JPS6234397B2 - - Google Patents
Info
- Publication number
- JPS6234397B2 JPS6234397B2 JP14819479A JP14819479A JPS6234397B2 JP S6234397 B2 JPS6234397 B2 JP S6234397B2 JP 14819479 A JP14819479 A JP 14819479A JP 14819479 A JP14819479 A JP 14819479A JP S6234397 B2 JPS6234397 B2 JP S6234397B2
- Authority
- JP
- Japan
- Prior art keywords
- leucine
- thienylalanine
- resistant
- producing
- strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 14
- 229960003136 leucine Drugs 0.000 claims description 8
- 239000004395 L-leucine Substances 0.000 claims description 6
- 235000019454 L-leucine Nutrition 0.000 claims description 6
- WTOFYLAWDLQMBZ-LURJTMIESA-N beta(2-thienyl)alanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CS1 WTOFYLAWDLQMBZ-LURJTMIESA-N 0.000 claims description 6
- 244000005700 microbiome Species 0.000 claims description 4
- 241000588722 Escherichia Species 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000011785 micronutrient Substances 0.000 description 2
- 235000013369 micronutrients Nutrition 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 229960000344 thiamine hydrochloride Drugs 0.000 description 2
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 2
- 239000011747 thiamine hydrochloride Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- ZAYJDMWJYCTABM-CRCLSJGQSA-N (2s,3r)-2-azaniumyl-3-hydroxy-4-methylpentanoate Chemical compound CC(C)[C@@H](O)[C@H]([NH3+])C([O-])=O ZAYJDMWJYCTABM-CRCLSJGQSA-N 0.000 description 1
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000004254 Ammonium phosphate Substances 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241001646716 Escherichia coli K-12 Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 1
- 235000019289 ammonium phosphates Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- ZAYJDMWJYCTABM-UHFFFAOYSA-N beta-hydroxy leucine Natural products CC(C)C(O)C(N)C(O)=O ZAYJDMWJYCTABM-UHFFFAOYSA-N 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 150000002696 manganese Chemical class 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910021654 trace metal Inorganic materials 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14819479A JPS5672695A (en) | 1979-11-15 | 1979-11-15 | Preparation of l-leucine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14819479A JPS5672695A (en) | 1979-11-15 | 1979-11-15 | Preparation of l-leucine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5672695A JPS5672695A (en) | 1981-06-16 |
| JPS6234397B2 true JPS6234397B2 (de) | 1987-07-27 |
Family
ID=15447351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14819479A Granted JPS5672695A (en) | 1979-11-15 | 1979-11-15 | Preparation of l-leucine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5672695A (de) |
Cited By (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007100009A1 (ja) | 2006-03-03 | 2007-09-07 | Ajinomoto Co., Inc. | Ｌ－アミノ酸の製造法 |
| WO2007125954A1 (ja) | 2006-04-28 | 2007-11-08 | Ajinomoto Co., Inc. | Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法 |
| WO2007136133A1 (en) | 2006-05-23 | 2007-11-29 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
| WO2008102861A1 (ja) | 2007-02-22 | 2008-08-28 | Ajinomoto Co., Inc. | Ｌ－アミノ酸の製造法 |
| WO2009031565A1 (ja) | 2007-09-04 | 2009-03-12 | Ajinomoto Co., Inc. | アミノ酸生産微生物及びアミノ酸の製造法 |
| EP2055771A2 (de) | 2006-03-23 | 2009-05-06 | Ajinomoto Co., Inc. | Methode zur Produktion einer L-Aminosäure unter Verwendung eines Bakteriums der Enterobacteriaceae Familie mit einer abgeschwächten Expression eines Gens kodierend für sRNA |
| DE102008049533A1 (de) | 2007-09-27 | 2009-06-18 | Ajinomoto Co., Inc. | Verfahren zum Herstellen von Aminosäuren unter Verwendung eines Bakteriums der Familie Enterobacteriaceae |
| WO2009093703A1 (ja) | 2008-01-23 | 2009-07-30 | Ajinomoto Co., Inc. | Ｌ-アミノ酸の製造法 |
| EP2093291A1 (de) | 2008-02-19 | 2009-08-26 | Ajinomoto Co., Inc. | Verfahren zum Bau eines Operons mit translational gekoppelten Genen |
| WO2010084995A2 (en) | 2009-01-23 | 2010-07-29 | Ajinomoto Co.,Inc. | A method for producing an l-amino acid |
| EP2345667A2 (de) | 2010-01-15 | 2011-07-20 | Ajinomoto Co., Inc. | Verfahren zur Herstellung einer L-Aminosäure unter Verwendung eines Bakteriums der Familie Enterobacteriaceae |
| WO2011096554A1 (ja) | 2010-02-08 | 2011-08-11 | 味の素株式会社 | 変異型ｒｐｓＡ遺伝子及びＬ－アミノ酸の製造法 |
| WO2011102305A2 (en) | 2010-02-18 | 2011-08-25 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE Enterobacteriaceae FAMILY HAVING A MUTANT ADENYLATE CYCLASE |
| WO2012011595A1 (en) | 2010-07-21 | 2012-01-26 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY HAVING ATTENUATED EXPRESSION OF THE astCADBE OPERON |
| WO2012011596A1 (en) | 2010-07-21 | 2012-01-26 | Ajinomoto Co.,Inc. | A method for producing an l- amino acid using a bacterium of the enterobacteriaceae family with enhanced expression of the bssr gene |
| EP2460873A1 (de) | 2006-12-12 | 2012-06-06 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung eines Bakteriums der Enterobacteriaceae-Familie mit abgeschwächter Expression eines der Gene cynT, cynS, cynX oder cynR oder einer Kombination davon |
| WO2012077739A1 (ja) | 2010-12-10 | 2012-06-14 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| EP2559754A2 (de) | 2011-08-18 | 2013-02-20 | Ajinomoto Co., Inc. | Verfahren zur Herstellung einer L-Aminosäure unter Verwendung eines Bakteriums der Familie Enterobacteriaceae mit verstärkter Expression von Genen der Formung von Flagellen und der Motilitätskaskade |
| WO2013151174A1 (en) | 2012-04-02 | 2013-10-10 | Ajinomoto Co.,Inc. | Auto-inducible expression system, and the use thereof for producing useful metabolites using a bacterium of the family enterobacteriaceae |
| EP2796560A1 (de) | 2013-04-23 | 2014-10-29 | Ajinomoto Co., Inc. | Verfahren zur Herstellung einer L-Aminosäure mit einem Bakterium der Familie Enterobacteriaceae mit abgeschwächter Expression des yjjK-Gens |
| WO2015005406A1 (ja) | 2013-07-09 | 2015-01-15 | 味の素株式会社 | 有用物質の製造方法 |
| WO2015030019A1 (en) | 2013-08-30 | 2015-03-05 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE HAVING ATTENUATED EXPRESSION OF THE znuACB GENE CLUSTER |
| WO2015041265A1 (ja) | 2013-09-17 | 2015-03-26 | 味の素株式会社 | 海藻由来バイオマスからのｌ－アミノ酸の製造方法 |
| WO2015050276A1 (en) | 2013-10-02 | 2015-04-09 | Ajinomoto Co.,Inc. | A method for producing an l-amino acid using a bacterium of the family enterobacteriaceae having attenuated expression of a phosphate transporter-encoding gene |
| WO2015060314A1 (ja) | 2013-10-21 | 2015-04-30 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| WO2015122544A1 (en) | 2014-02-14 | 2015-08-20 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE HAVING OVEREXPRESSED THE yajL GENE |
| EP3098319A1 (de) | 2015-05-28 | 2016-11-30 | Ajinomoto Co., Inc. | Verfahren zur herstellung einer l-aminosäure unter verwendung eines bakteriums der familie enterobacteriaceae mit abgeschwächter expression eines gsha-gens |
| WO2017146195A1 (en) | 2016-02-25 | 2017-08-31 | Ajinomoto Co., Inc. | A method for producing l-amino acids using a bacterium of the family enterobacteriaceae overexpressing a gene encoding an iron exporter |
| EP3385389A1 (de) | 2017-04-03 | 2018-10-10 | Ajinomoto Co., Inc. | Verfahren zur herstellung von l-aminosäure aus fructose |
| WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| WO2020171227A1 (en) | 2019-02-22 | 2020-08-27 | Ajinomoto Co., Inc. | METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE |
| EP3716274A1 (de) | 2019-03-29 | 2020-09-30 | Ajinomoto Co., Inc. | Steuerungsvorrichtung, steuerungsverfahren, computerprogramm und verfahren zur herstellung einer organischen verbindung |
| WO2020204179A1 (en) | 2019-04-05 | 2020-10-08 | Ajinomoto Co., Inc. | Method of producing l-amino acids |
| WO2021060438A1 (en) | 2019-09-25 | 2021-04-01 | Ajinomoto Co., Inc. | Method for producing l-amino acids by bacterial fermentation |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2152885C (en) | 1994-06-30 | 2007-05-01 | Tetsuo Nakano | Process for producing l-leucine |
| JP3510331B2 (ja) * | 1994-06-30 | 2004-03-29 | 協和醗酵工業株式会社 | 発酵法によるｌ−アミノ酸の製造法 |
-
1979
- 1979-11-15 JP JP14819479A patent/JPS5672695A/ja active Granted
Cited By (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007100009A1 (ja) | 2006-03-03 | 2007-09-07 | Ajinomoto Co., Inc. | Ｌ－アミノ酸の製造法 |
| EP2055771A2 (de) | 2006-03-23 | 2009-05-06 | Ajinomoto Co., Inc. | Methode zur Produktion einer L-Aminosäure unter Verwendung eines Bakteriums der Enterobacteriaceae Familie mit einer abgeschwächten Expression eines Gens kodierend für sRNA |
| WO2007125954A1 (ja) | 2006-04-28 | 2007-11-08 | Ajinomoto Co., Inc. | Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法 |
| WO2007136133A1 (en) | 2006-05-23 | 2007-11-29 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
| EP2460873A1 (de) | 2006-12-12 | 2012-06-06 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung eines Bakteriums der Enterobacteriaceae-Familie mit abgeschwächter Expression eines der Gene cynT, cynS, cynX oder cynR oder einer Kombination davon |
| WO2008102861A1 (ja) | 2007-02-22 | 2008-08-28 | Ajinomoto Co., Inc. | Ｌ－アミノ酸の製造法 |
| WO2009031565A1 (ja) | 2007-09-04 | 2009-03-12 | Ajinomoto Co., Inc. | アミノ酸生産微生物及びアミノ酸の製造法 |
| DE102008049533A1 (de) | 2007-09-27 | 2009-06-18 | Ajinomoto Co., Inc. | Verfahren zum Herstellen von Aminosäuren unter Verwendung eines Bakteriums der Familie Enterobacteriaceae |
| WO2009093703A1 (ja) | 2008-01-23 | 2009-07-30 | Ajinomoto Co., Inc. | Ｌ-アミノ酸の製造法 |
| EP2093291A1 (de) | 2008-02-19 | 2009-08-26 | Ajinomoto Co., Inc. | Verfahren zum Bau eines Operons mit translational gekoppelten Genen |
| WO2010084995A2 (en) | 2009-01-23 | 2010-07-29 | Ajinomoto Co.,Inc. | A method for producing an l-amino acid |
| EP2345667A2 (de) | 2010-01-15 | 2011-07-20 | Ajinomoto Co., Inc. | Verfahren zur Herstellung einer L-Aminosäure unter Verwendung eines Bakteriums der Familie Enterobacteriaceae |
| WO2011096554A1 (ja) | 2010-02-08 | 2011-08-11 | 味の素株式会社 | 変異型ｒｐｓＡ遺伝子及びＬ－アミノ酸の製造法 |
| WO2011102305A2 (en) | 2010-02-18 | 2011-08-25 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE Enterobacteriaceae FAMILY HAVING A MUTANT ADENYLATE CYCLASE |
| WO2012011595A1 (en) | 2010-07-21 | 2012-01-26 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY HAVING ATTENUATED EXPRESSION OF THE astCADBE OPERON |
| WO2012011596A1 (en) | 2010-07-21 | 2012-01-26 | Ajinomoto Co.,Inc. | A method for producing an l- amino acid using a bacterium of the enterobacteriaceae family with enhanced expression of the bssr gene |
| WO2012077739A1 (ja) | 2010-12-10 | 2012-06-14 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| WO2013024904A1 (en) | 2011-08-18 | 2013-02-21 | Ajinomoto Co.,Inc. | A method for producing an l-amino acid using a bacterium of the family enterobacteriaceae having enhanced expression of the flagella formation and motility cascade genes |
| EP2559754A2 (de) | 2011-08-18 | 2013-02-20 | Ajinomoto Co., Inc. | Verfahren zur Herstellung einer L-Aminosäure unter Verwendung eines Bakteriums der Familie Enterobacteriaceae mit verstärkter Expression von Genen der Formung von Flagellen und der Motilitätskaskade |
| WO2013151174A1 (en) | 2012-04-02 | 2013-10-10 | Ajinomoto Co.,Inc. | Auto-inducible expression system, and the use thereof for producing useful metabolites using a bacterium of the family enterobacteriaceae |
| EP2796560A1 (de) | 2013-04-23 | 2014-10-29 | Ajinomoto Co., Inc. | Verfahren zur Herstellung einer L-Aminosäure mit einem Bakterium der Familie Enterobacteriaceae mit abgeschwächter Expression des yjjK-Gens |
| EP3521433A1 (de) | 2013-07-09 | 2019-08-07 | Ajinomoto Co., Inc. | Verfahren zur herstellung von l-glutaminsäure |
| WO2015005406A1 (ja) | 2013-07-09 | 2015-01-15 | 味の素株式会社 | 有用物質の製造方法 |
| WO2015030019A1 (en) | 2013-08-30 | 2015-03-05 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE HAVING ATTENUATED EXPRESSION OF THE znuACB GENE CLUSTER |
| WO2015041265A1 (ja) | 2013-09-17 | 2015-03-26 | 味の素株式会社 | 海藻由来バイオマスからのｌ－アミノ酸の製造方法 |
| WO2015050276A1 (en) | 2013-10-02 | 2015-04-09 | Ajinomoto Co.,Inc. | A method for producing an l-amino acid using a bacterium of the family enterobacteriaceae having attenuated expression of a phosphate transporter-encoding gene |
| WO2015060314A1 (ja) | 2013-10-21 | 2015-04-30 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| WO2015122544A1 (en) | 2014-02-14 | 2015-08-20 | Ajinomoto Co.,Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE HAVING OVEREXPRESSED THE yajL GENE |
| EP3098319A1 (de) | 2015-05-28 | 2016-11-30 | Ajinomoto Co., Inc. | Verfahren zur herstellung einer l-aminosäure unter verwendung eines bakteriums der familie enterobacteriaceae mit abgeschwächter expression eines gsha-gens |
| WO2017146195A1 (en) | 2016-02-25 | 2017-08-31 | Ajinomoto Co., Inc. | A method for producing l-amino acids using a bacterium of the family enterobacteriaceae overexpressing a gene encoding an iron exporter |
| EP3385389A1 (de) | 2017-04-03 | 2018-10-10 | Ajinomoto Co., Inc. | Verfahren zur herstellung von l-aminosäure aus fructose |
| WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| WO2020171227A1 (en) | 2019-02-22 | 2020-08-27 | Ajinomoto Co., Inc. | METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE |
| EP3716274A1 (de) | 2019-03-29 | 2020-09-30 | Ajinomoto Co., Inc. | Steuerungsvorrichtung, steuerungsverfahren, computerprogramm und verfahren zur herstellung einer organischen verbindung |
| WO2020204179A1 (en) | 2019-04-05 | 2020-10-08 | Ajinomoto Co., Inc. | Method of producing l-amino acids |
| WO2021060438A1 (en) | 2019-09-25 | 2021-04-01 | Ajinomoto Co., Inc. | Method for producing l-amino acids by bacterial fermentation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5672695A (en) | 1981-06-16 |
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