JPS6160050B2 - - Google Patents
Info
- Publication number
- JPS6160050B2 JPS6160050B2 JP58148588A JP14858883A JPS6160050B2 JP S6160050 B2 JPS6160050 B2 JP S6160050B2 JP 58148588 A JP58148588 A JP 58148588A JP 14858883 A JP14858883 A JP 14858883A JP S6160050 B2 JPS6160050 B2 JP S6160050B2
- Authority
- JP
- Japan
- Prior art keywords
- csf
- molecular weight
- activity
- ultrafiltration membrane
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012528 membrane Substances 0.000 claims description 20
- 238000000108 ultra-filtration Methods 0.000 claims description 15
- 210000002700 urine Anatomy 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 8
- 230000005757 colony formation Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000000638 stimulation Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 description 17
- 239000000243 solution Substances 0.000 description 13
- 238000000034 method Methods 0.000 description 10
- 238000011084 recovery Methods 0.000 description 6
- 150000001450 anions Chemical class 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 238000011814 C57BL/6N mouse Methods 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 210000002798 bone marrow cell Anatomy 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 229920002492 poly(sulfone) Polymers 0.000 description 2
- 229920002239 polyacrylonitrile Polymers 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003887 myelocyte Anatomy 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58148588A JPS6041615A (ja) | 1983-08-12 | 1983-08-12 | コロニ−形成刺激因子の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58148588A JPS6041615A (ja) | 1983-08-12 | 1983-08-12 | コロニ−形成刺激因子の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6041615A JPS6041615A (ja) | 1985-03-05 |
| JPS6160050B2 true JPS6160050B2 (enrdf_load_stackoverflow) | 1986-12-19 |
Family
ID=15456102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58148588A Granted JPS6041615A (ja) | 1983-08-12 | 1983-08-12 | コロニ−形成刺激因子の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6041615A (enrdf_load_stackoverflow) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3689391T2 (de) * | 1985-02-05 | 1994-06-30 | Cetus Oncology Corp., Emeryville, Calif. | Rekombinanter koloniestimulierender faktor-1. |
| US6146851A (en) * | 1985-02-05 | 2000-11-14 | Chiron Corporation | DNA encoding NV2 (long form) and carboxy truncated fragments thereof |
| US5573930A (en) | 1985-02-05 | 1996-11-12 | Cetus Oncology Corporation | DNA encoding various forms of colony stimulating factor-1 |
| US6156300A (en) * | 1985-02-05 | 2000-12-05 | Chiron Corporation | Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof |
| JP2537935B2 (ja) * | 1987-12-29 | 1996-09-25 | 住友製薬株式会社 | 生理活性物質の農縮・脱塩方法 |
| JP2723175B2 (ja) * | 1995-02-21 | 1998-03-09 | 工業技術院長 | 石油系燃焼灰からそれに含まれる金属を抽出する方法 |
-
1983
- 1983-08-12 JP JP58148588A patent/JPS6041615A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6041615A (ja) | 1985-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313115 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| LAPS | Cancellation because of no payment of annual fees |