JPH0259123B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Field of Application] The present invention relates to a novel deodorant cosmetic product.
More specifically, the present invention relates to a deodorant cosmetic product containing a specific metal oxide powder as an active ingredient for reducing bad odor originating from living organisms. [Prior Art] Most explanations for the causes of body-derived bad odors such as armpit odor, sweat odor, foot odor, hair odor, and menstrual odor are that they are caused by bacterial decomposition of sweat (e.g., Labows and Kligman). (Kligman) et al., J.Soc.Cosmet., Volume 34, 1982
, p. 193}. There are many deodorant cosmetics on the market aimed at reducing these bad odors, but most of these are based on antiperspirants such as aluminum hydroxychloride, disinfectants such as quaternary ammonium compounds, and pleasant odors such as eugenol. It contains a masking agent or an adsorbent such as activated carbon alone or in combination. [Problems to be Solved by the Invention] However, these conventional deodorant cosmetics have insufficient effects, lack long-lasting effects, or are not fully satisfactory in terms of safety and usability when applied locally. It wasn't. In view of the above circumstances, the present inventors have determined that the safety is high,
As a result of intensive research to create deodorant cosmetics that have truly excellent deodorizing effects and long-lasting effects, they are used in the medical field to treat eczema, and in the cosmetic field as white pigments, anti-inflammatory agents, and astringents. We have discovered a completely new fact that metal oxides such as zinc oxide with a specific particle size have a strong deodorizing effect. The present invention has been made based on this knowledge. [Means for Solving the Problems] That is, the present invention provides a deodorant cosmetic product characterized by containing metal oxide powder with a particle size of 0.5 μm or less as an active ingredient,
Product forms include aerosol, roll-on,
Includes external deodorants such as powders, lotions, creams, and stickers. The present invention will be explained in detail below. Examples of the metal oxide used in the present invention include zinc oxide, magnesium oxide, calcium oxide, etc., and one or more of them can be arbitrarily selected and used. The particle size of the metal oxide is not particularly limited as long as it is 0.5 μm or less, but the smaller the particle size, the greater the deodorizing effect. It is preferable that the particle size is small, as this leads to a transparent feeling when applied to the skin, for example. Among the metal oxides mentioned above, zinc oxide is the most effective. The effect is achieved when the metal oxide is added in an amount of 0.1% by weight or more in the deodorant cosmetic base. There is no upper limit. [Effects of the Invention] Hereinafter, the present invention will be explained in more detail by giving examples of deodorizing effect tests using the metal oxides of the present invention. The test method is as follows. Deodorization test (test method) Healthy male panel 6 who are aware of having armpit odor
The test was conducted using the name. A total of 4 doses of the test product with the following formulation were administered once in the morning and once in the afternoon every day for 2 days.
It was applied to one armpit of each subject. The other armpit, which is not applied, is used as a control. (Formulation of test product) Zinc oxide (0.5 μm) 50% by weight Talc 50% by weight (Judgment and evaluation) The effectiveness was judged based on the following 5-level criteria. 0: No armpit odor 1: Slight armpit odor 2: Distinct armpit odor 3: Armpit odor 4: Very strong armpit odor Average underarm odor of 6 people over time The value was calculated and used to evaluate the deodorizing effect. The results are shown in Table-1. The effect of zinc oxide in the deodorant cosmetic product of the present invention is clear.

[Table] Tests were conducted by changing the particle size of zinc oxide to 0.1 μm. The results are shown in Table-2.

[Table] According to the above test method, the deodorizing effects of the two formulations of deodorant cosmetics shown in Table 3 below were evaluated. The control side is a deodorant cosmetic containing aluminum hydroxychloride, which has been widely used in the past, as an active ingredient.

[Table] The results are shown in Table 4. It can be seen that the deodorant cosmetics of the present invention are more effective than conventional products.

[Table] Zinc oxide used in the present invention is non-toxic and has astringent, protective and antiseptic properties, so it can be used as an active ingredient in deodorant cosmetics that are applied to a wide range of living organisms, including not only humans but also animals. It is most suitable for containing. Particle size dependence test for the deodorizing effect of zinc oxide Next, the particle size dependence of the deodorizing effect of zinc oxide was measured and evaluated as follows. (Test Method) The deodorizing effect was evaluated based on how much isovaleric acid was reduced from the upper space when the drug was added to a control solution of isovaleric acid. This evaluation was based on the control isovaleric acid.
This was done by comparing the GC peak area with the GC peak area of isovaleric acid after adding the drug to the control. First, sample about 80 mg (±0.2 mg) of the drug, and then add exactly 1 ml of 0.5% isovaleric acid aqueous solution using a whole pipette. Then HS-GC
(Headspace gas chromatography) vial is tightly capped and subjected to ultrasonic dispersion for 5 minutes. This is to uniformly disperse the drug in the isovaleric acid aqueous solution. Further, this vial is placed in a constant temperature bath at 60° C. for 1 hour to allow the head space to reach an equilibrium state. After this, set the vial in the HS-GC and measure. The value obtained by converting the decrease in the peak area of the data thus obtained into a unit drug amount was defined as the isovaleric acid consumption amount. Measurements and evaluations were carried out using the methods described above using zinc oxide powders having average particle diameters of 1 μm, 0.5 μm, and 0.1 μm, respectively. (Test results) The results are shown in Figure 1. From the same figure, isovaleric acid consumption depends on the particle size of zinc oxide powder, especially 0.5μ
It can be seen that the consumption amount increases with particle sizes of m or less. In the figure, the vertical axis is in counts/mg drug. The count number has no unit because it is a displayed value of the indegrator, but it can be used as an index of relative deodorizing effect. [Example] Examples are shown below, but the present invention is not limited thereto. Example 1 A deodorizing powder having the following composition was prepared. Calcium oxide (0.5 μm) 50.0% by weight Talc 30.0 〃 Kaolin 20.0 〃 A deodorizing effect test was conducted using the above powder, and after the start of the test, the intensity of armpit odor in the test area was lower than that in the control area. There was a significant decrease with a risk rate of 5%. Example 2 A deodorizing cream having the following composition was prepared. Stearic acid 10.0% by weight Stearyl alcohol 4.0 Butyl stearate 8.0 Glyceryl monostearate 2.0 Zinc oxide (0.1μm) 1.6 Glycerin 14.0 Potassium hydroxide 0.4 Purified water 60.0 Using the above deodorant cream, deodorizing effect When the test was conducted, after the start of the test, the intensity of armpit odor in the test area was significantly reduced in all panels compared to the control area at a risk rate of 5%. Example 3 A deodorizing spray having the following composition was prepared. Freon 11 76.8% Freon 12 19.2% Zinc oxide (0.1 μm) 0.6% Talc 2.4% Isopropyl-myristate 0.5% Tetra-2-ethylhexanoate diglycerol sorbitan 0.5% In actual use tests using this spray,
After the start of the test, the intensity of armpit odor in the test area was significantly reduced at a risk rate of 5% compared to the control area for all panels. Example 4 A deodorant lotion having the following composition was prepared. Purified water 82.0% by weight Ethanol 15.0 Sorbit 2.0 Zinc oxide (0.1μm) 1.0 In actual use tests using this lotion, after the start of the test, the intensity of armpit odor in the test area was lower than that in the control area. , the risk rate was significantly reduced at 5%, supporting its effectiveness.

[Brief explanation of the drawing]

FIG. 1 is a characteristic diagram showing an example of the particle size dependence of the deodorizing effect of the metal oxide contained in the deodorant cosmetic of the present invention.

Claims (1)

[Claims] 1. A deodorant cosmetic product characterized by containing metal oxide powder with a particle size of 0.5 μm or less as an active ingredient.