JPS6094966A - 医薬組成物、それに使用される１―ヒドロキシピリド―２―オンである化合物及びその塩 - Google Patents

医薬組成物、それに使用される１―ヒドロキシピリド―２―オンである化合物及びその塩

Info

Publication number
JPS6094966A
JPS6094966A JP59201407A JP20140784A JPS6094966A JP S6094966 A JPS6094966 A JP S6094966A JP 59201407 A JP59201407 A JP 59201407A JP 20140784 A JP20140784 A JP 20140784A JP S6094966 A JPS6094966 A JP S6094966A
Authority
JP
Japan
Prior art keywords
aliphatic
substituted
alkoxy
hydroxy
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59201407A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0566385B2 (enExample
Inventor
ロバート・チヤールズ・ハイダー
ジヨージ・コントギオルゲス
ジヤツク・シルバー
マイケル・アーサー・ストツクハム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corporation
Original Assignee
National Research Development Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corporation filed Critical National Research Development Corporation
Publication of JPS6094966A publication Critical patent/JPS6094966A/ja
Publication of JPH0566385B2 publication Critical patent/JPH0566385B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP59201407A 1983-09-23 1984-09-25 医薬組成物、それに使用される１―ヒドロキシピリド―２―オンである化合物及びその塩 Granted JPS6094966A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8325496 1983-09-23
GB838325496A GB8325496D0 (en) 1983-09-23 1983-09-23 Pharmaceutical compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP4248272A Division JPH0811729B2 (ja) 1983-09-23 1992-09-17 １−ヒドロキシピリド−２−オン、又はその塩から成る、患者の体内になる毒性レベルの金属を減少させるのに有効な医薬組成物

Publications (2)

Publication Number Publication Date
JPS6094966A true JPS6094966A (ja) 1985-05-28
JPH0566385B2 JPH0566385B2 (enExample) 1993-09-21

Family

ID=10549201

Family Applications (2)

Application Number Title Priority Date Filing Date
JP59201407A Granted JPS6094966A (ja) 1983-09-23 1984-09-25 医薬組成物、それに使用される１―ヒドロキシピリド―２―オンである化合物及びその塩
JP4248272A Ceased JPH0811729B2 (ja) 1983-09-23 1992-09-17 １−ヒドロキシピリド−２−オン、又はその塩から成る、患者の体内になる毒性レベルの金属を減少させるのに有効な医薬組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP4248272A Ceased JPH0811729B2 (ja) 1983-09-23 1992-09-17 １−ヒドロキシピリド−２−オン、又はその塩から成る、患者の体内になる毒性レベルの金属を減少させるのに有効な医薬組成物

Country Status (11)

Country Link
US (1) US4587240A (enExample)
EP (1) EP0138420B1 (enExample)
JP (2) JPS6094966A (enExample)
CY (1) CY1574A (enExample)
DE (1) DE3480599D1 (enExample)
DK (1) DK161703C (enExample)
GB (2) GB8325496D0 (enExample)
GR (1) GR80444B (enExample)
HK (1) HK7091A (enExample)
SG (1) SG93290G (enExample)
ZA (1) ZA847409B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05246992A (ja) * 1983-09-23 1993-09-24 British Technol Group Ltd １−ヒドロキシピリド−２−オン、又はその塩から成る、患者の体内にある毒性レベルの金属を減少させるのに有効な医薬組成物
JP2014509624A (ja) * 2011-03-29 2014-04-21 ヴィフォール （インターナショナル） アクチェンゲゼルシャフト 鉄欠乏症状および鉄欠乏性貧血の治療および予防のための鉄（ｉｉｉ）錯体化合物
JP2015512436A (ja) * 2012-04-05 2015-04-27 ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ 鉄欠乏症状及び鉄欠乏性貧血の治療及び予防のためのＦｅ（ＩＩＩ）錯体化合物

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308055D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
GB8308054D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
USRE34313E (en) * 1983-09-23 1993-07-13 National Research Development Corporation Pharmaceutical compositions
US4912118A (en) * 1983-09-23 1990-03-27 National Research Development Corporation Pharmaceutical compositions
GB8329043D0 (en) * 1983-10-31 1983-11-30 Hider R C Pharmaceutical compositions
US5177068A (en) * 1984-04-19 1993-01-05 National Research Development Corporation Pharmaceutical compositions
US5010191A (en) * 1985-08-19 1991-04-23 The Regents Of The University Of California Imaging agents for in vivo magnetic resonance and scintigraphic imaging
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
US4908371A (en) * 1987-11-10 1990-03-13 Ciba-Geigy Corporation Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload
GB8910521D0 (en) * 1989-05-08 1989-06-21 Nat Res Dev The stabilization of organic compounds
US5443813A (en) * 1991-06-06 1995-08-22 Associated Universities, Inc. Loading and conjugating cavity biostructures
EP0833627B1 (en) 1995-06-10 2004-08-18 Vitra Pharmaceuticals Ltd. Iron compounds, compositions, methods of making the same and uses thereof
US5667933A (en) * 1996-02-26 1997-09-16 Polaroid Corporation Image-recording element
GB9625638D0 (en) * 1996-12-10 1997-01-29 Cenes Ltd Therapeutic antioxidants for alzheimer's diease
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP2298311B1 (en) 1999-01-13 2012-05-09 Bayer HealthCare LLC w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
CA2421410C (en) * 2000-09-19 2009-11-10 Vitra Pharmaceuticals Limited Iron compositions
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
GB0211500D0 (en) * 2002-05-18 2002-06-26 Vitra Pharmaceuticals Ltd Method of forming iron hydroxypyrone compounds
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
US7595073B2 (en) * 2003-02-28 2009-09-29 Kraft Foods Global Brands Llc Use of siderophores and organic acids to retard lipid oxidation
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
PL1663978T3 (pl) 2003-07-23 2008-04-30 Bayer Healthcare Llc Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów
WO2008116301A1 (en) 2007-03-28 2008-10-02 Apotex Technologies Inc. Fluorinated derivatives of deferiprone
BRPI0822206B8 (pt) 2008-04-25 2021-05-25 Apotex Tech Inc formulação líquida para deferiprona com um sabor agradável.
CN102712591B (zh) 2009-07-03 2014-06-25 阿普泰克斯科技公司 3-羟基吡啶-4-酮的氟化衍生物
AU2011231710B2 (en) 2010-03-23 2013-07-25 Vifor (International) Ag Fe(III) complex compounds for the treatment and prophylaxis of iron deficiency symptoms and iron deficiency anemias
AR086606A1 (es) 2011-05-31 2014-01-08 Vifor Int Ag Compuestos del complejo de fe(iii) para el tratamiento y profilaxis de los sintomas de la deficiencia de hierro y las anemias por deficiencia de hierro
RU2641030C2 (ru) 2012-12-21 2018-01-15 Вифор (Интернациональ) Аг Комплексные соединения трехвалентного железа для лечения и профилактики симптомов дефицита железа и железодефицитных анемий

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2748142A (en) * 1956-05-29 - process of production
GB778871A (en) * 1955-02-14 1957-07-10 Sadolin & Holmblad As Pyridinediol oxides and acetates thereof and their preparation
GB791719A (en) * 1955-02-15 1958-03-12 Sadolin & Holmblad As Improvements in or relating to the production of cyclic hydroxamic acids of the pyridine series
GB790584A (en) * 1955-02-15 1958-02-12 Sadolin & Holmblad As Improvements in or relating to the production of cyclic hydroxamic acids of the pyridine series
FR3691M (fr) * 1963-05-06 1965-11-15 Olin Mathieson Nouvelle composition pharmaceutique utile en tant que fongicide.
US3968118A (en) * 1968-08-31 1976-07-06 Hoechst Aktiengesellschaft Process for the manufacture of 1-hydroxy-2-pyridones
NL156397B (nl) * 1968-08-31 1978-04-17 Hoechst Ag Werkwijze voor het bereiden van preparaten tegen schimmelaandoeningen, gevormde preparaten, alsmede werkwijze voor het bereiden van daarvoor geschikte actieve stoffen.
US3705943A (en) * 1969-07-18 1972-12-12 Olin Corp Dialkyltin salts of substituted pyridine-1-oxides as fungicides and bactericides
EG10850A (en) * 1972-03-25 1976-06-30 Hoechst Ag Process for the preparation of 1-hydroxy-pyridones
DE2705562A1 (de) * 1977-02-10 1978-08-17 Basf Ag Verfahren zur herstellung von pyridonen
US4358455A (en) * 1980-12-23 1982-11-09 Merck & Co., Inc. Aralkylamindethanol heterocyclic compounds
JPS5832812A (ja) * 1981-08-21 1983-02-25 Lion Corp 毛髪化粧料
GB2117766B (en) * 1982-03-24 1985-08-29 Nat Res Dev Pharmaceutical compositions
GB2118176B (en) * 1982-03-24 1985-12-04 Nat Res Dev Pharmaceutical compositions
DE3278014D1 (en) * 1982-10-01 1988-02-25 Merck & Co Inc Aralkylaminoethanol heterocyclic compounds
GB8325496D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
US4698431A (en) * 1985-11-12 1987-10-06 The United States Of America As Represented By The United States Department Of Energy Hydroxypyridonate chelating agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05246992A (ja) * 1983-09-23 1993-09-24 British Technol Group Ltd １−ヒドロキシピリド−２−オン、又はその塩から成る、患者の体内にある毒性レベルの金属を減少させるのに有効な医薬組成物
JP2014509624A (ja) * 2011-03-29 2014-04-21 ヴィフォール （インターナショナル） アクチェンゲゼルシャフト 鉄欠乏症状および鉄欠乏性貧血の治療および予防のための鉄（ｉｉｉ）錯体化合物
JP2015512436A (ja) * 2012-04-05 2015-04-27 ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ 鉄欠乏症状及び鉄欠乏性貧血の治療及び予防のためのＦｅ（ＩＩＩ）錯体化合物

Also Published As

Publication number Publication date
DK453584D0 (da) 1984-09-21
DK161703C (da) 1992-01-20
GB8325496D0 (en) 1983-10-26
SG93290G (en) 1991-01-18
ZA847409B (en) 1986-05-28
CY1574A (en) 1991-12-20
EP0138420A2 (en) 1985-04-24
JPH0566385B2 (enExample) 1993-09-21
DK161703B (da) 1991-08-05
HK7091A (en) 1991-02-01
GB2146990B (en) 1987-05-20
DE3480599D1 (de) 1990-01-04
US4587240A (en) 1986-05-06
EP0138420A3 (en) 1987-05-20
GR80444B (en) 1985-01-23
JPH0811729B2 (ja) 1996-02-07
JPH05246992A (ja) 1993-09-24
DK453584A (da) 1985-03-24
EP0138420B1 (en) 1989-11-29
GB2146990A (en) 1985-05-01
GB8423800D0 (en) 1984-10-24

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