JPH0737362B2 - Industrial sterilization composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The composition of the present invention is an industrial product or an industrial material, especially a latex emulsion, an aqueous paint, a metal working oil, a starch paste, a coating color for paper, a fiber oil lignin liquid. The present invention relates to a bactericidal / bacteriostatic composition used for controlling and controlling deterioration / contamination by microorganisms such as, and for preventing slime damage caused by microorganisms in a papermaking process or a factory cooling water system.

(B) Conventional technology For industrial products and industrial materials such as latex emulsions, water-based paints, paper coating fluids, fiber oils, cutting fluids, and electrical insulating materials, paper pulp industry and various industrial fields In the cooling water system in, bacteria, molds,
Harmful microorganisms such as yeasts easily proliferate, which causes deterioration of product quality such as decay, deterioration and contamination of products, and productivity deterioration due to slime troubles. Up to now, many agents such as organometallic compounds, organic sulfur compounds, quaternary ammonium salt compounds and phenol compounds have been used as agents for suppressing or controlling the generation of these harmful microorganisms. Each of them has various drawbacks such as toxicity and pollution, and foaming and deterioration of product quality when used for a specific purpose. Further, in terms of efficacy, it is not satisfactory as an industrial bactericide because it has drawbacks such as insufficient bactericidal and bacteriostatic effects against some kinds of microorganisms and lack of sustainability of effects.

(C) Objectives and effects of the invention The present inventors have conducted intensive studies to solve the problems of these conventionally used drugs and provide a useful industrial bactericidal / bacteriostatic agent. , 2-Benzisothiazolone-
3-on (hereinafter abbreviated as BIT), 5-chloro-
2-Methyl-4-isothiazolin-3-one (hereinafter CMT
Abbreviated) and 2-methyl-4-isodiazolin-3-
The present invention has been completed based on the finding that a composition containing a mixture of ON (hereinafter abbreviated as MT) has characteristics as an excellent industrial bactericidal / bacteriostatic composition as described below.

Features of the composition of the present invention 1. A synergistic effect is exhibited.

2. A continuous bacteriostatic effect can be obtained compared to the use of each single agent.

3. Even when applied to products such as latex and paint, it does not adversely affect condensation and coloring.

4. Excellent storage stability.

5. It contains no metal, has low toxicity, and is free from pollution.

6. There is almost no emergence of resistant bacteria with a broad antibacterial spectrum.

BIT, which is one component of the composition of the present invention, is a compound known as an industrial pest control agent, and is usually used in the form of an alkaline liquid preparation dissolved in an aqueous dispersion or an amine or an amine mixture. However, formulations in the form of aqueous dispersions have storage stability problems, and amine-containing preparations cannot be used in combination with other acidic agents when used for specific purposes due to the adverse effects of amines on the target product and the alkalinity. There were problems such as.

In terms of efficacy, the bactericidal and bacteriostatic effects against specific microorganisms such as yeasts are insufficient, and they are not satisfactory as industrial bactericides. In addition, CM which is a component of the composition of the present invention
Similar to BIT, T and MT mixtures are known as industrial bactericides, and are usually used as liquid solutions containing magnesium nitrate in the form of a complex salt such as magnesium chloride from the Rohm and Haas company (KATHO) in consideration of storage stability.
N) 886 (CMT: MT = about 3: 1 weight ratio) is marketed.

However, such a strongly acidic metal complex salt solution, when applied to a latex emulsion or the like, due to its liquidity,
There was a problem such as deterioration of quality due to condensation of the target product. Further, when it is applied as a slime control agent in the paper manufacturing process, there is a problem that pitch (resin component) in white water is bound to magnesium and an adhesive resin trouble occurs. In terms of efficacy, the bactericidal and bacteriostatic effects on Gram-negative bacteria and anaerobic bacteria are insufficient, and the efficacy persistence is not satisfactory.

The bactericidal / bacteriostatic composition of the present invention can be basically prepared by dissolving each of the above-mentioned components in a hydrophilic organic solvent or the like at an arbitrary ratio, but the total content of active ingredients in the composition is about 0.5
-30% by weight is suitable. In addition, in the composition of the present invention,
Water, surfactants, and optionally other fungicides (e.g., 2,2-dibromo-3-nitrilopropionamide, 4,5-dichloro-1,2dithiol-3-one, 2-
Bromo-2-nitropropanediol 1,3, methylenebisthiocyanate, bistribromomethylsulfone, etc.) may be added appropriately.

When using the composition of the present invention, the addition amount varies depending on the object, purpose, etc., but generally when applied as an antiseptic / antifungal agent for industrial products or industrial materials, the sum of the active ingredient contents is 0.5 at the final concentration. It is preferable to add it to about 300 ppm. When applied as a slime control agent in the papermaking process, it is preferable to add semi-continuously to the white water system so that the total content of the present active ingredient is maintained at about 0.1 to 5 ppm for 8 to 12 hours a day. Furthermore, when it is used as a bactericidal agent for industrial cooling water system, it is recommended to add it every 2 to 7 days so that the total content of this active ingredient is about 0.05 to 5 ppm with respect to the amount of water held in the cooling water system. preferable.

(D) Examples Hereinafter, the present invention will be described in detail with reference to Examples, but the scope of the present invention is not limited thereto. % In the example
Indicates weight percentages.

Formulation Example 1 BIT 10%, CMT and MT 3: 1 (weight ratio) 2%, and monoethylene glycol 88% are mixed and dissolved to obtain a product. At the time of use, it is added as it is or after being diluted with a solvent to a predetermined concentration.

Formulation example 2 6% BIT, 6% 3: 1 (weight ratio) mixture of CMT and MT, and 88% diethylene glycol are mixed and dissolved to obtain a product. At the time of use, it is added as it is or after being diluted with a solvent to a predetermined concentration.

Formulation example 3 BIT 20%, 3: 1 (weight ratio) mixture of CMT and MT 10%, and propylene glycol 88% are mixed and dissolved to obtain a product. At the time of use, it is added as it is or after being diluted with a solvent to a predetermined concentration.

Experimental Example 1 The antibacterial activity of the compositions of the present invention prepared in Formulation Examples 1 to 3 was compared with a single composition having the same active ingredient content and a composite composition using each salt of the composition of the present invention. The test method is the multiple dilution method using Waxmann's medium at pH 6.5, and after culturing at 30 ° C for 24 hours, the presence or absence of growth of the test strain is visually observed to determine the minimum inhibitory concentration (MIC, μg / ml). It was Water was used for dilution. The test results are shown in Table 1.

Reagent 1. Composition of formulation example 1. Composition of formulation example 2.

3. Composition of Formulation Example 3. 4. 12% BIT and 88% monoethylene glycol are mixed and dissolved to obtain a product. At the time of use, the same operation as the formulation example is performed.

5. CMT and MT 3: 1 (weight ratio) 12% mixture and propylene glycol 88% are mixed and dissolved to obtain a product. The usage is the same as the formulation example.

6. BIT 6% Ethylenediamine 5%, CMT and MT 3: 1 (weight ratio) mixture 6% Diethylene glycol 83% are mixed and dissolved to obtain a product. The usage is the same as the formulation example.

7. BIT 2%, 3: 1 (weight ratio) mixture of CMT and MT 10%, magnesium chloride 8%, magnesium nitrate 14%, propylene glycol 20%, water 46% are mixed and dissolved to obtain a product. The usage is the same as the formulation example.

As shown in Table 1, the compositions of the present invention of the above-mentioned formulation examples 1 to 3 are different from the single agents and the composite agents using salts of the composition of the present invention, as compared to the deterioration / alteration of various industrial products / industrial materials. It showed a synergistic antibacterial effect against slime-causing bacteria in paper pulp, papermaking process and cooling water system.

Experimental Example 2 Each reagent used in Experimental Example 1 was added to the synthetic polymer emulsion as a stock solution so that the content of the active ingredient was the same, and the effect on the emulsion and the antiseptic effect were compared. The test method was to use SBR latex with a pH of 7 and add each reagent to a 100 ml latex solution in an equivalent amount of 1000 ppm.
After stirring and mixing for a minute, filter with a 100 mesh wire mesh,
The latex coagulum remaining on the wire mesh was visually determined, and the filtrate was placed in a mayonnaise bottle, sealed, and left outdoors,
The viable cell count was measured daily and the presence or absence of coloration was visually observed. The results are shown in Table 2.

As shown in Table 2, the compositions of the present invention of the reagent components 1 to 3 are
It was shown that the antiseptic effect is persistent without adversely affecting the latex, such as formation of coagulation and coloring.

Experimental Example 3 In the papermaking process of a certain paper mill, the product of the reagent reagent 3 used in Experimental Example 1 was added to the white water pit for 8 hours per day so that the concentration in water was 15 ppm, and continuously operated for 14 days. Then, after machine washing, the product of the reagent reagent 7 was added under the same conditions and continuous operation was carried out for 14 days, and the number of paper breaks due to slime and the number of pitch spots during each operation period were examined. The results are shown in Table 3.

As shown in Table 3, the composition of the present invention significantly reduced slime troubles, improved production efficiency, and did not adversely affect product quality.

Claims (3)

[Claims] 1. 5-Chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one
An industrial germicidal composition comprising a mixture of one and 1,2-benzisothiazolone-3-one as an active ingredient. 2. 5-Chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3.
The industrial sterilizing composition according to claim 1, wherein the mixing ratio with ON is 10: 1 to 1:10 by weight. 3. A mixture of a 2-methyl-4-isothiazolin-3-one compound and 1,2-benzisothiazolin-3-one in a ratio of 1:10 to 10: 1 by weight. Industrial sterilizing composition.