JPS6143101A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic, having a superior antiseborrheic action with high safety even in a long period use, and composed of using an antiseborrheic in combination with carbon dioxide having a vasodilative action or a substance capable of generating carbon dioxide. CONSTITUTION:A cosmetic such as a lotion, milky lotion, hair lotion, hair tonic, rinse and hair growing agent, prepared by incorporating >=60ppm carbon dioxide gas into a cosmetic composition containing an antiseborrheic such as diethylstilbestrol and chlormadinone acetate (the content to be incorporated is preferably 0.001-5wt%) by such as enclosing the high pressure gas into a pressure vessel containing the cosmetic composition, or prepared by supporting both a carbonate such as sodium bicarbonate and an acid such as succinic acid on a carrier substantially in the absence of water, and further supporting said cosmetic composition on the carrier together, thereby the carbon dioxide can be generated by adding water thereto.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to cosmetics, and more particularly to cosmetics containing an antiseborrheic agent and carbon dioxide gas.

[Conventional technology]

Recent cosmetic concerns regarding the skin, scalp, and hair include oil stains on the skin and scalp and oily, sticky hair caused by excessive secretion of sebaceous glands present in the skin and pores. Many attempts have therefore been made to normalize the secretion of the sebaceous glands by means of appropriate drugs, thereby reducing the oil secretion of the skin, scalp and hair, giving them a smooth and healthy appearance. For example, for the eradication of seborrhea on the head with hair, cosmetics containing additives of sulfur, mercury or tar were used. However, these known antiseborrheic additives often cause side effects when used for a long period of time, and no satisfactory results have been obtained in terms of efficacy and practicality.

[Problem that the invention seeks to solve]

Therefore, it has been desired to develop a cosmetic that is highly safe even during long-term use and has excellent anti-N leakage properties.

[Failure to solve the problem]

The present inventors have conducted various studies on improving the effects of antiseborrheic agents, and have found that they are known to have vasodilatory effects as well as antiseborrheic agents), and have also been clinically used as carbon dioxide gas baths such as Rehabilitation 7. The anti-seborrheic effect is dramatically improved when used in combination with carbon dioxide or a substance that generates carbon dioxide, compared to the use of an anti-seborrheic agent alone, and that these agents should be incorporated into cosmetic compositions. The present invention was completed based on the discovery that a cosmetic having excellent antiseborrheic action can be obtained by applying the same method.

Therefore, the present invention provides a cosmetic composition characterized in that a cosmetic composition containing an antiseborrheic agent is blended with carbon dioxide gas or a carbon dioxide gas generating substance. Embodiments of the cosmetic composition of the present invention include: , the following can be exemplified.

■ A cosmetic composition containing all conventional antiseborrheic agents is placed in a pressure-resistant container, and high-pressure carbon dioxide gas is blown into the container, or a carbonate and acid, or a carbon dioxide gas generating source such as dry ice is added, and the container is sealed. .

When using this cosmetic, the contents are discharged and applied to the area to be applied.

(2) Carbonate and R are supported on a single carrier such as nonwoven fabric, cloth, paper, etc. in a substantially water-free state. Furthermore, this carrier also carries a known antiseborrheic agent-containing cosmetic composition.When using this cosmetic, it is applied to the area to be applied, and then a steamed towel is placed on top of it, or water is added to it. By the method described above, water is supplied to the cosmetic, and the carbonate and acid are reacted to completely generate carbon dioxide gas.

(2) Carbonate and ak are supported on two different carriers. A known antiseborrheic agent-containing cosmetic composition may be supported on one or both of these carriers in the same manner as in (2).
It can also retain moisture.

When using this cosmetic, apply it in layers to the area to be applied, and if necessary (if the cosmetic does not contain water), water is supplied in the same manner as in (2) to generate all carbon dioxide gas.

The antiseborrheic agents used in the present invention include diethylstilbestrol, cyclotene acetate, chlormadinone acetate, glogesterone, S-carboxy-methyl-L-cystine,
Oxendrone, androstenedione, testosterone-17β-710 acetate, deoxycortico-7, etc., as well as allantoin chlorhydroxyaluminum, which is also known as an astringent, allantoin dihydroxyaluminum, aluminum hydroxychloride, zinc chloride, aluminum chloride, chloride Also included are ferric iron, calamine, dry potassium aluminum sulfate, zinc paraphenolsulfonate, and the like.

Among these, diethylstilbestrol and chlormadinone acetate are particularly preferred. It is preferable to use this antiseborrheic agent by blending it with a solvent such as water or water-lower alcohol. The antiseborrheic agent is preferably blended in the cosmetic composition of the present invention in an amount of 0.001 to 5% by weight (hereinafter simply referred to as "excellent"). 0.
If it is less than 0.001%, a sufficient effect cannot be obtained, and if it is added more than 5%, it gives an unpleasant irritation to the skin, which is not preferable.

On the other hand, it is known that the carbon dioxide gas used in step (2) exists as CO2 molecules when the solution in which it is dissolved is acidic, exhibits a vasodilatory effect, and exhibits an effect of promoting percutaneous absorption. Therefore, it is preferable that the liquid properties of the cosmetics of the present invention be adjusted to pi (7 or less, especially ≠4.5 to 6.5). The acidity becomes even stronger as the solution is added, but it should be adjusted so that the final voice is within the above range. Examples of pH moderators include organic acids such as citric acid, tartaric acid, and lactic acid, or their salts, and phosphorus. Acids or their salts or solid acids such as acid clay are preferably used.

Further, carbonates used in the present invention include, for example, sodium hydrogen carbonate, sodium carbonate, sodium sesquicarbonate, potassium hydrogen carbonate, potassium carbonate, potassium sesquicarbonate, aqueous ammonium carbonate, ammonium carbonate,
Examples include ammonium sesquicarbonate salts, and these can be used alone or in combination of 28 or more.

Further, as the acid, both organic acids and inorganic acids can be used, but water-soluble and solid acids are preferred.

Examples of organic acids include straight chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid; oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, Dicarboxylic acid such as isophthalic acid and terephthalic acid; acidic amino acids such as glutamic acid and aspartic acid; glycolic acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid,
Malic acid, tartaric acid, citric acid, salicylic acid (o, m.

p) Oxyacids such as gallic acid, mandelic acid, tronosic acid, ascorbic acid, gluconic acid; cinnamic acid, benzoic acid, phenylacetic acid, nicotinic acid, kainic acid, sorbic acid,
Examples include pyrrolidonecarboxylic acid, trimellitic acid, benzenesulfonic acid, toluenesulfonic acid, and acid salts of these organic acids. Examples of inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, potassium sulfite, potassium sulfite, sodium pyrosulfite (sodium metabisulfite), potassium pyrosulfite (potassium metabisulfite), Sodium acid hexametaphosphate,
Examples include acidic potassium hexametaphosphate, acidic sodium birophosphate, acidic potassium birophosphate, and sulfamic acid. Among these, aliphatic dicarboxylic acids such as phosphoric acid, fumaric acid, phosphoric acid, and acid salts thereof are preferred. In the present invention, carbon dioxide gas generation can be achieved by adjusting the amounts of these carbonates and acids. It is preferable to adjust the atmosphere level to 4-7. For example, when used in combination with a known antiseborrheic agent-containing cosmetic composition, the amount of carbonate and acid should be adjusted to 1 to 20% by weight of the total composition. preferable. Further, the carbon dioxide concentration in the cosmetic of the present invention is preferably 60 ppm or more,
If there is less than this, the sufficient effect will not be achieved.

To prepare the cosmetic of the present invention according to aspect (2), the cosmetic composition is placed in a pressure-resistant container and a high-pressure gas is sealed in the container, or hydrogen carbonate is added to the pressure-resistant container. A method is adopted in which a dry ice pellet is placed in a container, a direct regulating agent is added to generate carbon dioxide gas, and the mixture is immediately sealed, or a dry ice pellet is placed in a container and sealed. A method of encapsulating is preferred.

When this is done, part of the carbon dioxide gas is dissolved and blended into the cosmetic, and part of it is present in the container as a gas. In the present invention, it is important that carbon dioxide gas is dissolved in the cosmetic and blended, and it is preferable that the concentration of carbon dioxide gas is 60 ppm or more. No leakage effect can be expected, and the effects of the present invention cannot be obtained.

The amount of carbon dioxide gas blended can be adjusted by changing the amount of carbon dioxide gas injected (pressure-injected), and generally the pressure in the container is 35
It is preferable to adjust the pressure to 12 to 8 Kp/cJ (gauge pressure) at a temperature of .degree.

In addition, the pressure-resistant container used in the present invention must be able to withstand the above pressure and keep the cosmetic in a sealed state in the trench where it is used after preparation.For example, it must be made of metal such as aluminum or tin. Containers, synthetic resin containers such as acetal resin, polycarbonate resin, etc., and glass containers are used.

On the other hand, if the diameter of the discharge nozzle is small, the filling liquid is sprayed in the form of mist, and if the diameter is large, the filling liquid is sprayed in the form of foam or liquid. The spray form also varies depending on the internal pressure of the can, but generally the diameter of the discharge nozzle of an aerosol spray container is α3W or less, and when this is applied to the cosmetic of the present invention, it is sprayed in the form of a mist and carbon dioxide gas is immediately dispersed. As a result, sufficient effects cannot be obtained. In order to enhance the effects of the present invention, it is necessary to lengthen the residence time of carbon dioxide gas in the cosmetic, so the cosmetic of the present invention is applied directly to the scalp in foam or liquid form without adhering to the hair. It is preferable to foam it on the scalp. For this reason, it is preferable that the discharge nozzle has a diameter of 0.3 to 1.5 txm and a length of 1 to 15 mm. Furthermore, in order to prevent the amount of dissolved carbon dioxide gas from decreasing due to the decrease in the internal pressure of the can due to use, and to maintain a constant injection condition, a mini cylinder of carbon dioxide gas is completely built into the container.
It is preferable to combine it with an aerosol injection device such as that disclosed in JP-A-57-153752, which supplies all of the carbon dioxide gas again when the pressure during use decreases. In this way, the carbon dioxide concentration can be maintained constant from the beginning of use to the end of use.

In addition to the above-mentioned essential ingredients, ingredients commonly used in cosmetics, such as oily bases, emollients, gelling agents, various emulsifiers, fragrances,
Preservatives such as parahydroxybenzoic acid ester, antioxidants such as butylhydroxyanisole, coloring agents such as dyes,
Wetting agents such as propylene glycol, film agents, thickeners, blood circulation promoters, vitamins, and the like may be blended as appropriate.

〔effect〕

The cosmetic composition of the present invention obtained as described above has an excellent antiseborrheic effect.

〔Example〕

Next, the present invention will be fully explained with reference to Examples.

Example L Hair tonic: A hair tonic having the composition shown in Table 1 was produced, and when applied to hair, the oiliness and stickiness of the hair were evaluated. The evaluation was conducted after washing the hair, using the hair tonic of the present invention and the comparison product every day, and after prohibiting hair washing for 3 days.
A sensory test was conducted by a panel of 10 experts. The evaluation was based on the following criteria) and was an absolute evaluation.

Hair: (+2) Not oily at all (+1)
) Not sweet and oily (0) Can't say either (
-Technical) Slightly oily (-2) Oily hair stickiness: (+2) Not sticky at all (+l)
I) Not sticky (0) Can't say either (
-1) Slightly sticky < (-2) Sticky The results are shown in Table 2.

CM Formation] (Manufacturing method) An antiseborrheic agent and a pH adjuster were added to a 50 V/V chetanol aqueous solution and thoroughly stirred, and the mixture was filled into a pressure container and carbon dioxide gas was blown into the container.

(Results) From the evaluation results in Table 2, it is clear that the product of the present invention, which contains carbon dioxide gas and an antiseborrheic agent, makes the hair feel less oily and sticky than the comparative product. ◇ Example 2 Hair tonic: (Composition) ■Ethanol S O, O (φ) ■Carbon dioxide 1.0 ■Acetate chlormadinone 0.5■Hinokitiol
0.05 ■ Lactic acid 0.
133■Sodium lactate 0.3■Fragrance appropriate amount■Water remainder (M method) Mix ■, ■～■ at room temperature, put in a pressure-resistant container, attach full power to the injection device and seal, fill with ■ and combine with the product. do. The obtained hair tonic had an excellent antiseborrheic effect and kept the hair feeling good.

Example 3 Skin lotion (composition) ■ Ethanol 10.0 (chi) ■ Carbon dioxide i.

■Diethylstilbestrol 0.002■Acetic acid dt-
α-Tocopherol o, 05 ■ Lactic acid
0.133 ■ Sodium lactate
0.3 ■ Polyoxyethylene hydrogenated castor oil (
20g, o,) 0.5■Fragrance
Appropriate amount ■Water Remainder (manufacturing method) ■, ■～■ Mix everything at room temperature, put it in a pressure-resistant container, attach an injection device and seal it, and ■ completely fill it to make a product. The obtained skin lotion had an excellent antiseborrheic effect, did not make the skin oily and dirty, and did not make the skin dry.

Example 4 Skin Lotion (D') A skin lotion was prepared in the same manner as in Example 4, except that ethylstilbestrol total Q and 5% chloride layer aluminum were replaced.

Example 5 Shampoo: (Composition) ■ Coconut fatty acid jetanolamide 3.
0 ■ Carbon dioxide gas 1.00
Chlormazonone acetate 0.5■
Lactic acid 0.133■ Sodium lactate 0.3■ Flavoring
Appropriate amount ■ Water
Remaining portion (manufacturing method) Mix ①, ②, and ② to ③ at room temperature, put it in a pressure-resistant container, attach an injection device, seal it, and fill it with ③ to make a product. The resulting shancy had excellent antiseborrheic activity.

Example 6 Hair rinse: (group g) ■ Stearyl alcohol i,
.

■ Lactic acid 0.133■
Sodium lactate 0.3 ■ Flavoring
Appropriate amount ■ Water
Remainder (#! method) Heat and mix ■, ■, ■, ■ at 70℃, add here, ■, ■
, (2) are mixed and dissolved and heated to 70°C, then emulsified, returned to room temperature, placed in a pressure-resistant container, fitted with an injection device and sealed, and filled with (2) to produce a product. The resulting nine rinse had excellent antiseborrheic activity.

that's all

Claims (1)

[Scope of Claims] 1. A cosmetic product comprising a cosmetic composition containing an antiseborrheic agent and a carbon dioxide gas or a carbon dioxide gas generating substance added thereto. 2. The cosmetic according to claim 1, wherein the amount of the antiseborrheic agent is 0.001 to 5% by weight. 3. The cosmetic according to claim 1, which contains carbon dioxide in an amount of 60 ppm or more.