JPS5922558A - 体液分離用限外ろ過モジユ−ルのパイロジエン汚染防止法 - Google Patents
体液分離用限外ろ過モジユ−ルのパイロジエン汚染防止法Info
- Publication number
- JPS5922558A JPS5922558A JP57132496A JP13249682A JPS5922558A JP S5922558 A JPS5922558 A JP S5922558A JP 57132496 A JP57132496 A JP 57132496A JP 13249682 A JP13249682 A JP 13249682A JP S5922558 A JPS5922558 A JP S5922558A
- Authority
- JP
- Japan
- Prior art keywords
- water
- cleaning
- membrane
- endotoxin
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000108 ultra-filtration Methods 0.000 title claims description 24
- 239000002510 pyrogen Substances 0.000 title claims description 9
- 239000007788 liquid Substances 0.000 title description 6
- 230000002265 prevention Effects 0.000 title description 2
- 239000012528 membrane Substances 0.000 claims description 59
- 238000000034 method Methods 0.000 claims description 57
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42
- 239000002158 endotoxin Substances 0.000 claims description 33
- 210000001124 body fluid Anatomy 0.000 claims description 26
- 239000010839 body fluid Substances 0.000 claims description 26
- 239000000126 substance Substances 0.000 claims description 25
- 239000012466 permeate Substances 0.000 claims description 22
- 238000000926 separation method Methods 0.000 claims description 15
- 230000005251 gamma ray Effects 0.000 claims description 14
- 239000013060 biological fluid Substances 0.000 claims description 11
- 238000011109 contamination Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000008213 purified water Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 description 38
- 238000005406 washing Methods 0.000 description 21
- 241000894006 Bacteria Species 0.000 description 15
- 239000012510 hollow fiber Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- 230000001580 bacterial effect Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 238000000502 dialysis Methods 0.000 description 9
- 230000001954 sterilising effect Effects 0.000 description 9
- 241000239218 Limulus Species 0.000 description 7
- 239000011148 porous material Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000000356 contaminant Substances 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 239000004926 polymethyl methacrylate Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000001223 reverse osmosis Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000001879 gelation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 229920006008 lipopolysaccharide Polymers 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000001891 gel spinning Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000008214 highly purified water Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011076 safety test Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 108700023418 Amidases Proteins 0.000 description 1
- 108010065152 Coagulase Proteins 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- 241000048246 Gallicrex cinerea Species 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000004614 Process Aid Substances 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 102000005922 amidase Human genes 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 150000002632 lipids Chemical group 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011046 pyrogen test Methods 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008054 sulfonate salts Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57132496A JPS5922558A (ja) | 1982-07-29 | 1982-07-29 | 体液分離用限外ろ過モジユ−ルのパイロジエン汚染防止法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57132496A JPS5922558A (ja) | 1982-07-29 | 1982-07-29 | 体液分離用限外ろ過モジユ−ルのパイロジエン汚染防止法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5922558A true JPS5922558A (ja) | 1984-02-04 |
| JPH0323177B2 JPH0323177B2 (enrdf_load_stackoverflow) | 1991-03-28 |
Family
ID=15082726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57132496A Granted JPS5922558A (ja) | 1982-07-29 | 1982-07-29 | 体液分離用限外ろ過モジユ−ルのパイロジエン汚染防止法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5922558A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673506A (en) * | 1983-05-28 | 1987-06-16 | Akzo Nv | Cleaning treatment for blood compartments of dialyzators |
| JP2004049921A (ja) * | 2002-07-19 | 2004-02-19 | Sanyo Chem Ind Ltd | 創傷被覆材 |
-
1982
- 1982-07-29 JP JP57132496A patent/JPS5922558A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673506A (en) * | 1983-05-28 | 1987-06-16 | Akzo Nv | Cleaning treatment for blood compartments of dialyzators |
| JP2004049921A (ja) * | 2002-07-19 | 2004-02-19 | Sanyo Chem Ind Ltd | 創傷被覆材 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0323177B2 (enrdf_load_stackoverflow) | 1991-03-28 |
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