JPS62158112A - 部分親水化シリカゲル及びその製造方法 - Google Patents
部分親水化シリカゲル及びその製造方法Info
- Publication number
- JPS62158112A JPS62158112A JP29916085A JP29916085A JPS62158112A JP S62158112 A JPS62158112 A JP S62158112A JP 29916085 A JP29916085 A JP 29916085A JP 29916085 A JP29916085 A JP 29916085A JP S62158112 A JPS62158112 A JP S62158112A
- Authority
- JP
- Japan
- Prior art keywords
- silica gel
- groups
- pores
- hydrophobic
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 114
- 229910002027 silica gel Inorganic materials 0.000 title claims abstract description 106
- 239000000741 silica gel Substances 0.000 title claims abstract description 106
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 125000001165 hydrophobic group Chemical group 0.000 claims abstract description 39
- 125000005372 silanol group Chemical group 0.000 claims abstract description 36
- 239000011148 porous material Substances 0.000 claims abstract description 32
- 238000009832 plasma treatment Methods 0.000 claims abstract description 18
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 8
- 102000004169 proteins and genes Human genes 0.000 abstract description 25
- 108090000623 proteins and genes Proteins 0.000 abstract description 25
- 230000002209 hydrophobic effect Effects 0.000 abstract description 9
- 239000000945 filler Substances 0.000 abstract description 7
- 239000003463 adsorbent Substances 0.000 abstract description 6
- 239000003054 catalyst Substances 0.000 abstract description 6
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 abstract description 4
- 239000007789 gas Substances 0.000 abstract description 4
- 229910052786 argon Inorganic materials 0.000 abstract description 2
- 238000004587 chromatography analysis Methods 0.000 abstract description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract description 2
- 238000007789 sealing Methods 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 28
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 27
- -1 amino acids Chemical class 0.000 description 23
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 18
- 125000000962 organic group Chemical group 0.000 description 14
- 239000012488 sample solution Substances 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 11
- 210000002966 serum Anatomy 0.000 description 11
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 description 11
- 235000010290 biphenyl Nutrition 0.000 description 9
- 239000004305 biphenyl Substances 0.000 description 9
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 9
- 229960002695 phenobarbital Drugs 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000003480 eluent Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 238000000862 absorption spectrum Methods 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000012856 packing Methods 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 229910001882 dioxygen Inorganic materials 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000000921 elemental analysis Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000002798 polar solvent Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 101150069512 RHO1 gene Proteins 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 125000005647 linker group Chemical group 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 2
- 238000002211 ultraviolet spectrum Methods 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000004103 aminoalkyl group Chemical group 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- YBQPKOVSNHDRKD-UHFFFAOYSA-N chloro-dimethyl-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound C[Si](C)(Cl)CCCOCC1CO1 YBQPKOVSNHDRKD-UHFFFAOYSA-N 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 125000004966 cyanoalkyl group Chemical group 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 229910001872 inorganic gas Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000008040 ionic compounds Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- DQZNLOXENNXVAD-UHFFFAOYSA-N trimethoxy-[2-(7-oxabicyclo[4.1.0]heptan-4-yl)ethyl]silane Chemical compound C1C(CC[Si](OC)(OC)OC)CCC2OC21 DQZNLOXENNXVAD-UHFFFAOYSA-N 0.000 description 1
- BPSIOYPQMFLKFR-UHFFFAOYSA-N trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CO[Si](OC)(OC)CCCOCC1CO1 BPSIOYPQMFLKFR-UHFFFAOYSA-N 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Silicon Compounds (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29916085A JPS62158112A (ja) | 1985-12-27 | 1985-12-27 | 部分親水化シリカゲル及びその製造方法 |
| US06/946,078 US4694092A (en) | 1985-12-27 | 1986-12-24 | Partially hydrophilicized silica gel and process for producing the same |
| DE8686118093T DE3682886D1 (de) | 1985-12-27 | 1986-12-29 | Teilweise hydrophylisiertes silicagel und verfahren zu dessen herstellung. |
| EP86118093A EP0228090B1 (en) | 1985-12-27 | 1986-12-29 | Partially hydrophilicized silica sel and process for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29916085A JPS62158112A (ja) | 1985-12-27 | 1985-12-27 | 部分親水化シリカゲル及びその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62158112A true JPS62158112A (ja) | 1987-07-14 |
| JPH0461809B2 JPH0461809B2 (enrdf_load_stackoverflow) | 1992-10-02 |
Family
ID=17868906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29916085A Granted JPS62158112A (ja) | 1985-12-27 | 1985-12-27 | 部分親水化シリカゲル及びその製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62158112A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002256169A (ja) * | 2001-02-28 | 2002-09-11 | Mitsubishi Materials Corp | シリカ粉末及びその製造方法 |
| US6900157B2 (en) * | 2001-09-10 | 2005-05-31 | Tosoh Corporation | Process for production of partially hydrophilized porous adsorbents |
| KR100613685B1 (ko) | 2004-10-20 | 2006-08-21 | 한국화학연구원 | 실리카의 표면 개질 방법 |
| JP2010014716A (ja) * | 1997-09-29 | 2010-01-21 | Merck Patent Gmbh | 電気的中性の親水性外側表面を有する化学的に変性された多孔質材料 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4544485A (en) * | 1984-08-31 | 1985-10-01 | Purdue Research Foundation | Chromatographic method and means |
-
1985
- 1985-12-27 JP JP29916085A patent/JPS62158112A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4544485A (en) * | 1984-08-31 | 1985-10-01 | Purdue Research Foundation | Chromatographic method and means |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010014716A (ja) * | 1997-09-29 | 2010-01-21 | Merck Patent Gmbh | 電気的中性の親水性外側表面を有する化学的に変性された多孔質材料 |
| JP2002256169A (ja) * | 2001-02-28 | 2002-09-11 | Mitsubishi Materials Corp | シリカ粉末及びその製造方法 |
| US6900157B2 (en) * | 2001-09-10 | 2005-05-31 | Tosoh Corporation | Process for production of partially hydrophilized porous adsorbents |
| KR100613685B1 (ko) | 2004-10-20 | 2006-08-21 | 한국화학연구원 | 실리카의 표면 개질 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0461809B2 (enrdf_load_stackoverflow) | 1992-10-02 |
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