | Государственное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ГОУ ВПО ВГУ) | Method of phenylalanine and sodium chloride separation by dialysis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB179919A (en) * | 1921-05-11 | 1923-07-24 | Jenaro Puglia | Improvements in, and apparatus for, effecting the removal of chlorides from milk |
| FR1080485A (en) * | 1951-11-17 | 1954-12-09 | Kodak Pathe | Process for removing excess bromide from spent photographic developers |
| EP0097863A3 (en) * | 1982-06-30 | 1984-04-18 | Gambro Lundia AB | Mixing fluids by means of semipermeable membranes |
| US4523998A (en) * | 1983-12-05 | 1985-06-18 | General Electric Company | Continuous ion exchange process using thermally regenerable liquid ion exchangers |
| JPS61167907U (en) * | 1985-04-05 | 1986-10-18 |
-
1989
- 1989-04-13 DE DE3912221A patent/DE3912221A1/en not_active Ceased
- 1989-04-14 GB GB8908502A patent/GB2217230B/en not_active Expired - Lifetime
- 1989-04-14 JP JP1095083A patent/JP2901638B2/en not_active Expired - Lifetime
- 1989-04-14 FR FR8904994A patent/FR2630021B1/en not_active Expired - Fee Related
- 1989-04-17 CA CA000596836A patent/CA1327756C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9025506B2 (en) | 2012-08-30 | 2015-05-05 | Kabushiki Kaisha Toshiba | Wireless communication device, wireless communication system and wireless communication method |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2901638B2 (en) | 1999-06-07 |
| GB8908502D0 (en) | 1989-06-01 |
| FR2630021A1 (en) | 1989-10-20 |
| GB2217230B (en) | 1991-09-18 |
| CA1327756C (en) | 1994-03-15 |
| DE3912221A1 (en) | 1989-10-26 |
| GB2217230A (en) | 1989-10-25 |
| FR2630021B1 (en) | 1993-03-26 |
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