ES8703476A1 - Un procedimiento para la preparacion de una composicion de un antibioticos de peben y un aminoacido n-acilado. - Google Patents

Un procedimiento para la preparacion de una composicion de un antibioticos de peben y un aminoacido n-acilado.

Info

Publication number
ES8703476A1
ES8703476A1 ES547896A ES547896A ES8703476A1 ES 8703476 A1 ES8703476 A1 ES 8703476A1 ES 547896 A ES547896 A ES 547896A ES 547896 A ES547896 A ES 547896A ES 8703476 A1 ES8703476 A1 ES 8703476A1
Authority
ES
Spain
Prior art keywords
penem
antibiotic
composition containing
carbapenem antibiotic
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547896A
Other languages
English (en)
Other versions
ES547896A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59215683A external-priority patent/JPS6193117A/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES547896A0 publication Critical patent/ES547896A0/es
Publication of ES8703476A1 publication Critical patent/ES8703476A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION DE UN ANTIBIOTICO DE PENEM Y UN AMINOACIDO N-ACILADO. CONSISTE EN DISPERSAR EN AGUA EL AMINOACIDO Y DESPUES CONVERTIRLO EN UNA SAL ADECUADA POR ADICION DE UNA SOLUCION ACUOSA DE UNA BASE APROPIADA PARA AJUSTAR EL PH DE LA MEZCLA ENTRE 5,5 Y 9, EFECTUANDOSE ESTAS OPERACIONES A TEMPERATURA ENTRE 10 Y 30º, A PRESION ATMOSFERICA Y CON AGITAICON; AGREGAR EL ANTIBIOTICO DE PENEM A LA SOLUCION RESULTANTE TALES QUE LAS RELACIONES DE AMINOACIDO Y ANTIBIOTICO ESTAN ENTRE 0,1:1 Y 4:1, A TEMPERATURA ENTRE 0 Y 100º A PRESION ATMOSFERICA Y CON AGITACION; Y LIOFILIZAR EL PRODUCTO OBTENIDO A TEMPERATURA ENTRE C 20º Y 50º BAJO PRESION REDUCIDA DE 0,01 TORR Y DURANTE 15 HORAS PARA PRODUCIR UNA COMPOSICION EN POLVO. TIENE APLICACIONES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES547896A 1984-10-15 1985-10-15 Un procedimiento para la preparacion de una composicion de un antibioticos de peben y un aminoacido n-acilado. Expired ES8703476A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59215683A JPS6193117A (ja) 1984-10-15 1984-10-15 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤
JP1400185 1985-01-28

Publications (2)

Publication Number Publication Date
ES547896A0 ES547896A0 (es) 1987-02-16
ES8703476A1 true ES8703476A1 (es) 1987-02-16

Family

ID=26349871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547896A Expired ES8703476A1 (es) 1984-10-15 1985-10-15 Un procedimiento para la preparacion de una composicion de un antibioticos de peben y un aminoacido n-acilado.

Country Status (12)

Country Link
EP (1) EP0178911B1 (es)
KR (1) KR910009050B1 (es)
AU (1) AU589377B2 (es)
CA (1) CA1268708A (es)
DE (1) DE3585262D1 (es)
DK (1) DK165665C (es)
ES (1) ES8703476A1 (es)
FI (1) FI854014L (es)
HU (1) HU200922B (es)
IE (1) IE59395B1 (es)
NO (1) NO172099C (es)
NZ (1) NZ213829A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH24782A (en) * 1985-10-24 1990-10-30 Sankyo Co Composition containing a penem or carbapenem antibiotic and the use of the same
EP0722945A1 (en) 1995-01-18 1996-07-24 Zeneca Limited 9-oxo-1-azabicyclo(5.2.0)non-2,3-diene-2-carboxylic acid derivatives as antibiotics
KR960040364A (ko) * 1995-05-16 1996-12-17 유충식 토라인(taurine)과 페넴 또는 카바페넴 유도체를 함유하는 의약조성물
ES2323527T3 (es) 2002-05-29 2009-07-20 MERCK & CO., INC. Compuestos utiles en el tratamiento del carbunco y en la inhibicion del factor letal.
EP1747212A4 (en) 2004-05-11 2009-03-25 Merck & Co Inc PROCESS FOR PRODUCING N-SULFINATED AMINO ACID DERIVATIVES
WO2014070774A1 (en) * 2012-10-29 2014-05-08 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR244550A1 (es) * 1978-07-24 1993-11-30 Merck & Co Inc Procedimiento para obtener una composicion de antibioticos del tipo de la tienamicina con inhibidores de la dipeptidasa
NZ201471A (en) * 1981-08-10 1985-09-13 Merck & Co Inc Antibacterial compositions containing penems and dipeptidase inhibitors
JPS58170479A (ja) * 1982-03-30 1983-10-07 Sanraku Inc ジペプチダ−ゼ阻害剤
PH24782A (en) * 1985-10-24 1990-10-30 Sankyo Co Composition containing a penem or carbapenem antibiotic and the use of the same

Also Published As

Publication number Publication date
FI854014L (fi) 1986-04-16
IE59395B1 (en) 1994-02-23
AU589377B2 (en) 1989-10-12
NO172099C (no) 1993-06-09
KR860003263A (ko) 1986-05-21
HU200922B (en) 1990-09-28
DK469385A (da) 1986-04-16
NO172099B (no) 1993-03-01
DK165665C (da) 1993-06-14
DK469385D0 (da) 1985-10-14
IE852522L (en) 1986-04-15
EP0178911A3 (en) 1989-02-01
HUT38537A (en) 1986-06-30
NO854056L (no) 1986-04-16
ES547896A0 (es) 1987-02-16
KR910009050B1 (ko) 1991-10-28
NZ213829A (en) 1989-04-26
DE3585262D1 (de) 1992-03-05
CA1268708A (en) 1990-05-08
EP0178911B1 (en) 1992-01-22
FI854014A0 (fi) 1985-10-15
EP0178911A2 (en) 1986-04-23
AU4873085A (en) 1986-06-12
DK165665B (da) 1993-01-04

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