JPS61291512A - Dermatic agent - Google Patents

Abstract

PURPOSE:To provide a dermatic agent containing oxygen-adsorbed zeolite, giving high moistness to the skin and having excellent wound-remedying effect. CONSTITUTION:Oxygen is adsorbed to a synthetic zeolite expressed preferably by the formula (M is metallic atom having a valence n; x is 0.7-1.5; y is 0.8-10; z is >=0) in an amount of >=0.05mol per 1mol of zeolite and added to various drug-active agent or base for dermatic agent to give an oxygen content of >=300ppm. The adsorption of oxygen in zeolite can be carried out by heating and activating zeolite at 280-600 deg.C and contacting the activated zeolite with oxygen under anhydrous condition in the absence of gas having higher adsorptivity to zeolite than oxygen.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to dermatology, and more particularly to a novel dermatology containing oxygen-adsorbed zemalite. Dermatology refers to compositions that are applied directly to the skin, ie, skin and hair cosmetics, external skin preparations, and bath preparations.

It is widely known that retaining an appropriate amount of moisture in the stratum corneum of the skin is extremely important for the skin.
The problem of how to increase the water content in the stratum corneum has become a major challenge in dermatology, including skin cosmetics, external skin preparations, etc.

To solve this problem, moisturizers, emollients, etc. are commonly used, but oils and fats are effective in increasing the water content in the stratum corneum and inhibiting evaporation of water from the skin. A highly occlusive base is often used. This is especially true for external preparations for the skin, as the higher the water content in the stratum corneum, the higher the transdermal absorption of medicinal ingredients.

[Problem that the invention seeks to solve]

However, when the occlusive properties are increased in this way, even though the water content in the stratum corneum increases, when used repeatedly, the moisturized feeling of the skin may not be sufficiently improved, and the healing of wounds may be delayed. There were problems such as

[Means for solving problems]

In order to solve these problems, the inventors of the present invention have made extensive studies and have found that by incorporating oxygen into the skin material, the skin feels firm and tight, and the wound treatment effect is improved. The present invention was completed by discovering that high dermatological properties can be obtained and that it is sufficient to incorporate zeolite that adsorbs oxygen for this purpose. That is, the present invention provides a skin material characterized by containing zeolite that has adsorbed oxygen.

The zeolite used in the present invention may be a natural zeolite or a synthetic zeolite, but a synthetic zeolite represented by the following general formula, which contains fewer impurities and impurities, is preferred.

(M2/l0)xII leakage 0.・(Stow)y-(Ht
o) z (where M is a metal atom with a valence of n, and X is 0.7
~1.5. y is 0.8 to 10. (z indicates a number of 0 or more) Among the synthetic zeolites of the above general formula, the metal atoms represented by M include sodium, potassium, calcium, magnesium, etc., and 2 is 0, that is, substantially contains water. Preferably one that does not.

Oxygen can be adsorbed onto zeolite by, for example, bringing oxygen into contact with zeolite.

The adsorption is carried out after activation of the zeolite by heating it to 280-600°C, but under anhydrous conditions.

Further, it is preferable to carry out the reaction under conditions where there is no gas such as nitrogen or carbon dioxide which has a stronger adsorption property than oxygen on zeolite. .

The oxygen adsorbed on zeolite is
It is preferably 0.05 mol or more.

Further, the adsorbed oxygen can be used in any state, but it is preferably in a gaseous state.

If necessary, this zeolite that has adsorbed oxygen can be further coated to improve its oxygen retention during storage.

The skin preparation of the present invention is prepared by blending the oxygen-adsorbed zeolite as described above with various medicinal agents and a skin material base according to a conventional method.

The amount of zeolite adsorbed with oxygen is not particularly limited, but it is preferable that the skin material contains 300 ppm or more of oxygen. For this purpose, it is preferable that 5% or more of zeolite adsorbed with oxygen be blended.

Further, as the skin material base, various bases commonly used for skin materials can be used, but non-aqueous bases are preferred. Non-aqueous bases include, for example, inorganic powders such as tank and bentonite; liquid paraffin, vaseline, silicone oil, aliphatic higher alcohols, higher fatty acids, fatty acid esters, vegetable oils, lanolin and its derivatives, squalene, Various materials such as squalane and polyethylene can be used.

The thus obtained skin material of the present invention can be put into various dosage forms depending on its use, such as cream, bag, beauty powder,
Skin cosmetics such as foundation, lipstick, face wash, and body shampoo; Hair cosmetics such as hair cream, shampoo, and conditioner; Bath preparations such as lotus oil and bubble bath; Ointments, lotions, sprays, liniments, pasta,
It can be used as a skin preparation for external use such as pap. Also,
Depending on the dosage form, ingredients that are normally included in the above agents may be added to the extent that the effects of the present invention are not impaired.
Of course it is possible. These ingredients that can be mixed include:
surfactants, wetting agents, water-soluble polymers, preservatives, bactericidal agents,
Examples include antioxidants, colorants, fragrances, and the like.

[Effects of the present invention]

When applied to the skin, the skin preparation of the present invention significantly improves the moist feeling of the skin and is also excellent in terms of overall feeling of use.

Next, the results of evaluating the effects of the skin preparation of the present invention using the following method will be shown.

Evaluation 1: Skin cosmetic Example 1 below. The skin cosmetic (cosmetic oil) shown in Comparative Example 1 was used by 10 female subjects and subjected to sensory evaluation. It was used for one month. The results are shown in Table 1.

It can be seen that the product of the present invention is superior.

Margin Table 1 Unit: Name Evaluation 2: Hair Cosmetics Postscript Example 2. The hair cosmetic (hair oil) shown in Comparative Example 2 was
0 subjects used the product for two weeks and compared the feeling of use, occurrence of itching, and occurrence of dandruff. Table 2 shows the results. This result shows that the product of the present invention is superior.

Margin Table 2 below Unit: Name Evaluation 3: External skin preparations Using the external skin preparations shown in Example 3 and Comparative Example 3 below,
Blood methyl salicylate content was measured by the method shown below.

The results are shown in FIG.

(Measurement method) Weight 2.5 kl? A white male rabbit (male) was fixed in a dorsal position, the abdomen was carefully pricked with hair clippers, and sample IF (methyl salicylate content 50 μm) was applied to 482 undamaged skin areas. After application 0.5, 1.0, 2.0, 3.0
.

Blood was collected 5.0 hours later. The blood methyl salicylate content was measured by a conventional method using high performance liquid chromatography after converting the methyl salicylate into salicylic acid.

〔Example〕

Next, examples will be shown, but the present invention is not limited to these examples.

Example 1 Cosmetic oil Varnish Qualan 50 parts Castor oil 39.5 parts Oxygen adsorbing zeolite 10 parts! - Menthol
0.1 part 100.0 part 4 Oxygen adsorbing zeolite is zeolite (Zeolam 4-A
; manufactured by Toyo Soda Co., Ltd.) was dehydrated at approximately 300℃ and heated to 3k.
A material in which oxygen was adsorbed at a pressure of g/Crl was used. Zeolite 100. 1.2g of oxygen was adsorbed to F.

Example 2 Hair oil: Camellia oil 60.0 parts Methylpolysiloxane 20.0 parts d7! -α-Tocopherol 5.0 parts Zinc pyrithione 1.0 parts 100.0 parts Example 3 Ointment: Purified lanolin 5 parts Lascivious beeswax 5 parts White petrolatum 70 parts Oxygen-adsorbing zeolite 15 parts 100 parts Example 4 Bath agent: Hydrogen carbonate Sodium 30 parts Sodium carbonate 15 parts Succinic acid 40 parts Glauber's salt 4 parts Oxygen-adsorbing zeolite 10 parts 100 parts Comparative Example 1 Cosmetic oil Varnish Qualan 55 parts Castor oil 44.5 parts L-menthol 0.1 part 100.0 parts Comparison Example 2 Oil production: Camellia oil 60.0 parts Methylpolysiloxane 20.0 parts dl-α-tocopherol
5. ° 0 parts Zinc pyrithione 1.0 parts Zeolite 14.0 parts 100.0 parts Comparative Example 3 Ointment: Purified lanolin 5 parts Rashi beeswax 5 parts White petrolatum 85 parts 100 parts

[Brief explanation of drawings]

FIG. 1 is a diagram showing changes in blood salicylic acid concentration over time when the ointments of Example 3 and Comparative Example 3 were applied to white rabbits. that's all

Claims (1)

[Claims] 1. A skin material characterized by containing zeolite that has absorbed oxygen.