JPH01110614A - Aqueous hydrogen peroxide dental gel - Google Patents

Abstract

PURPOSE: To obtain the subject stable and hard gel having improved chemical and cosmetic stability, comprising a combination of hydrophilic and hydrophobic aerosol silica gelling agents, a polyethylene glycol moisturizing agent, nonionic surfactant and others. CONSTITUTION: This gel as a stable water-based hydrogen peroxide dental gel, having pH 3-6 (pref. pH 4.5-5), comprises (A) 1.5-3.5wt.% hydrogen peroxide as a single chemical activator, (B) a combination of hydrophilic and hydrophobic aerosol silica gelling agents (pref. 8-10wt.% hydrophilic silica plus 0.5-1.5wt.% hydrophobic silica), (C) 20-40wt.% of a polyethylene glycol moisturizing agent 200-1,000 in average molecular weight, (D) 0.5-5wt.% of a nonionic surfactant, pref. a 10-18C fatty acid-bearing sorbitol polyoxyethylene monoester, (E) 0.2-1wt.% of a sweetener such as sodium saccharin, (F) 0.35-5wt.% sodium benzoate, and (G) a perfume.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application: The present invention consists of a compatible system of specific amounts of specific dental ingredients, preferably created by a specific order of addition of each ingredient. The present invention relates to the formation of cosmetic, chemically stable, hydrogen peroxide-containing dental gels.

Conventional Technology: In this first step, a cosmetic, chemically stable hydrogen peroxide gel is combined with suitable thickening/gelling agents, humectants, surfactants and fragrances for oral use applications. It was difficult to mix. However, after extensive experimentation with various mixtures of ingredients in sensitized hydrogen dental gel products, water, a combination of hydrophobic and hydrophilic fumed silica as a gelling agent, a polyethylene glycol humectant, a non-ionic A combination of surfactants, sweeteners, sodium benzoate, and flavoring agents was discovered. The order of addition of these components is important in forming a stable gel.

Thus, by using a specific sequential step method, a combination of hydrophilic and hydrophobic fumed silica as a gelling agent, a non-ionic surfactant, a sweetener, sodium benzoate, and a flavoring agent is included. It has been discovered that it is possible to create stable a'4 compounds of i4 hydrogen oxide dental gel. A stable hydrogen peroxide gel is produced by homogenizing fumed silica in a polyethylene glycol phase and an aqueous phase, followed by premixed homogenized hydrophobic fumed silica (phase A) in polyethylene glycol with hydrogen peroxide. Pre-mixed homogenized hydrophilic fumed silica (phase B) in water containing sodium saccharin and benzoin #l and mixed for approximately 30 minutes keeping the temperature at room temperature and pre-dissolved in water. (Phase C) is added with mixing to immediately cause gelation, non-ionic surfactant and flavor pre-solubilized in water are added, and a clear homogeneous hard stable dental gel is formed. Approximately 5-10 minutes until obtained
Made by mixing for a minute.

The finished oral product has a stable, hard gel with improved chemical and cosmetic stability and improved taste. Hydrogen peroxide and other peracid-containing agents can cause caries, plaque, gingivitis, periodontitis, bad breath, and tooth plaque.
) Reorder aphthous cancer, am value, orthodontic appliance trauma, post-extraction surgery and post-periodontitis surgery, traumatic intraoral wounds, and mucosal h! It has been recognized that it is effective in the therapeutic and preventive treatment of stomatitis, herpetic stomatitis, and the like. Peracid-containing agents in the oral cavity exert a chemical mechanistic action that generates thousands of microscopic oxygen bubbles, which are generated by the interaction of mucus and salivary enzymes.

Peroyobide mouth rinse and other oral preparations are known to be effective against the defoliation and pa
*Hinder. Where selective treatment of localized areas for more than a few seconds is required, peracid-containing gels or pastes are indicated and/or desired; tends to remain at the site for a sufficient period of time for the peroxide to exhibit its maximum efficiency.

Most peracid compounds, such as hydrogen peroxide, in oral compositions are incompatible with other common ingredients in the composition and/or
It is also said that they tend to be unstable during storage due to interactions and lose their ability to release active or nascent oxygen in a relatively short period of time. This has negative effects on both the chemical stability of the composition as well as the cosmetic stability of the final product, especially in gel products containing hydrogen peroxide.

In the prior art, US Patent No. 44 discloses a gargle containing hydrogen peroxide, fragrance, zinc chloride, and water-soluble vitamin E, which stabilizes the hydrogen peroxide in the gargle.
, 226, 851, various stabilizers are added to single-family compositions in various forms such as tablets, chewing gum, gargling liquid, kneaded meat delta, or powdered books containing hydrogen peroxide. Attempts have been made to solve the above problems by using U.S. Patent No. 4,302,441 describes gelata/glutotsy% rubber latex,
Contains urea-hydrogen peroxide in rubber substrates such as vinylite resin, and in methyl, ethyl and sodium Φ carboxymethyl cellulose supports, but does not contain glycerin, and also contains sodium terracalinate, xylitol, Solid oral products (tablets and chewing gum) are disclosed that contain sweetening agents such as sorbitol and mannitol, and flavoring agents. US patent magic 4,47
6.108 contains peroxidases, peroxides, and donor molecules such as phenyl-ethylamine, tyrosine, tryptophan, benzoic acid, salicylic acid, hydroquinone, tehydrophenylalani/, vanillan, and para-aminobenzoic acid. Discloses the admixtures in such carriers or in the form of pastes, gels or powders. U.S. Pat. No. 44,431.631 contains hydrogen peroxide, glycerin and/or esorbitol humectants, 0.5-3% pluronic type surfactants, polyoxyethylated sorbitol monofatty acid ester surfactants, sweeteners and An oral aqueous solution containing a fragrance is disclosed.

Conventionally, Hiroshi discloses dental compositions containing hydrogen peroxide and additional stabilizing ingredients, such as ascorbic acid in U.S. Pat. No. 43,886,265; Disclosed are tablets, lorenz, chewing gum canisters or aerosol or bubble forms containing a peroxide such as hydrogen oxide and a terminal diol compound such as ascorbic acid which is effective against bad breath.

U.S. Patent A64,521.403 discloses cleaning teeth with an aqueous or alcoholic aqueous solution of hydrogen peroxide and a povidone-iodide complex (complex of iodine and 1-vinyl-2-pyrrolidone polymer). discloses a method for inhibiting periodontitis. These two components are mixed only before use. U.S. Patent No. 4,592,487 covers both of these components,
peroxide, 2 and povidone-iodine complex, each mixed with conventional dentifrice ingredients and containing a special dual-compartment
ntα1sar) /mixer/dispensing device to mix and
Separated in one dispensed nta'! 1, an anti-plaque toothpaste in the form of a toothpaste or gel is disclosed. U.S. Pat. No. 44,592,488 includes an iodophor or quaternary ammonium compound and a peracid compound, such as hydrogen peroxide, and the components are combined in a water bath solution or an alcoholic aqueous solution before being combined into a mouthwash solution. Discloses an oral mouthwash in the form of: U.S. Pat. No. 4,592,489 discloses a two-part container for dispensing oral gargle water which contains a povidone-iodine combination solution separately from the hydrogen peroxide bath and is mixed prior to dispensing.

Dental compositions containing other oxidizing agents in place of hydrogen peroxide have also been disclosed in the prior art. U.S. Patent 44,40
No. 5,599 contains anti-aging agents such as carbamide peroxide, which dissociates into urea and hydrogen peroxide in the oral cavity, anionic anti-angulation agents, sorbitol and glycerin humectants, and
A toothpaste is disclosed that includes a pasty carrier backing comprising a thickening agent such as gum tragacanth, sodium alginate, or sodium Φ carboxydimethylcellulose.

U.S. Patent M4.405,599 describes Calcium Peroxide and Sodium Perborate; Dicalcium Phosphate, Calcium Carbonate, and Magnesium Carbonate Detergents: Cornstarch and Cellulose Gum Thickeners: and Anionic Detergents:
Discloses a toothpaste containing.

However, all of the above patents describe a safe and specific polyethylene glycol moisturizer, a non-ionic surfactant, a fragrance,
Preparation of a Hydrogen Peroxide Gel Comprising a Combination of Na1-IJ Um Saccharin, Sodium Benzoate, and a Hydrophilic and Hydrophobic Atomized Silica Gelling/Thickening Agent in a Stable Dental Gel Compound Shell has not been disclosed.

The prior art is 1 U.S. Patent yi63,657,413 and the article "Stability of hydrogen peroxide in a certain oak medical gel" by Ara Takeshi et al., Cosmatias a%dTo
ilatriaa 54-56 + 91 + 197
6, discloses a method for making a peroxide gel. This patent covers urea peroxide, glycerin, carboxypolymethylene polymer and
The polymer is dispersed in glycerin with high speed stirring using a vacuum knife, and then the urea peroxide and other ingredients are dissolved in the thickened polymer/glycerin solution to form a viscous gel. Discloses a gel. The paper describes the use of 0.1 ml for surface cutting, hair bleaching, and as a stabilizer for hydrogen peroxide.
3 discloses a methylcellulose gel for deodorizing purposes containing 3% oxine, which is prepared by dispersing the methylcellulose in water using a pneumatic stirrer and then neutralizing the triethanolamine to form the gel. Alternatively, the aqueous phase may be sufficiently dispersed in hot water at 1, assimilated, frozen at 1 and stirred until a gel is obtained, the stabilizer oxine added to the gel, followed by hydrogen peroxide. It is made by adding. Other stabilizing agents that are not as effective as oxine include hexamine, benzoin, or urea.

A hydrogen peroxide gel with a block copolymer of polyoxyethylene-polyoxypropynone as a gelling/viscosity agent is disclosed in US Pat.
discloses a stable hydrogen peroxide gel for use in hair removal and surface cutting processes using a block copolymer of polyoxyethylene-polyoxypropynone with a 79% density; Bath the copolymer in water that has been heated to a temperature of 716 mm, slowly add hydrogen peroxide to the cooled polymer solution, and add the solution to the
It may be made by heating the glass with a knife to form a clear gel. This method is 1zuH2(h
It may be modified by adding the copolymer to cold water and then adding the copolymer to this cold water solution, mixing until completely dissolved, and then allowing it to gel at 1 at room temperature. This is not a dental gel and does not contain polyethylene glycol humectants, sodium/saccharin sweeteners, or artificial flavors, all of which are key ingredients in dental gels.

A cleaning agent that keeps a mixture of homogeneous components in a free-flowing state and prevents agglomeration, including 0.5-1.0% CABO-SIL, a colloidal and super-accurate pyrolytic silica, is available in the United States. Disclosed in Patent No. 3.372.125.

US Patent No. 4,223,003 contains dyes, high-foaming surfactants that produce foam when using a toothbrush, peroxide-containing compounds such as magnesium peroxide, and carboxymethylcellulose thickeners, Discloses 111M and 111M, which include conventional dental ingredients such as silica, humectants, abrasives, fragrances, fluorides, and the like.

U.S. Pat. No. 44,537.765 has a pH of 9.2-10.5 and includes thickeners such as peroxydiphosphate salts, polyethylene glycol humectants, colloidal silica, divinyl polymers in carboxylic acid, cellulose gum or hectorite. Discloses a toothpaste containing an abrasive agent, such as a silica or hydrated alumina, and an anionic or nonionic surfactant, such as Pluronic F108.

Therefore, in the prior art, the key ingredients are a combination of hydrophilic and hydrophobic fumed silica gelling agents, polyethylene glycol humectants, nonionic surfactants, sweeteners, None disclose a cosmetic, chemically stable, aqueous hydrogen peroxide dental gel containing sodium benzoate, and a fragrance, made by a novel process using a specific process sequence, the new process being , phase A, i.e., premixed homogenized hydrophobic fumed silica in polyethylene glycol, is mixed into phase B, i.e., premixed homogenized hydrophilic fumed silica in water containing hydrogen peroxide and at room temperature for about 30 minutes. Mix and add phase C1, i.e., pre-dissolved sodium saccharin and sodium benzoate in water, to phase AB to cause gelation, and phase D, i.e., non-ionic surfactant and pre-dissolved sodium benzoate in water. It consists of a specific sequence of steps: adding to the soluble perfume phase ABC and mixing for about 5-10 minutes until a clear, homogeneous, hard gel is obtained.

PROBLEM TO BE SOLVED BY THE INVENTION An aqueous hydrogen peroxide dental gel is prepared in the presence of polyethylene glycol, sodium hydroxide, sodium benzoate, a non-ionic surfactant, and a fragrance, as a gelling agent. It has now been shown that stabilization can be achieved when using a combination of hydrophilic and hydrophobic fumed silica at a level of 0.5-1.5% by weight hydrophilic fumed silica and 0.5-1.5% by weight hydrophobic fumed silica. It was discovered in

Fumed silica gelling agents are compatible with hydrogen peroxide, whereas natural gums derived from Miso materials such as alginates, methylcellulose, etc. are degraded by hydrogen peroxide to produce unstable gels. .

Similarly, synthetic organic polymers such as polyvinylpyrrolidone form drawable gels, which are not the clear, homogeneous, hard gels of the novel dental gel products of the present invention. The presence of stabilizers such as sodium stannate, sodium pyrophosphate, oxine EDTA, and calcium disodium EDTA is problematic and desirable as their presence provides no benefit to the composition. It was discovered that something was wrong. Their presence tends to adversely affect the chemical stability of MaOxue. It has been discovered that the combination of a polyethylene glycol humectant and a fumed silica gelling agent produces a more stable η-dairy gel than the gel produced in the absence of polyethylene glycol. It has been discovered that the presence of nonionic surfactants has acceptable stability in aqueous peroxide environments. Anionic surfactants do not have acceptable stability in the presence of hydrogen peroxide. The novel stable hydrogen peroxide dental gel of the present invention is therefore based on the specificity of compatible components.

It has additionally been discovered that a new method of making hydrogen peroxide gels further aids in obtaining stable H20 gels.

The seventh method is one that uses a specific step sequence, which involves the formation of four separate phases, i.e., the hydrophobic particles dispersed in polyethylene glycol by mixing in 1 to homogeneity. Phase A1 consisting of hydrophilic fumed silica and Phase B consisting of hydrophilic fumed silica and hydrogen peroxide dissolved in water.

A phase C1 consisting of sodium saccharin and sodium benzoate; a phase D consisting of a nonionic surfactant and a flavor dissolved OT in water; and then sequentially add phase A to phase B, mix to obtain a homogeneous translucent liquid, and further homogenize the mixture by ladle at room temperature for 30 minutes in the same homogenizer; Mix to form a gel. Add the two phases to Phase ABC for approximately 5-10 minutes.
and mixing for a minute to form a stiff, homogeneous, stable dental gel. This stable gel product is approximately 3-6
If necessary, it may be acidified with a suitable acid such as citric acid or phosphoric acid to a pH of . The final product is packaged in a suitable container compatible with hydrogen peroxide, such as a metal tube in a plastic enclosure, or in a double chamber container or kit with bicarbonate. It's fine.

Conveniently, a first object of the present invention is to use a combination of hydrophilic and hydrophobic fumed silica as a gelling agent with a pH of about 3-6, preferably 4.5-5. Compatible with H202 with 8-10% by weight of hydrophilic fumed silica, about 0.5
- To formulate a cosmetically and chemically stable hydrogen peroxide oral gel comprising in an amount of 1.5% by weight hydrophobic fumed silica.

Another object of the present invention is to provide a cosmetically stable gel of Hz (h = hydrophilic and hydrophobic fumed silica) containing a polyethylene glycol humectant that is compatible with other dental ingredients. That's true.

Yet another object of the invention is a fumed silica gelling agent, a polyethylene glycol humectant, a nonionic surfactant, a flavoring agent, a sweetening agent such as sodium saccharin,
An object of the present invention is to provide a cosmetically and chemically stable aqueous H202 dental gel with improved taste that includes a compatible formulation of IJum and benzoic acid.

Another object of the present invention is to prepare hydrophilic and hydrophobic fumed silica gelling agents with improved compatibility of all components by using a novel method consisting of a stepwise addition order of the various components. The table gel is based on a stable HzOdJll family gel.

Additional objects, advantages and novel features of the present invention will, in part, be set forth in the following description, and in part will be apparent to those skilled in the art from a consideration of the following description, or will be apparent to those skilled in the art from a consideration of the following description. You can learn by doing. The objects and advantages of the invention may be realized and attained by means of the instrumentalities and combinations particularly pointed out in the appended claims.

SUMMARY OF THE INVENTION In order to accomplish these and other objects in accordance with the present invention, the novel stable aqueous hydrogen peroxide composition of the present invention, as embodied and broadly described herein, is provided. Dental gels contain a single chemical activator and have a high temperature of about 1.5-3.5 degrees Celsius. , about 8-10% by weight hydrophilic fumed silica as a gelling agent, and 0.5-1.0% by weight hydrophobic fumed silica, about 20-40% by weight polyethylene glycol humectant. Consisting of nonionic surfactants, sweeteners, flavors, and sodium benzoate, the gel has an acidic pH of about 3-6. Sodium saccharin is the preferred sweetening agent. Sodium benzoate is a key additive in the gelation of this formulation.

Moisture gold flakes in the gel constitute approximately 20=40% by weight of this dental composition. Distilled or deionized water is preferred to prevent trace contamination.

The stable hydrogen peroxide dental gel of the present invention comprises hydrophilic fumed silica in polyethylene glycol forming phase A, and hydrogen peroxide? (IJ: Hydrophilic fumed silica containing aqueous content, phase B1, is homogenized separately, and the two phases are mixed to form a translucent liquid, which is sequentially dissolved in water) Phase C, consisting of um-saccharin and sodium benzoate, is mixed with the translucent liquid of Phase AB to form a gel, which is then mixed with a non-ionic surfactant and a fragrance solubilized in water. It is made by a novel method consisting of mixing the phase with the gel of phase ABC to obtain a clear, homogeneous, hard and stable dental gel.

This order of addition of specific ingredients is critical to the formulation of a stable hydrogen peroxide formulation gel. If sodium benzoate is omitted from the formulation, no gelation will occur.

Similarly, if the phase is added to phase AH before phase C, no gelation is observed.

More specifically, the present invention provides a combination of hydrophilic and hydrophobic fumed silica gelling/thickening agents, polyethylene glycol humectants, nonionic surfactants, sweeteners,
Concerning a new method for making a cosmetic and chemically stable aqueous 1h(hflll) gel consisting of sodium benzoate, and fragrance, method 7 sequentially comprises a premixing of polyethylene glycol A. Add the homogenized hydrophobic fumed silica (Phase A) to the premixed homogenized hydrophilic fumed silica (Phase B) in water containing hydrogen peroxide and mix for about 30 minutes while maintaining the temperature at room temperature for 30 minutes. , pre-dissolved sodium saccharin and sodium benzoate 9 in water
Add the nonionic surfactant and the pre-solubilized fragrance (Phase D) in a batch of about 5 to 10 minutes with mixing to induce gelation. It consists essentially of homogenizing the fumed silica in the polyethylene glycol phase and the aqueous phase by mixing until a hard, stable dental gel of minute-excretable quality is obtained.

The hydrogen peroxide formulations of the present invention contain an effective amount of hydrogen peroxide in intraperitoneal anti-gingivitis applications, preferably about 1.5-3.5 μg of the composition. Hydrogen peroxide is usually 1.5-3.5
% of active ingredient and is supplied as a 30-35% aqueous solution. No. 7 hydrogen peroxide is stable in the presence of polyethylene glycol, sodium saccharin, nonionic surfactants, fragrances, and fumed silica gelling agents.

A key ingredient in the H202 gel dentifrice of the present invention is a compatible peroxide-stable thickening gelling agent, which is approximately 8-
It is a combination of hydrophilic and hydrophobic fumed silica with 10 wt.

The preferred Nf ratio of the fumed silica mixture in the inventive dentifrice gel is in the range of 16:1 to 6=1 hydrophilic fumed silica to hydrophobic fumed silica. The combination of hydrophilic and hydrophobic fumed silica provides greater stability properties to the hydrogen peroxide gel than when using a single fumed silica or other types of colloidal silica. This combination passes freeze/thaw cycles without showing any separation. Aging of some formulations for 3 weeks resulted in a significant improvement in the cosmetic stability of this hydrogen peroxide gel. Fumed silica is an extremely small particle size condensed silicon dioxide produced by the hydrolysis of silicon tetrachloride in a flame of hydrogen and oxygen, as described in the paper entitled ``Use of fumed silica in cosmetics.'' John Varday 3 and Lyria Moon (1980), pp. 35-39. In this method of combustion, molten spheres of silica are formed, forming 7 to 14 mi! J Micron average If diameter and 400 th”/t maybe 200-
It has a final surface area in the range of 7V. The molten spheres fuse together to form branched three-dimensional chain condensates. During the formation of fumed silica, 3a! The following types of hydroxyl groups are formed: arc V hydroxyls, hydrogen bonded hydroxyls, and siloxanes (Si -0-S i ).

Isolated and hydrogen-bonded hydroxyl groups are hydrophilic sites, whereas cinxane is nonpolar and hydrophobic. Fumed silica is a dry powder available as "Aerosil" from Degussa. Depending on the manufacturing method, various types of aerosilica can be obtained. Aerosil 200tX Table 1fi
200±25 m”/? 1 average grain size is about 10-
12 nanometers, compression apparent ￥fj degree is approximately 5Q 77
1, a hydrophilic fumed silica. Aerosil 300
and 2.00 m”/9 like Aerosil 380
Aerosil with a surface area greater than or equal to that may also be used. Aerosil R972 has a surface area of 110 ± 20 m”/t, 1
It is a hydrophobic fumed silica with an average particle size of 6 nanometers and a compacted apparent density of about 50 t/L.

Another key component of the inventive H202 gel formulation is hydrogen peroxide, nonionic surfactants, fragrance, and
A polyethylene glycol humectant that is compatible with fumed silica gelling agents.

Polyethylene glycol, known by the trademark Carbowax, is a nonionic polymer of ethylene oxide with the general formula %, where % is the average number of oxyethylene groups.

Carbowax polyethylene glycol is 400°6
A number symbol such as 00 is attached, which represents the approximate half-average molecular weight. Polyethylene 177 Gri': 1-, At 2Q Q, 300.400's? and 600 are clear viscous liquids at room temperature. They are less hygroscopic than glycerin and simple glycols;
It is water soluble and forms clear aqueous solutions.

Polyethylene glycol imparts a different aesthetic feel and taste to dental products than glycerin or sorbitol. It has been discovered that polyethylene glycol humectants help create H202 gels with improved stability compared to gels containing glycerin. The polyethylene glycol humectant is approximately 20-4% of this H,02 gel formulation.
It constitutes 0 quintillion t%.

Typically, polyethylene glycol humectants have an average molecular weight of about 1000-! : and preferably about 400-
600, most preferably about 600.

Another key component of the aqueous H202 gel formulation of the present invention is a nonionic surfactant that is compatible with 11202 and is peroxide stable. Nonionic surfactants are useful as solubilizing, dispersing, emulsifying and wetting agents, especially in perfumery? Particularly effective in solubilizing.

A non-ionic surfactant useful for oxen is C't, known under the dark name Tween.

(I is a water-soluble polyoxyethylene monoester of sorbitol with l fat [').
G (:'! = mixture of fatty acid esters, approximately 1
0-30, good 11. < consists primarily of a monoester condensed with about 20 moles of ethylene oxide. Fatty acids (aliphatic hydrocarbon monocarboxylic acids) may be saturated or unsaturated, for example lauric acid, valmitic acid,
These are stearic acid and oleic acid. Porinlupine #R salt 20 (e.g., Tween 20) is particularly preferred, typically polyoxyethylene(20)rubitan monolau V-
It is called to. These nonionic surfactants represent about 0.5-5% and preferably 0.5-5% by weight of the gel composition.
It constitutes 3%.

Another key ingredient of the inventive aqueous H202 gel toothpaste is an effective aromatic amount of a fragrance that is compatible with and stable in the presence of hydrogen peroxide. Perfume ingredients constitute about 0.5-2% by weight of the composition.

Suitable flavoring ingredients are perfume oils, such as spearmint,
These are Petupabant, Koji Koji, Jyutsuburasu, Clove, Sage, Eucalyptus, Marjoram, Cinnamon, and Methyl Salicylate, and Menthol.

Sweeteners are used as a supplement to other flavoring substances. Excessive sweeteners are water soluble and include sodium putucalin, sodium cyclamate, xylitol, perillatin, D-, in concentrations of about 0.01 to 1.0% by weight.
tryptophan, aspartame, dihydrochalcone,
Examples include.

Natriwam's saccharin is my favorite.

The pH of the H202 gel toothpaste of the present invention is 3-6 J, i
The optimal value for use in the oral cavity is about 4.5 to 5. A pH below 4.5 may be too acidic for optimal use in the oral cavity, and at a pH above 5 the stability of the gel decreases. pH of the composition produced
is generally adjusted to 5.0 with a suitable acid such as phosphoric acid or citric acid. This acidic pH provides greater stability to the gel products of the present invention. The lower the pH, the greater the stability.

The hydrogen peroxide gel toothpaste of the present invention is 1, color remover or whitening agent, or 5% 1, preferably 1%
1. Minimum amount of preservatives, such as customary additional ingredients such as chemical and cosmetic (physical)
may contain scratches that do not interfere with the stability of the material.

By utilizing a specific combination of ingredients, a non-ionic surfactant, a polyethylene glycol humectant, a combination of hydrophilic and hydrophobic fumed silica gelling agents, a sweetener, sodium benzoate, and fragrance. It has been discovered that it is possible to formulate an aqueous hydrogen peroxide gel #I polish with improved taste and chemical stability.

Furthermore, the fumed silica is homogenized in a polyethylene glycol phase and an aqueous phase, and a gelling agent, a humectant, a nonionic surfactant, sodium benzoate, and a sweetener are added.
Using special ingredients such as saccharin) and fragrance,
A novel formulation method that sequentially adds Phases A, E, C, and D provides superior chemical and cosmetic stability for an aqueous hydrogen peroxide gel toothpaste with improved taste. It was discovered that.

The final product may be described as a gel with a sticky jelly-like consistency (rf% g6%
g) It is a gel, i.e. when the gel is packed into a jar and the sides of the container are pounded, the gel moves but retains its original form. The dental gel product of the present invention is a mouthwash, not a mouthwash, and dissolves in the oral cavity only upon brushing.

In the practice of the invention to promote oral hygiene, the gel toothpaste according to the invention is regularly applied to the tooth enamel by brushing the teeth for 30-90 seconds at least once a day.

The following examples further illustrate the nature of the invention, but the invention is not limited thereto. The compositions are made in conventional manner, and all amounts and proportions referred to herein and in the claims are by weight, not specified.

Actual Example 1 and Percentage A Polyethylene Glycol 600 40.0 4
0.0 (Union Carbide) Aerosol R972C Degutsu 0.5 1.5
) B Distilled, deionized water 33.65 11.00 Aerosil 200 (Degussa) 8.0
9.0H20z (35% water bath liquid) 8.6
28.60 #Tame, deionized water 1
．． 5 1.5 sodium 9m saccharin 0
．． 2 0.2 Sodium benzoate 0
．． 35 0.5D #Storage, deionized water
5.0 5,0 polyoxyethylene (20)
1.2 1.2 Lupitan monolaurate fragrance 1.0 1.5
pH: Approximately 4.5-5 Steps: 1. Aerosil R972 (hydrophobic atomized silica) with PE
Disperse until homogeneous with a light double mixer in a G-600.

2. Add phase A to phase B and premix in a hover mixer or Ross mixer until homogeneous (translucent).

3. The above mixture is further homogenized using a homomixer for an additional 30 minutes while maintaining the temperature at room temperature.

4. Add pre-dissolved sodium saccharin and sodium benzoate (phase C) to phase A with homogenization mixing.
Add to H. Gelation occurs immediately.

5. Transfer phase ABC to Ross or Hobart mixer.

Next, add the fragrance (phase D) that has been adjusted in advance, and then add 5-
Mix for 10 minutes. A stable gel is formed.

Example 1' is repeated, but with the substitution of polyethylene glycol 4001t?lJ ethylene glycol 600. It shows the stability of

Aerogi #200 (deg 79) 8,0 10.
Ox7 o Sill R972 (def 7-17 0
．． 5 1.0 hydrogen peroxide (35 ka aqueous solution)
8.6 86 Sodium/Tsukarin 0.
2 0.20,007 is sodium 0
．． 35 0.5 examination 1
．． 0 1.5 steamed, deionized water 60.
35 37. OpH: about 4.5-5.0 The above dental superplated water gel formulation is made by the same procedure outlined in Example 1. The final Tenreki products of Examples 4 and 5 also showed excellent storage stability;
It is in the form of a stable, hard, clear gel.

Although the invention has been disclosed with respect to preferred embodiments, it is intended that various modifications and variations thereof be included within the spirit and scope of the invention and the scope of the claims.

(4 others) Written amendment 1, Indication of the case Patent Application No. 95351 of 1988 2, Name of the invention Aqueous hydrogen peroxide dental gel 3, Person making the amendment Relationship to the case Patent applicant address Name Colgate・Details printed using Vermolive Company type printing

Claims (1)

Claims: 1. About 1.5-3.5% by weight hydrogen peroxide as the single chemical activator, a combination of hydrophilic and hydrophobic fumed silica gelling agents, about 20 to 40% by weight. A stable aqueous hydrogen peroxide dental gel having an acidic pH of about 3-6, consisting of weight percent polyethylene glycol humectant, nonionic surfactant, sweetener, sodium benzoate, and flavor. 2. The hydrophilic fumed silica comprises about 8-10% by weight of the composition and the hydrophobic fumed silica makes up about 0.5-1.5% by weight.
The dental gel according to claim 1, comprising the following. 3. The dental gel of claim 2, wherein the sweetener is sodium saccharin in an amount of about 0.2-1% by weight. 4. The dental gel of claim 3, wherein the nonionic surfactant comprises about 0.5-5% by weight of the composition. 5. Nonionic surfactant is C_1_0 to C_1_8
Dental gel according to claim 4, which is a polyoxyethylene monoester of sorbitol with fatty acids. 6. The dental gel of claim 4, wherein the water content consists of about 20-40% by weight of deionized water. 7. The dental gel according to claim 6, wherein the fragrance content is about 0.5-2% by weight. 8. The nonionic surfactant is polyoxyethylene (20
6. Dental gel according to claim 5, which is sorbitan monolaurate. 9. Sodium benzoate accounts for about 0.35 to about 5 of the composition.
Dental gel according to claim 7, comprising % by weight. 10. The dental gel of claim 2 having a pH of about 45-5. 11. The dental gel of claim 1, wherein the polyethylene glycol has an average molecular weight of about 200-1000. 12. The molecular weight of polyethylene glycol is approximately 400-6
12. The dental gel according to claim 11, which is 00. 13. Hydrophobic fumed silica in polyethylene glycol forming phase A and hydrophilic fumed silica in a prescribed amount of water containing hydrogen peroxide (phase B) are homogenized separately and both phases are mixed. to form a translucent liquid, followed by
A fragrance in which Phase C, consisting of sodium, saccharin and sodium benzoate dissolved in water, is mixed with the translucent liquid of Phase AB to form a gel and solubilized in a non-ionic surfactant and water. Phase D consisting of: is mixed with the gel of phase ABC to obtain a transparent, homogeneous, hard and stable dental gel;
10. The hydrogen peroxide gel of claim 9, made by a method comprising: 14. 1.5-3.5% by weight as a single chemical activator
of hydrogen peroxide, a combination of hydrophilic and hydrophobic fumed silica gelling agents, about 20-40% by weight of a polyethylene glycol humectant, a nonionic surfactant, a sweetener, sodium benzoate, and flavoring. , homogenizing the fumed silica in a polyethylene glycol phase and an aqueous phase, followed by premixing homogenized hydrophobic fumed silica (phase A) in polyethylene glycol and premixing homogenized hydrophilic in water containing hydrogen peroxide. fumes silica (phase B
) and mixed for approximately 30 minutes while maintaining the temperature at room temperature, pre-dissolved sodium saccharin in water and sodium benzoate (phase C) were added with mixing to immediately cause gelation, and the non-ionic surfactant about 300 ml of powder, prepared by adding the pre-dissolved fragrance (Phase D) in the agent and water and mixing for about 5-10 minutes until a clear homogeneous hard stable dental gel is obtained. p between -6
Cosmetic and chemically stable aqueous hydrogen peroxide dental gel with H. 15. The dental gel of claim 14, wherein the pH is adjusted to about 4.5-5 with an acid. 16. The hydrophilic fumed silica accounts for about 0.1 to 1.1% of the composition.
15. The dental gel of claim 14, wherein the dental gel comprises 5% by weight and the hydrophobic fumed silica comprises about 0.1 to 1.5% by weight. 17. The dental gel of claim 14, wherein the polyethylene glycol humectant has a molecular weight of 600. 18. Claim 1, wherein the nonionic surfactant is a polyoxyethylene monoester of sorbitol with C_1_0 to C_1_8 fatty acids in an amount of about 0.5-3% by weight.
4. Dental gel according to item 4. 19. Sodium benzoate 0.35 to 0.5% by weight
15. The dental gel according to claim 14, comprising: 20. The dental gel of claim 14, wherein the sweetener is sodium saccharin and the nonionic surfactant is polyoxyethylene (20) sorbitan monolaurate.