JPS61227512A - External preparation for skin - Google Patents

Abstract

PURPOSE:An external preparation fort the skin activating metabolism of the skin, increasing elasticity of the skin and improved effect on protection of the skin and water retention properties, containing protein, protein decomposition product, etc., and a hydroquinone glycoside. CONSTITUTION:An external preparation for the skin containing 0.01-10wt% one or more selected from protein and a protein decomposition product (e.g., soybean protein, collagen, elastin, gelatin, or fibrinogen) and 6-20wt% hydroquinone glycoside (preferably hydroquinone beta-D-glycoside) shown by the formula (R is petose reside, hexose residue, amino sugar residue, uronic acid residue, or methylated substances thereof). This external preparation for the skin increases synergistically water retention properties, makes the skin smooth and provides it with wetting and tension. It is used for any purpose for the face, body, hair, etc.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a novel skin preparation for external use, and its purpose is to activate skin metabolism, increase skin elasticity, and protect the skin. An object of the present invention is to provide a skin preparation for external use that has excellent moisture retention effects.

[Prior Art] Histological analysis of the skin shows that collagen fibers and elastic fibers form a network in the dermis, which is said to provide the skin with elasticity and tensile strength. recent years,
Collagen and elastin obtained by making these fibers obtained from animals soluble through scientific treatment, or by extracting soluble fiber molecules from these fibers, have been incorporated into external skin preparations as skin protection and moisturizing agents. . Also, from the same point of view, combinations of gelatin, casein, soybean protein, etc. have also been proposed.

[Problems to be solved by the invention] However, when these proteins are added alone to external skin preparations, the expected effects are still not sufficient, and therefore, increasing the amount incorporated may improve the stability of external skin preparations. It has disadvantages such as having an adverse effect on the product and causing stickiness.

[Means for Solving the Problems] In view of the above circumstances, the present inventors have conducted intensive research and found that one or more selected from the group consisting of proteins and protein decomposition products, and a specific glycoside of hydroquinone. We have discovered that external skin preparations formulated with the skin synergistically increase water retention, make the skin smooth, and provide appropriate ``moisturization'' and ``firmness.'' Based on this knowledge, we developed this book. The invention was completed.

Hereinafter, the configuration of the present invention will be explained in detail.

The proteins and protein decomposition products used in the present invention include soybean protein, wheat protein, glutelin, glucagon, collagen,
gelatin, elastin, egg white lysozyme, amylase,
These are fibrinogen, myosin, enolase, chymotrypsinogen, histones, fish protein, avidin, pepsin, globulin, casein, succinylated casein, and salts thereof.

One or more of these may be appropriately selected and blended into the skin external preparation of the present invention.

The blending amount of protein and protein decomposition product is 0.01 to 20% by weight, preferably 0.01-1% by weight in the skin external preparation of the present invention.
The content is 0% by weight.

If the amount is less than 0.01%, the moisturizing effect on the skin will be poor, and if it is added in an amount of 20% or more, no substantial increase in the effect can be expected, and problems such as stickiness may occur, which is not preferable.

The hydroquinone glycoside used in the present invention can be represented by the following general formula.

[In the formula, R is a tertiary sugar residue, a hexose sugar residue, an amino sugar residue,
Uron l! indicates the residue or its methylated product. ] In the formula, RLtL-arabinose, D-arabinose, D
- Residues of tertiary sugars such as xylose, D-ribose, L-xylose, L-lyxose, D-ribulose, D-glucose, L-galactose, D-galactose, D-
Hexose residues of mannose, D-talose, D-fructose, L-sorbose, D-tagatose, D-psicose, amino sugars such as D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, and muramic acid. residue,
It refers to residues of uronic acids such as D-glucuronic acid, D-galacturonic acid, D-mannuronic acid, L-iduronic acid, and L-guluronic acid, or their methylated products, and has a whitening effect, easy availability, and stability. When R is a D-glucose residue, it is particularly preferable to use hydroquinone β-D-glucoside (generic name: arbutin, hereinafter referred to as arbutin), in which D-glucose is β-bonded to hydroquinone, from the viewpoint of both properties and safety.

The blending amount is 0.1 to 30% by weight, preferably 6 to 20% by weight, based on the total amount of the skin external preparation.

In addition to the above-mentioned essential components, the skin external preparation of the present invention includes:
If necessary, other ingredients commonly used in the pharmaceutical and cosmetic fields, such as edetic acid, sequestering agents such as di-, tri- or tetra-sodium, sodium citrate, sodium metaphosphate, butylated hydroxyanisole (BHA)
, butylated hydroxytoluene (BHT), propyl gallate, acid inhibitors such as dl-α-tocopherol, surfactants, ultraviolet absorbers, fragrances, water, alcohols such as ethanol and isopropanol, thickeners, colorants, powders,
Drugs, organic acids such as citric acid and malic acid, and inorganic acids such as phosphoric acid can be blended. Naturally, these components must be used within a qualitative and quantitative range that does not impair the effects of the present invention.

The dosage form of the skin external preparation of the present invention is arbitrary, and any dosage form may be used, such as a solution type, a solubilized type, an emulsion type, a powder dispersion type, a water-two-layer type, a water-oil-one-powder three-layer type, etc. I do not care.

In addition, the use of the skin external preparation of the present invention is arbitrary, including skin external preparations for facial or body use such as lotions, emulsions, creams, and bags, and external skin preparations for hair such as hair tonics, hair creams, shampoos, and hair rinses. It can also be used.

[Examples] Next, examples and comparative examples will be given to specifically clarify the present invention. The present invention is not limited thereby. The blending amount is in weight%.

Example 1 Lotion A lotion was produced by a conventional method according to the following recipe.

Ethanol 8.02-
Sodium pyrrolidone-5-carboxylate 2.0 Polyoxyethylene (20:el) Oleyl alcohol ether 1.8 Arbutin 0.1 Collagen
0.5 pullulan
0.05 jojoba oil
0.5 caustic potash
0.015E DT A-3N a
O,01 fragrance
0.1 ion exchange water
Residual Amount Example 2 Cream A cream was prepared by a conventional method according to the following recipe.

1.3-Butylene glycol 5.0 Polyethylene glycol 4000C.

Glycerin 2.0 Squalane 20.0 Vaseline
5.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20
Mol) Oleyl Alcohol Ether 1.5 Glyceryl Monostearate 1.5 Arbutin
20.0 elastin
10.0 Sodium lactate
2.0 Xanthan gum (Keltrol brand name) O,OS Methylparaben
0.1 ethylparaben
0.2 caustic potash
0.01E DT A-3N a
O,01 fragrance
0.2 ion exchange water
Remaining amount (hereinafter referred to as margin) Example 3 Emulsion A milky lotion was produced by a conventional method according to the following recipe.

Glycerin 2.0 Squalane 5.0 Vaseline
1.0 Cetostearyl alcohol 0.3 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Glyceryl monooleate 1.5 Arbutin 10.0 Sodium polyacrynoate 0.03 Ethyl paraben 0.2 Gelatin
7.0 caustic potash
0. IE D T A-3N a
O,03 fragrance
0.2 ion exchange water
Remaining Amount Example 4 Bag A bag was manufactured by a conventional method according to the following recipe.

Propylene glycol 2.0 Polyethylene glycol 4000 3.0 Glycerin 15.0 Ethanol
10. 〇Hydroquinone-β
-D-arabinose 15.0 Polyvinyl alcohol 10.0 Olive oil
3.0 lactic acid
1.0 casein
10.0 carboxymethylcellulose
0.07 Methylparaben 0.
1 ethylparaben 0.1 caustic potash 0.02 EDT
A-3Na O,01 fragrance
0.1 ion-exchanged water Remaining amount Example 5 Hair cream A hair cream was produced by a conventional method according to the following formulation.

Beeswax 3.0 Vaseline 15.0 Liquid paraffin 42.0 Polyoxyethylene (5 moles) Stearate 3.0 Polyoxyethylene (6 moles) Oleyl alcohol ether 2.0 Polyoxyethylene (6 moles) Cetylano! Cole ether 1.0 Arbutin 7.0 Elastin 5.0 Purified water
residual fragrance
Appropriate amount of preservative
In view of the effects of the present invention, a proper amount test was conducted. In the usage test, 30 women were tested 3 times each.
Groups were divided into panels. The first group was tested using the lotion of Example 1, the second group was tested using the cream of Example 2, and the third group was tested using the lotion of Example 3. The test was carried out by applying an appropriate amount of cosmetics to the face twice a day, once in the morning and once at night, after washing the face for two weeks.

The evaluation was based on the effectiveness of the following three items. The results are shown in Tables 1 to 3.

(Hereinafter in the margin) Table 1 Table 2 (Hereinafter in the margin) As is clear from the results in Tables 1 to 3, the cosmetics of the present invention made the skin feel moisturized, firmer, and moisturized the next morning. Furthermore, it also had an excellent whitening effect.

Claims (1)

[Scope of Claims] An external preparation for skin, characterized in that it contains one or more selected from the group consisting of proteins and protein decomposition products, and a glycoside of hydroquinone represented by the following general formula. ▲There are mathematical formulas, chemical formulas, tables, etc.▼ [In the formula, R is a pentose residue, a hexose residue, an amino sugar residue,
Indicates uronic acid residues or their methylated products. ]