JPH0414310B2 - - Google Patents
Info
- Publication number
- JPH0414310B2 JPH0414310B2 JP21492884A JP21492884A JPH0414310B2 JP H0414310 B2 JPH0414310 B2 JP H0414310B2 JP 21492884 A JP21492884 A JP 21492884A JP 21492884 A JP21492884 A JP 21492884A JP H0414310 B2 JPH0414310 B2 JP H0414310B2
- Authority
- JP
- Japan
- Prior art keywords
- endotoxin
- gel
- amount
- concentration
- limulus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002158 endotoxin Substances 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 20
- 238000001879 gelation Methods 0.000 claims description 12
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 230000000977 initiatory effect Effects 0.000 claims description 9
- 241000239218 Limulus Species 0.000 claims description 7
- 238000000149 argon plasma sintering Methods 0.000 claims description 7
- 239000006166 lysate Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 description 9
- 238000001514 detection method Methods 0.000 description 8
- 239000000758 substrate Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000011088 calibration curve Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 description 4
- 239000012480 LAL reagent Substances 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241001529572 Chaceon affinis Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000000701 coagulant Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 208000037487 Endotoxemia Diseases 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 101000882917 Penaeus paulensis Hemolymph clottable protein Proteins 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 108010045487 coagulogen Proteins 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 108010072542 endotoxin binding proteins Proteins 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21492884A JPS6193958A (ja) | 1984-10-13 | 1984-10-13 | エンドトキシンの定量法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21492884A JPS6193958A (ja) | 1984-10-13 | 1984-10-13 | エンドトキシンの定量法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6193958A JPS6193958A (ja) | 1986-05-12 |
| JPH0414310B2 true JPH0414310B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-03-12 |
Family
ID=16663893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21492884A Granted JPS6193958A (ja) | 1984-10-13 | 1984-10-13 | エンドトキシンの定量法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6193958A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329538B2 (en) | 2003-03-17 | 2008-02-12 | Charles River Laboratories, Inc. | Methods and compositions for the detection of microbial contaminants |
| EP1842069A2 (en) | 2004-12-02 | 2007-10-10 | Charles River Laboratories, Inc. | Methods and compositions for the detection and/or quantification of gram positive bacterial contaminants |
| EP1836492B1 (en) * | 2005-01-13 | 2008-12-31 | Charles River Laboratories, Inc. | Method for classifying a microorganism in a biological sample |
| US20100129260A1 (en) * | 2007-05-01 | 2010-05-27 | Yoshiaki Shirasawa | Gelation measuring apparatus and sample cell |
| US8462340B2 (en) | 2008-03-19 | 2013-06-11 | Toru Obata | Gel particle measuring apparatus |
| JP5188311B2 (ja) | 2008-07-30 | 2013-04-24 | 興和株式会社 | 生物由来の生理活性物質の測定方法及び測定装置 |
| JP5401115B2 (ja) * | 2009-02-13 | 2014-01-29 | 興和株式会社 | 生物由来の生理活性物質の測定方法及び測定装置 |
| CN104838268B (zh) * | 2012-10-08 | 2017-10-24 | 通用电气公司 | 微流体lal反应物质测试方法和设备 |
-
1984
- 1984-10-13 JP JP21492884A patent/JPS6193958A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6193958A (ja) | 1986-05-12 |
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