JPS6156128A - ドキソルビシンおよびその類縁体と陰イオン性ポリマ−との新規配合体、その製造法、および該配合体を含有する制癌作用を有する医薬組成物 - Google Patents

ドキソルビシンおよびその類縁体と陰イオン性ポリマ−との新規配合体、その製造法、および該配合体を含有する制癌作用を有する医薬組成物

Info

Publication number
JPS6156128A
JPS6156128A JP60110620A JP11062085A JPS6156128A JP S6156128 A JPS6156128 A JP S6156128A JP 60110620 A JP60110620 A JP 60110620A JP 11062085 A JP11062085 A JP 11062085A JP S6156128 A JPS6156128 A JP S6156128A
Authority
JP
Japan
Prior art keywords
doxorubicin
anionic polymer
polycarboxylate
analogs
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP60110620A
Other languages
English (en)
Japanese (ja)
Inventor
フランコ・ツミノ
ロモロ・アキレ・ガンベツタ
セルジオ・ペンコ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of JPS6156128A publication Critical patent/JPS6156128A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP60110620A 1984-05-25 1985-05-24 ドキソルビシンおよびその類縁体と陰イオン性ポリマ−との新規配合体、その製造法、および該配合体を含有する制癌作用を有する医薬組成物 Pending JPS6156128A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8413464 1984-05-25
GB848413464A GB8413464D0 (en) 1984-05-25 1984-05-25 Anthracycline-anionic polymer conjugates

Publications (1)

Publication Number Publication Date
JPS6156128A true JPS6156128A (ja) 1986-03-20

Family

ID=10561522

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60110620A Pending JPS6156128A (ja) 1984-05-25 1985-05-24 ドキソルビシンおよびその類縁体と陰イオン性ポリマ−との新規配合体、その製造法、および該配合体を含有する制癌作用を有する医薬組成物

Country Status (4)

Country Link
JP (1) JPS6156128A (de)
BE (1) BE902344A (de)
DE (1) DE3515178A1 (de)
GB (2) GB8413464D0 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1001051A4 (fr) * 1987-03-11 1989-06-20 Erba Carlo Spa Conjugue d'immunoglobuline contenant de l'idarubicine, medicament le contenant et procede de depletion in vitro d'un sous-groupe de lymphocytes t d'une population cellulaire utilisant ce conjugue.
EP0292964B1 (de) * 1987-05-28 1995-04-05 Hiroshi Maeda Superoxid-Dismutase-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
IT1230505B (it) * 1988-10-11 1991-10-25 Sicor Spa Procedimento per la conversione della daunorubicina in doxorubicina.
JPH03101616A (ja) * 1989-07-12 1991-04-26 Union Carbide Chem & Plast Co Inc 製薬学的活性誘導体の放出系
US5378456A (en) * 1993-03-25 1995-01-03 American Cyanamid Company Antitumor mitoxantrone polymeric compositions
US5609867A (en) 1994-11-01 1997-03-11 American Cyanamid Company Polymeric antitumor agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602967A (en) * 1977-07-16 1981-11-18 Hercules Inc Reaction prodcut of methotrexate with divinyl ether and maleic anhydride copolymer

Also Published As

Publication number Publication date
GB2158078A (en) 1985-11-06
GB2158078B (en) 1987-09-16
BE902344A (fr) 1985-09-02
GB8413464D0 (en) 1984-07-04
GB8510222D0 (en) 1985-05-30
DE3515178A1 (de) 1985-11-28

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