JPS6223576B2 - - Google Patents
Info
- Publication number
- JPS6223576B2 JPS6223576B2 JP54143417A JP14341779A JPS6223576B2 JP S6223576 B2 JPS6223576 B2 JP S6223576B2 JP 54143417 A JP54143417 A JP 54143417A JP 14341779 A JP14341779 A JP 14341779A JP S6223576 B2 JPS6223576 B2 JP S6223576B2
- Authority
- JP
- Japan
- Prior art keywords
- sheet
- erodible
- rumen
- drug
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004767 rumen Anatomy 0.000 claims description 34
- 229940079593 drug Drugs 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 25
- 239000000463 material Substances 0.000 claims description 19
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 15
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 15
- 229920003023 plastic Polymers 0.000 claims description 12
- 239000004033 plastic Substances 0.000 claims description 12
- 230000008602 contraction Effects 0.000 claims description 8
- 239000000273 veterinary drug Substances 0.000 claims description 8
- 230000000507 anthelmentic effect Effects 0.000 claims description 5
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 5
- 241000282849 Ruminantia Species 0.000 claims description 4
- 238000010276 construction Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 19
- 229920001577 copolymer Polymers 0.000 description 13
- 241001494479 Pecora Species 0.000 description 11
- YRWLZFXJFBZBEY-UHFFFAOYSA-N N-(6-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCCC1=CC=C2N=C(NC(=O)OC)NC2=C1 YRWLZFXJFBZBEY-UHFFFAOYSA-N 0.000 description 9
- 229950007337 parbendazole Drugs 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 229940124339 anthelmintic agent Drugs 0.000 description 7
- 239000000921 anthelmintic agent Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 229920002261 Corn starch Polymers 0.000 description 6
- 108010010803 Gelatin Proteins 0.000 description 6
- 239000008273 gelatin Substances 0.000 description 6
- 229920000159 gelatin Polymers 0.000 description 6
- 235000019322 gelatine Nutrition 0.000 description 6
- 235000011852 gelatine desserts Nutrition 0.000 description 6
- -1 lavamisole Chemical compound 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 5
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 5
- 239000005977 Ethylene Substances 0.000 description 5
- 239000008120 corn starch Substances 0.000 description 5
- 229920000609 methyl cellulose Polymers 0.000 description 5
- 239000001923 methylcellulose Substances 0.000 description 5
- 235000010981 methylcellulose Nutrition 0.000 description 5
- 238000013268 sustained release Methods 0.000 description 5
- 239000012730 sustained-release form Substances 0.000 description 5
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000003628 erosive effect Effects 0.000 description 4
- 229960001614 levamisole Drugs 0.000 description 4
- 239000010959 steel Substances 0.000 description 4
- NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 description 3
- 239000001856 Ethyl cellulose Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229960005121 morantel Drugs 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000000604 anti-edema agent Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 229960005134 pyrantel Drugs 0.000 description 2
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- YWDWYOALXURQPZ-CYBMUJFWSA-N 2-methyl-n-[3-[(6s)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazol-6-yl]phenyl]propanamide Chemical compound CC(C)C(=O)NC1=CC=CC([C@@H]2N=C3SCCN3C2)=C1 YWDWYOALXURQPZ-CYBMUJFWSA-N 0.000 description 1
- RFAYUIIWPKWNKY-UHFFFAOYSA-N 6-(3-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole Chemical compound [O-][N+](=O)C1=CC=CC(C2N=C3SCCN3C2)=C1 RFAYUIIWPKWNKY-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- RAOCRURYZCVHMG-UHFFFAOYSA-N N-(6-propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCOC1=CC=C2N=C(NC(=O)OC)NC2=C1 RAOCRURYZCVHMG-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960002669 albendazole Drugs 0.000 description 1
- HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 201000008680 babesiosis Diseases 0.000 description 1
- 239000013533 biodegradable additive Substances 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 229950000536 butamisole Drugs 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 229960003475 cambendazole Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000003224 coccidiostatic agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 229960003974 diethylcarbamazine Drugs 0.000 description 1
- RCKMWOKWVGPNJF-UHFFFAOYSA-N diethylcarbamazine Chemical compound CCN(CC)C(=O)N1CCN(C)CC1 RCKMWOKWVGPNJF-UHFFFAOYSA-N 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 229960004500 flubendazole Drugs 0.000 description 1
- CPEUVMUXAHMANV-UHFFFAOYSA-N flubendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=C(F)C=C1 CPEUVMUXAHMANV-UHFFFAOYSA-N 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229960003439 mebendazole Drugs 0.000 description 1
- BAXLBXFAUKGCDY-UHFFFAOYSA-N mebendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CC=C1 BAXLBXFAUKGCDY-UHFFFAOYSA-N 0.000 description 1
- 229940029985 mineral supplement Drugs 0.000 description 1
- 235000020786 mineral supplement Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229950006763 nitramisole Drugs 0.000 description 1
- SGKGVABHDAQAJO-UHFFFAOYSA-N nitroxynil Chemical compound OC1=C(I)C=C(C#N)C=C1[N+]([O-])=O SGKGVABHDAQAJO-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 description 1
- 229960004454 oxfendazole Drugs 0.000 description 1
- 229960002762 oxibendazole Drugs 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- QZWHWHNCPFEXLL-UHFFFAOYSA-N propan-2-yl n-[2-(1,3-thiazol-4-yl)-3h-benzimidazol-5-yl]carbamate Chemical compound N1C2=CC(NC(=O)OC(C)C)=CC=C2N=C1C1=CSC=N1 QZWHWHNCPFEXLL-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 235000010296 thiabendazole Nutrition 0.000 description 1
- 239000004308 thiabendazole Substances 0.000 description 1
- YFNCATAIYKQPOO-UHFFFAOYSA-N thiophanate Chemical compound CCOC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OCC YFNCATAIYKQPOO-UHFFFAOYSA-N 0.000 description 1
- 201000002311 trypanosomiasis Diseases 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7843555 | 1978-11-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5588759A JPS5588759A (en) | 1980-07-04 |
| JPS6223576B2 true JPS6223576B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-05-23 |
Family
ID=10500865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14341779A Granted JPS5588759A (en) | 1978-11-07 | 1979-11-07 | Device for continuously discharging medicine |
Country Status (10)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0595483U (ja) * | 1992-05-25 | 1993-12-27 | 健順 藤原 | ミシンの突起付き定規 |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2966275D1 (en) * | 1978-11-07 | 1983-11-10 | Beecham Group Plc | Device for oral administration to a ruminant animal |
| DE3067332D1 (en) * | 1979-06-27 | 1984-05-10 | Beecham Group Plc | Veterinary preparations for ruminant animals |
| US4381780A (en) * | 1981-01-19 | 1983-05-03 | Research Corporation | Sustained release delivery system |
| EP0076622A1 (en) * | 1981-10-07 | 1983-04-13 | Beecham Group Plc | Anthelmintics |
| US4563184A (en) * | 1983-10-17 | 1986-01-07 | Bernard Korol | Synthetic resin wound dressing and method of treatment using same |
| GB8328916D0 (en) * | 1983-10-28 | 1983-11-30 | Castex Prod | Pharmaceutical pellet |
| IN162525B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1984-02-08 | 1988-06-04 | Pfizer | |
| FR2560768A1 (fr) * | 1984-03-07 | 1985-09-13 | Crb Virbac Sa | Dispositif a liberation programmee |
| US5000957A (en) * | 1984-03-19 | 1991-03-19 | Alza Corporation | Dispenser comprising hydrophilic osmopolymer |
| NZ212100A (en) * | 1984-06-02 | 1988-07-28 | Castex Prod | Rumen bolus; outer casing sheds in segments |
| GB2164557B (en) * | 1984-09-15 | 1987-10-28 | Standard Telephones Plc | Rumen bolus of soluble glass |
| US4735804A (en) * | 1985-05-10 | 1988-04-05 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| DE3680024D1 (de) * | 1985-05-10 | 1991-08-08 | Merck & Co Inc | Abgabesystem fuer arzneimittel, das waehrend einer kontrollierten zeitspanne im magen zurueckgehalten werden kann. |
| US5618547A (en) * | 1985-05-20 | 1997-04-08 | British Technology Group Limited | Control of ectoparasites |
| US4767627A (en) * | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4758436A (en) * | 1985-05-29 | 1988-07-19 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4717568A (en) * | 1985-08-09 | 1988-01-05 | Alza Corporation | Laminar arrangement for increasing delivery of beneficial agent from dispenser |
| US4710191A (en) * | 1985-12-16 | 1987-12-01 | Jonergin, Inc. | Therapeutic device for the administration of medicaments |
| US5407685A (en) * | 1986-02-06 | 1995-04-18 | Steris Corporation | Controlled oxygen/anti-microbial release films |
| US4808412A (en) * | 1987-06-11 | 1989-02-28 | Eastman Kodak Company | Rumen-stable compositions |
| GB8815968D0 (en) * | 1988-07-05 | 1988-08-10 | Pfizer Ltd | Veterinary devices |
| US5141810A (en) * | 1988-10-04 | 1992-08-25 | Pfizer Inc. | Means for constraining a rumen drug delivery device in a rolled configuration |
| NZ228382A (en) * | 1989-03-17 | 1992-08-26 | Carter Holt Harvey Plastic Pro | Drug administering coil-like device for insertion in body cavity of animal |
| AU702746B2 (en) * | 1995-09-20 | 1999-03-04 | Cochlear Limited | Bioresorbable polymer use in cochlear and other implants |
| FR2754711B1 (fr) * | 1996-10-21 | 1999-01-29 | Vandamme Thierry | Dispositif de liberation avec effet retard d'une substance active, notamment veterinaire |
| DE19715794C1 (de) * | 1997-04-16 | 1998-12-03 | Roehm Gmbh | Laminare Arzneiform und Verfahren zu ihrer Herstellung |
| US6096328A (en) * | 1997-06-06 | 2000-08-01 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
| US6146655A (en) * | 1997-08-29 | 2000-11-14 | Softy-Flex Inc. | Flexible intra-oral bandage and drug delivery system |
| MD1567G2 (ro) * | 1998-01-27 | 2001-06-30 | "Р.И.Ф." А.О. | Procedeu de preparare a cataplasmei de muştar, linie pentru executarea ei şi cataplasmă de muştar, preparată prin acest procedeu |
| MD1573G2 (ro) * | 1999-01-19 | 2001-06-30 | "Р.И.Ф." А.О. | Procedeu de ambalare a cataplasmei de muştar |
| CZ20014709A3 (cs) | 1999-07-02 | 2002-09-11 | The Procter & Gamble Company | Dávkovací systém pro dodávání látky ústní hygieny do dutiny ústní a způsob dávkování |
| DE19946822A1 (de) * | 1999-09-30 | 2001-04-26 | Lohmann Therapie Syst Lts | Wirk- und/oder Hilfsstoffe enthaltende Zubereitung mit steuerbarer Freisetzung dieser Stoffe, sowie ihre Verwendung und Herstellung |
| US20040219186A1 (en) * | 2001-08-16 | 2004-11-04 | Ayres James W. | Expandable gastric retention device |
| FR2839645B1 (fr) * | 2002-05-15 | 2005-08-05 | Backert Marie Elisabeth Cuine | Systeme multilamellaire pour l'administration de substances actives (en particulier des medicaments) par ingestion par la voie orale |
| WO2003099263A1 (de) * | 2002-05-24 | 2003-12-04 | Agfa-Gevaert | Wirkstoff enthaltende, zumindest teilweise abbaubare folien und verfahren zuderen herstellung |
| US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
| US20080089933A1 (en) | 2006-10-16 | 2008-04-17 | Amir Alon | Device and method for reducing calorie intake |
| US8095268B2 (en) | 2004-10-29 | 2012-01-10 | Bose Corporation | Active suspending |
| US7699863B2 (en) * | 2005-03-01 | 2010-04-20 | Tulip Medical Ltd. | Bioerodible self-deployable intragastric implants |
| US7785291B2 (en) * | 2005-03-01 | 2010-08-31 | Tulip Medical Ltd. | Bioerodible self-deployable intragastric implants |
| US8722066B2 (en) | 2011-03-29 | 2014-05-13 | Primigenia, LLC | Devices and methods for weight control and weight loss |
| WO2012149326A1 (en) | 2011-04-29 | 2012-11-01 | Massachusetts Institute Of Technology | Layer processing for pharmaceuticals |
| BR112014021678B1 (pt) * | 2012-03-07 | 2022-05-03 | Global Life Sciences Solutions Usa Llc | Sistema de reator pressurizado |
| US10507127B2 (en) | 2012-06-07 | 2019-12-17 | Epitomee Medical Ltd. | Expandable device |
| MX361101B (es) | 2012-10-17 | 2018-11-27 | Procter & Gamble | Tira para el suministro de un activo para el cuidado bucal y métodos para aplicar activos para el cuidado bucal. |
| ES2926480T3 (es) | 2013-12-05 | 2022-10-26 | Epitomee Medical Ltd | Dispositivos y sistemas retentivos para la liberación in situ de principios activos farmacéuticos |
| WO2015179461A1 (en) | 2014-05-20 | 2015-11-26 | Massachusetts Institute Of Technology | Plasticity induced bonding |
| WO2022089588A1 (zh) * | 2020-10-30 | 2022-05-05 | 南京三迭纪医药科技有限公司 | 胃滞留药物剂型 |
| JP2023553202A (ja) | 2020-12-08 | 2023-12-20 | ルミナント バイオテク コーポレーション リミテッド | 動物に物質を送達するための装置および方法の改善 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2625158A (en) * | 1945-12-15 | 1953-01-13 | John W Lee | Subcutaneous medication |
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| AU449029B2 (en) * | 1969-08-28 | 1974-04-17 | Commonwealth Scientific And Industrial Research Organisation | Device for administration to ruminants |
| US3625214A (en) * | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US3832252A (en) * | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
| US3903880A (en) * | 1972-08-17 | 1975-09-09 | Alza Corp | Intrauterine device for managing the reproductive process |
| GB1333576A (en) * | 1970-10-21 | 1973-10-10 | Alza Corp | Sustained release drug dosage device |
| US3892238A (en) * | 1971-09-16 | 1975-07-01 | Abbott Lab | Drug supporting anchor |
| US3796217A (en) * | 1972-03-10 | 1974-03-12 | Hydr Med Sciences Inc | Drug release system |
| GB1425550A (en) * | 1973-04-25 | 1976-02-18 | Alza Corp | Device for releasing active agent and process for producing the same |
| GB1471465A (en) * | 1974-06-04 | 1977-04-27 | Groves H | Vaginal medicator |
| ZA767136B (en) * | 1975-12-15 | 1977-10-26 | Hoffmann La Roche | Novel dosage form |
| US4029757A (en) * | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
| US4031200A (en) * | 1975-12-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
| US4055178A (en) * | 1976-03-10 | 1977-10-25 | Harrigan Roy Major | Drug delivery device for preventing contact of undissolved drug with the stomach lining |
| US4180558A (en) * | 1978-08-21 | 1979-12-25 | Hoffmann-La Roche Inc. | Unit dosage forms |
| GB1601923A (en) * | 1977-06-09 | 1981-11-04 | Beecham Group Ltd | Sustained release compositions |
| DE2966275D1 (en) * | 1978-11-07 | 1983-11-10 | Beecham Group Plc | Device for oral administration to a ruminant animal |
-
1979
- 1979-11-05 DE DE7979302445T patent/DE2966275D1/de not_active Expired
- 1979-11-05 AU AU52510/79A patent/AU528190B2/en not_active Ceased
- 1979-11-05 EP EP79302445A patent/EP0010987B1/en not_active Expired
- 1979-11-05 DK DK468379A patent/DK156375C/da active
- 1979-11-06 IE IE2127/79A patent/IE48982B1/en not_active IP Right Cessation
- 1979-11-06 NZ NZ192048A patent/NZ192048A/xx unknown
- 1979-11-06 CA CA000339311A patent/CA1146821A/en not_active Expired
- 1979-11-07 US US06/092,178 patent/US4268497A/en not_active Expired - Lifetime
- 1979-11-07 JP JP14341779A patent/JPS5588759A/ja active Granted
- 1979-11-07 ZA ZA00795997A patent/ZA795997B/xx unknown
-
1980
- 1980-12-09 US US06/214,778 patent/US4308250A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0595483U (ja) * | 1992-05-25 | 1993-12-27 | 健順 藤原 | ミシンの突起付き定規 |
Also Published As
| Publication number | Publication date |
|---|---|
| US4268497A (en) | 1981-05-19 |
| IE792127L (en) | 1980-05-07 |
| NZ192048A (en) | 1982-03-09 |
| AU528190B2 (en) | 1983-04-21 |
| DK468379A (da) | 1980-05-08 |
| EP0010987A1 (en) | 1980-05-14 |
| ZA795997B (en) | 1980-10-29 |
| DK156375C (da) | 1990-03-05 |
| US4308250A (en) | 1981-12-29 |
| AU5251079A (en) | 1980-05-15 |
| JPS5588759A (en) | 1980-07-04 |
| CA1146821A (en) | 1983-05-24 |
| EP0010987B1 (en) | 1983-10-05 |
| DK156375B (da) | 1989-08-14 |
| IE48982B1 (en) | 1985-06-26 |
| DE2966275D1 (en) | 1983-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS6223576B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| US4228149A (en) | Sustained release compositions | |
| JP5757682B2 (ja) | 活性成分粒子を含み増大した活性成分流量を有する経皮治療システム | |
| CA2294744C (en) | Multiple unit effervescent dosage form | |
| JP2535339B2 (ja) | 活性物質の制御速度制御用装置 | |
| EP1191926B1 (en) | New omeprazole and (s)-omeprazole formulation | |
| ES2355099T3 (es) | Dispositivo osmótico dentro de un dispositivo osmótico. | |
| US5002772A (en) | Gastric retention system for controlled drug release | |
| Chien | Potential development and new approaches in oral controlled-release drug delivery systems | |
| JP2001508068A (ja) | 胃腸系での活性物質の制御放出を用いた膨張性胃内貯留治療システム | |
| CN111372569A (zh) | 具有高有效物质含量的囊袋状口腔溶解膜 | |
| CN115475048A (zh) | 滥用和误用制止透皮系统 | |
| NO872924L (no) | Fibre inneholdende legemiddel for kontrollert frigjing. | |
| JP2605183B2 (ja) | 送達開始を遅延させた経皮送達装置 | |
| EP0021758B1 (en) | Veterinary preparations for ruminant animals | |
| JPH0374575B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| PT1414407E (pt) | Formas de dosagem que compreendem partículas que contêm ingrediente activo para a aplicação na pele ou na membrana mucosa | |
| HK1214136A1 (zh) | 硝酸氨基烷基酯的延长释放组合物 | |
| Wadher et al. | Recent (Aspects) trend on sustained drug delivery system | |
| PL145663B1 (en) | Method of obtaining sustained-action drug tablets | |
| CN100411613C (zh) | 一种奥美拉唑速释固体制剂及其制备方法 | |
| CN110882227A (zh) | 一种高效肠溶包衣组合物及其制备方法 |