JPH013112A - Aqueous hydrogen peroxide dental gel - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION Industrial Field of Application: The present invention has an acidic pI-I'& of about 4.5 to 6.0;
Rice containing a compatible system consisting of specified amounts of specific components, 2
The present invention relates to the production of a chemically stable aqueous dental gel containing hydrogen peroxide.

Conventional technology: To date, suitable thickeners/gelling agents, humectants.

It has been difficult to produce oral hydrogen peroxide-containing gels that are chemically stable due to their surfactant and flavor content. However, after extensive experimentation with various mixtures of ingredients in hydrogen peroxide-containing dental gel products, water, polyoxyethylene-polyoxypropylene block copolymer gelling agents, polyethylene glycol humectants.

Compatible systems consisting of nonionic surfactants, sweeteners and flavors have been discovered. This dental product is in the form of a stable, hard gel with improved chemistry, cosmetic properties and taste.

Hydrogen peroxide and other peroxygen compounds can cause dental caries,
Dental plaque, gingivitis, periodontitis 1 Bad breath, colored deposits, recurrent aphthous ulcers, denture irritation, orthodontic appliance lesions, after tooth extraction, after periodontal ligament surgery, traumatic oral lesions.

Treatment and/or treatment of mucosal infections, herpetic stomatitis, etc.
or is recognized in the art to be effective for preventive treatment. Peroxide-containing agents in the oral cavity exert a chemomechanical effect, generating numerous fine oxygen bubbles through interaction with tissue and salivary enzymes. Peroxide-containing mouthwashes and other oral preparations inhibit colonization and proliferation of anaerobic bacteria known to be associated with periodontal ligament disease.

Peroxygen-containing gels or pastes are indicated and/or desirable when it is necessary to selectively treat an area for more than a few seconds. Such gels and pastes tend to remain at the application site long enough for the peroxide to exert its maximum effect.

Most peroxygen compounds, such as hydrogen peroxide, in oral compositions become unstable during storage due to incompatibility or interaction with other common ingredients in the composition, or have a relatively short shelf life. During this period, they tend to lose their ability to release active oxygen, or nascent oxygen. This has a detrimental effect both on the chemical stability of the composition as well as on the cosmetic stability of the final product, especially for gel products containing hydrogen peroxide.

To solve the above problems, the prior art has developed various methods for dental compositions containing peroxide in various dosage forms, such as tablets, chewing gum, rinsing water, tooth paste or toothpaste. For example, U.S. Pat. No. 4,226,851 attempts to use stabilizers such as hydrogen peroxide, flavor.

A mouthwash containing water-soluble vitamin EY stabilized by zinc chloride and hydrogen peroxide 7 is disclosed. U.S. Patent No. 4,30
No. 2,851 is, for example, a jelutong.
).

Containing urea, hydrogen peroxide in a gum base such as rubber latex, vinylite resin, etc. and in a glycerin-free methyl, ethyl and sodium carboxymethyl cellulose carrier, as well as, for example, sodium saccharate, xylitol.

Solid oral products (tablets and chewing gum) containing sweeteners and flavors such as sorbitol and mannitol are disclosed. No. 4,476,108, in a carrier such as water (mouthwash) or in a paste,
Discloses a mixture comprising peroxidase, peroxide and donor molecules such as phenylethylamine, tyrosine, tryptophan, benzoic acid, salicylic acid, hydroquinone, dihydrophenylalanine, vanillan and para-aminobenzoic acid in gel or powder form. . U.S. Pat. No. 4,431,331 is a hydrogen peroxide, glycerin and/or sorbitol humectant.

An aqueous oral solution is disclosed that includes a 05-6% pluronic type surfactant, a polyoxyethylated sorbitol fatty acid ester surfactant, a sweetener and a flavor.

Prior art also. The patent also discloses dental compositions containing hydrogen peroxide and additional ingredients for stabilization, such as ascorbic acid in U.S. Pat. No. 3,886,265, which patent also discloses Disclosed are tablets, lozenges, chewing gums or aerosol or spray forms effective against halitosis, comprising oxides and 5-naene diol compounds such as ascorbic acid.

U.S. Pat. No. 4,521,403 discloses dental root disease caused by cleaning teeth with an aqueous or hydroalcoholic solution of hydrogen peroxide and a povidone-iodine complex (a combination of iodine and 1-vinyl-2-pyrrolidone polymer). Methods for suppressing and treating the disease are disclosed. The above two components are first mixed before use. US Pat. No. 4,592,487 discloses an anti-plaque dentifrice.

In toothpaste paste or gel formulations containing two components (peroxide and povidone-iodine complex), each component is mixed separately with regular toothpaste ingredients, stored separately, and mixed at the time of use. , dispensed from a specific two-compartment container/mixer/dispenser device.

U.S. Pat. No. 4,592,488 discloses an oral composition comprising an iodophor or quaternary ammonium compound and a peroxy compound, such as hydrogen peroxide, as an aqueous or hydroalcoholic solution before mixing the two components in a mouthwash. is disclosed. U.S. Pat. No. 4,592,489 includes a povidone-iodine complex solution separate from the hydrogen peroxide solution.
A two-part container for dispensing wash water that is mixed prior to dispensing is disclosed.

Dental compositions containing other oxidizing agents in place of hydrogen peroxide have also been disclosed in the prior art.

U.S. Patent Nos. 4,522,805 and 4.567.03
No. 6 is a superhydric acid which dissociates in the oral cavity into urea and hydrogen peroxide in a pasty carrier consisting of an anionic detergent, a sorbitol and glycerin humectant and a thickening agent such as gum tragacanth, sodium alginate or sodium carboxymethyl cellulose. A stable toothpaste is disclosed that contains an oxidizing agent, such as an oxidized carbamide, and is useful for treating root disease.

U.S. Pat. No. 4,405,599 discloses calcium peroxide and sodium perborate oxidizing agent dicalcium diphosphate;
A toothpaste paste is disclosed that includes a calcium and magnesium carbonate detergent; a sorbitol humectant; a cornstarch and cellulose gum thickener; and an anionic detergent. U.S. Pat. No. 4,223,003 discloses a toothpaste containing a peroxide-containing material, such as magnesium peroxide, and conventional dentifrice ingredients. U.S. Patent No. 4,537,765 has a pH of 9,
2 to 105, peroxydiphosphate salts, polyethylene glycol humectants; thickeners such as colloidal silica, carboxyvinyl polymers, cellulose gum or hectorite; polishing agents such as silica or alumina hydrates; Pluronic F108 (Plu
toothpastes containing anionic or nonionic surfactants such as ronic F 108) are disclosed.

However, none of the above patents disclose the production of hydrogen peroxide dental gels, including specific ingredients essential to the production of stable dental gels, namely polyethylene glycol humectants, nonionic surfactants, flavors and polyethylene polypropylene block copolymer thickeners. I haven't.

The prior art also includes U.S. Pat. No. 3,657.413 and Assay et al.
of Hydrogen Peroxide in G
ertain yen] armaceutical Ge1s
) J, Soefu, -Esox and Toiletries (q-g, lcS, -ans Toiletri
es), Vol. 91 (September 1976), pp. 54-56, discloses another method for producing peracid gels. This patent is for urea peroxide.

Chrycerol, which contains a carboxypolymethylene polymer, is prepared by dissolving the polymer in glycerol under reduced pressure with high speed stirring and then dissolving urea peroxide and other ingredients in the thickened polymer/glycerol solution to form a viscous solution. We disclose a transparent gel prepared by obtaining a gel at °C. The document discloses a methylcellulose gel for surface cut treatment, hair bleaching and deodorization containing 0.1% oxine as a stabilizer for hydrogen peroxide; this gel is prepared by dissolving methylcellulose in water using an electric stirrer. Disperse and then neutralize with triethanolamine to form a gel Z, or disperse in hot water until methylcellulose is sufficiently hydrated (1), freeze until solidified, and form a gel until 3 g. Stir to obtain gel 7, then add stabilizer Oxine 7 to this gel.

Produced by adding hydrogen peroxide.

Oxine is not effective. Other stabilizers are hexamine.

Benzoic acid or L is urea.

Hydrogen peroxide gels containing polyoxyethylene/polyoxypropylene block copolymers as gelling/thickening agents are disclosed in U.S. Pat. Nos. 3,639,574 and 4.53Z.
No. 778. The former patent uses a polyoxyethylene/polyoxypropylene block copolymer as a gelling agent in an amount of 22 to 79% of the total composition;
A stable hydrogen peroxide gel for hair bleaching and surface cut treatment is disclosed. This is not a dental gel and does not contain polyethylene glycol humectants, sodium saccharin sweeteners or flavors, which are essential ingredients in dental gels. The latter patent is for hydrogen peroxide.

Flavor, thickener (for gel form) 20%.

Mouth rinses, pastes or gel forms containing 1-20% polyhydric alcohols such as glycerol and sorbitol, non-ionic surfactants such as Tweens (polysorbates) and/or 01-10% pluronics. Discloses an aqueous oral formulation. Pluronic (F127) is a better gelling agent (5-50%
). The only effective humectants used in this formulation are polyethylene glycol humectants.

Furthermore, the prior art has a pH of 4.5 to 60 and polyoxyethylene/polyoxypropylene as one essential component.
Block copolymer gelling agent, polyethylene glycol humectant, nonionic surfactant.

A cosmetic, chemically stable, aqueous hydrogen peroxide dental gel containing proportions of a sweetener, sodium saccharin, and a flavor is not disclosed.

When using a polyethylene/polypropylene block copolymer (Pluronics) at a level of about 18-25% by weight as the gelling agent, aqueous hydrogen peroxide dental It was recently discovered that the gel was stabilized. Pluronic gelling agents are compatible with aqueous hydrogen peroxide solutions, such as alginates.

Natural gums derived from organic materials such as methylcellulose are degraded by hydrogen peroxide to form gels. Similarly, synthetic organic polymers such as polyvinylpyrrolidone produce viscous gels, but this is not the clear, homogeneous, hard gel consistent with the novel dental gel products of the present invention. stannic acid) IJum.

The presence of stabilizers such as sodium pyrophosphate, oxine EDTA and calcium disodium EDTA has been found to be unnecessary and undesirable as they do not provide any benefit to the composition. As a practical matter, their presence tends to adversely affect the chemical stability of 1202. It has been found that the combination of a polyethylene glycol humectant and a block copolymer gelling agent produces a gel that is more stable and harder than a gel made with a block copolymer gelling agent without the use of a polyethylene glycol humectant. The use of nonionic surfactants has been found to provide acceptable stability in aqueous peroxide environments. Anionic surfactants do not have acceptable stability in the presence of hydrogen peroxide.

Problems to be solved by the invention: Therefore, the first object of the present invention is to have a pH of 4.5 to 60.

The present invention is to produce a cosmetically and chemically stable hydrogen peroxide dental gel that includes a polyethylene/polypropylene block copolymer gelling agent that is compatible with H2O2 in an amount of about 18-25% by weight of the composition.

Another object of the invention is to produce a cosmetically stable H202-polyethylene/polypropylene block copolymer gel containing a polyethylene glycol humectant that is compatible with other dental ingredients.

Yet another object of the present invention is to provide a rice product with improved taste comprising a compatible composition of a block copolymer gelling agent, a polyethylene glycol humectant, a nonionic surfactant, a flavor and a sweetener, such as sodium saccharin. , a strong and chemically stable aqueous I-I
202 dental gel.

Some of the other objects, advantages and novel features of the invention include:
Other portions are set forth in the description below and will be apparent to those skilled in the art from consideration of the description or may be learned by practice of the invention. The objects and advantages of the invention may be realized and attained by means of the instrumentalities and combinations particularly pointed out in the appended claims.

SUMMARY OF THE INVENTION In order to achieve the above and other objects, the present invention as embodied and extensively described herein provides: The novel stable aqueous hydrogen peroxide dental gel of the present invention is uniquely chemically active. H202Fl as agent 1.5-6.5% by weight, solid flakes or powder polyoxyethylene/polypropylene block copolymer gelling agent (Pluronic) approx. 18
~25% by weight, polyethylene glycol humectant approx. 15~
Contains 40% by weight, nonionic surfactants, sweeteners and flavors, and has an acidic pH of about 4.5-6.0. Sodium saccharin is a preferred sweetener. The water content in the gel constitutes about 60-60% by weight of the oral composition.

Distilled or deionized water is preferred to prevent even minimal contamination.

The hydrogen peroxide formulations of the present invention contain an effective amount of hydrogen peroxide for the prevention of oral gingivitis, preferably in an amount of about 1.5 to 6.5% by weight of the composition. Hydrogen peroxide usually has an active ingredient of 1.5 to
Supplied as a 30-35% aqueous solution containing 6.5%. Hydrogen peroxide is stable in the presence of polyethylene glycol, sodium saccharin, nonionic surfactants, flavors and pluronic gelling agents.

The essential ingredients of the H202 gel dentifrice of the present invention are a polyoxyethylene/polyoxypropylene block copolymer and a compatible peroxide-stable thickening/gelling agent in an amount of about 18-25% by weight of the composition. be. If the amount is less than about 18%, the hydrogen peroxide gel dentifrice will not thicken sufficiently;
If the amount is more than 5%, manufacturing becomes difficult. Possible agents are non-ionic (7) and have the following formula: % formula %) [a is such that the hydrophobic base represented by (C3H60) has a molecular weight of about 2750 to 400 units. and b is an integer such that the hydrophilic moiety (component) represents about 70-80% by weight of the copolymer.

A hydrophobic component with a molecular weight of approximately 2750-4C100 and a hydrophobic component with a molecular weight of approximately 2750-4C100 and
Pluronic polyol of type F (solid flake or powder form) having 0% by weight of hydrophilic polyoxyethylene groups is H2O218-25 in the Pluronic gel formulation.
Forms a gel in weight percent. Examples of suitable Pluronic compounds are Pluronic F88°F1a, H1O8 and F127. The most preferred gelling agent has a molecular weight of 40
Pluronic F127 has 0Y and contains 70% of a hydrophilic polyoxyethylene component. It is most preferably used in gel dentifrices in an amount of about 18-19% by weight.
Water-based pluronic acid with or without stabilizer.

The completed 12 week accelerated temperature aging data for the Co-H2O2 gels were both cosmetically and chemically acceptable, with the exception of the composition containing sodium lauryl sulfate, an anionic surfactant.

Sodium stannate, sodium pyrophosphate, oxine,
Phosphoric acid and disodium EDTA are effective in stabilizing aqueous H2O2 systems. However, based on the results from the active oxygen data, a system without stabilizers appears to be chemically the best. 90% of H2O2 activity is available after 6 weeks of cosmetic aging (accelerated temperature aging). Rheology results.

We show that Pluronic gels are very stable in terms of yield point, resolidification point, and tail. This gel did not thicken over time, and after 12 weeks at 100 °C, the yield point decreased by only 10%, within the margin of error.

Other essential ingredients of the H2O2 gel of the present invention are hydrogen peroxide, nonionic surfactants, flavors, and polyethylene glycol humectants that are compatible with pluronic gelling agents. Polyethylene glycol, known by the trademark CARBOWAX, is a nonionic polymer of ethylene oxide having the general formula: %, where n represents the average number of ethylene groups.

Carbowax polyethylene glycols are named by a number, such as 400, 600, etc., representing the average molecular weight. The average molecular weight of the polyethylene glycol used here is about 200-1000.
Preferably 400-600. Most preferably it is 600. Polyethylene glycol 200. It is a clear and viscous liquid at room temperature. These substances have lower hygroscopicity than glycerin and simple glycols, are more water soluble, and are transparent aqueous solutions. Polyethylene glycol gives dental products a different feel and taste than glycerin or sorbitol. Polyethylene glycol humectants have been found to promote the production of hard Pluronic H202 gel gels that are more stable than glycerin-containing gels. The polyethylene glycol humectant accounts for about 15-40% by weight of the H2O2 formulation.

Other essential ingredients in the aqueous H2O2 gel formulations of the present invention are nonionic surfactants that are compatible with H2O2 and are peroxide stable. Nonionic surfactant is solubilizer 1
It serves as a dispersant, emulsifier and wetting agent and is particularly effective in solubilizing flavors. A particularly useful nonionic surfactant is a water-soluble polyoxyethylene monoester with sorbitol C1o-C+s fatty acids, known under the trademark Tween. Tween surfactants are C10-C of sorbitol (and sorbitol anhydride)
] is a mixture of eight fatty acid esters, consisting primarily of monoesters condensed with about 10 to 60 moles, preferably about 20 moles, of ethylene oxide. Fatty acids (aliphatic hydrocarbon monocarboxylic acids) can be saturated or unsaturated, such as lauric acid, palmitic acid, stearic acid, oleic acid. Polysorbate 20 (e.g. Tween 20) is particularly preferred;
) It is called sorbitan monolaurate. The nonionic surfactant constitutes about 0.5-50%, preferably 05-6% by weight of the gel composition.

Yet another essential ingredient of the aqueous H2O2 gel dentifrice of the present invention is a seasoning effective amount of a flavor that is compatible and stable with hydrogen peroxide. Flavor component is approximately 05-2
% by weight. Suitable seasoning ingredients include seasoning oils, such as Dutch mustard oil, mustard oil, wintergreen oil, sassafras oil, clove oil, sage oil, eucalyptus oil, marjoram oil, cinnamon,
Methyl salicylate and menthol.

It is also preferred to use sweeteners as supplements to flavorings. Suitable sweeteners are water soluble, sodium saccharin, sodium cyclamate.

About 001 to 1.
0% concentration by weight. Saccharin sodium is most preferred.

The pH of the H202 gel dentifrice of the present invention ranges from about 4.5 to 0. The pH of the prepared composition is adjusted using a suitable acid, such as phosphoric acid or citric acid.

Generally adjusted to about 5.0-6.0, the pH drops to about 4.5 after 12 weeks of accelerated aging. This acidic pH confers great stability to the gel formulations of the present invention; the lower the pH, the greater the stability.

The hydrogen peroxide gel dentifrices of the present invention contain, for example, colorants or whitening agents, or preservatives such as sodium benzoate, which may affect the chemical and cosmetic properties of the final formulation.
It can be included in a minimum amount of up to 5% by weight, preferably up to 1% by weight, as long as it does not interfere with physical) stability.

Nonionic surfactant, polyethylene glycol humectant,
Polyoxyethylene/Polyoxypropylene Block Copolymer (Fluronic) A cosmetically and chemically stable aqueous peroxide with improved taste only through the use of a specific combination of gelling agents, sweeteners and flavoring ingredients. It was found that hydrogen gel toothpaste chips can be manufactured.

Heat to a temperature of about 32-32.5℃ and add a certain amount of water,
Dissolve hydrogen peroxide, saccharin and pluronic gelling agent, preferably in deionized water (to prevent even minimal contamination), for example in a Ross mixer (R,oss M
The hard, stable hydrogen peroxide gels of the present invention can be prepared by mixing under vacuum in a suitable mixer, such as an electric mixer, for about 60 minutes until a gel forms. Add the flavor, nonionic surfactant and polyethylene glycol to the gel and mix under vacuum for an additional approximately 15-60 minutes. A hard, clear, homogeneous and stable gel dentifrice is obtained which, if desired, can be acidified with phosphoric or citric acid to a pH of about 5-5. The final product can be packaged in a suitable container compatible with hydrogen peroxide, such as a plastic or metal tube, or in a three-compartment container or kit with a bicarbonate dentifrice. This method is a preferred manufacturing method because it is quick and simple.

Another method for making the hydrogen peroxide dental gel of the present invention is to dissolve the pluronic gelling agent in a volume of water cooled to about 4-10°C; then add hydrogen peroxide and saccharin to the aqueous phase formed. In addition, apart from this, the flavor mixture is emulsified with a nonionic surfactant in a small amount of water to form an emulsion: Add the humectant and the above emulsion to the Pluronic water phase and vacuum until a transparent homogeneous gel is formed. Including a step of mixing below.

The final product can be described as a gel with a hard jelly-like consistency of 7. It is a hard gel that makes a crunchy sound when chewed; that is, when the gel is placed in a jar-shaped container and the side of the container is lightly pressed, the gel vibrates but retains its original shape. The dental gel preparation of the present invention is a dentifrice, and dissolves in the oral cavity only during tooth brushing, not in oral water.

In the practice of the invention to promote oral hygiene, the gel dentifrice according to the invention is regularly applied to the tooth enamel by brushing the teeth for 60 to 90 seconds at least once a day.

The following examples further illustrate the nature of the invention, but it is understood that the invention may not be limited to these examples. Let's be a JV. The compositions of the invention are prepared in conventional manner in all amounts and proportions set forth in the detailed description and claims.

By weight unless otherwise specified.

Deionized water 42.10 Pluronic F127 25.0[]Na
Saccharin 0.20H202
(60% aqueous solution) (6% A, 1.) 10.00 Polyethylene glycol (molecular weight 600) 15.00 Deionized water 5.00 Tween 2
0* 1.20 Flavor 1.50 pH 6,5 *Polyoxyethylene (20) Sorbitan Monolaurate A quantity of deionized water is heated to approximately 22°C and mixed with saccharin and hydrogen peroxide in a Ross mixer. Completely cover the surface with the pluronic compound and stir under vacuum at speed 2 for % time. Add the mixture of Tween, flavor and 5% deionized water and polyethylene glycol to the aqueous phase in the Ross mixer and mix for about 15-25 minutes at speed B under vacuum. A clear, homogeneous, hard gel with a pH of 6.5' is obtained, which is adjusted to a pI-I of 5-6 with 10% phosphoric acid or citric acid. A stable hard gel is obtained which has excellent storage stability with respect to flavor, color, appearance, taste and peroxy content.

After 12 weeks of accelerated aging, the pH drops to about 4.5.

The data show that the loss of active oxygen is less than 10%. This formulation initially has 2.9% active oxygen, but after 9 weeks aging at 466°C it still has 2.8% active oxygen.

Deionized water 48.50 Pluronic F127 20. O[]Na
Saccharin 0.20H202
(35% aqueous solution) (3,01% A, 1.) 8. (S
.

Polyethylene glycol (molecular weight 600) 15.0
0 Deionized water 5.00 Tween 20 1.20 Flavor 1.50 Example 1
stated. A dental hydrogen peroxide gel formulation is prepared by the same method. The obtained product also shows immediate n7C storage stability and is in the form of a stable, hard, transparent gel.

Example 6 Polyethylene glycol (molecular weight 600) (7')
Polyethylene glycol (molecular weight 400) instead
Example 2 is repeated except that f is used. The final product is equally effective against gingivitis-associated bacteria and also has excellent chemical and cosmetic stability. The product initially has 276% active oxygen and after 9 weeks aging at 4°C still has 2.59% active oxygen.

Example 4 Saccharin sodium was omitted and the deionized water content was 48
．． Example 2 is repeated except for increasing the fill point to 7%. Omission of sodium saccharin did not adversely affect the final hydrogen peroxide dental gel.

Example 5 Pluronic P127'& 18% instead of 25% ℃・
, Example 1 except that the water content Y was increased to 49.10%.
Repeat. The product obtained has the same excellent chemical and cosmetic stability as in Example 1.

Although the invention has been described in connection with preferred embodiments,
Various modifications and variations of this invention that are obvious to those skilled in the art are intended to be included within the spirit and scope of this application and the claims.

Procedural amendment 1, Indication of the case Patent Application No. 95352 of 1988 2, Name of the invention Aqueous hydrogen peroxide dental gel 3, Person making the amendment Relationship to the case Patent applicant Address Name Name Colgate-Palmolive Company New Major Town building 206 Ward type stamped detailed statement 5" as per Mr. 1 (Contents I of the detailed description have been changed J'=L)
6■56, Contents of amendment

Claims (15)

[Claims] (1) about 1.5-3.5% by weight hydrogen peroxide; about 18-25% by weight polyoxyethylene polyoxypropylene block copolymer gelling agent in solid flake or powder form;
About 15-40% by weight of polyethylene glycol humectant, including non-ionic surfactants and flavors, about 4.5-40% by weight
Stable aqueous hydrogen peroxide dental gel with acidic pH of 6.0. (2) Dissolve hydrogen peroxide and the block copolymer gelling agent in a blended amount of water heated to about 90°F (32.2°C) and mix under vacuum for about 30 minutes to form a gel. ; polyethylene glycol, flavor and nonionic surfactant are added to the gel and heated under vacuum for about 15-60 min.
A method for producing a hydrogen peroxide dental gel as defined in claim 1, comprising mixing for a period of minutes until a clear, homogeneous, hard gel is obtained. (3) The dental gel according to claim 1, which contains a sweetener. (4) The dental gel according to claim 6, wherein the sweetener is sodium saccharin. (5) the gelling agent is a solid polyoxyethylene polyoxypropylene copolymer, the polyoxypropylene hydrophobic component of said copolymer has a molecular weight of about 2,250 to 4,000, and the hydrophilic polyoxyethylene component of the copolymer has a molecular weight of about 70%; The dental gel according to claim 1, comprising ~80%. 6. The dental gel of claim 5, wherein the gelling agent comprises about 18-19% by weight of the composition. (7) Polyethylene glycol humectant is about 200-10
The dental gel of claim 1 having an average molecular weight of 0.00. (8) The dental gel according to claim 7, wherein the polyethylene glycol has an average molecular weight of about 400-600. 9. The dental gel of claim 1, wherein the nonionic surfactant comprises about 0.5 to 5% by weight. (10) Nonionic surfactants are sorbitol and C_1_
The dental gel according to claim 9, which is a polyoxyethylene monoester with 0-C_1_8 fatty acid. 11. The dental gel of claim 1, wherein the aqueous content is about 30-60% by weight of deionized water. 12. The dental gel of claim 12, wherein the nonionic surfactant comprises about 0.5-2% by weight and the flavor content is about 0.5-2% by weight. (13) The dental gel according to claim 10, wherein the nonionic surfactant is polyethylene (20) sorbitan monolaurate. 14. The dental gel of claim 5, wherein the hydrophobic component of the gelling agent has a molecular weight of 4000 and the hydrophilic component constitutes 80% by weight of the copolymer. (15) Dissolving hydrogen peroxide, sodium saccharin, and copolymer gelling agent in a formulation of deionized water heated to about 32-32.5°C and mixing under vacuum for about 30 minutes to form a gel; Add polyethylene glycol, flavor and non-ionic surfactant to the gel and stir under vacuum for about 15-30 minutes until a clear homogeneous hard gel is obtained.
A method for producing a hydrogen peroxide gel as defined in claim 2, comprising mixing for a minute.