JPS60116620A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic, obtained by incorporating soluble collagen and a derivative thereof with pantothenic acid and a derivative thereof together, and having improved effect on improvement in skin roughening and more synergistically enhanced effect thereof than in individual use thereof. CONSTITUTION:A cosmetic, containing one or two or more selected from the group consisting of soluble collagen and derivatives thereof, e.g. soluble succinylated collagen, in an amount of 0.001-1.5wt% based on the total weight of the cosmetic and one or two or more selected from the group consisting of pantothenic acid and derivatives thereof, e.g. pantothenyl alcohol or pantetheine, in an amount of 0.0001-3.0wt%, preferably 0.005-1.0wt%, and having improved effect on improvement in skin roughening. The form of the cosmetic may be a nutrient cream, hand cream, milky lotion, lotion and pack, etc. A surfactant, oil, humectant, etc. may be suitably incorporated with the cosmetic in addition to the essential components.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel cosmetic that has significantly improved effects on improving rough skin.

The stratum corneum of the skin maintains an appropriate amount of water through water supply from the body and water absorption from the outside, and generally has a water content of 10
~20% amount is said to be optimal. When this amount is less than 10%, the skin becomes dry, so-called rough skin, and in extreme cases, cracks may occur. To solve this problem, cosmetics containing moisturizing agents such as sodium lactate, glycerin, sodium pyrrolidone carboxylate, and propylene glycol have been used.

However, these moisturizers have a physicochemical effect on the skin surface and function to supply moisture to the stratum corneum, and their effect is temporary and is greatly influenced by environmental conditions. It had the disadvantage of being

On the other hand, other than the above-mentioned moisturizers, cosmetics containing soluble collagen, pantothenic acid, etc. have been proposed as having effects such as preventing rough skin and imparting flexibility to the skin.
The effect could not be confirmed in actual usage conditions.

In view of these circumstances, the present inventors have devised a method to obtain cosmetics that are effective in improving rough skin. The above objective can be achieved by combining and blending one or more selected from the group consisting of pantothenic acid and its derivatives, and the effect on improving rough skin is greater than when each is used alone. They have found that the increase occurs synergistically, and have completed the present invention based on this finding.

That is, 1. The present invention provides a cosmetic comprising one or more selected from the group consisting of soluble collagen and its derivatives, and one or more selected from the group consisting of pantothenic acid and its derivatives. It provides a fee.

Hereinafter, the configuration of the present invention will be explained in detail.

The soluble collagen used in the present invention may be any type of collagen as long as it is soluble in water, but in particular, soluble collagen solubilized by protease treatment (Japanese Unexamined Patent Application Publication No. 5-1-1-33E: Atelocollagen/) is used. Since telopeptide has been removed, it is preferable in terms of skin safety, such as non-allergenic properties. A soluble collagen derivative obtained by treating soluble collagen with succinic acid or the like is also preferable because it has good hydrophilicity and can be dissolved well regardless of the pl+ of the system. Therefore, it can be said that soluble succinated collagen obtained by treating soluble collagen obtained by protease treatment with succinic acid or the like, for example, is particularly preferable for use in cosmetics. - The blending amount is 0.001 to 1.5% by weight (hereinafter not simply referred to as %) based on the total amount of the cosmetic of the present invention. If it is less than 0.001%, the effect of the present invention will not be exhibited, and if it exceeds 1.5%, the solubility will be poor, the viscosity of the system will increase too much, and gelation will occur, which is not preferable.

Pantothenic acid used in the present invention is a type of vitamin B complex widely distributed in nature, and has the following structural formula.

Because it is unstable, it is generally commercially available in the form of a calcium salt. In the present invention, it is also used in the form of calcium pantothenate.

Derivatives of pantothenic acid used in the present invention include pantothenyl alcohol, v/tetei/(pantotin), pantethyl/, bytothinyl ethyl ether, acetyl pantothenyl ethyl ether, be/diylbantothenyl ethyl ether, dicarboethoxy Examples include bantothenic acid ethyl ester.

In the present invention, one or more of these pan-1thenic acids and derivatives thereof are appropriately selected and blended.

The blending amount is generally 0.0001 to 3.0%, preferably 0.005 to 1.0%. If it is less than o,oooi%, a sufficient effect cannot be expected, and 3. Ot! If it exceeds %, it is not only unnecessary for the skin, but also undesirable from the viewpoint of product manufacturing process and safety.

In addition to the above-mentioned essential ingredients, the cosmetic of the present invention contains a surfactant, an oil, a humectant, an ultraviolet absorber, an Alpur, and a chelating agent% pHK! 4. Ingredients commonly used in cosmetics, such as stabilizers, preservatives, thickeners, pigments, and fragrances, can be appropriately blended. Of course, these must be within a range that does not impair the effects of the present invention.

The cosmetics of the present invention have excellent effects on improving rough skin, and can be used as nutritional creams, hand creams, body creams, milky lotions, etc.
It can be used not only for skin cosmetics such as lotions and bags, but also for hair cosmetics, especially scalp cosmetics, and can be used for cracks, chapped skin, rough skin in winter, skin after shaving, rough hands, and scalp damaged by dyed or permed hair. Suitable for drying.

Next, the effect of the cosmetics of the present invention on improving rough skin will be explained with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

(Hereinafter referred to as "Test Method for Improving Effect of Rough Skin (Test Method)" Example 1, Comparative Example 2, and Comparative Example 3 were tested using 24 women aged 20 to 40 who suffer from rough skin in winter as subjects. Divided into groups, with 8 people in each group.The period of use was 2 in the winter.
For one week, the cosmetic of Comparative Example 1 was applied to one cheek, and the cosmetic of Example 1, Comparative Example 2 or 3 of each group was applied to the other cheek at least twice a day, in the morning and evening.

(Measurement and judgment method) Measurement and judgment were carried out by the following method on the day after the two-week application was completed.

■ Evapolymeter Epl (Sweden 5ervo
Med, Inc.).

The larger the value of this judgment TWL value, the more severe the rough skin is.

■We investigated the surface morphology of the skin, which is closely related to the appearance of the skin, by collecting skin replicas using silicone resin and observing them with a stereoscopic microscope.

Book judgment It has become.

Comparative Examples 1 to 3 and Example 1 (Production method) ■■■ and ■ are dissolved in [phase]. Separately 70°
■■■■■ [phase] and ■ dissolved in C were added and mixed, @ was added thereto, and the mixture was emulsified using a homomixer to obtain the cream of Example 1. Comparative Examples 1 to 3 were also produced in the same manner as Example 1. The results are shown in Table 1. The numbers in the table are
Represents the number of subjects judged for that item.

(Results) As is clear from Table 1, the cosmetic of the present invention has a superior effect on improving rough skin compared to a cosmetic containing soluble succinated collagen and pantothenic acid alone. It was proven that they act synergistically.

Example 2 Lotion (A) Soluble collagen (protease treatment) 1.5 Ion exchange water 82.6 Dipropylene glycol 3.0 Glycerifu 1. '(J Bantothenyl alcohol 0.5 (B) Ethanol 10.0 Methyl roseoxybenzoate 0.1 Fragrance 0.1 Polyoxyethylene (15 mol) 1.2 Oleyl alcohol ether (manufacturing method) Bantotenyl in ion-exchanged water After dissolving alcohol and glycerin, soluble collagen pre-moistened with dipropylene glycol was gradually added and dissolved uniformly (A
) got the phase.

Next, add methyl roseoxybenzoate, iF agent, to ethanol,
After dissolving POE (15 mol) oleyl alcohol ether, it was gradually added to phase (A) with stirring to solubilize,
A lotion was obtained by filtration.

Example 3 Scalp treatment ■Liquid paraffin 15. .

■Vaseline 2.0 ■Cetanol 2.0 ■Polyethylene glycol 1500 7.0 ■Stearic acid 2.5 ■l”0E(0) Sorbitan monostearate 1.0
■Glyceryl monostearate 1. .

■ Caustic Potash 1.0 ■ Pantetheine 0.1 [Phase] Soluble Collagen 0.001 ■ Quinoline Yellow 11ffi @ Brilliant Blue Appropriate amount [Phase] Fragrance 0.5 ■ Ion exchange water 67.8 @ Ethylparaben 0.05 (Production method) Heat and dissolve ■■■ [Phase] ■ and ■ in ■ and keep at 70°C (Part A). Other components were mixed, heated and dissolved, and kept at 70° C. (Part B) a Part B was added to Part A, mixed with stirring, and then emulsified in a homomixer. After emulsification, the mixture was cooled to 30° C. while stirring to obtain a milky scalp treatment.

Example 4 Emulsion (A) Squalane 0.5 2-ethylhexane triglyceride 3.5 Methylphenynohybolysiloxane 1.5 Fragrance 0.2 Methyl paraoxybenzoate 0.1 (B) Propylene glycol 5.0 1.3 Butylene glycol 2.0 FOE (15 mol) Dihydrocholestol 0.2 (
C) Ion exchange water 81. (15 Bar/techin 0.05 Pantothenyl alcohol 0.05 Ethanol 5.0 Soluble collagen 0.05 Chondroitin sulfate sodium 0.05 Carboxy vinyl polymer 0.15 (Production method) To prepare the component (A), Squalane, 2-ethylhexane triglyceride, methylphenylpolysiloxane, fragrance, and preservative are heated to 50"C to dissolve.

To prepare component (B), propylene glycol,
1.3 Butylene glycol, POE (15 mol) Dihydrocholestanol is heated to 50"C and dissolved.

To prepare component (C), dissolve pantethine and pantothenyl alcohol in ion-exchanged water, gradually add soluble collagen and dissolve it uniformly, and then gradually add carboxyvinyl polymer and dissolve it uniformly. .

Phase (A) is gradually added to phase (I3) to emulsify it, and the mixture is subjected to homomixer treatment. Furthermore, after stabilizing by adding ion-exchanged water, it was gradually added to phase (C) to obtain a milky lotion.

Example 5 Back vinyl acetate resin emulsion! 17 15.0 Polyvinyl alcohol 1000 Olive oil 5.0 ° Glycerin 5.0 Titanium oxide 8.0 Kaori 7 7.0 Hexametari/i! ! Sodium 0.05 Edyyl alcohol 5.0 Ion exchange water 33.95 Fragrance 0.3 Ethyl roseoxybenzoate 02 Pantothenylethyl alcohol 0.5 Soluble succinated collagen aqueous solution (2%) 10.0 (Protease treatment) (Manufacturing) Method) Wet polyvinyl alcohol with a portion of ethyl alcohol, add it to ion-exchanged water in which titanium oxide, kaolin, and sodium hexametaphosphate are dispersed, heat it to 70°C, and stir to uniformly disperse it.

Glycerin, vinyl acetate resin emulsion, fragrance dissolved in the remainder of ethyl alcohol, ethyl paraoxybenzoate, and olive oil were added to the chicken, stirred thoroughly to form a uniform paste, and further dissolved in a portion of ion-exchanged water. % soluble succinated collagen aqueous solution and vanthotenyl ethyl alcohol were gradually added to obtain a bag.

The cosmetics of Examples 2 to 5 thus obtained were all excellent in improving effects on rough skin.

Applicant: Shiseido Co., Ltd.

Claims (1)

[Claims] A cosmetic comprising one or more selected from the group consisting of soluble collagen and its derivatives, and one or more selected from the group consisting of pantothenic acid and its derivatives.