GB2217230A - Method and apparatus for preparing solutions - Google Patents
Method and apparatus for preparing solutions Download PDFInfo
- Publication number
- GB2217230A GB2217230A GB8908502A GB8908502A GB2217230A GB 2217230 A GB2217230 A GB 2217230A GB 8908502 A GB8908502 A GB 8908502A GB 8908502 A GB8908502 A GB 8908502A GB 2217230 A GB2217230 A GB 2217230A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compartment
- pressure
- solution
- pyrogenic
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1672—Apparatus for preparing dialysates using membrane filters, e.g. for sterilising the dialysate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F21/00—Dissolving
- B01F21/30—Workflow diagrams or layout of plants, e.g. flow charts; Details of workflow diagrams or layout of plants, e.g. controlling means
Description
2217Z6U g 2 METHOD AND APPARATUS FOR PREPARING SOLUTIONS This invention
relates to a method for preparing solutions, and more particularly to a method for preparing sterile non-pyrogenic solutions for infusion into patients.
It has previously been proposed to prepare sterile non-pyrogenic solutions for infusion into patients by placing the solution in a bag and then sterilizing its contents. Alternatively, filters have been used. Finally, distillation has been used.
We have discovered that such solutions may be desirably provided by introducing into distilled water the desired solutes through a dialyzer membrane while maintaining in the dialyzer a higher pressure on the distilled water side of the membrane than on the solute solution side.
The present invention provides in one aspect thereof, a method for preparing non-pyrogenic solution comprising the step of providing distilled water to a first compartment of a dialyzer at a first pressure and providing a solution to a second compartment of said dialyzer at a second pressure, the compartments being separated by a membrane permeable to a solute of said and said first pressure being sufficiently higher than said second pressure to maintain pressure throughout said first compartment higher than pressure throughout said second compartment.
In a second alternative aspect, the invention 0 2 provides apparatus for preparing non-pyrogenic solutions, comprising: a dialyzer having two compartments separated from each other by a membrane permeable to desired solute; and a source of distilled water adapted to provide distilled water to an inlet of one said compartment, there being an outlet from said one compartment for non-pyrogenic solution, the second compartment having.an inlet for a solution of desired solute, the apparatus being further adapted so that in operation, pressure in the first compartment is maintained higher than in the second compartment.
The invention will hereinafter be described by way of example only. with reference to the single figure of accompanying drawings, which shows a diagramatic representation of apparatus for use in conjunction with a method according to the present invention.
Tap water enters still 10 to provide distilled water to compartment 12 of dialyzer 14. Extending between compartment 12 and compartment 16 is solute-permeable membrane 18.
The salt solution introduced into chamber 16 has approximately the concentrations of salts desired to be c 1 3 provided into the distilled water emerging from the compartment 12. for example:
Solute Na K Mg Ca ci C2H302 HC03 Milliequivalents/litre-(mM) 124.87 1.97 0.74 2.95 103.99 1.97 24.56 Hydrostatic pressure at the inlet to compartment 12 is 75mm Hg (104N.m-2) greater than that at the inlet to compartment 16, to maintain a greater pressure on the compartment 12 side of diaphragm 18 therealong despite pressure drops therealong on both sides thereof.
Flow is concurrent, at 50 ml/min in water compartment 121 and 500 ml/min in solution compartment 16.
1 z
Claims (4)
1. A method for preparing a non-pyrogenic solution comprising the step of providing distilled water to a first compartment of a dialyzer at a first pressure and providing a solution to a second compartment of said dialyzer at a second pressure, the compartments being separated by a membrane permeable to a solute of said solution, and-said first pressure being sufficiently highe r than said second pressure to maintain pressure throughout said first compartment higher than pressure throughout said second compartment.
Apparatus for preparing non-pyrogenic solutions, comprising: a dialyzer having two compartments separated from each other by a membrane permeable to desired solute; and a source of distilled water adapted to provide distilled water to a inlet of one said compartment. there being an outlet from said one compartment for non-pyrogenic solution. the second compartment having an inlet for a solution of desired solute. the apparatus being further adapted so that in operation, pressure in the first compartment is maintained higher than in the second compartment.
3. A method for preparing a non-pyrogenic solution substantially as hereinbefore described, with reference to the accompanying drawing.
4. Apparatus for preparing non-pyrogenic solutions, substantially as hereinbefore described, with reference to and as shown in the accompanying drawing. a Publiabbil 19N atThefttentOffloe. ROUSe, 86"71 EE%h HOIbOrn. LOndOn WCIR 4TP. Further 00PIeS Maybe obtLinedfroM The pjtmt Office. Sees Brandh; St Mary Cray, OrPington. Kent ER5 3W. P=ted by Multiplex tacbxdques ltd. St MLry Cray, xent, Con. I/S7
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18192488A | 1988-04-15 | 1988-04-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8908502D0 GB8908502D0 (en) | 1989-06-01 |
| GB2217230A true GB2217230A (en) | 1989-10-25 |
| GB2217230B GB2217230B (en) | 1991-09-18 |
Family
ID=22666376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8908502A Expired - Lifetime GB2217230B (en) | 1988-04-15 | 1989-04-14 | Method and apparatus for preparing solutions |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2901638B2 (en) |
| CA (1) | CA1327756C (en) |
| DE (1) | DE3912221A1 (en) |
| FR (1) | FR2630021B1 (en) |
| GB (1) | GB2217230B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19640034A1 (en) * | 1996-06-10 | 1997-12-11 | Eichenauer Johannes Dipl Agr I | Process for disinfecting and / or sterilizing medical instruments or materials and device for carrying out the process |
| US6582385B2 (en) * | 1998-02-19 | 2003-06-24 | Nstage Medical, Inc. | Hemofiltration system including ultrafiltrate purification and re-infusion system |
| RU2457894C1 (en) * | 2010-12-27 | 2012-08-10 | Государственное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ГОУ ВПО ВГУ) | Method of phenylalanine and sodium chloride separation by dialysis |
| JP5808719B2 (en) | 2012-08-30 | 2015-11-10 | 株式会社東芝 | Wireless communication device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB179919A (en) * | 1921-05-11 | 1923-07-24 | Jenaro Puglia | Improvements in, and apparatus for, effecting the removal of chlorides from milk |
| GB709179A (en) * | 1951-11-17 | 1954-05-19 | Kodak Ltd | Improvements in reconditioning used photographic developer solutions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0097863A3 (en) * | 1982-06-30 | 1984-04-18 | Gambro Lundia AB | Mixing fluids by means of semipermeable membranes |
| US4523998A (en) * | 1983-12-05 | 1985-06-18 | General Electric Company | Continuous ion exchange process using thermally regenerable liquid ion exchangers |
| JPS61167907U (en) * | 1985-04-05 | 1986-10-18 |
-
1989
- 1989-04-13 DE DE3912221A patent/DE3912221A1/en not_active Ceased
- 1989-04-14 FR FR8904994A patent/FR2630021B1/en not_active Expired - Fee Related
- 1989-04-14 JP JP1095083A patent/JP2901638B2/en not_active Expired - Lifetime
- 1989-04-14 GB GB8908502A patent/GB2217230B/en not_active Expired - Lifetime
- 1989-04-17 CA CA000596836A patent/CA1327756C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB179919A (en) * | 1921-05-11 | 1923-07-24 | Jenaro Puglia | Improvements in, and apparatus for, effecting the removal of chlorides from milk |
| GB709179A (en) * | 1951-11-17 | 1954-05-19 | Kodak Ltd | Improvements in reconditioning used photographic developer solutions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2630021B1 (en) | 1993-03-26 |
| DE3912221A1 (en) | 1989-10-26 |
| JP2901638B2 (en) | 1999-06-07 |
| CA1327756C (en) | 1994-03-15 |
| JPH029418A (en) | 1990-01-12 |
| GB2217230B (en) | 1991-09-18 |
| FR2630021A1 (en) | 1989-10-20 |
| GB8908502D0 (en) | 1989-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20000414 |