JPS6119496A - Ｌ−フエニルアラニンの製造法 - Google Patents
Ｌ−フエニルアラニンの製造法Info
- Publication number
- JPS6119496A JPS6119496A JP13938784A JP13938784A JPS6119496A JP S6119496 A JPS6119496 A JP S6119496A JP 13938784 A JP13938784 A JP 13938784A JP 13938784 A JP13938784 A JP 13938784A JP S6119496 A JPS6119496 A JP S6119496A
- Authority
- JP
- Japan
- Prior art keywords
- phenylalanine
- ammonia
- reaction
- producing
- carried out
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 title claims description 28
- 229960005190 phenylalanine Drugs 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 22
- 102000004118 Ammonia-Lyases Human genes 0.000 claims description 11
- 108090000673 Ammonia-Lyases Proteins 0.000 claims description 11
- 229910021529 ammonia Inorganic materials 0.000 claims description 10
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 9
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 8
- 235000013985 cinnamic acid Nutrition 0.000 claims description 8
- 229930016911 cinnamic acid Natural products 0.000 claims description 8
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 8
- 244000005700 microbiome Species 0.000 claims description 7
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims 1
- 241000222290 Cladosporium Species 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000001888 Peptone Substances 0.000 description 3
- 108010080698 Peptones Proteins 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 229940041514 candida albicans extract Drugs 0.000 description 3
- 239000013028 medium composition Substances 0.000 description 3
- 235000019319 peptone Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000012138 yeast extract Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000034303 cell budding Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000001965 potato dextrose agar Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241001149955 Cladosporium cladosporioides Species 0.000 description 1
- 244000046038 Ehretia acuminata Species 0.000 description 1
- 235000009300 Ehretia acuminata Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000223253 Rhodotorula glutinis Species 0.000 description 1
- 241000221523 Rhodotorula toruloides Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000123675 Sporobolomyces roseus Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229940114081 cinnamate Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012533 medium component Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13938784A JPS6119496A (ja) | 1984-07-05 | 1984-07-05 | Ｌ−フエニルアラニンの製造法 |
| DE8585304829T DE3581238D1 (de) | 1984-07-05 | 1985-07-05 | Mikrobiologische herstellung von l-phenylalanin. |
| EP85304829A EP0167411B1 (en) | 1984-07-05 | 1985-07-05 | Microbiological preparation of l-phenylalanine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13938784A JPS6119496A (ja) | 1984-07-05 | 1984-07-05 | Ｌ−フエニルアラニンの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6119496A true JPS6119496A (ja) | 1986-01-28 |
| JPH052315B2 JPH052315B2 (cs) | 1993-01-12 |
Family
ID=15244120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13938784A Granted JPS6119496A (ja) | 1984-07-05 | 1984-07-05 | Ｌ−フエニルアラニンの製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6119496A (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01147970U (cs) * | 1988-03-30 | 1989-10-13 |
-
1984
- 1984-07-05 JP JP13938784A patent/JPS6119496A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01147970U (cs) * | 1988-03-30 | 1989-10-13 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH052315B2 (cs) | 1993-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI111738B (fi) | Rhodococcus rhodochrous-kanta nitriilihydrataasin tuottajana | |
| DE69421425T2 (de) | Verfahren zur Herstellung von Phenylgruppe enthaltende optisch-aktiven Alpha-Hydroxycarbonsäuren | |
| DE69420754T2 (de) | Verfahren zur Herstellung von Phenylgruppe enthaltende optisch-aktiven Alpha-Hydroxycarbonsäuren | |
| DE69519638T2 (de) | Verfahren zur Herstellung von Alpha-Hydroxysäuren oder Alpha-Hydroxyamiden durch Mikroorganismen | |
| JPH0655148B2 (ja) | アミドの生物学的製造法 | |
| JPH0217159B2 (cs) | ||
| DE3875953T2 (de) | Verfahren zur herstellung von organischen chemischen verbindungen. | |
| DE69506430T2 (de) | Enzymatische hydrolyse von den 4-methylthiobutyronitrilen | |
| DE3629242C2 (de) | Verfahren zur Herstellung von L-Aminosäuren | |
| JPS63273486A (ja) | １−（４−メトキシフェニル）−２−アミノプロパンの製法 | |
| EP0502525B1 (de) | Biotechnologisches Verfahren zur Herstellung von S-(+)-2,2-Dimethylcyclopropancarboxamid und R-(-)-2,2-Dimethylcyclopropancarbonsäure | |
| JP2696424B2 (ja) | Ｒ（‐）―マンデル酸の製造法 | |
| DE68926922T2 (de) | Verfahren zur Herstellung von L-alpha-Aminosäuren | |
| JPS6119496A (ja) | Ｌ−フエニルアラニンの製造法 | |
| DE69738080T2 (de) | Biokatalysatoren mit amin-acylase aktivität | |
| DE2502706A1 (de) | Verfahren zur herstellung von 7-amino-cephem-verbindungen | |
| DE2723463C3 (de) | Verfahren zur Herstellung von 7-Aminocephem-Verbindungen | |
| DE3878421T2 (de) | Verfahren zur herstellung von carnitin. | |
| US3320135A (en) | Method of producing l-glutamic acid from hydantoinpropionic acid | |
| JP3081649B2 (ja) | Ｓ−（＋）−マンデルアミドおよびその誘導体の製造法 | |
| DE3689181T2 (de) | Thermostabile Tryptophanase, Verfahren zu deren Herstellung und thermostabile Tryptophanase erzeugender Mikroorganismus. | |
| JPH0638776A (ja) | （Ｓ）−γ−ハロゲン化−β−ハイドロキシ酪酸エステルの製造方法 | |
| DE69325602T2 (de) | Gamma-Polyglutaminsäure-Hydrolase und Verfahren zu ihrer Herstellung | |
| DE2157970C3 (de) | Verfahren zur Herstellung von 6-Aminopenicillansäure durch Spaltung von Penicillin G mittels trägergebundener Penicillinacylase | |
| JPH08258A (ja) | キャンディダ属に属する微生物およびそれを用いたイノシトールの製造方法 |