JPS61227515A - External preparation for skin - Google Patents

Abstract

PURPOSE:An external preparation for the skin preventing change in smell of amino acid with time, providing the skin with proper wetting and tension, and improved beautifying effect, obtained by blending an external preparation for the skin with an amino acid or its derivative and a specific hydroquinone glycoside. CONSTITUTION:An external preparation for the skin such as cosmetic, milky lotion, cream, external preparation for the skin of the body, hair tonic, hair cream, etc., blended with (0.05-10wt%) one or more selected from an amino acid such as glycine, serine, cystine, alanine, aspartic acid, alginine, etc., and an amino acid derivative such as acylsarcosine, acrylglutamic acid, its salts, etc., and (6-20wt%) hydroquinone derivative (preferably hydroquinone beta-D- glycoside) shown by the formula (R is pentose residue, hexose residue, amino acid residue, uronic acid residue or methylated substances thereof).

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention provides an external preparation for skin that has the effect of imparting appropriate "moisturization" and "firmness" to the skin, and the effect of whitening the skin.

[Prior Art] In general, a state in which the stratum corneum of the skin contains 10 to 15% of water is said to be "is" skin. If the skin contains too much water, it will become flaky, and if it contains too little water, it will become dry. To solve this problem, external skin preparations such as lotions, creams, and emulsions are used. These external skin preparations include moisturizers such as sodium lactate, glycerin,
1.3-Butylene glycol, propylene glycol, etc. are used in relatively large amounts (3-butylene glycol, etc.) from the viewpoint of affinity for the skin and feeling of use.
~10%). Amino acids are also used in the hope of restoring hydration to aging and hardened epidermis.

[Problems to be Solved by the Invention] However, in skin preparations for external use that particularly appeal to a rich feeling, there is a tendency to incorporate extremely large amounts of the above-mentioned humectants, resulting in a sticky feeling on the skin.

In addition, when these external skin preparations containing moisturizers are used in low humidity conditions, the humidity in the outside air is low, so water is drawn from the skin into the external skin preparations containing humectants, leaving the skin dry and dry. There were times when I was disappointed.

On the other hand, external skin preparations containing amino acids do not have the drawbacks of the above-mentioned moisturizers. , odor over time was a problem.

[Means for Solving the Problems] In view of the above circumstances, the present inventors have developed the following method. As a result of repeated research into 1llF, we have found that a skin preparation containing one or more selected from the group consisting of amino acids and their derivatives and a specific glycoside of hydroquinone has been found to be effective against deodorization of amino acids over time. The present inventors have discovered that the present invention has an excellent whitening effect that not only provides appropriate "moisture" and "firmness" to the skin, but also significantly improves age spots, freckles, dark skin, etc., leading to the completion of the present invention.

That is, the present invention provides an external preparation for skin, characterized in that it contains one or more selected from the group consisting of amino acids and derivatives thereof, and a glycoside of hydroquinone represented by the following general formula. be.

[In the formula, R is a tertiary sugar residue, a hexose sugar residue, an amino sugar residue,
Indicates uronic acid residues or their methylated products. ] Hereinafter, the structure of the present invention will be explained in detail.

Amino acids used in the present invention include glycine, serine,
Neutral amino acids such as cystine, alanine, threonine, cysteine, valine, phenylalanine, methionine, leucine, tyrosine, proline, isoleucine, tryptophan, and hydroxyproline; acidic amino acids such as aspartic acid, asparagine, glutamine, and glutamic acid;
Examples include basic amino acids such as arginine, histidine, and lysine.

Amino acid derivatives include acylsarcosine and its salts, acylsarcosinic acid and its salts, acyl-β-alanine and its salts, glutathione, pyrrolidone carboxylic acid and its salts, as well as glutatine, carnosine, gelamsigin S1 tyrosidine A1 tyrosidine Examples include oligopeptides such as B.

One or more of these may be appropriately selected and blended into the skin external preparation of the present invention.

The blending amount is 0.01-20% by weight, preferably 0.05-10% by weight in the skin external preparation of the present invention.

If the blending amount is less than 0.01%, the moisturizing effect on the skin will be weak, and on the other hand, if it is added in an amount of 20% or more, no substantial increase in the effect can be expected, and it tends to be difficult to prevent odor from amino acids.

The hydroquinone glycoside used in the present invention can be represented by the following general formula.

[In the formula, R is a tertiary sugar residue, a hexose sugar residue, an amino sugar residue,
Indicates uronic acid residues or their methylated products. ] In the formula, R is L-arabinose, D-arabinose, D-
Residues of tertiary sugars such as xylose, D-ribose, xylose, L-lyxose, D-ribulose, D-glucose, L-galactose, D-galactose, D-mannose, D-talose, D-fructose, Residues of hexoses such as sorbose, D-tagatose, and D-psicose; residues of amino sugars such as D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, and muramic acid;
- Residues of uronic acids such as glucuronic acid, D-galacturonic acid, D-mannuronic acid, L-iduronic acid, and guluronic acid, or their methylated products; When R is a D-glucose residue, D-
-Glucose is β-linked, ie, hydroquinone β-li glucoside (-ship name: arbutin, hereinafter referred to as arbutin) is preferred.

The blending amount is 0.1 to 30% by weight, preferably 6 to 20% by weight, based on the total amount of the skin external preparation.

In addition to the above-mentioned essential components, the skin external preparation of the present invention includes:
If necessary, other ingredients commonly used in external skin preparations such as pharmaceuticals and cosmetics, such as edetic acid, sequestering agents such as di-, tri-, or tetrasodium, sodium citrate, and sodium metaphosphate, butylated hydroxytoluene (
BHT), antioxidants such as propyl gallate and tocopherol, surfactants, ultraviolet absorbers, fragrances, water, lower alcohols such as ethanol and isopropanol, thickeners, colorants, powders, drugs, citric acid , organic acids such as malic acid, and inorganic acids such as phosphoric acid. Naturally, these components must be used within a qualitative and quantitative range that does not impair the effects of the present invention.

The dosage form of the skin external preparation of the present invention is arbitrary, and any dosage form may be used, such as a solution type, a solubilized type, an emulsion type, a powder dispersion type, a water-two-layer type, a water-oil-one-powder three-layer type, etc. I do not care.

Furthermore, the use of the skin external preparation of the present invention is arbitrary.
Facial and body skin preparations such as lotions, emulsions, creams, and packs, hair tonics, hair creams,
It can be used in external preparations for hair and skin such as shampoos and hair rinses.

(The following is a blank space) [Examples] Next, examples and comparative examples will be given to specifically clarify the present invention. The present invention is not limited thereby. The blending amount is in weight%.

Example 1 Lotion A lotion was produced by a conventional method according to the following recipe.

Ethanol 8.01.
3-Butylene glycol 5.0 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.8 Arbutin 0.1 Sodium pyrrolidone carboxylate -0.5 Pullulan
0.05 jojoba oil
0.5 caustic potash
0.015E DT A-3N a
O,01 fragrance
0.1 ion exchange water
Residual Amount Example 2 Cream A cream was produced by a conventional method according to the following recipe.

1.3-Butylene glycol 3.0 Polyethylene glycol 4000 1.0 Glycerin 2.0 Squalane
20.0 Vaseline
5.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Glyceryl monostearate 1.5 Arbutin 20, O cysteine 10.0 Sodium lactate 2.0 Xanthan gum (Keltrol brand name) O, OS Mechi J! Paraben
0.1 ethylparaben
0.2 caustic potash
0.01E DT A-3N a
O,01 fragrance
0.2 ion exchange water
Residual Amount Example 3 Emulsion A milky lotion was produced by a conventional method according to the following recipe.

Glycerin 2.0 Squalane 5.0 Vaseline
1.0 Cetostearyl alcohol 0.3 Polyoxyethylene (20
mole) Oleyl alcohol ether 1.5 Glyceryl monooleate 1.5 Heid r1 quinone-β-D-arabinose
10.0 Sodium polyacrylate 0.03 Ethylparaben
0.2 aspartic acid
10.0 caustic potash
0゜IE D T A-3N a
O,03 fragrance
0.2 ion exchange water
Remaining Amount Example 4 Pack A pack was manufactured by a conventional method according to the following recipe.

Polyethylene glycol 4000 3.0 Ethanol 10.0 Arbutin 15.0 Polyvinyl alcohol 10.0 Olive oil
3.0 lactic acid
1.0 glutathione
10,0 glutamic acid
10.0 carboxymethylcellulose
0.07 Methylparaben
0.1 Ethylparaben 0.1
Caustic potash 0.02E
DTA-3Na O,01 Fragrance 0.1 Ion-exchanged water Remaining amount Example 56 Hair cream Beeswax 3.0 Vaseline 15.0 Liquid paraffin 42.0 Polyoxyethylene (5 mol) Stearate ester 3.0 Polyoxyethylene ( 6 moles) Oleyl alcohol ether 2.0 Polyoxyethylene (6 moles) Cetyl alcohol ether 1.0 Arbutin 7.0 Glutamic acid 5.0 Purified water
residual fragrance
Appropriate amount of preservative
The effect of the skin external preparation according to the present invention in an appropriate amount was confirmed through a usage test. In the usage test, 3 o women were each
Groups were divided into panels. The first group was given the lotion of Example 1, the second group was given the cream of Example 2, and the third group was given the lotion of Example 3, twice a day in the morning and at night, in appropriate amounts after washing their face. was applied to the face for two weeks, and its effectiveness was evaluated in three areas: skin moisture, skin firmness, and skin moisture the next morning. The results are shown in Tables 1 to 3.

(Hereinafter in the margin) Table 1 Table 2 (Hereinafter in the margin) Table 3 As is clear from the results in Tables 1 to 3, the skin external preparation of the present invention was excellent in skin moisture, skin firmness, and next morning skin moisture. It was something. Furthermore, there was no stickiness, there was no odor at all over time, and the skin whitening effect was excellent.

Claims (1)

[Scope of Claims] An external preparation for skin, characterized in that it contains one or more selected from the group consisting of amino acids and derivatives thereof, and a glycoside of hydroquinone represented by the following general formula. ▲There are mathematical formulas, chemical formulas, tables, etc.▼ [In the formula, R is a pentose residue, a hexose residue, an amino sugar residue,
Indicates uronic acid residues or their methylated products. ]