JPS6091998A - 体液及び尿中のｄ―３―ヒドロキシ酪酸の測定法並びにそのための測定試薬 - Google Patents
体液及び尿中のｄ―３―ヒドロキシ酪酸の測定法並びにそのための測定試薬Info
- Publication number
- JPS6091998A JPS6091998A JP19992883A JP19992883A JPS6091998A JP S6091998 A JPS6091998 A JP S6091998A JP 19992883 A JP19992883 A JP 19992883A JP 19992883 A JP19992883 A JP 19992883A JP S6091998 A JPS6091998 A JP S6091998A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- urine
- measuring
- measurement
- hydroxybutyric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 238000005259 measurement Methods 0.000 title claims abstract description 34
- WOWBFOBYOAGEEA-UHFFFAOYSA-N diafenthiuron Chemical compound CC(C)C1=C(NC(=S)NC(C)(C)C)C(C(C)C)=CC(OC=2C=CC=CC=2)=C1 WOWBFOBYOAGEEA-UHFFFAOYSA-N 0.000 title claims abstract description 32
- WHBMMWSBFZVSSR-UHFFFAOYSA-N R3HBA Natural products CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 title claims abstract description 31
- WHBMMWSBFZVSSR-GSVOUGTGSA-N (R)-3-hydroxybutyric acid Chemical compound C[C@@H](O)CC(O)=O WHBMMWSBFZVSSR-GSVOUGTGSA-N 0.000 title claims abstract description 27
- 210000002700 urine Anatomy 0.000 title claims description 22
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 21
- 230000002255 enzymatic effect Effects 0.000 title 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims abstract description 26
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 claims abstract description 14
- 239000003112 inhibitor Substances 0.000 claims abstract description 6
- 101710088194 Dehydrogenase Proteins 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 31
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 18
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 18
- 210000001124 body fluid Anatomy 0.000 claims description 15
- 239000010839 body fluid Substances 0.000 claims description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 14
- 229960004275 glycolic acid Drugs 0.000 claims description 14
- 102000034279 3-hydroxybutyrate dehydrogenases Human genes 0.000 claims description 12
- 108090000124 3-hydroxybutyrate dehydrogenases Proteins 0.000 claims description 12
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 11
- 229950006238 nadide Drugs 0.000 claims description 11
- 238000000502 dialysis Methods 0.000 claims description 7
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims description 4
- 230000003544 deproteinization Effects 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 229930024421 Adenine Natural products 0.000 claims 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 3
- 229960000643 adenine Drugs 0.000 claims 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 230000002087 whitening effect Effects 0.000 claims 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract description 21
- 238000006243 chemical reaction Methods 0.000 abstract description 9
- 150000001495 arsenic compounds Chemical class 0.000 abstract description 2
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 abstract description 2
- IFUOBZFWJGMTBT-UHFFFAOYSA-M (2-carboxyphenoxy)mercury Chemical compound [Hg+].OC(=O)C1=CC=CC=C1[O-] IFUOBZFWJGMTBT-UHFFFAOYSA-M 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 description 23
- 239000000243 solution Substances 0.000 description 22
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 20
- 210000002966 serum Anatomy 0.000 description 13
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 12
- 239000012085 test solution Substances 0.000 description 12
- 229940107700 pyruvic acid Drugs 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 239000005515 coenzyme Substances 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000012086 standard solution Substances 0.000 description 7
- 102000009027 Albumins Human genes 0.000 description 6
- 108010088751 Albumins Proteins 0.000 description 6
- 239000004310 lactic acid Substances 0.000 description 6
- 235000014655 lactic acid Nutrition 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 5
- WHBMMWSBFZVSSR-GSVOUGTGSA-M (R)-3-hydroxybutyrate Chemical compound C[C@@H](O)CC([O-])=O WHBMMWSBFZVSSR-GSVOUGTGSA-M 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 239000012954 diazonium Substances 0.000 description 4
- 150000001989 diazonium salts Chemical class 0.000 description 4
- 238000000691 measurement method Methods 0.000 description 4
- FUSNOPLQVRUIIM-UHFFFAOYSA-N 4-amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)-n-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide Chemical compound O=C1NC(C)(C)CN1C(N=C1N)=NC=C1C(=O)NC1=CC=CC(C(F)(F)F)=C1 FUSNOPLQVRUIIM-UHFFFAOYSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000006911 enzymatic reaction Methods 0.000 description 3
- 239000012493 hydrazine sulfate Substances 0.000 description 3
- 229910000377 hydrazine sulfate Inorganic materials 0.000 description 3
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- -1 azo compound Chemical class 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- MVEOHWRUBFWKJY-UHFFFAOYSA-N 7-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=CC(S(O)(=O)=O)=CC2=CC(O)=CC=C21 MVEOHWRUBFWKJY-UHFFFAOYSA-N 0.000 description 1
- 101150111329 ACE-1 gene Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 108091006149 Electron carriers Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010023379 Ketoacidosis Diseases 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 241000208204 Linum Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000190984 Rhodospirillum rubrum Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229940093920 gynecological arsenic compound Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- NBPUSGBJDWCHKC-UHFFFAOYSA-M sodium 3-hydroxybutyrate Chemical compound [Na+].CC(O)CC([O-])=O NBPUSGBJDWCHKC-UHFFFAOYSA-M 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19992883A JPS6091998A (ja) | 1983-10-27 | 1983-10-27 | 体液及び尿中のｄ―３―ヒドロキシ酪酸の測定法並びにそのための測定試薬 |
| EP19840306671 EP0140589B1 (en) | 1983-10-27 | 1984-09-28 | Enzymatic determination of d-3-hydroxybutyric acid or acetoacetic acid, and reagents therefor |
| DE8484306671T DE3471496D1 (en) | 1983-10-27 | 1984-09-28 | Enzymatic determination of d-3-hydroxybutyric acid or acetoacetic acid, and reagents therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19992883A JPS6091998A (ja) | 1983-10-27 | 1983-10-27 | 体液及び尿中のｄ―３―ヒドロキシ酪酸の測定法並びにそのための測定試薬 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8456591A Division JPH0673480B2 (ja) | 1991-03-26 | 1991-03-26 | 体液及び尿中のアセト酢酸の測定法並びにそのための測定試薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6091998A true JPS6091998A (ja) | 1985-05-23 |
| JPH0353920B2 JPH0353920B2 (enExample) | 1991-08-16 |
Family
ID=16415923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19992883A Granted JPS6091998A (ja) | 1983-10-27 | 1983-10-27 | 体液及び尿中のｄ―３―ヒドロキシ酪酸の測定法並びにそのための測定試薬 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0140589B1 (enExample) |
| JP (1) | JPS6091998A (enExample) |
| DE (1) | DE3471496D1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6352897A (ja) * | 1986-04-01 | 1988-03-07 | Konica Corp | 分析素子 |
| JPH01117799A (ja) * | 1987-10-30 | 1989-05-10 | Sekisui Chem Co Ltd | 生体成分測定用試験紙 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0698029B2 (ja) * | 1985-12-10 | 1994-12-07 | 株式会社三和化学研究所 | 獣乳の品質検査と乳獣の健康診断とを同時に行う方法 |
| US4937047A (en) * | 1986-04-01 | 1990-06-26 | Konishiroku Photo Industry Co., Ltd. | Analytical element |
| FR2596865B1 (fr) * | 1986-04-04 | 1989-09-01 | Elf Aquitaine | Nouveau procede et dispositif pour le dosage de la carnitine |
| US5190863A (en) * | 1990-06-29 | 1993-03-02 | Miles Inc. | Composition for determining the presence or concentration of D-β-hydroxybutyrate |
| US5690944A (en) * | 1994-12-20 | 1997-11-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic compositions containing lactate dehydrogenase inhibitors |
| ES2189888T3 (es) * | 1995-11-02 | 2003-07-16 | Dade Behring Marburg Gmbh | Metodos para eliminar interferencias debidas a deshidrogenasas endogenas en ensayos enzimaticos. |
| US5861269A (en) * | 1996-11-01 | 1999-01-19 | Dade Behring Marburg Gmbh | Methods for removing interferences due to endogenous dehydrogenases in enzyme assays |
| EP2253711B1 (en) * | 2009-04-28 | 2014-01-01 | Bühlmann Laboratories AG | Methods, compositions and a kit suitable for determining the concentration of gamma-hydroxy butyric acid (GHB) in a sample |
| US20210003564A1 (en) * | 2017-03-06 | 2021-01-07 | Medtronic Minimed, Inc. | Ketone body sensing device and method |
| CN116018084A (zh) * | 2020-09-18 | 2023-04-25 | 美敦力迷你迈德公司 | 酮体感测装置和方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2518862A1 (de) * | 1974-04-29 | 1975-11-13 | Abbott Lab | Enzymatisches analyseverfahren und reagens zur durchfuehrung desselben |
| JPS5535232A (en) * | 1978-09-05 | 1980-03-12 | Yukio Shigeta | High-sensitivity simple fractional colorimetry method for ketone body in blood |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4242446A (en) * | 1978-07-26 | 1980-12-30 | Coulter Electronics, Inc. | Method for determining a substance in a biological fluid and reagent combination for use in the method |
-
1983
- 1983-10-27 JP JP19992883A patent/JPS6091998A/ja active Granted
-
1984
- 1984-09-28 EP EP19840306671 patent/EP0140589B1/en not_active Expired
- 1984-09-28 DE DE8484306671T patent/DE3471496D1/de not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2518862A1 (de) * | 1974-04-29 | 1975-11-13 | Abbott Lab | Enzymatisches analyseverfahren und reagens zur durchfuehrung desselben |
| JPS5535232A (en) * | 1978-09-05 | 1980-03-12 | Yukio Shigeta | High-sensitivity simple fractional colorimetry method for ketone body in blood |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6352897A (ja) * | 1986-04-01 | 1988-03-07 | Konica Corp | 分析素子 |
| JPH01117799A (ja) * | 1987-10-30 | 1989-05-10 | Sekisui Chem Co Ltd | 生体成分測定用試験紙 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3471496D1 (en) | 1988-06-30 |
| EP0140589A1 (en) | 1985-05-08 |
| EP0140589B1 (en) | 1988-05-25 |
| JPH0353920B2 (enExample) | 1991-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |