JPS61291511A - Dermatic agent - Google Patents

Abstract

PURPOSE:To obtain a dermatic agent effective to improve the blood flow acceleration effect of carbon dioxide gas, by combining carbon dioxide gas (generating substance) and oxygen gas (generating substance). CONSTITUTION:The objective agent can be produced by combining (A) carbon dioxide gas or a substance capable of generating carbon dioxide gas (e.g. a combination of a carbonate and an acid) and (B) oxygen gas or a substance capable of generating oxygen gas (e.g. sodium perborate) in a manner to generate >=60ppm of carbon dioxide gas and >=300ppm of oxygen gas. The agent is effective to improve the wound-curing promotion effect of a dermatic drug for external use, the moistening effect of cosmetic to the skin and hair, and the fatigue-restoration effect and shoulder discomfort remedying effect of bathing agent. The agent is used either by (i) dissolving carbon dioxide gas and oxygen gas in a base and sealing the base in a closed vessel, (ii) adsorbing carbon dioxide gas and oxygen gas in respective carrier (e.g. zeolite) and compounding the carriers to a base, or (iii) compounding the substances generating each gas to a base and reacting the substances at need, or their arbitrary combination.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to dermatology containing and generating carbon dioxide gas and oxygen gas.

[Conventional technology and its problems]

In this specification, dermatology refers to compositions that are applied directly to the skin, ie, skin and hair cosmetics, external skin preparations, and bath preparations.

Conventionally, carbon dioxide gas has been known to have an excellent blood circulation promoting effect, and has been used in external preparations for skin, skin, and hair roots for the purpose of treating wounds and intractable ulcers in the ischemic limbs of chronic occlusive diseases of peripheral arteries. It is used in skin and hair cosmetics to activate the metabolism of the skin, and in bath preparations to help relieve fatigue, stiff shoulders, lower back pain, hemorrhoids, etc., and has shown its effectiveness.

However, it has been desired to further improve the blood circulation promoting effect of carbon dioxide gas in dermatology. After conducting various studies on carbon dioxide gas, we found that the blood circulation promoting effect of carbon dioxide gas was improved when combined with oxygen gas.
The present invention was completed after discovering that external skin preparations have a significantly higher effect on promoting wound healing, skin and hair cosmetics on moisturizing the skin and hair, and bath preparations on relieving fatigue and relieving stiff shoulders. did.

Accordingly, the present invention provides a dermatological product containing carbon dioxide or a carbon dioxide gas-generating substance and oxygen gas or an oxygen gas-generating substance.

Dermatological aspects of the present invention include (1) carbon dioxide or/
and oxygen gas dissolved or dissolved in a dermatological base under normal or pressurized conditions and filled in a sealed container (2) Carbon dioxide and/or oxygen gas retained in zeolite, cyclodextrin, or its derivatives, etc. (3) A substance that is adsorbed and retained by a substance and blended with a dermatological base; (3) A substance that generates carbon dioxide gas and/or oxygen gas upon reaction is blended with a dermatological base and reacted at the time of use; Examples include combinations of 1) to (3).

The dermatological treatment according to the embodiment (1) is generally prepared by first preparing a dermatological base, filling it into a pressure-resistant container, and then blowing carbon dioxide gas and/or oxygen gas into the container.

The dermatological preparation according to the aspect (2) is carried out by combining a holding substance such as zeolite, schiflovkis, or a derivative thereof with carbon dioxide gas or/and oxygen gas, preferably under anhydrous conditions and under normal pressure or pressurization, e.g. 1 to 10 kP. This is carried out by contacting and adsorbing under a pressure of /, liter, and blending this into a dermatological base by a conventional method. The zeolite used as a retention substance may be either a natural zeolite or a synthetic zeolite, but a synthetic zeolite represented by the following general formula with less impurities and other impurities is preferred. A&Os・(S tOt )y
・(Hz O)2 (wherein M is a metal atom with a valence of n,
X represents 0.7 to i, s represents 0.8 to IO, and z represents a number of 0 or more. ) Among the synthetic zeolites of the general formula, metal atoms represented by M include sodium, potassium, calcium, magnesium, etc., and 2 is preferably OI, that is, one that does not substantially contain water. Further, as the cyclodextrin, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, etc. are used.

Furthermore, as a cyclodextrin derivative, glucosyl-
Branched cyclodextrin such as α-'/crof-kistrin, glucosyl-β-cyclodextrin, glucosyl-γ-cyclodextrin, maltosyl-α-cyclodextrin, maltotriosyl-α-cyclodextrin: 0-di-methyl- Methylated cyclodextrin such as β-cyclodextrin, 0-trimethyl-β-cyclodextrin; cyclodextrin polymers such as low polymerization polymers made by crosslinking cyclodextrin with epichlorohydrin; acylated cyclodextrin, altylated cyclodextrin, aminated cyclodextrin Cyclodextrin etc. are used.

When carbon dioxide is brought into contact with and adsorbed on zeolite, it is preferable to adsorb 5 I or more per 100.9 (zeolite) at room temperature. In addition, when adsorbing oxygen,
It is preferable to adsorb 0.5 g or more of zeolite per 100 g of zeolite.

In addition, when carbon dioxide gas is brought into contact with and adsorbed on cyclodextrin or its derivatives, 1 kg/crI or more,
It is preferable to carry out the reaction under a pressure of 5 to 15 kg/cII and at a temperature of 30° C. or less, preferably 20° C. or less. Note that the cyclodextrin or its derivative used preferably contains substantially no water.

The amount of carbon dioxide gas adsorbed by the thus obtained Sifurobukis IJ or its derivatives can be adjusted depending on the application, but it is preferably 2 g or more per 100 I Zeolite.

The carbon dioxide gas generator used in dermatology according to the aspect (3) may be any substance that generates carbon dioxide gas by reaction, and a combination of carbonate and acid is particularly preferred.

Examples of carbonates include sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, potassium bicarbonate, potassium carbonate, potassium sesquicarbonate, ammonium bicarbonate, ammonium carbonate, and ammonium sesquicarbonate, which may be used alone or in combination. 2f11 or more can be used in combination.

Further, as the acid, both organic acids and inorganic acids can be used, but water-soluble and solid acids are preferred.

Examples of organic acids include straight chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid; oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, Dicarboxylic acids such as inphthalic acid and terephthalic acid; acidic amino acids such as glutamic acid and aspartic acid; glycolic acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid,
Sungic acid, tartaric acid, citric acid, salicylic acid (o, m
.

p), oxyacids such as gallic acid, mantelic acid, trobic acid, ascorbic acid, gluconic acid; cinnamic acid, benzoic acid, phenylacetic acid, nicotinic acid, kainic acid, sorbic acid, pyrrolidonecarboxylic acid, trimellitic acid, benzenesulfone acid, toluenesulfonic acid, and acid salts of these organic acids. Examples of inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite (sodium metabisulfite), potassium pyrosulfite (potassium metabisulfite), acidic Examples include sodium xametaphosphate, acidic potassium hexametaphosphate, acidic sodium pyrophosphate, acidic potassium pyrophosphate, and sulfamic acid. Among these, carboxylic acids such as succinic acid, tartaric acid, malic acid, and citric acid are preferred.

In addition, as the oxygen generator, any substance that generates oxygen through reaction can be used, but it is preferable to use sodium perborate, sodium percarbonate, potassium percarbonate, hydrogen peroxide-urea complex salt, etc. .

In the dermatology of the present invention, it is preferable to generate carbon dioxide gas containing 60 ppm or more and oxygen containing 300 ppm or more. For example, in the embodiment (2), the blending amount of zeolite and cyclodextrin is 0.1 to 5% by weight. % is preferable.

Specific dosage forms for the dermatology of the present invention include skin cosmetics such as creams, hacks, beauty howders, foundations, lipsticks, and cleansers; hair cosmetics such as hair creams, shampoos, and conditioners; and bath oils and bubble baths. Bath preparation;
Examples include ointments, lotions, sprays, liniments, pasta, poultices, and other skin preparations.

The dermatology of the present invention further includes disinfectants, anti-inflammatory agents,
In addition to various medicinal agents such as moisturizers and wound healing promoters, various bases commonly used in dermatology as described above can be used, and various dosage forms can be used.

[Action and effect]

The dermatological agent of the present invention has a high effect of promoting wound healing and a very high effect of moisturizing the skin.

These dermatological effects of the present invention are thought to be due to the synergistic effect of the blood flow increasing effect of carbon dioxide gas and the increase in local oxygen concentration due to the application of oxygen.

Next, the results of evaluating the dermatological effects of the present invention using the following method will be shown.

Evaluation 1: Effect on promoting wound healing A group of 8 male Wistar rats weighing around 150 y were given hair on their backs, and then placed under anesthesia with bentoparbital sodium for about 1 y on each side so that they were symmetrical about the midline. A skin incision was made and one suture was placed in the center. After suturing, apply the external preparation (ointment) obtained in the Examples and Comparative Examples described below 3 times a day.
Applied twice.

The sutures were removed on the 3rd day, and on the 6th day, the animal was sacrificed, the back skin was peeled off, the wound was cut into a rectangular shape, and both ends were pulled to measure and compare the force required to rupture the wound. The results are shown in Table 1.

Table 1 It is clear that the product of the present invention (Example 1) exhibits an excellent wound healing promoting effect.

Evaluation 2: Skin cosmetics The skin cosmetics shown in Example 2 and Comparative Example 3 described later were used by 10 subjects and subjected to sensory evaluation. The use is
Table 2 shows the results after one week.

Margin Table 2 below: It is clear that the product of the present invention (Example 2) is superior.

〔Example〕

Examples will be shown next, but the present invention is not limited to these examples.

Example 1 Soft 1! F (external skin preparation) Purified lanolin 5 parts White petrolatum 76 parts Sasu beeswax 4 parts'''1 Carbon dioxide-containing zeolite 5 parts 100 parts + 1 Carbon dioxide-containing zeolite is zeolite (Zeolam 4-A; manufactured by Toyo Soda Co., Ltd.) ) was dehydrated at about 30,000 ml and carbon dioxide was adsorbed at a pressure of 5 kg/liter.11 g of carbon dioxide was adsorbed to 100 g of zeolite.

Bone 2 oxygen-containing zeolite is zeolite (Zeolam 4-
A) was dehydrated at about 300° C. and oxygen was adsorbed at a pressure of 3 liters. Zeolite) 100.9 to 1
．． Example 2 Skin cosmetics Nisqualan 50.0 parts arsenic oil adsorbed 2g of oxygen
34.5 parts "1 Carbon dioxide adsorption zeolite 5.0 parts" 2 Oxygen adsorption zeolite) io, o part No menthol 0.1 part 100.0 parts Example 3 Skin cosmetic Nisqualane 84.95 parts Methyl polysiloxane 10 .00 part Azur Lane
0.05 parts 100.00 parts After mixing the above ingredients, the mixture is placed in a pressure-resistant container and maintained at 3 atm for 3 hours while blowing oxygen, and then used as a product.

Example 4 Bath agent: Sodium hydrogen carbonate 31 parts Sodium carbonate 12 parts Succinic acid
38 parts Glauber's salt 3 parts 2 Oxygen adsorption zeolite 10 parts 1 Carbon dioxide adsorption zeolite 5 parts 100 parts Comparative Example 1 Same as Example 1 except that the carbon dioxide adsorption zeolite and oxygen adsorption zeolite in Example 1 were changed to zeolite. An ointment was made.

Comparative Example 2 An ointment was produced in the same manner as in Example 1, except that the oxygen gas adsorbing zeolite in Example 1 was replaced with zeolite.

Comparative Example 3 A cosmetic was prepared in the same manner as in Example 2 except that the carbon dioxide adsorbing zeolite and oxygen adsorbing zeolite in Example 2 were replaced with zeolite.

that's all

Claims (1)

[Claims] 1. A skin material containing carbon dioxide gas or a carbon dioxide gas generating substance and oxygen gas or an oxygen gas generating substance.