JPS6146468B2 - - Google Patents
Info
- Publication number
- JPS6146468B2 JPS6146468B2 JP4029877A JP4029877A JPS6146468B2 JP S6146468 B2 JPS6146468 B2 JP S6146468B2 JP 4029877 A JP4029877 A JP 4029877A JP 4029877 A JP4029877 A JP 4029877A JP S6146468 B2 JPS6146468 B2 JP S6146468B2
- Authority
- JP
- Japan
- Prior art keywords
- glycine
- hydrogen chloride
- reaction
- water
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 54
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 51
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 38
- 238000006243 chemical reaction Methods 0.000 claims description 36
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 35
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000004471 Glycine Substances 0.000 claims description 27
- TXTWXQXDMWILOF-UHFFFAOYSA-N (2-ethoxy-2-oxoethyl)azanium;chloride Chemical compound [Cl-].CCOC(=O)C[NH3+] TXTWXQXDMWILOF-UHFFFAOYSA-N 0.000 claims description 25
- 235000019441 ethanol Nutrition 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 12
- 238000010533 azeotropic distillation Methods 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 48
- 239000007788 liquid Substances 0.000 description 26
- 229960002449 glycine Drugs 0.000 description 24
- 239000012071 phase Substances 0.000 description 14
- 238000004821 distillation Methods 0.000 description 13
- 239000012452 mother liquor Substances 0.000 description 12
- 239000000706 filtrate Substances 0.000 description 9
- 239000008346 aqueous phase Substances 0.000 description 8
- 239000013078 crystal Substances 0.000 description 8
- 238000010992 reflux Methods 0.000 description 8
- IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 239000007789 gas Substances 0.000 description 5
- 229960001269 glycine hydrochloride Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000007423 decrease Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000004064 recycling Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- -1 ester hydrochloride Chemical class 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- NTNZTEQNFHNYBC-UHFFFAOYSA-N ethyl 2-aminoacetate Chemical compound CCOC(=O)CN NTNZTEQNFHNYBC-UHFFFAOYSA-N 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4029877A JPS53127412A (en) | 1977-04-11 | 1977-04-11 | Preparation of glycine ethyl ester hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4029877A JPS53127412A (en) | 1977-04-11 | 1977-04-11 | Preparation of glycine ethyl ester hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS53127412A JPS53127412A (en) | 1978-11-07 |
| JPS6146468B2 true JPS6146468B2 (en, 2012) | 1986-10-14 |
Family
ID=12576695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4029877A Granted JPS53127412A (en) | 1977-04-11 | 1977-04-11 | Preparation of glycine ethyl ester hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS53127412A (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63286721A (ja) * | 1987-05-07 | 1988-11-24 | ベクトン・ディッキンソン・アンド・カンパニー | 液体の液面検出装置 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111548281B (zh) * | 2020-05-25 | 2022-10-14 | 江苏巨莱生物医药有限公司 | 一种甘氨酸乙酯盐酸盐的生产方法及其生产设备 |
-
1977
- 1977-04-11 JP JP4029877A patent/JPS53127412A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63286721A (ja) * | 1987-05-07 | 1988-11-24 | ベクトン・ディッキンソン・アンド・カンパニー | 液体の液面検出装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS53127412A (en) | 1978-11-07 |
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