JPS609311B2 - 粒子識別装置 - Google Patents
粒子識別装置Info
- Publication number
- JPS609311B2 JPS609311B2 JP51119904A JP11990476A JPS609311B2 JP S609311 B2 JPS609311 B2 JP S609311B2 JP 51119904 A JP51119904 A JP 51119904A JP 11990476 A JP11990476 A JP 11990476A JP S609311 B2 JPS609311 B2 JP S609311B2
- Authority
- JP
- Japan
- Prior art keywords
- particle
- substrate
- particles
- signal
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002245 particle Substances 0.000 title claims description 150
- 239000000758 substrate Substances 0.000 claims description 54
- 230000004044 response Effects 0.000 claims description 20
- 230000015654 memory Effects 0.000 claims description 19
- 239000000725 suspension Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 11
- 238000005259 measurement Methods 0.000 description 6
- 239000004020 conductor Substances 0.000 description 4
- 230000003111 delayed effect Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000002596 correlated effect Effects 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000003909 pattern recognition Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 238000000151 deposition Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
- G01N15/1492—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties within droplets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1028—Sorting particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1481—Optical analysis of particles within droplets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Image Analysis (AREA)
- Image Processing (AREA)
- Particle Formation And Scattering Control In Inkjet Printers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/620,658 US4009435A (en) | 1973-10-19 | 1975-10-08 | Apparatus for preservation and identification of particles analyzed by flow-through apparatus |
| US620658 | 1975-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5247353A JPS5247353A (en) | 1977-04-15 |
| JPS609311B2 true JPS609311B2 (ja) | 1985-03-09 |
Family
ID=24486820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51119904A Expired JPS609311B2 (ja) | 1975-10-08 | 1976-10-07 | 粒子識別装置 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS609311B2 (fr) |
| DE (1) | DE2645324A1 (fr) |
| FR (1) | FR2328960A1 (fr) |
| GB (1) | GB1555091A (fr) |
| SE (1) | SE434436B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997029354A1 (fr) * | 1996-02-05 | 1997-08-14 | Bayer Aktiengesellschaft | Procede et dispositif pour trier et recuperer des objets biologiques deposes sur un support plat, tels que des cellules biologiques ou des organites cellulaires, des coupes histologiques, des particules de chromosomes etc., au moyen de faisceaux laser |
| DE19603996C2 (de) * | 1996-02-05 | 2002-08-29 | P A L M Gmbh Mikrolaser Techno | Sortierverfahren für planar ausgebrachte biologische Objekte mit Laserstrahlen |
| DE10304653B4 (de) * | 2003-02-05 | 2005-01-27 | Evotec Technologies Gmbh | Mehrparametrige Detektion in einem fluidischen Mikrosystem |
| DK2577254T3 (en) | 2010-06-10 | 2015-06-01 | Albert Ludwigs Universität Freiburg | An apparatus and method for delivering cells or particles that are encased in a freely suspended droplet |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE793185A (fr) * | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
| US3924947A (en) * | 1973-10-19 | 1975-12-09 | Coulter Electronics | Apparatus for preservation and identification of particles analyzed by flow-through apparatus |
-
1976
- 1976-10-06 FR FR7630102A patent/FR2328960A1/fr active Granted
- 1976-10-07 SE SE7611159A patent/SE434436B/xx unknown
- 1976-10-07 JP JP51119904A patent/JPS609311B2/ja not_active Expired
- 1976-10-07 DE DE19762645324 patent/DE2645324A1/de active Granted
- 1976-10-07 GB GB41801/76A patent/GB1555091A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2328960A1 (fr) | 1977-05-20 |
| JPS5247353A (en) | 1977-04-15 |
| SE7611159L (sv) | 1977-04-09 |
| FR2328960B1 (fr) | 1982-04-16 |
| SE434436B (sv) | 1984-07-23 |
| DE2645324A1 (de) | 1977-04-21 |
| GB1555091A (en) | 1979-11-07 |
| DE2645324C2 (fr) | 1987-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4009435A (en) | Apparatus for preservation and identification of particles analyzed by flow-through apparatus | |
| US11204309B2 (en) | Image processing device, fine particle sorting device, and image processing method | |
| US3963606A (en) | Semi-automatic adjusting delay for an electronic particle separator | |
| JPS5833587B2 (ja) | リユウシノトクセイジヨウホウオウルホウホウ オヨビ ソウチ | |
| US4317520A (en) | Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus | |
| US5483469A (en) | Multiple sort flow cytometer | |
| CN104487820B (zh) | 流式细胞计数的自动化且准确液滴延迟 | |
| JP6991129B2 (ja) | 試験システム及び試験方法 | |
| US3609043A (en) | Spray droplet analyzer | |
| JPS609311B2 (ja) | 粒子識別装置 | |
| JP2004361234A (ja) | 液滴吐出評価試験装置 | |
| JPS61159135A (ja) | 粒子解析装置 | |
| JP2001091416A (ja) | におい・ガス流可視化装置およびにおい・ガス流計測装置 | |
| Mar et al. | Improved search for elementary particles with fractional electric charge | |
| US4434647A (en) | Dynamic spot calibration for automatic particle counters | |
| JPH06288896A (ja) | セルソータ | |
| CN108885211A (zh) | 细胞收纳芯片和使用该细胞收纳芯片的筛选方法 | |
| JP2003028696A (ja) | 液滴量測定方法、液滴量測定装置及びそれを備えたインクジェットプリンタの製造システム | |
| JP2749906B2 (ja) | 粒子測定装置 | |
| JPH04337460A (ja) | 尿中の細胞分析装置および方法。 | |
| JPH085543A (ja) | 粒子分析用染色液のモニタ方法及び粒子分析用校正方法 | |
| US6439068B2 (en) | Process and device for determining the volume of liquid droplets | |
| Macdonald et al. | A photographic technique for investigating the splashing of water drops on leaves | |
| CN108152176A (zh) | 一种雾滴传感器标定装置及其标定方法 | |
| JPH0229184B2 (fr) |