JPS61103816A - Cream composition - Google Patents

Abstract

PURPOSE:A cream composition that contains, as an active ingredient, an extract from mycelia of SHIITAKE mushrooms, thus showing good recovering effect for roughened skins, rash or dried skin and having the action to inhibit the formation of melanine, lighten the color of deposited melanine and the antibacterial action. CONSTITUTION:A cream composition that contains an extract from SHIITAKE mushroom mycelia. The extract shows actions not only to inhibit the formation of melanine, but also lighten; the color of melanine. The extract is obtained by inoculating mycelia of SHIITAKE mushrooms in a solid culture medium mainly containing bagasse, loosening the medium, mixing the medium with water, when needed, with enzymes such as protease, extracting crushed solid medium and heating it up to 95 deg.C to effect deactivation of enzymes and steriliza tion. The extenders into a power and the power is added together with water or an organic solvent to a cream base.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a cream composition, and more specifically, to a cream composition that provides the skin with nutritional ingredients to promote skin metabolism;
In addition to the cream's original purpose of smoothing and moisturizing the skin surface, it relates to a cream composition that is capable of inhibiting melanin production and lightening already deposited melanin.

Technical Background of the Invention and its Problems The skin consists of the epidermis, dermis, and subcutaneous tissue, and has various functions.As the outer skin of the human body, it has a protective effect that protects the internal organs from the outside world, and a sensory effect. 1. It has functions such as body temperature regulation and substance metabolism. When such skin is exposed to harmful stimuli directly from the outside world, the skin surface becomes rough, resulting in so-called rough skin.
Rash.

Symptoms called sores may appear.

Alternatively, the skin's ability to retain moisture may be reduced, causing the skin to become dry and flaky.

It is widely practiced to apply cream compositions to skin in such rough conditions.

The cream composition is applied to the skin, especially the outermost layer of the stratum corneum, to moisturize the skin and promote blood circulation in the skin.

It is used for skin cleansing. In addition to cosmetic skin creams such as those described above, cream compositions with specific 9X purposes have also been developed. Cream compositions with such special purposes include, for example, ultraviolet protection cream to prevent moderate sunburn on the skin, hair remover to remove hair on the liquid surface, deodorant cream to prevent armpit odor, etc. These include shaping creams that are applied after shaving, and whitening creams that suppress melanin production in the skin or lighten the melanin that has already been deposited. drugs are added to the cream base.

The present invention is more effective against symptoms such as rough skin, rashes, sores, and dry skin, and also suppresses melanin production and reduces the light color of melanin that has already been deposited. As a result of intensive research to develop a cream that can act on the skin, it was found that when a cream composition obtained by incorporating shiitake mushroom mycelium extract into the skin was applied to the skin, the above-mentioned symptoms were significantly and quickly recovered. The present invention was completed based on the discovery that the production of melanin is suppressed and the lightening of already deposited melanin is promoted.

' That is, the cream composition according to the present invention is characterized in that a shiitake mushroom mycelium extract is blended into the cream base as a melanin production inhibiting ingredient and a melanin lightening promoting ingredient.

The cream composition according to the invention has been found to be effective, especially when applied to rough skin after sunburn.

It has also been found that the cream composition according to the present invention has excellent antibacterial activity in addition to the above-mentioned symptom recovery and melanin production inhibiting effects.

The Shiitake mycelium extract blended into the cream composition is prepared by growing Shiitake fungi on a solid medium based on Bacchus.
Various active ingredients are extracted from a solid medium containing shiitake mushroom mycelium.
It is an extract obtained by extraction with water or a mixed solvent of water and an organic solvent such as alcohol. This shiitake mushroom mycelium extract contains large amounts of various amino acids, vitamins, lentinol, and the like.

Furthermore, it has been confirmed that the shiitake mushroom mycelium extract contains an extremely large amount of nutritional components and medicinal components compared to the shiitake mushroom extract. For example, in Shiitake mushroom mycelium, 100g of mycelium contains 2°070 threonine, which is an essential amino acid, while in Shiitake mushroom fruiting body, 0.8g of threonine is contained in 1009 fruiting bodies. Only.

This shiitake mushroom mycelium extract can be obtained by inoculating shiitake fungus into a solid medium based on Bacus, and then growing the mycelium.
Disentangle the solid medium containing the mycelium and add water and, if necessary, cellulase.

After adding an enzyme such as protease or glycosidase, the solid medium is crushed and crushed to extract the active ingredient, and then heated to a temperature of up to 95°C to deactivate the enzyme and sterilize it.

The time to unravel the solid medium containing mycelium is preferably when the mycelium has grown sufficiently in the solid medium and immediately before or immediately after the fruiting body appears.

41: II The thread body extract is added to the cream base, and a wide variety of conventionally known cream bases can be used as the cream base. Cream base is oil type,
Any of the W10 type, 0/W type, and oil-free type may be used. Oil-based ingredients include beeswax, cacao butter, stearic acid, lanolin, olive oil, tsubaya oil, solid paraffin, petrolatum, and liquid paraffin.

Silicone oil, synthetic ester oil, synthetic polyether oil, etc. are used. In addition, as aqueous components, glycerin,
Propylene glycol, sorbitol.

Humectants such as polyethylene glycol, quince seed gum, tragacanth gum, sodium alginate, and sodium carboxymethyl cellulose.

Mucilage substances such as polyvinyl alcohol, alcohols t3 such as ethyl alcohol and isopropanol, and water are used.

In addition, components normally used in cream bases, such as fragrances, preservatives (benzalkonium chloride, etc.), antioxidants, and pigments, can be added to the cream base as needed.

Cream compositions to which the shiitake mycelium extract is added can be used in a wide range of types, such as emollient creams, pine 4T-di creams, cleansing creams, makeup creams, base creams, makeup creams, xance creel creams, and deodorant creams. It can be cream.

In addition, Shiitake mycelium extract has antibacterial properties, so
Cream compositions containing this extract also have strong antibacterial properties.

The cream composition according to the present invention can be produced by a conventional method for producing a cream composition, except that the shiitake mycelium extract is added and contained in the cream base.

When adding the Shiitake mushroom mycelium extract to the cream base, the Shiitake mushroom mycelium extract may be used as a solution as an aqueous phase, or in some cases, a prismatic agent may be added to this extract to form a powder. Shiitake mycelium extract may be added to the cream base together with water or an organic solvent.

The cream composition according to the present invention is extremely safe because the shiitake mycelium extract is safe enough to drink and has little irritation to the skin.

Effects of the Invention Since the cream composition according to the present invention contains the shiitake mycelium extract, the following effects are observed.

(a) A cream composition capable of suppressing melanin production and lightening melanin is provided.

(b) 1q of IM cream composition having antibacterial activity is added.

(C) A cream composition that has a deep recovery effect against rough skin, rashes, dry skin, etc. is 1! ? It will be done.

Hereinafter, the present invention will be explained in detail with reference to Examples, but the present invention is not limited to these Examples.

stable - two A cream composition containing the following components was prepared.

Beeswax 10 parts by weight Liquid paraffin 50 parts by weight Shiitake mycelium extract 35 parts by weight Benzalkonium chloride 0.05 fA 11 parts Pigment, number
This cream composition was applied twice a day, morning and evening, to sunburn spots on human skin (FRCIN) for 4 weeks.

A total of one song was evaluated for the effect of promoting melanin lightening by applying this cream composition. C0LORTECl-17800). At this time, the strength of melanin deposition and the size of melanin deposition were also evaluated.

As a result, it was found that melanin lightening was promoted both subjectively and objectively. Moreover, it was also found by an objective evaluation method using colorimetry that the lightening of melanin was clearly promoted by applying this cream composition.

The following is data based on objective needle 1 city law based on colorimetry.

Skin color is measured on the chest, where there is no pigmentation and almost no sunburn due to ultraviolet rays, and on the shoulders, where pigmentation due to ultraviolet rays is observed, and is expressed as the difference in skin color brightness between the chest and shoulders. A cream composition according to the present invention was applied to the chest and shoulders, and a control cream composition containing ascorbic acid, which has been proven to have an excellent melanin lightening effect, was applied in the same way. A comparison was made between the cases.

The results are not shown in Table 1.

(Margins below) Table 1 Condition of initial second burn on the shoulder area ゛tI゛2゛clothing 4°1・-Δ Mr. Light brown and slightly Control area 6.86゜45.0 Largely scattered Invention area 6 .4 11.4 4.2 Mr. B Slightly brown Control area 11.9 9.9 7.5 Larger shoulders and invention area 9.6 9.5 1 in 8.3 Mr. 0 Slightly brown Control area 7 .7 5,7 6.9 Shoulder area only Present invention area 6.0 5.3 2.9 Small scattered spots From this result, the whitening effect of the cream composition according to the present invention is ascorbic m<vitamin C). -i was found to be almost the same as the cream composition.

Next, the antibacterial activity of the shiitake mycelium extract added to the cream composition according to the present invention will be described. First, they freeze-dried a shiitake mushroom mycelium extract, applied it to various fungi, and compared its antibacterial activity with that of methylparaben, a conventionally known antibacterial agent. The results are shown in Table 2.

(Left below) Table 2 Test Bacterium C, all) icans TFO-1594St, au
reus 209p M, Iysodeikticus ATCC4698P
s, aerugirosa ATCC10145E, c
oli K-120UT84013, typhimur
ium Kl, pneumoniae 0UT80173er,
marcescens Asp, n1ceer IFO4407MIC (%) -Methylparaben Shiitake mycelium extract 0, 2 >3 >0.2 1 >0.2 0.25 >0.2 0.5 0.025 1 0.05 1 0.2 1 0.1 1 0.05 >3 Table 2 shows that the cream composition according to the present invention has excellent antibacterial properties.

J5 Even when the cream composition according to the present invention was applied to the skin every day, no irritation such as rash was observed.

Example 2 A cream composition containing the following components was prepared.

Paraffin 4.0 parts by weight Microcrystalline wax 6.0 parts by weight Beeswax
6.0 parts by weight Vaseline
14.0 parts by weight liquid paraffin
42.5 parts by weight Sorbitan sesquioleic acid
3,7-part polyoxyethylene sorbitan 0.8fflffi
Part monooleic acid ester (20E, O) What [Zt Mycelia Egis 25.0 parts Benzalkonium chloride 0.1 parts Feeding, Pigment suitable
Example 3 A cream composition containing the following ingredients was prepared.

Stearic acid 2.0 parts by weight Stearic alcohol 7.0 parts by weight Reduced lanolin 2.0 parts by weight (2) parts squalane
5.0 parts by weight Octyldodecanol 6.0 parts by weight ffi Bl! Polyoxyethylene cetyl 3.0 suspended part Ether (25E, O) Lipophilic monostearic acid 2.0 parts Glycerin

Claims (1)

[Claims] A cream composition comprising a shiitake mushroom mycelium extract as a melanin production inhibiting component and a melanin lightening promoting component.