JPS62155204A - Skin external preparation - Google Patents

Abstract

PURPOSE:A skin external preparation applicable to exodermis, such as cosmetic, drug, quasi-drug, etc., having improved effects on chapped skin, etc., by adding ascorbigen to a skin external preparation. CONSTITUTION:A skin external preparation containing 0.001-30wt%, especially 0.01-20wt% based on total amount of skin external preparation of ascorbigen shown by formula I or formula II. This skin external preparation can shown a wide shape such as aqueous solution system, solubilized system, emulsion system, powder system, oily solution system, gelatinous system, ointment system, water-oil two layer system, water-oil-powder three layer system, etc. The skin external preparation can be properly blended with an oily component, wetting agent, drug, perfume, water, alcohol, thickening agent, coloring agent, etc., besides the above-mentioned essential component, as necessary.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a skin preparation for external use that is excellent in improving rough skin and imparting moisture and luster to the skin.

[Prior Art] One of the major purposes of external skin preparations such as cosmetics is to prevent and improve skin roughness. In order to achieve this objective, various moisturizing agents have conventionally been added.

[Problems to be Solved by the Invention] However, moisturizing agents such as polyhydric alcohols and chondroitin sulfate have the disadvantage that when incorporated in large amounts, they become sticky or give a sticky feeling.

[Means for Solving the Problems] In view of the above circumstances, the present inventors have conducted extensive research to obtain a skin external preparation with excellent effects on improving rough skin.
The present inventors have discovered that by incorporating ascorbigen into an external skin preparation, a skin preparation with excellent effects on improving rough skin can be obtained, and the present invention has been completed.

That is, the present invention is a skin external preparation characterized by containing ascorbigen.

Hereinafter, the configuration of the present invention will be explained in detail.

Ascorbigen used in the present invention includes ascorbigen A and ascorbigen B due to differences in steric configuration.
These are compounds represented by the following formulas (a) or (b), respectively.

Both are amorphous powders and soluble in ethanol. Any of these may be used in the skin external preparation of the present invention, or a mixture thereof may be used.

The blending amount is preferably 0.001 to 30% by weight, more preferably 0.01 to 20% by weight based on the total skin appearance. If it is less than 0.001%, the effect of the present invention cannot be exhibited.3
Even if it is added in excess of 0%, no increase in effect can be expected.

The skin external preparations of the present invention refer to those applied to the skin, such as cosmetics, pharmaceuticals, and quasi-drugs, and therefore, the dosage forms include aqueous solutions, solubilized systems, emulsified systems, powder systems, oil liquid systems, and gel systems. It can take a wide range of forms, such as an ointment system, a water-oil two-layer system, and a water-oil-powder three-layer system.

In addition to the above-mentioned essential ingredients, the external skin preparation of the present invention contains other ingredients normally used in external skin preparations such as cosmetics and pharmaceuticals, such as oil, humectants, ultraviolet absorbers, antioxidants, surfactants, and preservatives. agents, moisturizers, drugs, fragrances, water, alcohol,
Thickeners, coloring agents, etc. can be added as appropriate.

Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

Prior to working examples, the effectiveness testing method will be described.

Awn Difference in awn Tongue A replica of the skin surface of a healthy female person (face) was taken using a replica method using myristic resin and examined under a microscope (1
Observation was made at 7x magnification. That is, the skin roughness was evaluated as 1. based on the criteria shown in Table 1 based on the condition of the skin pattern and the peeling condition of the stratum corneum.
The creams of Example 1 and Comparative Example 1 were applied twice a day to the left and right half of the face of 30 people who were judged to have skin irritation of 2 (rough skin panel). Two weeks later, a replica was taken again and the condition of the skin was observed and evaluated according to the criteria shown in Table 1 in the same manner as above.

O: The proportion of panels rated 4 and 5 is 75% or more △: The proportion of panels rated 4 and 5 is 25% or more and less than 75% ×: The proportion of panels rated 4 and 5 is less than 25% Examples 1 and 2 Lotions having the formulation shown in Table 2 were manufactured by a conventional method.

Table 2 (blank below) As is clear from Table 2, the skin external preparation of the present invention is a novel skin external preparation with excellent effects on improving rough skin.

Example 3 Emulsion A milky lotion was produced by a conventional method according to the following recipe.

Stearic acid 2.0 Cetanol 1.0 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin
8.0 Squalane
3.0 S force roll 507
2.0 Ascorbigen
0.001POE (10) Monooleate 2.5 Triethanolamine 1.0 Propylene glycol
5.0 preservative
Appropriate amount of fragrance
Appropriate amount of distilled water Remaining Example 4 Nutritional Cream A nutritional cream was produced by a conventional method according to the following recipe.

Stearic acid 2.0 Stearyl alcohol 7.0 Reduced lanolin 2.0 Squalane
5.0 Octyldotecanol 6.0 POE (25) Cetyl ether 3.0 Glyceryl monostearate 2.0 Preservative
Appropriate amount of fragrance
Appropriate amount of propylene glycol
5.0 Ascorbigen 0.
05 Distilled water Remaining Example 5 Pack A bag was manufactured by a conventional method according to the following recipe.

Kaolin 65.0 Talc 19. O Propylene glycol 5.0 Calcium acetate 0.01 Urea
0.5 Ascorbigen
3.0 fragrance
0.39 Example 6 Lip Treatment A lip treatment having the following formulation was manufactured according to a conventional method.

Candelilla wax 9.0 Solid paraffin 8.0 Beeswax
5.0 carnauba wax
5.0 lanolin
11.0 Castor oil
residual ascorpigen
5.0 isopropyl myristate
10.0 fragrance
Appropriate amount of antioxidant Appropriate amount The skin preparations for external use of Examples 3 to d were excellent skin preparations for improving rough skin.

Claims (1)

[Claims] (1) A skin external preparation characterized by containing ascorbigen.