JPS62120311A - Hair nourishing cosmetic - Google Patents

Abstract

PURPOSE:A hair nourishing cosmetic showing effective and efficient growth promoting action on hair, obtained by combining three compounds such as an antiandrogen agent, etc. CONSTITUTION:A cosmetic base is blended with 0.25-2.5wt% antiandrogen agent (e.g., 16beta-ethyl-17beta-hydroxy-4-estren-3-one, etc.,), 0.1-1wt% 2,4-diamino-6- piperidinopyrimidin-3-oxide and 1-10wt% 1-dodecylazacycloheptan-2-one to give a hair nourishing cosmetic. Since the antiandrogen agent which is slightly soluble in a solvent is dissolved in 1-dodecylazacycloheptan-2-one, a cosmetic having more improved hair nourishing effect than a cosmetic obtained by blending only both the antiandrogen agent and 2,4-diamino-6-piperidino-pyrimidin-3- oxide can be obtained.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a hair nourishing cosmetic product that exhibits an effective hair growth promoting effect by combining three types of known compounds.

PRIOR ART AND PROBLEMS The present inventor has previously developed an anti-androgien agent.
rogen) and 2,4-noamino-6-bipericnobilimicin-3-oxide (2,4-diamino-
6-piperidinopyrimidine-3
The present inventors have discovered an effective hair growth promoting effect in combination with the above-mentioned hair growth cosmetics (-oxides), and have specifically proposed a hair-growth cosmetic containing these compounds as active ingredients in Patent No. 60-4625. However, the anti-andronodine agent, which is difficult to dissolve in ordinary solvents, was found to be 1-dodecyl azacycloheptane-2-
On (1-dodecylazacyclohepta
n-2-one), and completed the present invention.

Solution The gist of the present invention is to provide an anti-androgen agent.
rogen) to 1-dodecyl azacycloheptane-2-
By dissolving the 2.4-diamino-6-piberino/pyrimidine-3-oxide in a cosmetic base as an active ingredient, the anti-androgen agent and 2.4-:)ami/-6 can be combined. - Compared to cosmetics containing only biverizinobilimicin and 3-oxide,
Furthermore, it is possible to obtain cosmetics with excellent hair-nourishing effects. This will be explained in detail below.

The amount of anti-androgien agent added to the cosmetic base is approximately 0.25 to 2.5% by weight of the cosmetic base, and that of 2.4-noamino-6-biveridinobilimicin-3-oxide is: The purpose can be sufficiently achieved by using 0.1 to 1% and 1-dodecyl azacycloheptan-2-one in the range of 1 to 10%, respectively. As an anti-and-a-thiene agent, 16β-ethyl-17β-hydroxy-
Examples include 4-nystren-3-one.

Test examples and manufacturing examples showing the hair-nurturing effect of the cosmetics of the present invention are listed below.

[Test Example] In order to test the hair growth effect of the cosmetics of this application, the following A and 8 were tested.
Two types of test liquids were prepared, and the effectiveness was determined based on the change in the number of hairs removed during hair washing before and after using these test liquids. The test subjects were generally male, and they were divided into two groups of 5 people for each test solution, and hair was collected once a week for a total of 16 times over 4 months. The hair removal period was used as a collection period, and the latter two months were used as a period to observe the effects of applying test solutions A and B described later. The effects were compared using the average of eight times each during the period before the test solution was used (non-application period) and during the period during which the test solution was used (application period). The interval between each hair wash was 2 days.

Test solution A: 16β-ethyl-17β-hydroxy-4-nystren-3-one...0.5g2.
4-diamino-6-viverino/pyrimidine-3-oxide...0.5g95%
Ethanol: 50g distilled water
...49゜Test solution B: 16β-ethyl-17β-human axy-4-nystren-3-one...0.5g 1-horse chestnut
Sil7zasikhihebutan-2-one
・・・・・・5.0゜2.4-Noamino-6-biverino/pyrimidine-3-oxide ・・・O, 5g 95% ethyl alcohol ・・・・・・50g Distilled water
・・・・・・44g Results As shown in the table below, sample solution A showed a moderate effect (
+10 +) 1 person, significant effect (10) 2 people, moderate effect (
+) 2 people, but with sample solution B, 3 people had a significant effect and 2 people had a significant effect.

Group A panel NO No application period Application period Effect 1261±34
233±42+ 2313±52 222±38 -)++3
196 ±26 138 ±51 ++
4296±41264±25+ 5 352 ±53 309 ±33
←Group B Panel No. No application period Application period Effect 1397243
336±27 -i+2184±27 10
1+:56 →3 224+39 xz
s: 53 +++4 324 + 44
212”: 48 →5 289”28
22.6±31 ++-In addition, in the table below, the criteria for judgment are as follows.

Reduction in the number of hairs pulled: 170 or more effective hairs
V1 effect + 40-69 Considerable effect 11-39 Somewhat effective + 10 or less No effect - As is clear from the above, 16β-ethyl-17β-hydroxy-4-nystrene-3-one and 2. 1 Example 1 A synergistic effect is seen by adding 1-dodecyl azacycloheptan-2-one to these two rather than using 4-noamitsu-6-biberinonobiriminone-3-oxide in combination. Preparation of hair lotion 1. 0.5 g of 6β-ethyl-17β-hydroxy-4-nystren-3-one is dissolved in 5 g of 1-dodecyl azacycloheptan-2-one. On the other hand, 2,4-diamino-6-bivelinonobilimicin-3-oxide 0.
Dissolve 5 g in 95% ethanol 50...1, mix the obtained two solutions, add appropriate amounts of fragrance and hair nourishing agent, and further add purified water to make a total of 100 g, and mix into 7117-3.
get the results.

Claims (1)

[Claims] A hair nourishing cosmetic containing an antiandrogen, 1-dodecyl azacycloheptan-2-one, and 2,4-diamino-6-piperidinopyrimidine-3-oxide as hair nourishing ingredients.