JPS60149514A - Hair-tonic and hair-restorer - Google Patents

Abstract

PURPOSE:To provide a hair-tonic and hair-restorer agent composed of a hair- matrix cell activating agent in combination with carbon dioxide gas, exhibiting excellent hair-growing and hair-restoration activity and antidepilation effect, and capable of transporting the activating agent efficiently to the hair-matrix by the vasodilating activity of the carbon dioxide gas, and activating the function of the hair-matrix cell. CONSTITUTION:A hair-tonic and hair-restoration agent containing preferably 0.001-5wt% agent to activate the hair-matrix cell is incorporated preferably 60ppm of carbon dioxide gas, and sealed in a pressure vessel to obtain the objective hair-tonic and hair-restoration agent having a pH of preferably <=7, especially 4.5-6.5. In addition to the above effect, the combined use of carbon dioxide gas enables the decrease in the amount of the above activating agent having strong stimulation, and accordingly the continuous application of the agent to promote the above effect. Pleasant stimulation and massaging effect can be applied to the scalp by the foaming effect of the carbon dioxide gas, and the weakly acidic pH of the agent gives desirable effect to the skin.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hair nourishing and restoring agent, and more specifically to a hair nourishing and restoring agent containing a hair matrix cell activator and carbon dioxide gas.

Conventionally, synthetic or natural extracts that have hair matrix cell activating properties have been applied to hair nourishing and restoring products, but adding a small amount does not produce a significant effect, and adding a large amount Although it has some effect on the thighs, it gives an unpleasant irritating feeling to the application site, and furthermore, it has the disadvantage of causing skin J11 inflammation when used continuously.

On the other hand, it is known to counteract the vasodilating effect of carbon dioxide gas, and it is also used clinically as a carbon dioxide gas bath for rehabilitation.

Therefore, the inventor of the present invention has conducted various studies with the aim of incorporating carbon dioxide gas into hair growth and hair growth products, and has found that the combination of a hair matrix cell activator and carbon dioxide gas in hair growth and growth products is effective for the scalp. The present invention was completed based on the discovery that the capillaries of the hair expand, the hair matrix cell activator efficiently reaches the hair matrix, activates the function of the hair matrix cells, reduces hair loss, and promotes hair growth. .

That is, the present invention provides a hair nourishing/hair growing agent containing a hair matrix cell activator, mixed with carbon dioxide gas, and sealed in a pressure-resistant container.

The hair matrix cell activator used in the present invention includes synthetic or natural ingredients such as vitaminic acid 1. Q tothenic acid and its derivatives, non-9totenyl alcohol and its derivatives, t-as, Q lagging acid and its derivatives, photosensitive element 301
Among them, vitaminumic acid, potassium nonantothenate, nonantothenic acid, nonantotenyl alcohol, and silacenta extract are particularly preferred.

This hair matrix cell activator is used by blending it with a solvent such as water or water-lower alcohol. The hair matrix cell activator is preferably blended in the hair nourishing and restoring agent of the present invention in an amount of 0.001 to 5% by weight (hereinafter simply expressed as %).

o, o o A light effect can be obtained below 196,
Moreover, if it is added in an amount of 5% or more, it gives an unpleasant irritation to the scalp, which is not preferable.

By the way, carbon dioxide gas depends on the pH of the bath liquid in which it is dissolved.
It is known that when CO is hostile, CO exists as a molecule and exhibits a vasodilatory effect.

Therefore, it is preferable to adjust the liquid properties of the hair nourishing/growth preparation of the present invention to a pH of 7 or lower, particularly to a pH of 4.5 to 6.5. In addition,
The pH of the hair nourishing/hair growing agent will become even more acidic when carbon dioxide gas is pressurized and dissolved into the hair nourishing/hair growing agent, but it is best to adjust the final pH to within the above range. This pH
As the IJm agent, for example, citric acid, tartaric acid, lactic acid, or a salt thereof, or phosphoric acid or a salt thereof are preferably used. To incorporate carbon dioxide gas into a hair growth product, put the hair growth product into a pressure-resistant container and fill it with pressurized gas. A method of putting the soaked hair nourishment/hair growth agent into the container, adding a pH adjusting agent to it to generate carbon dioxide gas, and immediately sealing it.
Alternatively, a method of placing a dry ice pellet in a container and sealing the container may be adopted, but a method of sealing in high pressure gas is particularly preferred.

When this is done, part of the carbon dioxide gas is dissolved and incorporated into the hair nourishing/growth agent, and part of the carbon dioxide gas remains in the container as a gas. In the present invention, carbon dioxide gas is dissolved and blended into the hair nourishing/hair growth agent, and it is preferable that the concentration of carbon dioxide gas is 60 ppm or more.
If the amount is less than this, a significant vasodilatory effect cannot be expected, and the effects of the present invention cannot be obtained. To adjust the amount of carbon dioxide gas,
This can be done by injecting carbon dioxide gas (pressure injection).
Generally 1.2 to 8Lf at a pressure of 35 degrees Celsius
/cm" (Gouzo pressure).

In addition, the pressure-resistant container used in the present invention must be able to withstand the above pressure and keep the hair growth agent in a sealed state until it is used after being pierced. For example, it is made of aluminum, tin, etc. etc. metal containers.

A synthetic side container made of acetal fiber resin, polycarbonate-based ballast cape, and a glass container are used.

On the other hand, if the diameter of the discharge nozzle is small, the filling liquid is sprayed in the form of a mist, and if the diameter is large, the filling liquid is sprayed in the form of foam or liquid.

The spray form may also vary depending on the internal pressure of the can, or generally the diameter of the discharge nozzle of an aerosol spray container is 0.3 mm or less, and when this is applied to the hair nourishing/growth agent of the present invention,
It is sprayed in a mist and the carbon dioxide gas immediately scatters, making it impossible to obtain a sufficient effect. In order to enhance the effects of the present invention, it is necessary to lengthen the residence time of the order gas in the hair nourishing/hair growing agent, and to avoid crushing the hair nourishing/hair growing agent of the present invention onto the hair. It is preferable to apply the foam or liquid directly to the scalp and foam it on the scalp. For this reason, the diameter of the discharge nozzle is set to 0.
Preferably, the length is 3 to 1.5 mm and the length is 1 to 153 mm. Furthermore, in order to prevent the amount of dissolved carbon dioxide gas from decreasing due to a decrease in the internal pressure of the can during use, and to maintain a constant injection condition, a mini-filler for carbon dioxide gas is built into the container, and the pressure during use is kept constant. It is preferable to combine this with an aerosol injection device such as No. 57-153752 which supplies new acid gas when the #i! acid gas decreases.

In this way, the carbon dioxide gas production can be maintained constant from the beginning of use to the end of use.

The hair nourishing/growth preparation of the present invention contains the above-mentioned essential ingredients, an oily base used in ordinary cosmetics, emoliene (agents, gluing agents, various emulsifiers, fragrances, etc.) and q-hydroxybenzoic acid ester. Addition and blending of preservatives such as Shima, preservatives such as butylated hydroxyanisole, coloring agents such as dyes, cooling agents such as menthol, bactericidal agents such as Hino'f-f-ol, and wetting agents such as tulobylene glycol. I can do it.

As mentioned above, the hair nourishing and restoring agent of the present invention can efficiently deliver the hair matrix cell activator to the hair matrix due to the vasodilatory action of carbon dioxide gas, and has excellent hair nourishing and hair growth effects and hair loss inhibiting effects. shows. Furthermore, since the combined use of carbon dioxide gas can reduce the amount of the highly irritating hair follicle activator, continuous use is limited to 1 J, and the above effects can be further enhanced.

In addition, the bubbling effect of carbon dioxide gas can provide a comfortable tingling and pine surge effect to the scalp, and since the pH of the hair growth agent itself is slightly acidic, it has a pH close to that of fL crows, and the skin can be treated with a comfortable tingling effect. You can give a favorable impression.

Next, the present invention will be explained using an actual travel example.

Reference Example I The hair on the dorsal skin of a C3M mouse (female) in the telogen phase was shaved without damaging the skin, and the growth of the hair in the next anagen phase was observed. The area of the area where hair growth was observed to improve the skin surface was orally measured, and the ratio b) to the area of other hair areas was determined.

The results are shown in Table 1.

As shown in Table 1 below, the area of areas where the start of hair growth is delayed increased with age.

Example 1 The hair on the dorsal skin in the resting phase of a 108-day-old C3H mouse (male) was shaved without damaging the skin J#, divided into 8 groups, and the composition shown in Table 2 below was applied to the 7th shaved area. A hair growth agent was applied every day and subsequent growth was observed. Mycorrhiza in areas where hair growth was observed to improve the skin surface were measured over time, and the ratio (r) to the area of the shaved area was calculated. The results are shown in Table 3.

Below; white [Results] Table 3 *Same as Table 1.

As shown in Table 3, by using the hair nourishing and restoring composition of the present invention containing carbon dioxide gas, it was observed that hair growth started earlier.

Reference example 2: 3 who seems to have a family history of male pattern baldness
The hair cycle distribution on the top of the head was measured for men aged 0 to 40 years, and as a control, the hair cycle distribution was measured for normal people of the same age and those who had already been found to have this alopecia, and a comparative study was conducted. The results are shown in Table 4.

Table 4 *Average value.

Table 4 shows that the percentage of hair in the resting phase is higher in alopecia and those with a predisposition to alopecia than in normal people.

Example 2 A hair growth product with the composition shown in Table 5 below was administered daily for one year to subjects who had a predisposition to androgenetic alopecia, had increased number of dormant hairs, and those whose alopecia was currently progressing. We asked them to use the brush and examined the rate of paused brushing before and after use. The results are shown in Table 6.

The following margins [Composition] Table 5 and the following margins [Results] Table 6 As shown in Table 6, the use of the hair growth product of the present invention containing carbon dioxide resulted in a decrease in the telogen rate. Admitted.

Claims (1)

[Scope of Claims] 1. A hair nourishing and hair restoring composition containing a hair matrix cell activator and carbon dioxide gas mixed therein and sealed in a pressure-resistant container 2, wherein pn is 7 or more and 1 %1; Scope of visit The hair nourishing and hair growth agent according to item 1. , 3, hair matrix j1! lThe blending amount of activator is 0. ．． 001～
51/L amount of 9, the hair nourishing/hair growth preparation according to claim 1 of the patent claim. 4. The hair nourishing/growth preparation according to claim 1, which contains carbon dioxide sludge in an amount of 60 ppm or more.