JPS6129324B2 - - Google Patents
Info
- Publication number
- JPS6129324B2 JPS6129324B2 JP5589179A JP5589179A JPS6129324B2 JP S6129324 B2 JPS6129324 B2 JP S6129324B2 JP 5589179 A JP5589179 A JP 5589179A JP 5589179 A JP5589179 A JP 5589179A JP S6129324 B2 JPS6129324 B2 JP S6129324B2
- Authority
- JP
- Japan
- Prior art keywords
- diaminopropionic acid
- acid
- present
- administered
- platelet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002439 hemostatic effect Effects 0.000 claims description 8
- 230000001965 increasing effect Effects 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 9
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000978776 Senegalia senegal Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000003582 thrombocytopenic effect Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- AELCINSCMGFISI-DTWKUNHWSA-N (1R,2S)-tranylcypromine Chemical compound N[C@@H]1C[C@H]1C1=CC=CC=C1 AELCINSCMGFISI-DTWKUNHWSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 208000013544 Platelet disease Diseases 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000002887 neurotoxic effect Effects 0.000 description 1
- -1 organic acid salt Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000691 up-and-down procedure Toxicity 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5589179A JPS55147220A (en) | 1979-05-07 | 1979-05-07 | Hemostatic and thrombocyte number increaser comprising alpha,beta-diaminopropionic acid |
| IT25856/79A IT1166905B (it) | 1978-09-23 | 1979-09-20 | Agente emostatico e in grado di accrescere il numero delle piastrine, contenente acido alfa, beta-diamminopropionico e suoi derivati |
| EP79103565A EP0009728A1 (en) | 1978-09-23 | 1979-09-21 | Hemostatic and platelet increasing agent containing alpha, beta-diaminopropionic acid and derivatives thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5589179A JPS55147220A (en) | 1979-05-07 | 1979-05-07 | Hemostatic and thrombocyte number increaser comprising alpha,beta-diaminopropionic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55147220A JPS55147220A (en) | 1980-11-17 |
| JPS6129324B2 true JPS6129324B2 (xx) | 1986-07-05 |
Family
ID=13011725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5589179A Granted JPS55147220A (en) | 1978-09-23 | 1979-05-07 | Hemostatic and thrombocyte number increaser comprising alpha,beta-diaminopropionic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55147220A (xx) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0362388U (xx) * | 1989-10-20 | 1991-06-18 |
-
1979
- 1979-05-07 JP JP5589179A patent/JPS55147220A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0362388U (xx) * | 1989-10-20 | 1991-06-18 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55147220A (en) | 1980-11-17 |
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