JPS61238336A - 徐放性被覆物の製造法 - Google Patents
徐放性被覆物の製造法Info
- Publication number
- JPS61238336A JPS61238336A JP60079931A JP7993185A JPS61238336A JP S61238336 A JPS61238336 A JP S61238336A JP 60079931 A JP60079931 A JP 60079931A JP 7993185 A JP7993185 A JP 7993185A JP S61238336 A JPS61238336 A JP S61238336A
- Authority
- JP
- Japan
- Prior art keywords
- water
- coating agent
- solidified
- protected
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 9
- 239000011248 coating agent Substances 0.000 claims abstract description 21
- 239000007787 solid Substances 0.000 claims abstract description 12
- 239000000126 substance Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 238000000576 coating method Methods 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 239000003921 oil Substances 0.000 abstract description 12
- 230000032683 aging Effects 0.000 abstract description 8
- 239000001993 wax Substances 0.000 abstract description 6
- 238000010828 elution Methods 0.000 abstract description 5
- 238000010438 heat treatment Methods 0.000 abstract description 5
- 235000014593 oils and fats Nutrition 0.000 abstract description 3
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 abstract description 2
- 108010011485 Aspartame Proteins 0.000 abstract description 2
- 240000007594 Oryza sativa Species 0.000 abstract description 2
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract description 2
- 229960003438 aspartame Drugs 0.000 abstract description 2
- 235000010357 aspartame Nutrition 0.000 abstract description 2
- 239000000605 aspartame Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 235000013373 food additive Nutrition 0.000 abstract description 2
- 239000002778 food additive Substances 0.000 abstract description 2
- 235000009566 rice Nutrition 0.000 abstract description 2
- 239000000725 suspension Substances 0.000 abstract 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 abstract 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229940068041 phytic acid Drugs 0.000 abstract 1
- 235000002949 phytic acid Nutrition 0.000 abstract 1
- 239000000467 phytic acid Substances 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 239000002336 ribonucleotide Substances 0.000 abstract 1
- 239000003925 fat Substances 0.000 description 12
- 238000004090 dissolution Methods 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 239000011162 core material Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- 235000013339 cereals Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 235000019484 Rapeseed oil Nutrition 0.000 description 4
- 240000002791 Brassica napus Species 0.000 description 3
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- AANLCWYVVNBGEE-IDIVVRGQSA-L Disodium inosinate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 AANLCWYVVNBGEE-IDIVVRGQSA-L 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 239000011362 coarse particle Substances 0.000 description 2
- 235000013890 disodium inosinate Nutrition 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 230000005070 ripening Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- PVBRXXAAPNGWGE-LGVAUZIVSA-L disodium 5'-guanylate Chemical compound [Na+].[Na+].C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O PVBRXXAAPNGWGE-LGVAUZIVSA-L 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- -1 feed Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 229960005337 lysine hydrochloride Drugs 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Fodder In General (AREA)
- General Preparation And Processing Of Foods (AREA)
- Seasonings (AREA)
- Formation And Processing Of Food Products (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60079931A JPS61238336A (ja) | 1985-04-15 | 1985-04-15 | 徐放性被覆物の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60079931A JPS61238336A (ja) | 1985-04-15 | 1985-04-15 | 徐放性被覆物の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61238336A true JPS61238336A (ja) | 1986-10-23 |
| JPH0513691B2 JPH0513691B2 (enrdf_load_html_response) | 1993-02-23 |
Family
ID=13704054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60079931A Granted JPS61238336A (ja) | 1985-04-15 | 1985-04-15 | 徐放性被覆物の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61238336A (enrdf_load_html_response) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01309646A (ja) * | 1988-02-05 | 1989-12-14 | Takeda Chem Ind Ltd | 被覆製剤およびその用途 |
| WO2017183628A1 (ja) * | 2016-04-19 | 2017-10-26 | 味の素株式会社 | 造粒物およびその製造方法 |
| JP2022500367A (ja) * | 2018-09-07 | 2022-01-04 | アール．ピー．シェーラー テクノロジーズ，エルエルシー | 硬化および低ｈｌｂ界面活性剤の添加による固体または半固体脂質ベースの剤形の安定化 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5015742A (enrdf_load_html_response) * | 1973-05-09 | 1975-02-19 |
-
1985
- 1985-04-15 JP JP60079931A patent/JPS61238336A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5015742A (enrdf_load_html_response) * | 1973-05-09 | 1975-02-19 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01309646A (ja) * | 1988-02-05 | 1989-12-14 | Takeda Chem Ind Ltd | 被覆製剤およびその用途 |
| WO2017183628A1 (ja) * | 2016-04-19 | 2017-10-26 | 味の素株式会社 | 造粒物およびその製造方法 |
| JPWO2017183628A1 (ja) * | 2016-04-19 | 2019-02-21 | 味の素株式会社 | 造粒物およびその製造方法 |
| JP2022500367A (ja) * | 2018-09-07 | 2022-01-04 | アール．ピー．シェーラー テクノロジーズ，エルエルシー | 硬化および低ｈｌｂ界面活性剤の添加による固体または半固体脂質ベースの剤形の安定化 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0513691B2 (enrdf_load_html_response) | 1993-02-23 |
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