JPS61271222A - ヒトインターロイキン１ポリペプチド及びその製造法 - Google Patents
ヒトインターロイキン１ポリペプチド及びその製造法Info
- Publication number
- JPS61271222A JPS61271222A JP60112474A JP11247485A JPS61271222A JP S61271222 A JPS61271222 A JP S61271222A JP 60112474 A JP60112474 A JP 60112474A JP 11247485 A JP11247485 A JP 11247485A JP S61271222 A JPS61271222 A JP S61271222A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- vector
- dna
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000008188 pellet Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- YXCDJKQYFBEAOU-UHFFFAOYSA-N phenyl thiocyanate Chemical compound N#CSC1=CC=CC=C1 YXCDJKQYFBEAOU-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 108010051242 phenylalanylserine Proteins 0.000 description 1
- 108010083476 phenylalanyltryptophan Proteins 0.000 description 1
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 108010086652 phytohemagglutinin-P Proteins 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 108010070643 prolylglutamic acid Proteins 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 239000000007 protein synthesis inhibitor Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000003334 secondary amides Chemical class 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 108010069117 seryl-lysyl-aspartic acid Proteins 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- IHQKEDIOMGYHEB-UHFFFAOYSA-M sodium dimethylarsinate Chemical compound [Na+].C[As](C)([O-])=O IHQKEDIOMGYHEB-UHFFFAOYSA-M 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60112474A JPS61271222A (ja) | 1985-05-24 | 1985-05-24 | ヒトインターロイキン１ポリペプチド及びその製造法 |
| EP85309453A EP0188920B1 (en) | 1984-12-25 | 1985-12-23 | Interleukin 1 and its derivative |
| DE85309453T DE3587605T2 (de) | 1984-12-25 | 1985-12-23 | Interleukin-1 und dessen Derivat. |
| KR1019850009774A KR950000712B1 (ko) | 1984-12-25 | 1985-12-24 | 인터로이킨1활성을가지는폴리펩티드의제조방법 |
| US07/954,418 US5376639A (en) | 1984-12-25 | 1992-09-30 | Treatment of sarcoma with interleukin 1α polypeptides |
| US08/252,826 US5494663A (en) | 1984-12-25 | 1994-06-02 | Treatment of microbial infection with interleukin 1 polypeptides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60112474A JPS61271222A (ja) | 1985-05-24 | 1985-05-24 | ヒトインターロイキン１ポリペプチド及びその製造法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3124909A Division JPH04330282A (ja) | 1991-04-25 | 1991-04-25 | ヒト インターロイキン１αポリペプチドをコードするＤＮＡ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61271222A true JPS61271222A (ja) | 1986-12-01 |
| JPH0560480B2 JPH0560480B2 (enrdf_load_stackoverflow) | 1993-09-02 |
Family
ID=14587539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60112474A Granted JPS61271222A (ja) | 1984-12-25 | 1985-05-24 | ヒトインターロイキン１ポリペプチド及びその製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61271222A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008201801A (ja) * | 1999-02-22 | 2008-09-04 | Baxter Internatl Inc | アルブミンを含有していない新規の第ｖｉｉｉ因子処方物 |
| US10512674B2 (en) | 2008-11-07 | 2019-12-24 | Baxalta Incorporated | Factor VIII formulations |
-
1985
- 1985-05-24 JP JP60112474A patent/JPS61271222A/ja active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008201801A (ja) * | 1999-02-22 | 2008-09-04 | Baxter Internatl Inc | アルブミンを含有していない新規の第ｖｉｉｉ因子処方物 |
| JP2009046499A (ja) * | 1999-02-22 | 2009-03-05 | Baxter Internatl Inc | アルブミンを含有していない新規の第ｖｉｉｉ因子処方物 |
| JP2012072198A (ja) * | 1999-02-22 | 2012-04-12 | Baxter Internatl Inc | アルブミンを含有していない新規の第ｖｉｉｉ因子処方物 |
| JP2014024864A (ja) * | 1999-02-22 | 2014-02-06 | Baxter Internatl Inc | アルブミンを含有していない新規の第ｖｉｉｉ因子処方物 |
| US9352027B2 (en) | 1999-02-22 | 2016-05-31 | Baxalta Incorporated | Albumin-free factor VIII formulations |
| US9669076B2 (en) | 1999-02-22 | 2017-06-06 | Baxalta Incorporated | Albumin-free factor VIII formulations |
| US10512674B2 (en) | 2008-11-07 | 2019-12-24 | Baxalta Incorporated | Factor VIII formulations |
| US11020459B2 (en) | 2008-11-07 | 2021-06-01 | Baxalta Incorporated | Factor VIII formulations |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0560480B2 (enrdf_load_stackoverflow) | 1993-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| EXPY | Cancellation because of completion of term |