JPS5919088B2 - 水溶液からのピロジエン性物質の除去法 - Google Patents

水溶液からのピロジエン性物質の除去法

Info

Publication number
JPS5919088B2
JPS5919088B2 JP50018091A JP1809175A JPS5919088B2 JP S5919088 B2 JPS5919088 B2 JP S5919088B2 JP 50018091 A JP50018091 A JP 50018091A JP 1809175 A JP1809175 A JP 1809175A JP S5919088 B2 JPS5919088 B2 JP S5919088B2
Authority
JP
Japan
Prior art keywords
asparaginase
solution
column
pyrodiene
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50018091A
Other languages
English (en)
Japanese (ja)
Other versions
JPS50116681A (enExample
Inventor
ダブリユ グラブナ− ロイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS50116681A publication Critical patent/JPS50116681A/ja
Publication of JPS5919088B2 publication Critical patent/JPS5919088B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
JP50018091A 1974-02-15 1975-02-14 水溶液からのピロジエン性物質の除去法 Expired JPS5919088B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US443063A US3897309A (en) 1974-02-15 1974-02-15 Process for removing pyrogenic material from aqueous solutions
US443063 1974-02-15

Publications (2)

Publication Number Publication Date
JPS50116681A JPS50116681A (enExample) 1975-09-12
JPS5919088B2 true JPS5919088B2 (ja) 1984-05-02

Family

ID=23759282

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50018091A Expired JPS5919088B2 (ja) 1974-02-15 1975-02-14 水溶液からのピロジエン性物質の除去法

Country Status (7)

Country Link
US (1) US3897309A (enExample)
JP (1) JPS5919088B2 (enExample)
CH (1) CH610760A5 (enExample)
DE (1) DE2506260A1 (enExample)
FR (1) FR2261048B1 (enExample)
GB (1) GB1479851A (enExample)
NL (1) NL7500983A (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957582A (en) * 1974-11-20 1976-05-18 Abbott Laboratories Purification of urokinase
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4677194A (en) * 1985-08-09 1987-06-30 Biotech Research Laboratories, Inc. Isolation of an endotoxin inactivator from human plasma
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
IT1222427B (it) * 1987-07-31 1990-09-05 Sclavo Spa Procedimento per la purificazione di interferone
DE3907930C2 (de) * 1989-03-11 1994-02-24 Kabus Hans Peter Dr Puffer- und Reagenzsystem für die Trennung von Aminosäuren
US5578455A (en) * 1993-03-19 1996-11-26 Tanabe Seiyaku Co., Ltd. Method for determining endotoxin and apparatus therefor
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6194562B1 (en) 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
US6942802B2 (en) * 2001-04-13 2005-09-13 Wyeth Holdings Corporation Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography
CA2613094A1 (en) * 2005-07-01 2007-01-11 Promega Corporation Network of buoyant particles for biomolecule purification
US8030034B2 (en) * 2005-12-09 2011-10-04 Promega Corporation Nucleic acid purification with a binding matrix
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
EP3769362A4 (en) 2018-09-12 2021-06-02 Gelion Technologies PTY LTD BATTERY WITH HALOGEN SEQUESTRATION AGENT

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997425A (en) * 1959-05-05 1961-08-22 Ortho Pharma Corp Method of purification of streptokinase
DE1767389A1 (de) * 1968-05-06 1971-09-02 Bayer Ag Verfahren zur Abtrennung von Pyrogenen aus Rohpraeparaten von L-Asparaginase

Also Published As

Publication number Publication date
US3897309A (en) 1975-07-29
FR2261048B1 (enExample) 1980-06-20
JPS50116681A (enExample) 1975-09-12
CH610760A5 (enExample) 1979-05-15
NL7500983A (nl) 1975-08-19
GB1479851A (en) 1977-07-13
FR2261048A1 (enExample) 1975-09-12
DE2506260A1 (de) 1975-08-21

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