JPS62292802A - キトサンの精製法 - Google Patents
キトサンの精製法Info
- Publication number
- JPS62292802A JPS62292802A JP13479886A JP13479886A JPS62292802A JP S62292802 A JPS62292802 A JP S62292802A JP 13479886 A JP13479886 A JP 13479886A JP 13479886 A JP13479886 A JP 13479886A JP S62292802 A JPS62292802 A JP S62292802A
- Authority
- JP
- Japan
- Prior art keywords
- chitosan
- precipitate
- necessary
- salt
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 51
- 238000000746 purification Methods 0.000 title claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- 239000002253 acid Substances 0.000 claims abstract description 15
- 238000005406 washing Methods 0.000 claims abstract description 5
- 238000004090 dissolution Methods 0.000 claims abstract description 3
- 239000002244 precipitate Substances 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 238000001556 precipitation Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract description 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 18
- 239000012535 impurity Substances 0.000 abstract description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 6
- 238000005119 centrifugation Methods 0.000 abstract description 6
- 239000003513 alkali Substances 0.000 abstract description 5
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract description 4
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 abstract description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 abstract description 3
- 230000009965 odorless effect Effects 0.000 abstract description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract description 2
- 239000001110 calcium chloride Substances 0.000 abstract description 2
- 229910001628 calcium chloride Inorganic materials 0.000 abstract description 2
- 235000011148 calcium chloride Nutrition 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract description 2
- 239000001103 potassium chloride Substances 0.000 abstract description 2
- 235000010344 sodium nitrate Nutrition 0.000 abstract description 2
- 230000008021 deposition Effects 0.000 abstract 3
- 229910052925 anhydrite Inorganic materials 0.000 abstract 1
- 238000000151 deposition Methods 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 description 20
- 229920002101 Chitin Polymers 0.000 description 6
- 235000011121 sodium hydroxide Nutrition 0.000 description 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000017281 sodium acetate Nutrition 0.000 description 4
- 241000238557 Decapoda Species 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 239000002195 soluble material Substances 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WTOIRKBUWMPVHG-VEIQOZLZSA-N (3R,4R,5S,6R)-3-amino-2-hexadecyl-6-(hydroxymethyl)oxane-2,4,5-triol Chemical compound CCCCCCCCCCCCCCCCC1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N WTOIRKBUWMPVHG-VEIQOZLZSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241000131500 Chionoecetes opilio Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- -1 acids Chemical class 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000000850 deacetylating effect Effects 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13479886A JPS62292802A (ja) | 1986-06-12 | 1986-06-12 | キトサンの精製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13479886A JPS62292802A (ja) | 1986-06-12 | 1986-06-12 | キトサンの精製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62292802A true JPS62292802A (ja) | 1987-12-19 |
| JPH0133482B2 JPH0133482B2 (enrdf_load_stackoverflow) | 1989-07-13 |
Family
ID=15136777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13479886A Granted JPS62292802A (ja) | 1986-06-12 | 1986-06-12 | キトサンの精製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62292802A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998017693A1 (fr) * | 1996-10-23 | 1998-04-30 | Transgene S.A. | Composition contenant du chitosan |
| WO2003066682A1 (en) * | 2002-02-07 | 2003-08-14 | Abbott Laboratories De Costa Rica Ltd | Method for deproteinization of chitosan |
| JP2008094989A (ja) * | 2006-10-13 | 2008-04-24 | Hyogo Prefecture | キトサンの水への溶解方法及びその組成物 |
| EP1701980A4 (en) * | 2004-01-06 | 2011-07-06 | Commercialisation Des Produits De La Rech Appliquee Socpra Sciences Sante Et Humaines S F C Soc D | SIMPLIFIED PROCESS FOR EXTRACTING CHITOSANES FROM ACID SOLUTIONS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6176504A (ja) * | 1984-09-21 | 1986-04-19 | Fuji Boseki Kk | 粒状多孔質キトサンの製造法 |
-
1986
- 1986-06-12 JP JP13479886A patent/JPS62292802A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6176504A (ja) * | 1984-09-21 | 1986-04-19 | Fuji Boseki Kk | 粒状多孔質キトサンの製造法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998017693A1 (fr) * | 1996-10-23 | 1998-04-30 | Transgene S.A. | Composition contenant du chitosan |
| WO2003066682A1 (en) * | 2002-02-07 | 2003-08-14 | Abbott Laboratories De Costa Rica Ltd | Method for deproteinization of chitosan |
| EP1701980A4 (en) * | 2004-01-06 | 2011-07-06 | Commercialisation Des Produits De La Rech Appliquee Socpra Sciences Sante Et Humaines S F C Soc D | SIMPLIFIED PROCESS FOR EXTRACTING CHITOSANES FROM ACID SOLUTIONS |
| JP2008094989A (ja) * | 2006-10-13 | 2008-04-24 | Hyogo Prefecture | キトサンの水への溶解方法及びその組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0133482B2 (enrdf_load_stackoverflow) | 1989-07-13 |
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