JPS6058555A - 血液凝固測定方法および測定装置 - Google Patents
血液凝固測定方法および測定装置Info
- Publication number
- JPS6058555A JPS6058555A JP16735183A JP16735183A JPS6058555A JP S6058555 A JPS6058555 A JP S6058555A JP 16735183 A JP16735183 A JP 16735183A JP 16735183 A JP16735183 A JP 16735183A JP S6058555 A JPS6058555 A JP S6058555A
- Authority
- JP
- Japan
- Prior art keywords
- signal
- time
- light
- reagent
- digital signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000023555 blood coagulation Effects 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims abstract description 15
- 108010049003 Fibrinogen Proteins 0.000 claims abstract description 25
- 102000008946 Fibrinogen Human genes 0.000 claims abstract description 25
- 229940012952 fibrinogen Drugs 0.000 claims abstract description 25
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 23
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 claims abstract description 15
- 108010000499 Thromboplastin Proteins 0.000 claims abstract description 15
- 102000002262 Thromboplastin Human genes 0.000 claims abstract description 15
- 108010094028 Prothrombin Proteins 0.000 claims abstract description 11
- 102100027378 Prothrombin Human genes 0.000 claims abstract description 11
- 229940039716 prothrombin Drugs 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 230000015271 coagulation Effects 0.000 claims description 12
- 238000005345 coagulation Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 6
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 238000005259 measurement Methods 0.000 abstract description 17
- 239000000203 mixture Substances 0.000 abstract description 3
- 210000002966 serum Anatomy 0.000 abstract 3
- 230000001112 coagulating effect Effects 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 8
- 229960004072 thrombin Drugs 0.000 description 4
- 108090000190 Thrombin Proteins 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000190020 Zelkova serrata Species 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16735183A JPS6058555A (ja) | 1983-09-09 | 1983-09-09 | 血液凝固測定方法および測定装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16735183A JPS6058555A (ja) | 1983-09-09 | 1983-09-09 | 血液凝固測定方法および測定装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6058555A true JPS6058555A (ja) | 1985-04-04 |
| JPH043505B2 JPH043505B2 (enrdf_load_stackoverflow) | 1992-01-23 |
Family
ID=15848113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16735183A Granted JPS6058555A (ja) | 1983-09-09 | 1983-09-09 | 血液凝固測定方法および測定装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6058555A (enrdf_load_stackoverflow) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63305255A (ja) * | 1987-06-05 | 1988-12-13 | Kyoto Daiichi Kagaku:Kk | 血液凝固能測定方法 |
| EP0699909A2 (en) | 1994-09-02 | 1996-03-06 | Nippon Shoji Kaisha, Ltd. | Method for determining fibrinogen and reagent for determination thereof |
| JP2009126340A (ja) * | 2007-11-22 | 2009-06-11 | Aisin Seiki Co Ltd | 車両用ステップ装置 |
| WO2009122993A1 (ja) | 2008-03-31 | 2009-10-08 | シスメックス株式会社 | 血液凝固分析装置、血液凝固分析方法、及びコンピュータプログラム |
| JP2009244029A (ja) * | 2008-03-31 | 2009-10-22 | Sysmex Corp | 血液凝固分析装置、血液凝固分析方法、及びコンピュータプログラム |
| JP2009244027A (ja) * | 2008-03-31 | 2009-10-22 | Sysmex Corp | 血液凝固分析装置、血液凝固分析方法、及び、コンピュータプログラム |
| US7934737B2 (en) | 2006-11-07 | 2011-05-03 | Aisin Seiki Kabushiki Kaisha | Step device for vehicle |
| JP2020051824A (ja) * | 2018-09-26 | 2020-04-02 | キヤノンメディカルシステムズ株式会社 | 血液凝固分析装置 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5467496A (en) * | 1977-11-09 | 1979-05-30 | Itoman Kk | Device for measuring solidification of blood plasma |
| JPS5469497A (en) * | 1977-11-12 | 1979-06-04 | Kyoto Daiichi Kagaku Kk | Method and device for measuring blood solidification time |
| JPS56129843A (en) * | 1980-02-16 | 1981-10-12 | Compur Electronic Gmbh | Photometric method of and apparatus for measuring progress of reaction |
| JPS56140240A (en) * | 1980-04-04 | 1981-11-02 | Hitachi Ltd | Photometer for blood coagulation measurement |
| JPS5730954A (en) * | 1980-08-01 | 1982-02-19 | Hitachi Ltd | Measuring device for blood coagulation |
-
1983
- 1983-09-09 JP JP16735183A patent/JPS6058555A/ja active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5467496A (en) * | 1977-11-09 | 1979-05-30 | Itoman Kk | Device for measuring solidification of blood plasma |
| JPS5469497A (en) * | 1977-11-12 | 1979-06-04 | Kyoto Daiichi Kagaku Kk | Method and device for measuring blood solidification time |
| JPS56129843A (en) * | 1980-02-16 | 1981-10-12 | Compur Electronic Gmbh | Photometric method of and apparatus for measuring progress of reaction |
| JPS56140240A (en) * | 1980-04-04 | 1981-11-02 | Hitachi Ltd | Photometer for blood coagulation measurement |
| JPS5730954A (en) * | 1980-08-01 | 1982-02-19 | Hitachi Ltd | Measuring device for blood coagulation |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63305255A (ja) * | 1987-06-05 | 1988-12-13 | Kyoto Daiichi Kagaku:Kk | 血液凝固能測定方法 |
| EP0699909A2 (en) | 1994-09-02 | 1996-03-06 | Nippon Shoji Kaisha, Ltd. | Method for determining fibrinogen and reagent for determination thereof |
| US5851836A (en) * | 1994-09-02 | 1998-12-22 | Nippon Shoji Kaisha Ltd. | Method for determining fibrinogen and reagent for determination thereof |
| US7934737B2 (en) | 2006-11-07 | 2011-05-03 | Aisin Seiki Kabushiki Kaisha | Step device for vehicle |
| JP2009126340A (ja) * | 2007-11-22 | 2009-06-11 | Aisin Seiki Co Ltd | 車両用ステップ装置 |
| WO2009122993A1 (ja) | 2008-03-31 | 2009-10-08 | シスメックス株式会社 | 血液凝固分析装置、血液凝固分析方法、及びコンピュータプログラム |
| JP2009244029A (ja) * | 2008-03-31 | 2009-10-22 | Sysmex Corp | 血液凝固分析装置、血液凝固分析方法、及びコンピュータプログラム |
| JP2009244027A (ja) * | 2008-03-31 | 2009-10-22 | Sysmex Corp | 血液凝固分析装置、血液凝固分析方法、及び、コンピュータプログラム |
| CN101983338A (zh) * | 2008-03-31 | 2011-03-02 | 希森美康株式会社 | 凝血分析仪、凝血分析方法及计算机程序 |
| US8936753B2 (en) | 2008-03-31 | 2015-01-20 | Sysmex Corporation | Blood coagulation analyzer, blood coagulation analysis method, and computer program product |
| EP3432002A1 (en) | 2008-03-31 | 2019-01-23 | Sysmex Corporation | Blood coagulation analyzer, blood coagulation analysis method, and computer program |
| JP2020051824A (ja) * | 2018-09-26 | 2020-04-02 | キヤノンメディカルシステムズ株式会社 | 血液凝固分析装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH043505B2 (enrdf_load_stackoverflow) | 1992-01-23 |
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