JPS59198989A - ペプチド性抗生物質ｋ５８２ｍの濃縮精製法 - Google Patents
ペプチド性抗生物質ｋ５８２ｍの濃縮精製法Info
- Publication number
- JPS59198989A JPS59198989A JP7432783A JP7432783A JPS59198989A JP S59198989 A JPS59198989 A JP S59198989A JP 7432783 A JP7432783 A JP 7432783A JP 7432783 A JP7432783 A JP 7432783A JP S59198989 A JPS59198989 A JP S59198989A
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- solution
- nacl
- antibiotic
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003910 polypeptide antibiotic agent Substances 0.000 title claims abstract description 10
- 238000000746 purification Methods 0.000 title claims description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000002952 polymeric resin Substances 0.000 claims abstract description 7
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 7
- 238000005342 ion exchange Methods 0.000 claims abstract description 5
- 238000010828 elution Methods 0.000 claims description 2
- 239000000243 solution Substances 0.000 abstract description 16
- 238000011033 desalting Methods 0.000 abstract description 5
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 8
- 239000011780 sodium chloride Substances 0.000 abstract 4
- 241000223250 Metarhizium anisopliae Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- -1 aryl aldehyde Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000003808 methanol extraction Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7432783A JPS59198989A (ja) | 1983-04-27 | 1983-04-27 | ペプチド性抗生物質ｋ５８２ｍの濃縮精製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7432783A JPS59198989A (ja) | 1983-04-27 | 1983-04-27 | ペプチド性抗生物質ｋ５８２ｍの濃縮精製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59198989A true JPS59198989A (ja) | 1984-11-10 |
| JPH0342079B2 JPH0342079B2 (https=) | 1991-06-26 |
Family
ID=13543899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7432783A Granted JPS59198989A (ja) | 1983-04-27 | 1983-04-27 | ペプチド性抗生物質ｋ５８２ｍの濃縮精製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59198989A (https=) |
-
1983
- 1983-04-27 JP JP7432783A patent/JPS59198989A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0342079B2 (https=) | 1991-06-26 |
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