JP2001192308A - Industrial bactericidal antiseptic agent and method for bactericidal antiseptic treatment using the agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an industrial bactericidal antiseptic agent usable at a decreased amount for a long period of time against a wide variety of objects in a water system of various industrial fields to be subjected to bactericidal antiseptic treatment. SOLUTION: The objective industrial bactericidal antiseptic agent contains 1,2-benzoisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and 2-n-octyl-4- isothiazolin-3-one at ratios to develop synergistic effect.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[Industrial Application Field] The present invention suppresses deterioration and contamination of microorganisms such as latex emulsions, water-based paints, metalworking oils, starch paste, coating liquids for paper, fiber oil agents, lignin liquids, especially industrial products and industrial materials. The present invention relates to an industrial sterilization / preservation method used for controlling and preventing slime damage caused by microorganisms in a papermaking process and a factory cooling water system.

[0002]

2. Description of the Related Art Conventionally, latex emulsions, which are industrial products and materials,
In water-based paints and coating fluids for paper, textile oils, metal oils, electrical insulating materials, etc., and in cooling water systems in the paper pulp industry and various industrial fields, bacteria, molds, yeasts, etc. Harmful microorganisms are easy to propagate, causing quality deterioration such as putrefaction, deterioration, and contamination of products, and a cause of productivity reduction due to slime damage. Until now, many fungicides have been used for the purpose of suppressing or controlling the generation of these harmful microorganisms.

[0003] Many agents such as organometallic compounds, organic sulfur compounds, quaternary ammonium salt compounds, and phenolic compounds have been used as agents for controlling or preventing microbial disorders. It has various drawbacks such as foaming and deterioration of product quality when used for specific applications, as well as pollution.

[0004] 1,2-benzisothiazolin-3-one (hereinafter referred to as BIT) and 2-methyl-4-isothiazoline-
3-one (hereinafter referred to as MIT) and 2-n-octyl-4
-Isothiazolin-3-one (hereinafter referred to as OIT) is known as a bactericidal and preservative, but it has insufficient bactericidal and bacteriostatic effects on certain types of microorganisms and lacks long-lasting effects It has disadvantages such as. Among microorganisms, especially bacteria use the same disinfectant and preservative,
The resistant bacteria proliferate in the system, and the effect of the conventionally used disinfectant / preservative decreases significantly. In addition, fungicides composed of a combination of fungicides for the purpose of exhibiting a synergistic effect have a remarkable bactericidal activity against bacteria and yeast, but have no sustained effect, and have a bactericidal effect against mold. There was a drawback that the power was not sufficient, and it was not possible to sufficiently prevent microbial damage.

[0005] Therefore, there has been a demand for the development of a drug which can be used for a long time in a wide range of subjects in a smaller amount.

[0006]

Means for Solving the Problems The inventor of the present invention
From this point of view, as a result of studying the combination and content ratio of various industrial disinfectants and preservatives, BIT, MIT and OI
It has been found that by combining T with a specific ratio, an excellent bactericidal effect and a long-lasting antiseptic effect can be exerted on a wide range of microorganisms which cannot be predicted by the combination of two components.

Thus, according to the present invention, BIT and MI
An industrial disinfectant / preservative is provided, wherein T and OIT are contained as active ingredients in a ratio that produces a synergistic effect. Further, there is provided an industrial disinfection / preservation method characterized in that BIT, MIT and OIT are simultaneously or separately added to a water system to be disinfected / preserved at a ratio having a synergistic effect to perform disinfection / preservation.

The germicidal / preservative of the present invention is a decay-altered or contaminated bacterium or fungus such as emulsion paint, spinning oil, latex emulsion, water-based paint, cutting oil, starch paste, paper coating liquid, lignin liquid and the like. It exerts a synergistic sterilization and antibacterial effect in controlling and controlling slime, and is also effective in preventing slime damage caused by microorganisms in the papermaking process and factory cooling water system. In addition, it is a useful industrial disinfectant and preservative that has low toxicity, does not cause pollution, has no foaming on the target composition, and has no adverse effect.

The BIT, MIT and OIT of the present invention are:
Water or a suitable organic solvent, a nonionic surfactant or a combination thereof can be dispersed or dissolved and used as a solution (solution, suspension, slurry) having a suitable concentration. At this time, if necessary, other disinfectants and preservatives (for example, 2.2-dibromo-3-nitropropionamide, 4.5-dichloro-1.2-dithiol-3-one, methylenebisthiocyanate, Bistribromomethylsulfone, 5-chloro-2-methyl-4-isothiazolin-3-one, 1.2-bis-bromo-4-acetoxy-2-butene, 3.3.4.4-tetrachlorotetrahydrothiophene- 1.1-dioxide, benzalkonium chloride, etc.) may be appropriately added.

The active ingredient of the present invention is preferably used in the form of a liquid using the above-mentioned solvent.
Without being limited to this, it can be used as a solid preparation diluted with a solid diluent or a carrier (kaolin, clay, CMC, etc.) depending on the use object. According to the present invention, sterilization and preservation can be performed synergistically by adding the three active ingredients to the water system to be sterilized and preserved in combination as separate preparations.

The mixing ratio of BIT and MIT in the composition of the present invention is 10: 1 to 1:10 by weight, and OIT is 0.05 to 1.0 with respect to 1 of the total amount of BIT and MIT. 5
Exerts a powerful synergistic effect.

In using the composition of the present invention, the amount of addition differs depending on the object, the purpose, etc., but when it is applied as a preservative for industrial products or industrial materials, the sum of the contents of the active ingredients is generally the final concentration. 0.5 ~ 500m
It is preferable to add simultaneously or separately so that it may be about g / L. In addition, when it is applied as a slime control agent in a papermaking process, whether the total content of the present active ingredient is about 0.1 to 50 mg / L is added to the white water system for about 30 minutes to 60 minutes, 1 to 3 times a day. Or 0.05-20 mg /
It is preferable to add semi-continuously so as to maintain about L for 6 to 12 hours per day.

Further, when used as a slime inhibitor or algicide in an industrial cooling water system, the content of the present active ingredient is 0.1 to 50 mg / L with respect to the amount of water retained, and is adjusted weekly. It is preferable to impact-add. In each of the adaptation examples, if the addition amount is less than the lower limit, an effective synergistic effect is not exerted, which is not preferable, and the addition amount may be more than the upper limit, but is not preferable for economic reasons.

Next, examples of the preparation of the present invention will be described, but the present invention is not limited thereto. Formulation Example 1 BIT 10.0 parts by weight MIT 10.0 parts by weight OIT 5.0 parts by weight 73.0 parts by weight of dipropylene glycol 2.0 parts by weight of a polyoxyalkylene condensate of ethylenediamine are mixed to prepare a solution. Formulation Example 2 BIT 5.0 parts by weight MIT 15.0 parts by weight OIT 5.0 parts by weight Diethylene glycol monoethyl ether 70.0 parts by weight Propylene Crycol 5.0 parts by weight is mixed to prepare a solution preparation. Formulation Example 3 BIT 15.0 parts by weight MIT 5.0 parts by weight OIT 5.0 parts by weight Triethylene glycol 63.0 parts by weight Propylene glycol 10.0 parts by weight Polyoxyalkylene condensate of ethylenediamine 2.0 parts by weight mixed To prepare a solution. Formulation Example 4 BIT 10.0 parts by weight MIT 10.0 parts by weight OIT 2.0 parts by weight Neoperex (registered trademark: Kao Atlas Co., Ltd.) 5.0 parts by weight Sun extract (registered trademark: Nippon Paper Industries Co., Ltd.) ) 5.0 parts by weight of diatomaceous earth 68.0 parts by weight is uniformly mixed to obtain a wettable powder. Comparative Preparation Example 1 12.5 parts by weight of BIT 12.5 parts by weight of MIT 72.0 parts by weight of dipropylene glycol 3.0 parts by weight of a polyoxyalkylene condensate of ethylenediamine are mixed to prepare a solution preparation. Comparative Preparation Example 2 12.5 parts by weight of BIT 12.5 parts by weight of OIT 72.0 parts by weight of triethylene glycol 3.0 parts by weight of a polyoxyalkylene condensate of ethylenediamine are mixed to prepare a solution preparation. Comparative Preparation Example 3 MIT 12.5 parts by weight OIT 12.5 parts by weight 72.0 parts by weight of propylene glycol 3.0 parts by weight of 9 mol of nonylphenol ethylene oxide additive are mixed to prepare a solution preparation.

[0015]

EXAMPLES Hereinafter, the effects of the present invention will be described with reference to examples.

Example 1 Test of antiseptic effect on acrylic emulsion Acrylic emulsion (pH: 7.5, solid content 30%)
Spoiled emulsion (pH 6.4, bacteria: pseudomon)
as sp, flavobacterium sp bacteria count: 7.3 × 10 ⁶ cells / ml, fungi: Penicillium sp viable count: 1.8 × 10 ⁴ cells / ml) 10%
The added sample was used as a test sample. The test sample is dispensed into glass bottles in 20 g increments, and each drug is used as an active ingredient in an amount of 10 mg.
/ L and left in a thermostat at a temperature of 30 ° C. to determine the number of days for which the acrylic emulsion is not rotten. Table 1 shows the results.

[0017]

[Table 1] Test results

Example 2 Preservative test for polyacrylamide aqueous solution At a certain paper mill, the viable cell count of a polyacrylamide aqueous solution (solid content: 20%) used as a paper strength enhancer was measured. Ten thousand levels of bacteria were detected. Therefore, in order to preserve the aqueous solution of polyacrylamide contaminated with bacteria, each agent is used as an active ingredient in one
The solution was added to a concentration of 2.5 mg / L and placed in a thermostat at a temperature of 30 ° C. and a humidity of 90%, and the change in the number of viable bacteria in the sample was measured daily. Table 2 shows the results.

[0019]

[Table 2] Test results

Example 3 Preservative Effect Test on Ethylene Vinyl Acetate Adhesive Ethylene vinyl acetate adhesive (pH: 4.5, solid content: 30)
%), Spoiled products (pH 4.2, bacteria: corynebacterium sp,
proteus sp Viable cell count: 1.6 × 10 ⁶ cells / ml, mold: Aspergillu
s sp, Penicillium sp Viable cell count: 2.3 × 10 ⁴ cells / ml, yeast: C
andida sp viable cell count: 3.3 × 10 ⁵ cells / ml) was used as a test sample. 20 g of the test sample was dispensed into glass bottles, and various drugs were added as active ingredients so that the concentration became 25 mg / L. The sample was allowed to stand in a thermostat at a temperature of 30 ° C., and the number of viable bacteria was measured after one month. . Table 3 shows the results.

[0021]

[Table 3] Test results

Example 4 Test for confirming synergistic effect on urethane emulsion Urethane emulsion (pH: 8.7, solid content: 30)
w / w%, viable cell count: 7.3 × 10 ⁶ cells / ml, strain: pseudodomonas s
p, flavobacterium sp) was used as a test sample. BIT and M
A sample was prepared by adding OIT to each ratio of 1: 1 IT. 10 g of the test sample is dispensed into an L-shaped test tube, and each sample is used as a total amount of the active ingredient as 1%.
It was added to a concentration of 0 mg / l. Shake at 25 ° C,
Three days later, the viable cell count of each sample was measured. Table 4 shows the results.

[0023]

[Table 4] Test results

[0024]

According to the present invention, when BIT, MIT, and OIT are used in combination as industrial disinfectants and preservatives as in the above-described example, the BIT, MIT, and OIT are synergistically disinfected in a much smaller amount than when each is used in two components. An industrial germicidal / preservative and a bactericidal / antiseptic method are provided, which have an improved bacteriostatic power and exhibit an excellent bactericidal effect and a sustained preservative effect.

Claims (3)

[Claims] 1. Effective use of 1,2-benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and 2-n-octyl-4-isothiazolin-3-one in a proportion that produces a synergistic effect. An industrial disinfectant / preservative characterized by containing as an ingredient. 2. A mixture of 1,2-benzisothiazolin-3-one and 2-methyl-4-isothiazolin-3-one in a weight ratio of 10: 1 to 1:10, and 1,2-benzoisothiazoline -3-one and 2-methyl-4-isothiazoline-3-
2. The industrial germicidal and preservative according to claim 1, wherein 2-n-octyl-4-isothiazolin-3-one is 0.05 to 1.5 with respect to 1 of the total amount of the bactericide and the on. . 3. An aqueous system for sterilization and preservation, wherein 1,2-benzoisothiazolin-3-one and 2-methyl-4-isothiazoline-3 are used.
-One and 2-n-octyl-4-isothiazolin-3-one in the ratio described in claim 2 and in a total amount of 0.5.
An industrial disinfection / preservation method characterized by adding simultaneously or separately at a concentration of up to 500 mg / L.