JPH11130610A - Industrial germicide and industrial sterilization - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a low-toxic industrial germicide effective against a wide range of microorganisms such as bacterial or fungi and sustaining sterilizing effects and a provide a method for industrial sterilization using the industrial germicide. SOLUTION: This industrial germicide contains the first component containing an alkylamine-triphenylborane represented by the general formula: (Ph)3 -B-NH2 -R (Ph is phenyl group; R is a 3-30C alkyl group) and the second component containing an organonitrogensulfur-based germicide (e.g. methylene bisisothiocyanate), an organobromine-based germicide (e.g. 2-bromo-2- nitro-1,3-propanediol), an organonitrogen-based germicide (e.g. 2,4,5,6- tetrachloroisophthalonitrile) or an organosulfur-based germicide (e.g. diiodomethyl-p-tolylsulfone) as active ingredients.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an industrial disinfectant and an industrial disinfecting method using the same. More specifically, the invention relates to papermaking process water in the paper and pulp industry, cooling and washing water in various industries, paints, inks, dyes,
Various industrial raw materials or products such as glue, starch slurry, adhesive, latex, wood, leather, fiber, wet pulp, cutting oil, fiber oil, caulking agent, resin, wallpaper, gypsum board paper, The present invention relates to an industrial disinfectant for preventing contamination or deterioration by microorganisms such as fungi, and an industrial disinfecting method using the same.

[0002]

2. Description of the Related Art Conventionally, in the paper making process in the paper and pulp industry, and in cooling water and washing water systems in various industries, slime generated due to microorganisms such as bacteria and fungi causes deterioration in product quality and production efficiency. It is known that it causes obstacles such as a decrease in blood pressure. In addition, various industrial raw materials or products, such as paints, inks, dyes, pastes, starch slurries, adhesives, latex, wood, leather, fibers, wet pulp, cutting oils, fiber oils, caulking agents, resins, wallpapers, In gypsum board base paper and the like, it is known that spoilage and contamination caused by microorganisms such as bacteria and fungi cause deterioration in the quality of products obtained.

For example, starch slurries and sizing agents are used in large quantities as surface sizing agents, color binders and internal additives in the papermaking industry, and the above-mentioned obstacles are serious. Above all, underground stem starch such as potato starch and tapioca starch and wheat starch are obtained in a state in which bacteria of the bacterium of the genus Bacillus having heat-resistant spores, particularly bacteria having heat-resistant spores, are obtained. . Such heat-resistant spores have a viability even at 100 ° C. and easily propagate in a situation where starch, which is a nutrient source of bacteria, is abundant. Proliferation of these bacteria causes decay to proceed, causing problems such as generation of putrefaction odor, clogging of an aqueous strainer, and deterioration of quality due to a decrease in viscosity of the product and a decrease in pH.

[0004] Therefore, various industrial germicides have been developed and used in order to prevent the troubles caused by these microorganisms. In the past, organic mercury compounds, chlorinated phenol compounds and formalin were used.However, these drugs are highly toxic to the human body and fish and shellfish, causing environmental pollution, and their use has been regulated. Low-toxic organic nitrogen-sulfur fungicides, organic bromine-based fungicides, organic nitrogen-based fungicides, and organic sulfur-based fungicides are widely used. Encyclopedia of fungicides ”).

However, the above-mentioned low-toxicity bactericide alone is effective only in a narrow range of microorganisms in a system to be sterilized, and thus has a drawback that sufficient bactericidal efficacy cannot be obtained in a system in which various microorganisms are mixed. Was. Also,
Even for microorganisms that were initially effective, there was the problem that resistant bacteria appeared after long-term use, and the bactericidal efficacy was reduced.
In general, two types of germicides are used in combination to broaden the germicidal spectrum (the type of microorganism to be sterilized). However, in practice, a desired synergistic bactericidal effect is rarely obtained due to the compatibility of the bactericides to be combined. According to the “Encyclopedia of Fungicides and Fungicides”, the germicidal drug substance is about 500
Species are known and a combination of these two, about 124,7
It is difficult to find a combination having a synergistic bactericidal effect from 50 ways. In addition, the various fungicides described above,
Despite its low toxicity, it is desired to reduce its use as much as possible from the viewpoints of pollution, the environment, and the cost of sterilization treatment.

[0006]

SUMMARY OF THE INVENTION Accordingly, the present invention provides a low-toxic industrial bactericide which has an effective bactericidal activity against a wide range of microorganisms such as bacteria and fungi and maintains its bactericidal effect. It is an object of the present invention to provide an industrial sterilization method using the same.

[0007]

Means for Solving the Problems The inventors of the present invention provide:
From the above viewpoints, as a result of studying various industrial fungicide combinations and content ratios, by using a specific alkylamine-triphenylborane and a specific known industrial fungicide in combination, each of them can be used alone. The present inventors have found a synergistic bactericidal effect on a wide variety of microorganisms, which was unexpected compared to the bactericidal effect, and the sustainability of the bactericidal effect, thereby completing the present invention.

Thus, according to the present invention, general formula (I): (Ph) ₃ -B-NH ₂ -R (I) (where Ph is a phenyl group, R is an alkyl group having 3 to 30 carbon atoms) Effectively, a first component containing an alkylamine-triphenylborane represented by the formula (1), and a second component containing an organic nitrogen-based fungicide, an organic bromine-based fungicide, an organic nitrogen-based fungicide, or an organic sulfur-based fungicide. An industrial bactericide characterized by containing as an ingredient is provided.

Further, according to the present invention, the system to be sterilized includes:
There is provided an industrial sterilization method characterized by adding the above-mentioned industrial germicides simultaneously or separately.

[0010]

DETAILED DESCRIPTION OF THE INVENTION The first component alkylamine-triphenylborane (hereinafter referred to as AATB) used in the present invention.
Is abbreviated to the general formula (I). The substituent R in the general formula (I) is a linear or branched alkyl group having 3 to 30 carbon atoms, preferably 3 to 18 carbon atoms;
Specifically, n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-
Nonyl, n-decyl, n-undecyl, n-dodecyl,
linear alkyl groups such as n-tridecyl, n-tetradecyl, n-pentadecyl, n-hexadecyl, n-heptadecyl, n-octadecyl;

Iso-propyl, iso-butyl, sec-butyl,
tert-butyl, iso-pentyl, neo-pentyl, methylhexyl, methylheptyl, methyloctyl, methylnonyl, methyldecyl, methylundecyl, methyldodecyl, methyltridecyl, methyltetradecyl, methylpentadecyl, methylhexadecyl, methylhepta Decyl; dimethylhexyl, dimethylheptyl, dimethyloctyl, dimethylnonyl, dimethyldecyl, dimethylundecyl, dimethyldodecyl, dimethyltridecyl, dimethyltetradecyl, dimethylpentadecyl, dimethylhexadecyl; 2-ethylhexyl, ethylheptyl,
Examples include branched alkyl groups such as ethyl octyl, ethyl nonyl, ethyl decyl, ethyl undecyl, ethyl dodecyl, ethyl tridecyl, ethyl tetradecyl, ethyl pentadecyl, and ethyl hexadecyl, among which n-propyl, n- Octyl, 2-ethylhexyl, n
-Dodecyl, n-hexadecyl and n-octadecyl are particularly preferred.

Specific compounds of AATB represented by the general formula (I) (abbreviations in parentheses) include n-propylamine triphenylborane (PATB), n-octylamine triphenylborane (OATB), -Ethylhexylamine triphenyl borane (EHATB), n-dodecylamine triphenyl borane, n-hexadecylamine triphenyl borane (HDATAB) and n-octadecylamine triphenyl borane (ODATB), the first component of this invention. Can be particularly preferably used. In addition, these A contained in this 1st component
ATB may be used in combination of two or more kinds.

The above-mentioned AATB is known as an antifouling agent for fishing nets (a growth inhibitor and an adhesion inhibitor for marine organisms) (JP-A-8-295608 and JP-A-8-29).
No. 5609). However, the specific use of AATB alone or in combination with other known fungicides as an industrial fungicide is not known. Also, AA
TB is disclosed in JP-A-8-311074 or in Berichte, Vol. 57B, p. 813 (19).
24) can be synthesized.

The compound of the second component used in the present invention is known as an active ingredient of a bactericidal / bacteriostatic agent or an antiseptic / fungicide [Agrochemical Handbook 1992 Edition].
(Refer to "Encyclopedia of Bacterial and Fungicides" mentioned above (issued by the Japan Association of Biological Protection and Immunity)) and commercially available ones.

As a specific compound of the second component used in the present invention, methylene bisthiocyanate (MBT
C), 2-n-octyl-isothiazolin-3-one (OIT), 5-chloro-2-methyl-isothiazolin-3-one (CL-MIT), 4,5-dichloro-2-
n-octyl-isothiazolin-3-one (DCO
T), 1,2-benzisothiazolin-3-one (BI
T), 2- (4′-thiazolyl) benzimidazole (TBZ), 2- (4-thiocyanomethylthio) benzothiazole (TCMTB), 2,3,5,6-tetrachloro-4- (methylsulfonyl) pyridine (TCMS
P), organic nitrogen sulfur-based fungicides such as bis (2-pyridylthio-1-oxide) zinc (Z-pt);

Of 2-bromo-2-nitro-1,3-propanediol (BNPD), 2,2-dibromo-2-nitroethanol (DBNE) and 2,2-dibromo-3-nitrilopropionamide (DBNPA) Organic bromine-based germicides such as 2,4,5,6-tetrachloroisophthalonitrile (TCIPN), 3-iodo-2-propynylbutylcarbamate (IPBC), and 2-methoxycarbonylaminobenzimidazole (BCM). Organic nitrogen-based germicides; organic sulfur-based germicides such as diiodomethyl-p-tolylsulfone (DIMTS) and 4,5-dichloro-1,2-dithiol-3-one (DCDT).

Among the above-mentioned compounds, isothiazolones such as OIT, CL-MIT, and DCOT, which are organic nitrogen-sulfur fungicides, can be particularly preferably used as the second component of the present invention. , Magnesium chloride, calcium chloride, magnesium nitrate or copper nitrate as a metal salt complex. The above-mentioned various germicides contained in the second component may be used in combination of two or more.

The first component and the second component of the industrial germicide of the present invention.
The combination ratio (weight ratio) of the components differs depending on the type and combination of each component. The following shows specific synergistic combination ratios having a synergistic effect. The combination ratio of AATB and MBTC is
1: 49-29: 1, preferably 1: 29-19: 1,
More preferably, it is 1:10 to 5: 1. AATB and O
The combination ratio with IT is 1:49 to 29: 1, preferably 1:29 to 19: 1, and more preferably 1:10 to 5: 1.
It is. The ratio of the combination of AATB and CL-MIT is 1:
49-49: 1, preferably 1: 19-19: 1, more preferably 1: 10-10: 1. AATB and DC
The combined ratio with OT is 1:49 to 49: 1, preferably 1:19 to 19: 1, more preferably 1:10 to 10:
It is one.

The combined ratio of AATB and BIT is 1: 1.
The ratio is from 99 to 9: 1, preferably from 1:99 to 4: 1, more preferably from 1:49 to 2: 1. The combination ratio of AATB and TBZ is 1:49 to 49: 1, preferably 1:19.
１９19: 1, more preferably 1:10 to 10: 1. The combination ratio of AATB and TCMTB is 1:49 to
29: 1, preferably 1:29 to 19: 1, more preferably 1:10 to 5: 1. The ratio of the combination of AATB and TCMPS is 1:49 to 29: 1, preferably 1: 2.
It is from 9 to 19: 1, more preferably from 1:10 to 5: 1. The ratio of the combination of AATB and Z-pt is 1:99 to 1
9: 1, preferably 1:49 to 10: 1, more preferably 1:19 to 5: 1.

The combination ratio of AATB and BNPD is 1:
The ratio is from 199 to 19: 1, preferably from 1:99 to 9: 1, more preferably from 1:49 to 4: 1. AATB and DBN
The combination ratio with E is 1: 199 to 19: 1, preferably 1:99 to 9: 1, and more preferably 1:49 to 4: 1. The combination ratio of AATB and DBNPA is 1:19
The ratio is 9 to 19: 1, preferably 1:99 to 9: 1, and more preferably 1:49 to 4: 1.

The combination ratio of AATB and TCIPN is as follows:
1: 49-49: 1, preferably 1: 19-19: 1,
More preferably, it is 1:10 to 10: 1. The combination ratio of AATB and IPBC is 1:49 to 49: 1, preferably 1:19 to 19: 1, and more preferably 1:10 to 1: 1.
0: 1. The combination ratio of AATB and BCM is 1:
49-49: 1, preferably 1: 19-19: 1, more preferably 1: 10-10: 1. AATB and DI
The combined ratio with MTS is 1:49 to 29: 1, preferably 1:29 to 19: 1, more preferably 1:10 to 5:
It is one. The combined ratio of AATB and DCDT is 1: 4
The ratio is 9 to 49: 1, preferably 1:19 to 19: 1, more preferably 1:10 to 10: 1.

The industrial germicide of the present invention may be used directly in the system to be sterilized with the first component and the second component, or may be used as a formulation. In general, it is often used in the form of a liquid. For example, in the case of a target system such as a starch slurry, an adhesive, a wet pulp, a cutting oil, and a paint, the liquid is preferably used. In addition, although it is usually preferable to use the composition as a one-part preparation, if it is preferable to separate the respective active ingredients from the viewpoint of the long-term stability of the preparation, the preparation may be divided into the respective active ingredients. . In the case of a liquid preparation, it can be usually formulated using a hydrophilic organic solvent, a surfactant and water, but a thickener may be further added to form a flowable (flowable) preparation.

Examples of the hydrophilic organic solvent include amides such as N, N-dimethylformamide and N-methyl-2-pyrrolidone, glycols such as ethylene glycol, propylene glycol, diethylene glycol and dipropylene glycol, methyl cellosolve, Glycol ethers such as phenyl cellosolve, diethylene glycol monomethyl ether, dipropylene glycol monomethyl ether, tripropylene glycol monomethyl ether, alcohols having up to 8 carbon atoms or methyl acetate, ethyl acetate, 3-methoxybutyl acetate, 2-ethoxymethyl acetate Esters such as, 2-ethoxyethyl acetate, propylene carbonate, dimethyl succinate, dimethyl glutarate, dimethyl adipate . Among them N, N- dimethylformamide, N-methyl-2-pyrrolidone, diethylene glycol monomethyl ether preferable.

As the surfactant, any of anionic surfactants, cationic surfactants, nonionic surfactants and amphoteric surfactants can be used, but from the viewpoint of the stability of the preparation, anionic surfactants can be used. Is preferred. In particular,
Polyoxyalkylene styryl phenyl ether phosphate, polyoxyethylene alkyl phenyl ether sulfate, polyoxyethylene alkyl phenyl ether phosphate, and the like.

As the thickening agent, for example, xanthan gum, high molecular weight carboxymethyl cellulose and the like are used. When a thickener is added to form a flowable formulation, a hydrophilic organic solvent (eg, ethylene glycol, diethylene glycol, or a mono-lower alkyl ether thereof) may be further added.

Further, the industrial germicide of the present invention comprises:
The component and the second component may be dissolved in an organic solvent (for example, an aromatic solvent such as xylene or toluene), and a surfactant (for example, the surfactant) may be added to form an emulsion.

In any of the above liquid preparations, flowable preparations and emulsions, the total concentration of the first and second components contained in the preparation is 5 to 40% by weight (preferably 10 to 25% by weight). %). When the total concentration is lower than 5% by weight, the amount added to the system to be sterilized increases, the transportation cost increases, and the physical properties of the additive may change. Since the viscosity becomes low and the fluidity decreases, it is difficult to add a pump particularly in winter, which is not preferable.

When a surfactant is used, its ratio is preferably about 2 to 50% by weight of the bactericidal active ingredient. In the flowable preparation, the thickener is preferably about 0.1 to 10% by weight of the bactericidal active ingredient. Furthermore, when each active ingredient is formulated separately, each active ingredient can be formulated in the same manner as described above.

On the other hand, when the industrial germicide of the present invention is used for paints and adhesives, it is preferably in the form of a powder. When the powder is used, the powder can be diluted with a solid diluent [for example, kaolin, clay, bentonite, CMC (carboxymethylcellulose), etc.], and the above-mentioned surfactant may be used. In the same manner as in the case of the liquid preparation, the powder can be divided into each active ingredient and formulated. The total concentration of the first component and the second component contained in the powder is 5 to 50% by weight, preferably 10 to 3% by weight.
The content is preferably 0% by weight. In addition, a paste can be prepared by using an organic solvent or a surfactant. Of course, other uses of the drug, such as insecticides, may be used in combination or mixed.

The amount of the industrial fungicide of the present invention varies depending on the type of the system to be sterilized and the active ingredient to be combined.
Usually, it is preferable to add the active ingredient so as to have a total concentration of 1 to 5000 ppm. When the system to be sterilized is a paper product such as wood, leather, fiber, wet pulp, wallpaper or gypsum board base paper, the target concentration is usually 0.01 to 10 g / m ² as the total concentration of the active ingredient. It is preferable to immerse in the material of the system or apply it to the surface. When the system to be sterilized is a caulking agent, a resin or the like, the target system is usually adjusted to have a total concentration of the active ingredient of 0.5 to 50 kg / m ^3. Is preferably contained.

Examples of the system to be sterilized in the present invention include papermaking process water in the paper and pulp industry, cooling water and washing water in various industries, paints, inks, dyes, sizing agents, starch slurries, adhesives, latex, wood, and leather. , Fiber, wet pulp, cutting oil, fiber oil, caulking agent, resin, wallpaper,
Various industrial raw materials or industrial products such as gypsum board base paper are exemplified.

The industrial bactericide of the present invention exhibits a remarkable bactericidal effect even when a reducing substance such as a sulfite ion is present in the system to be sterilized. In the present invention, MBTC, OIT, CL-MI
T, DCOT, BIT, TBZ, TCMTB, TCMS
P, Z-pt, TCIPN, IPBC, BCM, DIM
When TS or DCDT is selected, Trichoderma s (Trichoderma s.
It exerts a remarkable bactericidal effect on p).

[0033]

EXAMPLES The present invention is illustrated by test examples, but the present invention is not limited thereto. The preparations used in the examples were preparations comprising the following two compounds, a first component and a second component. The preparation was carried out by stirring and mixing each active ingredient and dimethylformamide. In addition,
Comparative examples include the second component alone and a known bactericide, parachloromethaxylenol (PCMX) or 3,3,
4,4-tetrachlorotetrahydrothiophene (TCT
O) Comparative preparations used alone or in combination with ODATAB were used.

Each component is listed together with abbreviations. First component ODATAB: n-octadecylamine triphenylborane

Second component MBTC: methylenebisthiocyanate OIT: 2-n-octyl-isothiazoline-3
-One CL-MIT: 5-chloro-2-methyl-isothiazolin-3-one DCOT: 4,5-dichloro-2-n-octyl-
Isothiazolin-3-one BIT: 1,2-benzisothiazolin-3-one TBZ: 2- (4′-thiazolyl) benzimidazole TCMTB: 2- (4-thiocyanomethylthio) benzothiazole TCMPS: 2,3,5 6-tetrachloro-4-
(Methylsulfonyl) pyridine Z-pt: bis (2-pyridylthio-1-oxide) zinc

BNPD: 2-bromo-2-nitro-
1,3-propanediol DBNE: 2,2-dibromo-2-nitroethanol DBNPA: 2,2-dibromo-3-nitrilopropionamide TCIPN: 2,4,5,6-tetrachloroisophthalonitrile IPBC: 3- Iodo-2-propynylbutyl carbamate BCM: 2-methoxycarbonylaminobenzimidazole DIMTS: diiodomethyl-p-tolylsulfone DCDT: 4,5-dichloro-1,2-dithiol-3-one A known fungicide PCMX: parachlorometa Xylenol TCTO: 3,3,4,4-tetrachlorotetrahydrothiophene-1,1-dioxide

Test Example 1 [Test for Confirming Sterilization Efficacy of Starch Slurry] Starch slurry (pH: 5.3, solid content concentration: 40% by weight, bacterial species: Pseudomonas sp., Alcaligenes sp.) , Bacillus sp., Cladosporium sp., Viable cell count: 1.6 × 10 ⁵ cells / ml, sulfite ion concentration: 10 mg / l) and 30 mg / l of each drug.
The mixture was shaken at 30 ° C. for 7 days, and the viable cell count was measured thereafter. The obtained results are shown in Tables 1 and 2 together with the active ingredient of the drug and the combination ratio thereof.

[0038]

[Table 1]

[0039]

[Table 2]

Test Example 2 [Test for Confirming Bactericidal Efficacy to Adhesive] Each drug was added to a vinyl acetate adhesive (pH: 4.9, bacterial species: Flavobacterium, Candida, Penicillium, Trichoderma) at 50 mg / After addition, the mixture was allowed to stand at 27 ° C., and thereafter, the presence or absence of decay and the occurrence of mold were observed daily. The obtained results are shown in Tables 3 and 4 together with the active ingredient of the drug and the combination ratio thereof. In the table, "+" indicates "with rot" and "with mold", and "-" indicates "without rot" and "without mold".

[0041]

[Table 3]

[0042]

[Table 4]

Test Example 3 [Test for confirming synergistic effect on Trichoderma fungus] 10 ml of Czapek-Dox liquid medium was dispensed into a sterilized test tube with a silicon stopper, and the mold was grown on wet pulp at a paper mill. 0.1 ml of a spore suspension of the isolated bacterium (Trichoderma sp.) Was added.
Then, 100 ppm of an aqueous solution of sodium sulfite was added as a sulfite ion, each drug was added to each concentration, and the mixture was incubated at 27 ° C. for 7 days. After the culture, the presence or absence of growth of hypha was observed, and the minimum growth inhibitory concentration (TDMIC) was determined by a binary dilution method. The results are shown in FIGS. In addition, the numerical value of each component in a figure represents a weight ratio and 2
"O" of the point indicating the combination ratio of the components is "effective",
“■” indicates “no effect”.

As is clear from FIGS. 1 to 14, the industrial germicides of the present invention comprising the first component and the second component exhibit a synergistic effect. On the other hand, in the example using the comparative preparation (using PCMX and TCTO instead of the second component) in FIGS.
No synergistic effect is observed.

[0045]

The industrial germicide of the present invention contains a specific alkylamine-triphenylborane and a specific known industrial germicide as active ingredients. The effect is obtained, and an extremely useful industrial bactericide can be provided. In particular, a remarkable bactericidal effect is exhibited even when a reducing substance such as sulfite ion is present in the system to be sterilized. In addition, in a system to be sterilized such as paper, pulp or wood, contamination by Trichoderma especially occurs frequently, and an agent effective for Trichoderma has been demanded. Can also be suitably used.

[Brief description of the drawings]

FIG. 1 shows the synergistic effect of the fungicide of the present invention, ODATAB and OIT.

FIG. 2: Fungicides of the invention, ODATAB and CL-MIT
It is a figure which shows the synergistic effect with this.

FIG. 3 shows the synergistic effect of the fungicide of the present invention, ODATAB and DCOT.

FIG. 4 is a diagram showing the synergistic effect of the fungicide of the present invention, ODATAB and TCMTB.

FIG. 5 is a diagram showing the synergistic effect of the fungicide of the present invention, ODATAB and IPBC.

FIG. 6 shows the synergistic effect of the fungicide of the present invention, ODATAB and MBTC.

FIG. 7 is a diagram showing the synergistic effect of the fungicide of the present invention, ODATAB and DCDT.

FIG. 8 shows the synergistic effect of the fungicide of the present invention, ODATAB and DIMTS.

FIG. 9 shows the synergistic effect of the fungicide of the present invention, ODATAB, and TCIPN.

FIG. 10: Fungicides of the invention, ODATAB and TCMPS
It is a figure which shows the synergistic effect with this.

FIG. 11 shows the synergistic effect of the fungicide of the present invention, ODATAB and BCM.

FIG. 12 shows the synergistic effect of the fungicide of the present invention, ODATAB, and Z-pt.

FIG. 13 shows the synergistic effect of the fungicide of the present invention, ODATAB and TBZ.

FIG. 14 shows the synergistic effect of the fungicide of the present invention, ODATAB and BIT.

FIG. 15 shows the minimum inhibitory concentrations of the comparative preparations, ODTAB and PCMX.

FIG. 16 shows the minimum inhibitory concentrations of the comparative preparations, ODTAB and TCTO.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI (A01N 55/08 43:78) (A01N 55/08 43:40) (A01N 55/08 55:02) (A01N 55/08 33:20) (A01N 55/08 37:44) (A01N 55/08 47:12) (A01N 55/08 47:18) (A01N 55/08 41:10) (A01N 55/08 43:26)

Claims (7)

[Claims] 1. An alkyl represented by the general formula (I): (Ph) ₃ —B—NH ₂ —R (I) (wherein Ph is a phenyl group, and R is an alkyl group having 3 to 30 carbon atoms). As an active ingredient, a first component containing an amine-triphenylborane and a second component containing an organic nitrogen-based fungicide, an organic bromine-based fungicide, an organic nitrogen-based fungicide, or an organic sulfur-based fungicide. Characterized industrial fungicide. 2. An alkylamine-triphenylborane wherein the alkyl is n-propyl, n-octyl, 2-ethylhexyl, n-dodecyl, n-hexadecyl or n-propyl.
The industrial fungicide according to claim 1, which is octadecyl. 3. The organic nitrogen-sulfur fungicide is methylene bisthiocyanate, 2-n-octyl-isothiazoline-
3-one, 5-chloro-2-methyl-isothiazoline-
3-one, 4,5-dichloro-2-n-octyl-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 2- (4'-thiazolyl) benzimidazole, 2- (4-thio Cyanomethylthio) benzothiazole, 2,3,5,6-tetrachloro-4- (methylsulfonyl) pyridine or bis (2-pyridylthio-1)
The industrial bactericide according to claim 1, which is (oxide) zinc. 4. The method according to claim 1, wherein the organic bromine-based germicide is 2-bromo-2-.
Nitro-1,3-propanediol, 2,2-dibromo-2-nitroethanol or 2,2-dibromo-3-
The industrial fungicide according to claim 1, which is nitrilopropionamide. 5. The method according to claim 1, wherein the organic nitrogen-based fungicide is 2,4,5,6-
The industrial fungicide according to claim 1, which is tetrachloroisophthalonitrile, 3-iodo-2-propynylbutylcarbamate or 2-methoxycarbonylaminobenzimidazole. 6. The method according to claim 6, wherein the organic sulfuric acid disinfectant is diiodomethyl-
p-tolylsulfone or 4,5-dichloro-1,2-
The industrial fungicide according to claim 1, which is dithiol-3-one. 7. An industrial sterilization method comprising simultaneously or separately adding the industrial germicide according to claim 1 to a system to be sterilized.