JPS6160815B2 - - Google Patents
Info
- Publication number
- JPS6160815B2 JPS6160815B2 JP55041241A JP4124180A JPS6160815B2 JP S6160815 B2 JPS6160815 B2 JP S6160815B2 JP 55041241 A JP55041241 A JP 55041241A JP 4124180 A JP4124180 A JP 4124180A JP S6160815 B2 JPS6160815 B2 JP S6160815B2
- Authority
- JP
- Japan
- Prior art keywords
- general formula
- composition according
- derivative
- acylamino
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 230000004223 radioprotective effect Effects 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- -1 carboxyamidino Chemical group 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 239000003085 diluting agent Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 1
- MQVDHGSBXOIEKT-UHFFFAOYSA-N 2-(4-aminobutanoylamino)ethanesulfonic acid Chemical compound NCCCC(=O)NCCS(O)(=O)=O MQVDHGSBXOIEKT-UHFFFAOYSA-N 0.000 claims 1
- VBIJCBOMFUAELO-UHFFFAOYSA-N 2-(4-aminobutanoylamino)ethyl dihydrogen phosphate Chemical compound NCCCC(=O)NCCOP(O)(O)=O VBIJCBOMFUAELO-UHFFFAOYSA-N 0.000 claims 1
- NWPCXGGYSQHQGM-UHFFFAOYSA-N 2-aminoethyl carbamimidothioate Chemical compound NCCSC(N)=N NWPCXGGYSQHQGM-UHFFFAOYSA-N 0.000 claims 1
- SESNTBVJSISIMG-VKZKZBKNSA-N OP(=O)(O)OC(CN)C(=O)CC[C@H](N)C(O)=O Chemical compound OP(=O)(O)OC(CN)C(=O)CC[C@H](N)C(O)=O SESNTBVJSISIMG-VKZKZBKNSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005365 aminothiol group Chemical class 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- WGXUDTHMEITUBO-YFKPBYRVSA-N glutaurine Chemical compound OC(=O)[C@@H](N)CCC(=O)NCCS(O)(=O)=O WGXUDTHMEITUBO-YFKPBYRVSA-N 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
- 239000000126 substance Substances 0.000 description 3
- GAPFINWZKMCSBG-UHFFFAOYSA-N 2-(2-sulfanylethyl)guanidine Chemical compound NC(=N)NCCS GAPFINWZKMCSBG-UHFFFAOYSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- XDVMCVGTDUKDHL-UHFFFAOYSA-N [amino(2-azaniumylethylsulfanyl)methylidene]azanium;dibromide Chemical compound Br.Br.NCCSC(N)=N XDVMCVGTDUKDHL-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79CI1924A HU180443B (en) | 1979-04-02 | 1979-04-02 | Process for preparing a pharmaceutical preparation with synergetic action against radiation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55133312A JPS55133312A (en) | 1980-10-17 |
| JPS6160815B2 true JPS6160815B2 (US20080293856A1-20081127-C00150.png) | 1986-12-23 |
Family
ID=10994743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4124180A Granted JPS55133312A (en) | 1979-04-02 | 1980-04-01 | Synergistic radioactive ray protection pharmaceutic composition |
Country Status (6)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206484B (en) * | 1989-03-24 | 1992-11-30 | Orszagos Frederic Joliot Curie | Silicium-containing environment-protecting composition adsorbing radioactive metal-isotopes and toxic heavy metals and process for producing pharmaceutical compositions containing this active component |
| HU208072B (en) * | 1990-02-28 | 1993-08-30 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical composition suitable for preventing and curing autoimmune diseases and skin affections caused by heat and light radiacion |
| EP0481294B2 (de) * | 1990-10-19 | 2001-04-11 | Spirig Ag Pharmazeutische Präparate | Feste, schnell-lösliche Arzneimittelzubereitung enthaltend N-Acetylcystein |
| JPH0680964A (ja) * | 1991-12-27 | 1994-03-22 | Sogo Yatsukou Kk | 活性酸素消去剤 |
| EP1706104A2 (en) * | 2004-01-13 | 2006-10-04 | Omega Bio-Pharma (I.P.2) Limited | Methods for treating stress and affecting biological immune systems using a cysteamine compound |
| US20070191368A1 (en) * | 2004-03-23 | 2007-08-16 | Bissett Donald L | Inhibition of tissue damage to skin from radiation treatment therapy |
| US10420739B1 (en) * | 2013-06-13 | 2019-09-24 | Thermolife International, Llc | Glutaurine compositions and therapeutic uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47149A (en) * | 1974-04-29 | 1979-05-31 | Chinoin Gyogyszer Es Vegyeszet | Amino acid derivatives,their preparation and pharmaceutical compositions containing them |
| HU178199B (en) * | 1976-05-06 | 1982-03-28 | Chinoin Gyogyszer Es Vegyeszet | New process for producing amides of omega-amino-carboxylic acids |
-
1979
- 1979-04-02 HU HU79CI1924A patent/HU180443B/hu not_active IP Right Cessation
-
1980
- 1980-03-24 DE DE3011274A patent/DE3011274C2/de not_active Expired
- 1980-03-31 FR FR8007201A patent/FR2452929A1/fr active Granted
- 1980-04-01 JP JP4124180A patent/JPS55133312A/ja active Granted
- 1980-04-01 GB GB8010901A patent/GB2050164B/en not_active Expired
-
1984
- 1984-01-18 US US06/571,856 patent/US4563479A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2452929B1 (US20080293856A1-20081127-C00150.png) | 1983-04-29 |
| FR2452929A1 (fr) | 1980-10-31 |
| US4563479A (en) | 1986-01-07 |
| DE3011274C2 (de) | 1985-05-30 |
| GB2050164A (en) | 1981-01-07 |
| GB2050164B (en) | 1983-03-09 |
| HU180443B (en) | 1983-03-28 |
| JPS55133312A (en) | 1980-10-17 |
| DE3011274A1 (de) | 1980-10-09 |
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