JPS6216947B2 - - Google Patents

Info

Publication number
JPS6216947B2
JPS6216947B2 JP59500991A JP50099184A JPS6216947B2 JP S6216947 B2 JPS6216947 B2 JP S6216947B2 JP 59500991 A JP59500991 A JP 59500991A JP 50099184 A JP50099184 A JP 50099184A JP S6216947 B2 JPS6216947 B2 JP S6216947B2
Authority
JP
Japan
Prior art keywords
azaspiro
decane
mol
ethoxycarbonyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP59500991A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60500765A (ja
Inventor
Jozefu Teii Sutorapucheusukii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of JPS60500765A publication Critical patent/JPS60500765A/ja
Publication of JPS6216947B2 publication Critical patent/JPS6216947B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP59500991A 1983-02-09 1984-02-09 置換された１−アザスピロ〔４．５〕デカンおよび１−アザスピロ〔５．５〕ウンデカン Granted JPS60500765A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US465146 1983-02-09
US06/465,146 US4430335A (en) 1983-02-09 1983-02-09 Substituted 1-azaspiro[4,5]decanes and their analgesic compositions

Publications (2)

Publication Number Publication Date
JPS60500765A JPS60500765A (ja) 1985-05-23
JPS6216947B2 true JPS6216947B2 (en, 2012) 1987-04-15

Family

ID=23846664

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59500991A Granted JPS60500765A (ja) 1983-02-09 1984-02-09 置換された１−アザスピロ〔４．５〕デカンおよび１−アザスピロ〔５．５〕ウンデカン

Country Status (6)

Country Link
US (1) US4430335A (en, 2012)
EP (1) EP0116347B1 (en, 2012)
JP (1) JPS60500765A (en, 2012)
AT (1) ATE28631T1 (en, 2012)
DE (1) DE3465080D1 (en, 2012)
WO (1) WO1984003090A1 (en, 2012)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
US4570010A (en) * 1983-03-23 1986-02-11 The Upjohn Company Product
US5286723A (en) * 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
GB9223445D0 (en) 1992-11-09 1992-12-23 Boots Co Plc Therapeutic agents
SG43383A1 (en) * 1995-07-13 1997-10-17 Smithkline Beecham Corp N n-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2- propanamine dimaleate
DE10146910A1 (de) * 2001-09-24 2003-04-10 Bayer Cropscience Ag Spirocyclische 3-Phenyl-3-substituierte-4-ketolaktame und -laktone
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
DE10210190A1 (de) * 2002-03-07 2003-09-25 Sanol Arznei Schwarz Gmbh Aza-Spiroverbindungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH579547A5 (en, 2012) * 1973-07-25 1976-09-15 Ciba Geigy Ag
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.ORG.CHEM. *

Also Published As

Publication number Publication date
WO1984003090A1 (en) 1984-08-16
JPS60500765A (ja) 1985-05-23
EP0116347A1 (en) 1984-08-22
EP0116347B1 (en) 1987-07-29
US4430335A (en) 1984-02-07
ATE28631T1 (de) 1987-08-15
DE3465080D1 (en) 1987-09-03

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