JPS62273903A - Antiseptic - Google Patents

Abstract

PURPOSE:An antiseptic especially useful in paper making industry, exhibiting improved antiseptic effects at low concentration for a long period, containing N-(2-hydroxypropyl)-aminomethanol and an isothiazoline compound. CONSTITUTION:An antiseptic containing N-(2-hydroxypropyl)-aminomethanol shown by formula I and a compound (e.g. 1,2-benzisothiazolin-3-one or 5-chloro-2- methyl-4-isothiazolin-3-one) shown by formula II or formula III (X and Y are H or halogen; R is 1-12C alkyl or H) in a weight ratio of 20-99:80-1. The antiseptic can be applied to impact addition method at high concentration or to continuous addition method at low concentration when it is used; however, the antiseptic is generally added in such a way that total concentration of the active ingredients is 10-1,000ppm. The antiseptic is effective for starch slurry, paste, cutting oil, etc.

Description

[Detailed Description of the Invention] 3. Detailed Description of the Invention [Field of Industrial Application] The present invention relates to a preservative, and in particular to a preservative that can provide an excellent preservative effect even at low concentrations. It is.

[Prior Art] In addition to starch, the paper manufacturing industry uses large amounts of naturally produced auxiliary materials such as casein and guar gum, all of which are susceptible to decay. For example, starch easily spoils even at 50-60°C.

However, the following problems occur due to starch spoilage, and production efficiency is significantly hindered.

■Clogged strainer or nozzle.

■ Deterioration of product quality due to the formation of starch balls or a decrease in adhesive strength.

■ Decreased product value and deterioration of the working environment due to the production of putrid odors.

■ Due to the disposal of rotten starch, the cost of wastewater treatment increases and bulking occurs due to overload.

■ Increased cleaning work.

In addition to starch slurry in the paper industry, problems caused by such rot also occur in pastes, adhesives, paper coating fluids, polymer latex, cutting oil, pulp slurry, and lignin slurry, causing various problems due to rot. ing.

Conventionally, various industrial preservatives have been used to prevent problems caused by spoilage.
999, Japanese Patent Publication No. 46-4199) or a method using isothiazolin-3-one compounds (Japanese Patent Publication No. 46-12
723, Japanese Unexamined Patent Publication No. 48-48465), etc. have been proposed.

[Problems to be Solved by the Invention] However, all of the conventional preservatives have disadvantages in terms of preservative effect, and the use of these alone does not necessarily sufficiently prevent problems caused by putrefaction. Ta.

[Means for Solving the Problems] The present invention has been made to solve the above conventional problems, and is characterized by containing N-(2-hydroxypropyl)-aminomethanol and an isothiazoline compound. The gist is a preservative that protects the skin.

The present invention will be explained in detail below.

Among the active ingredients of the preservative of the present invention, N-(2-hydroxypropyl)-aminomethanol is represented by the following structural formula (I).
As the isothiazoline compound which is a compound represented by the above, a compound represented by the following general formula (1) or (ITI) is preferable.

Specifically, such a compound includes 5-chloro-2
-Methyl-4-isothiazolin-3-one, 4゜5-dichloro-2-octyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one on, 2-ethyl-4-
Examples include isothiazolin-3-one.

In the present invention, the blending ratio of N-(2-hydroxypropyl)-aminomethanol and isothiazoline compound is 20 to 99% by weight of N-(2-hydroxypropyl)-aminomethanol and 80 to 80% by weight of isothiazoline compound.
It is preferable to set the amount of M in the range of % because it provides excellent preservative power.

Further, the preservative of the present invention may be one in which the active ingredients are mixed in advance so as to achieve such a blending ratio, or may be one that is mixed in the processing system upon use.

The preservative of the present invention can be used either by adding at high concentrations in batches or by continuously adding at low concentrations.

Generally, the preservative of the present invention is added directly or diluted to the treatment system in question so that the total concentration of N-(2-hydroxypropyl)-aminomethanol and isothiazoline compound in the treatment system is ippm or more, preferably. is added in an amount of 10 ppm or more, for example, about 10 to 11,000 ppm.

Such preservatives of the present invention can be used in starch slurries, glues,
It is extremely effective for a wide range of processing systems such as adhesives, paper coating fluids, polymer latex, cutting oils, pulp slurries, and lignin slurries.

[Action] Due to the synergistic effect of the combined use of N-(2-hydroxypropyl)-aminomethanol and isothiazoline compounds, the bactericidal power is greatly improved, and excellent antiseptic effects can be obtained even when used at low concentrations. The effect can be sustained for a long period of time.

[Example] The present invention will be described in more detail with reference to Examples below, but the present invention is not limited to the following Examples unless the gist thereof is exceeded.

Examples 1 to 4, Comparative Example 1.2 Preservatives at the concentrations shown in Table 1 were added to a test solution prepared by mixing 20% by weight of corn starch, 70% by weight of water, and 1% of pre-rotted starch slurry, and the preservatives at the concentrations shown in Table 1 were added. ℃
The number of bacteria was measured after 1 day and 7 days.

The results are shown in Table 1.

The number of bacteria at the start of the test was 3.7 x 10' cells/ml.

From Table 1, the combined use of 5-chloro-2-methyl-4-isothiazolin-3-one and N-(2-hydroxypropyl)-aminomethanol exhibits a synergistic bactericidal effect, resulting in a good It is clear that an antiseptic effect can be obtained.

1st Surface treatment...N-(2-hydroxypropyl)-aminomethanol+1...5-chloro-2-methyl-4-isothiazolin-3-one Examples 5 to 7, Comparative Example 3.4 Oxidized starch A test liquid was prepared by adding 10% by weight of a sizing liquid that had been rotted in advance to a sizing liquid prepared by kneading a 3% by weight slurry.

A preservative in the proportion shown in Table 2 was added to this test solution.
After standing at 0° C. for 7 days, the degree of putrefaction was measured from the pH drop and odor of the test solution, and the minimum concentration of the preservative exhibiting the preservative effect was determined.

The results are shown in Table 2.

Table 2 ■... N-(2-hydroxypropyl)-aminomethanol + 1... 5-chloro-2-methyl-4-isothiazolin-3-one Examples 8 to 10, Comparative Example 5.6 Casein A preservative in the proportion shown in Table 3 was added to the paper coating solution used as a binder, and after standing at 30°C for 144 days, the degree of decay was measured from the pH decrease and odor of the test solution.
The minimum concentration of preservative that exhibits antiseptic effect was determined.

The results are shown in Table 3.

Table 3 ■...N-(2-hydroxypropyl)-aminomethanol II! ...1.2-benzisothiazolin-3-one From Tables 2 and 3, it is clear that the preservative of the present invention has a minimum concentration required to exhibit a preservative effect compared to when each active ingredient is used alone. It is clear that the combination of the two components exhibits a synergistic high preservative effect.

Example 11, Comparative Example 7.8 20 ppm of a preservative in the proportions shown in Table 4 was added to the emulsion paint, and the mixture was allowed to stand at 30° C. to determine the number of days for anti-rotation.

The results are shown in Table 4.

Table 4 shows that the preservative of the present invention extends the number of days for preventing spoilage, compared to when each active ingredient is used alone.
It is clear that a good antiseptic effect is exhibited due to the excellent synergistic effect of the combined use of the ingredients.

Table 4 ■...N-(2-hydroxypropyl)-aminomethanol IV...4.5-dichloro-2-octyl-4-thiazolin-3-one [Effects of the invention] As detailed above The preservative of the present invention contains N-(2-hydroxypropyl-aminomethanol and an isothiazoline compound, and the synergistic effect of using the two types of compounds in combination significantly improves the bactericidal activity. This broadens the bactericidal spectrum and improves the sustained bactericidal effect.

Therefore, since the preservative of the present invention exhibits an excellent preservative effect even when added in a small amount, it is possible to reduce the amount of preservative added, reduce processing costs, and reduce production efficiency caused by spoilage. This can be effectively prevented.

Claims (5)

[Claims] (1) A preservative characterized by containing N-(2-hydroxypropyl)-aminomethanol and an isothiazoline compound. (2) The blending ratio of N-(2-hydroxypropyl)-aminomethanol and isothiazoline compound is 20 to 99:80 to 1 by weight. Preservative. (3) The preservative according to claim 1 or 2, wherein the isothiazoline compound is a compound represented by the following general formula (II) or (III). ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(II) ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(III) However, in the formula, X, Y: hydrogen atom or halogen atom R: number of carbon atoms 1 to 12 alkyl groups or hydrogen atoms (4) The preservative according to claim 3, wherein the isothiazoline compound is 1,2-benzisothiazolin-3-one. (5) The preservative according to claim 3, wherein the isothiazoline compound is 5-chloro-2-methyl-4-isothiazolin-3-one.