JPS6193117A - 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤 - Google Patents
副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤Info
- Publication number
- JPS6193117A JPS6193117A JP59215683A JP21568384A JPS6193117A JP S6193117 A JPS6193117 A JP S6193117A JP 59215683 A JP59215683 A JP 59215683A JP 21568384 A JP21568384 A JP 21568384A JP S6193117 A JPS6193117 A JP S6193117A
- Authority
- JP
- Japan
- Prior art keywords
- carbapenem
- penem
- ornithine
- type
- mitigated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 11
- 230000000694 effects Effects 0.000 title claims abstract description 6
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims abstract description 16
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960003104 ornithine Drugs 0.000 claims abstract description 16
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims abstract description 15
- 150000002668 lysine derivatives Chemical class 0.000 claims abstract description 10
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 abstract description 13
- 125000002252 acyl group Chemical group 0.000 abstract description 10
- 231100000417 nephrotoxicity Toxicity 0.000 abstract description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract 4
- 238000013329 compounding Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- -1 isobutyryl Chemical group 0.000 description 11
- 210000003734 kidney Anatomy 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 3
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 125000001402 nonanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 3
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 3
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 206010029155 Nephropathy toxic Diseases 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
- 125000004744 butyloxycarbonyl group Chemical group 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 125000000268 heptanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000007694 nephrotoxicity Effects 0.000 description 2
- HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- CVCQLTQQMALEDZ-XCWJXAQQSA-N (2R)-2,5-diamino-2-benzoyl-6-oxo-6-phenylhexanoic acid Chemical compound NC(CC[C@](N)(C(O)=O)C(=O)c1ccccc1)C(=O)c1ccccc1 CVCQLTQQMALEDZ-XCWJXAQQSA-N 0.000 description 1
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 1
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241000723353 Chrysanthemum Species 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- JRLGPAXAGHMNOL-LURJTMIESA-N N(2)-acetyl-L-ornithine Chemical compound CC(=O)N[C@H](C([O-])=O)CCC[NH3+] JRLGPAXAGHMNOL-LURJTMIESA-N 0.000 description 1
- DTERQYGMUDWYAZ-ZETCQYMHSA-N N(6)-acetyl-L-lysine Chemical compound CC(=O)NCCCC[C@H]([NH3+])C([O-])=O DTERQYGMUDWYAZ-ZETCQYMHSA-N 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 150000001339 alkali metal compounds Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- NKLCHDQGUHMCGL-UHFFFAOYSA-N cyclohexylidenemethanone Chemical group O=C=C1CCCCC1 NKLCHDQGUHMCGL-UHFFFAOYSA-N 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 1
- 125000001148 pentyloxycarbonyl group Chemical group 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59215683A JPS6193117A (ja) | 1984-10-15 | 1984-10-15 | 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤 |
| DK469385A DK165665C (da) | 1984-10-15 | 1985-10-14 | Laegemiddel indeholdende et penem- eller carbapenemantibiotikum og et aminosyrederviat |
| IE252285A IE59395B1 (en) | 1984-10-15 | 1985-10-14 | Composition containing a penem or carbapenem antibiotic |
| NO854056A NO172099C (no) | 1984-10-15 | 1985-10-14 | Fremgangsmaate til fremstilling av et preparat som inneholder et penem -eller karbapenemantibiotikum og en n-acetylert aminosyre |
| ES547896A ES8703476A1 (es) | 1984-10-15 | 1985-10-15 | Un procedimiento para la preparacion de una composicion de un antibioticos de peben y un aminoacido n-acilado. |
| AT85307427T ATE71836T1 (de) | 1984-10-15 | 1985-10-15 | Zusammensetzung mit gehalt an einem penem- oder carbapenemantibiotikum. |
| CA000493012A CA1268708A (en) | 1984-10-15 | 1985-10-15 | Composition containing a penem or carbapenem antibiotic and a method of using the same |
| ZA857886A ZA857886B (en) | 1984-10-15 | 1985-10-15 | Composition containing a penem or carbapenem antibiotic and a method of using the same |
| EP85307427A EP0178911B1 (en) | 1984-10-15 | 1985-10-15 | Composition containing a penem or carbapenem antibiotic |
| HU853994A HU200922B (en) | 1984-10-15 | 1985-10-15 | Process for producing pharmaceutical compositions comprising penem or carbapenem antibiotic |
| DE8585307427T DE3585262D1 (de) | 1984-10-15 | 1985-10-15 | Zusammensetzung mit gehalt an einem penem- oder carbapenemantibiotikum. |
| AU48730/85A AU589377B2 (en) | 1984-10-15 | 1985-10-15 | Composition containing a penem or carbapenem antibiotic and a method of using the same |
| FI854014A FI854014A7 (fi) | 1984-10-15 | 1985-10-15 | Peneemiä tai karbapeneemiä sisältävä antibioottinen koostumus ja menetelmä niiden käyttämiseksi. |
| NZ213829A NZ213829A (en) | 1984-10-15 | 1985-10-15 | Antibiotic compositions containing a penem or carbapenem plus certain n-acylated amino acids |
| KR1019850007574A KR910009050B1 (ko) | 1984-10-15 | 1985-10-15 | 페넴 또는 카르바페넴 항생물질과 아미노산 유도체와의 조성물의 제조방법 |
| US06/917,793 US4757066A (en) | 1984-10-15 | 1986-10-10 | Composition containing a penem or carbapenem antibiotic and the use of the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59215683A JPS6193117A (ja) | 1984-10-15 | 1984-10-15 | 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6193117A true JPS6193117A (ja) | 1986-05-12 |
| JPH0461849B2 JPH0461849B2 (enExample) | 1992-10-02 |
Family
ID=16676427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59215683A Granted JPS6193117A (ja) | 1984-10-15 | 1984-10-15 | 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS6193117A (enExample) |
| ZA (1) | ZA857886B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853407A (en) * | 1987-05-22 | 1989-08-01 | Sanraku Incorporated | Aminoethylcysteine derivatives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS505520A (enExample) * | 1973-05-17 | 1975-01-21 |
-
1984
- 1984-10-15 JP JP59215683A patent/JPS6193117A/ja active Granted
-
1985
- 1985-10-15 ZA ZA857886A patent/ZA857886B/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS505520A (enExample) * | 1973-05-17 | 1975-01-21 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853407A (en) * | 1987-05-22 | 1989-08-01 | Sanraku Incorporated | Aminoethylcysteine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA857886B (en) | 1987-06-24 |
| JPH0461849B2 (enExample) | 1992-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU621470B2 (en) | Stabilized nitric oxide-primary amine complexes useful as cardiovascular agents | |
| US5750561A (en) | Compositions containing taxane derivatives | |
| IE80461B1 (en) | New compositions containing taxane derivatives | |
| IE47049B1 (en) | Tetracycline antibiotic compositions | |
| JPH08501276A (ja) | 心臓血管作用薬として有用な酸化窒素−求核剤付加物の混合配位子金属錯体 | |
| JP2002538095A (ja) | ミセル形成界面活性剤を含有するエキノカンジン薬学的処方物 | |
| JPWO1999002158A1 (ja) | ４，５−エポキシモルヒナン誘導体を含有する安定な医薬品組成物 | |
| US20040209843A1 (en) | Aqueous cilostazol preparation for injection | |
| HU181847B (en) | Process for producing acid additional salts of 16-beta-mono-quaterner-ammonium derivatives of 2-beta,16-beta-bis-piperidino-androstanes and pharmaceutical compositions containing them as active agents | |
| US11382927B2 (en) | Liquid medicinal preparation | |
| JP3208437B2 (ja) | 癌転移抑制剤 | |
| JPS6193117A (ja) | 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤 | |
| HU177873B (en) | Further developped process for preparing an aequous solution containing a complex of n-/3-chloro-4-/4-chloro-phenoxy/-phenyl/-2-hydroxy-3,5-diiodo-benzamide with polyvinyl-pyrrolidone | |
| EP0178911B1 (en) | Composition containing a penem or carbapenem antibiotic | |
| US5420124A (en) | Stable, painless piroxicam potassium injectable composition | |
| KR20250026146A (ko) | 붕소 화합물의 전구약물 및 박테리아 감염 치료에 있어서의 이의 용도 | |
| US6784315B2 (en) | Stilbene derivative crystal and method for producing the same | |
| US4089968A (en) | Stable solutions of ipronidazole | |
| EP1864664A1 (en) | Pharmaceutical preparation | |
| JPS62174015A (ja) | 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤 | |
| JPH04312596A (ja) | チャートルシン誘導体の塩及びそれらを含有する抗癌剤 | |
| PT91383B (pt) | Processo para a preparacao do acido (5r,6s)-2-carbamoiloximetil-6-{(1r)-hidroxi-etil}-2-penem-3-carboxilico sob a forma cristalina e de composicoes farmaceuticas que o contem | |
| JPH0236123A (ja) | 持続性を有するモルヒネ直腸投与製剤 | |
| JPS61267518A (ja) | 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤 | |
| JPS61249976A (ja) | グリシジルアミン含有細胞増殖抑制活性薬物 |