JPS60115852A - 反応用カラムを含むフロ−ラインのモニタリング装置 - Google Patents
反応用カラムを含むフロ−ラインのモニタリング装置Info
- Publication number
- JPS60115852A JPS60115852A JP22326983A JP22326983A JPS60115852A JP S60115852 A JPS60115852 A JP S60115852A JP 22326983 A JP22326983 A JP 22326983A JP 22326983 A JP22326983 A JP 22326983A JP S60115852 A JPS60115852 A JP S60115852A
- Authority
- JP
- Japan
- Prior art keywords
- flow line
- reaction
- electrodes
- reaction column
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 86
- 238000012806 monitoring device Methods 0.000 title claims description 5
- 238000001514 detection method Methods 0.000 abstract description 17
- 238000005259 measurement Methods 0.000 abstract description 14
- 238000004458 analytical method Methods 0.000 abstract description 9
- 230000008859 change Effects 0.000 abstract description 9
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 9
- 239000000872 buffer Substances 0.000 abstract description 6
- 239000000243 solution Substances 0.000 description 44
- 239000003795 chemical substances by application Substances 0.000 description 17
- 238000000034 method Methods 0.000 description 12
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 9
- 238000010494 dissociation reaction Methods 0.000 description 7
- 230000005593 dissociations Effects 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 238000004401 flow injection analysis Methods 0.000 description 5
- 239000011535 reaction buffer Substances 0.000 description 5
- 239000003792 electrolyte Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 238000005375 photometry Methods 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- -1 4-nonpurate Substances 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22326983A JPS60115852A (ja) | 1983-11-29 | 1983-11-29 | 反応用カラムを含むフロ−ラインのモニタリング装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22326983A JPS60115852A (ja) | 1983-11-29 | 1983-11-29 | 反応用カラムを含むフロ−ラインのモニタリング装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60115852A true JPS60115852A (ja) | 1985-06-22 |
| JPH0459585B2 JPH0459585B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-09-22 |
Family
ID=16795466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22326983A Granted JPS60115852A (ja) | 1983-11-29 | 1983-11-29 | 反応用カラムを含むフロ−ラインのモニタリング装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60115852A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990011291A1 (en) * | 1989-03-21 | 1990-10-04 | Biotech Instruments Limited | Monitoring reactions in solid-phase peptide synthesis by conductivity measurements |
| JP2015099166A (ja) * | 2015-03-02 | 2015-05-28 | コニカミノルタ株式会社 | 計測装置及び計測方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5838856A (ja) * | 1981-08-31 | 1983-03-07 | Kyoto Daiichi Kagaku:Kk | 自動化された液体クロマト装置 |
-
1983
- 1983-11-29 JP JP22326983A patent/JPS60115852A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5838856A (ja) * | 1981-08-31 | 1983-03-07 | Kyoto Daiichi Kagaku:Kk | 自動化された液体クロマト装置 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990011291A1 (en) * | 1989-03-21 | 1990-10-04 | Biotech Instruments Limited | Monitoring reactions in solid-phase peptide synthesis by conductivity measurements |
| JP2015099166A (ja) * | 2015-03-02 | 2015-05-28 | コニカミノルタ株式会社 | 計測装置及び計測方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0459585B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-09-22 |
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