JPS59152368A - メルカプト酢酸のアミド及び３―メルカプトプロヒオン酸から誘導される新規薬物 - Google Patents

メルカプト酢酸のアミド及び３―メルカプトプロヒオン酸から誘導される新規薬物

Info

Publication number
JPS59152368A
JPS59152368A JP59018511A JP1851184A JPS59152368A JP S59152368 A JPS59152368 A JP S59152368A JP 59018511 A JP59018511 A JP 59018511A JP 1851184 A JP1851184 A JP 1851184A JP S59152368 A JPS59152368 A JP S59152368A
Authority
JP
Japan
Prior art keywords
acid
formula
ethanethionate
oxoethyl
thiazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59018511A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0455188B2 (hu
Inventor
フランソワーズ・ドレバレ
ロジェ・ドラエ
オディル・ル・マルトレ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of JPS59152368A publication Critical patent/JPS59152368A/ja
Publication of JPH0455188B2 publication Critical patent/JPH0455188B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
JP59018511A 1983-02-07 1984-02-06 メルカプト酢酸のアミド及び３―メルカプトプロヒオン酸から誘導される新規薬物 Granted JPS59152368A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8301863A FR2540498B1 (fr) 1983-02-07 1983-02-07 Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant
FR8301863 1983-02-07

Publications (2)

Publication Number Publication Date
JPS59152368A true JPS59152368A (ja) 1984-08-31
JPH0455188B2 JPH0455188B2 (hu) 1992-09-02

Family

ID=9285652

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59018511A Granted JPS59152368A (ja) 1983-02-07 1984-02-06 メルカプト酢酸のアミド及び３―メルカプトプロヒオン酸から誘導される新規薬物

Country Status (16)

Country Link
US (1) US4567198A (hu)
EP (1) EP0117183B1 (hu)
JP (1) JPS59152368A (hu)
KR (1) KR910008183B1 (hu)
AT (1) ATE22555T1 (hu)
AU (1) AU569487B2 (hu)
CA (1) CA1215648A (hu)
DE (1) DE3460841D1 (hu)
DK (1) DK169254B1 (hu)
ES (1) ES528765A0 (hu)
FR (1) FR2540498B1 (hu)
GR (1) GR81411B (hu)
HU (1) HU191991B (hu)
NZ (1) NZ207057A (hu)
PT (1) PT78071B (hu)
ZA (1) ZA84571B (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011236185A (ja) * 2010-05-13 2011-11-24 Takasago Internatl Corp 含硫カルボン酸エステル類の製造方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4611002A (en) * 1977-07-14 1986-09-09 E. R. Squibb And Sons, Inc. Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
US4868310A (en) * 1986-08-04 1989-09-19 Rohm And Haas Company Process for preparing isothiazolones
DE3639322A1 (de) * 1986-11-17 1988-05-26 Henkel Kgaa Verfahren zur reinigung und desinfektion von endoskopen und mittel zur durchfuehrung des verfahrens
CA2698928A1 (en) * 2007-09-28 2009-04-09 Absolute Science, Inc. Compounds and methods for treating zinc matrix metalloprotease dependent diseases
WO2010033360A1 (en) * 2008-09-19 2010-03-25 1/3 Absolute Science, Inc. Methods of treating a botulinum toxin related condition in a subject

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2709706A (en) * 1950-05-06 1955-05-31 Goodrich Co B F Preparation of beta-dithiocarbamyl and beta-mercapto carboxylic acid amides and the corresponding hydrazides
FR1193289A (fr) * 1958-03-14 1959-11-02 Oreal Procédé pour la mise en plis permanentée de cheveux au moyen de nouveaux composés tensio-actifs et procédé pour préparer ces composés
US3878248A (en) * 1971-05-03 1975-04-15 Monsanto Co Substituted alpha, alpha-dichloro-methane-sulfenyl chlorides
US3770824A (en) * 1971-05-03 1973-11-06 Monsanto Co Substituted alpha,alpha-dichloromethane-sulfenyl chlorides and their manufacture
AU4091178A (en) * 1977-10-25 1980-04-24 Merck & Co Inc Substituted mercapto acid amides
US4329495A (en) * 1981-05-18 1982-05-11 Pfizer Inc. Enkephalinase enzyme inhibiting compounds
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011236185A (ja) * 2010-05-13 2011-11-24 Takasago Internatl Corp 含硫カルボン酸エステル類の製造方法

Also Published As

Publication number Publication date
ATE22555T1 (de) 1986-10-15
ES8500899A1 (es) 1984-11-01
GR81411B (hu) 1984-12-11
PT78071A (fr) 1984-03-01
PT78071B (fr) 1986-06-11
FR2540498A1 (fr) 1984-08-10
KR910008183B1 (ko) 1991-10-10
EP0117183A1 (fr) 1984-08-29
KR850001163A (ko) 1985-03-16
CA1215648A (fr) 1986-12-23
DK169254B1 (da) 1994-09-26
ZA84571B (en) 1985-02-27
US4567198A (en) 1986-01-28
DE3460841D1 (en) 1986-11-06
DK51484D0 (da) 1984-02-06
HU191991B (en) 1987-04-28
FR2540498B1 (fr) 1986-02-14
AU569487B2 (en) 1988-02-04
JPH0455188B2 (hu) 1992-09-02
EP0117183B1 (fr) 1986-10-01
DK51484A (da) 1984-08-08
ES528765A0 (es) 1984-11-01
NZ207057A (en) 1987-07-31
AU2420284A (en) 1984-08-16

Similar Documents

Publication Publication Date Title
KR910008182B1 (ko) ω-머캅토프로판아미드 유도체의 제조방법
CA1103676A (fr) Procede de preparation de nouveaux derives du piperidyl-indole et leurs sels
CA1282784C (fr) Derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant
DE69107959T2 (de) 3-Cycloalkylpropansäureamide, ihre Tautomere und Salze, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und sie enthaltende Zusammensetzungen.
JPS59152368A (ja) メルカプト酢酸のアミド及び３―メルカプトプロヒオン酸から誘導される新規薬物
FR2664269A1 (fr) Nouveaux derives n-substitues d'alpha-mercapto alkylamines, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.
CA1312333C (fr) Sel de strontium, son procede de preparation et les compositions pharmaceutiques le renfermant
RU2126387C1 (ru) 2-циано-3-гидроксипропенамиды, способы их получения и фармацевтическая композиция на их основе
CA1139763A (fr) Procede d'obtention de nouveaux aryltrifluoroethanols
FR2597865A1 (fr) Nouveaux derives d'un acide benzyl alkyl carboxylique substitue par un radical 4-pyridinyl aminocarbonyle, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
CA1218064A (en) Niflumic acid morpholinoethyl ester diniflumate, used in therapeutics as analgesic and anti-inflammatory
CH659469A5 (fr) Derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation et les medicaments et compositions les renfermant.
EP0022017B1 (fr) Nouveaux dérivés de benzoyl-2 nitro-4 anilides, leur préparation et leur application en tant que médicaments
US4301167A (en) 2-Amino thiazoline derivatives
FR2462438A1 (fr) Nouveaux derives de la 6-alkyl-7-phenyl-1,6-naphtyridine-5(6h)-one, leur preparation et leur application comme medicaments
EP0159254B1 (fr) Nouveaux dérivés de l'w-mercaptopropanamide et leurs sels, leur préparation, leur application comme médicaments et les compositions les renfermant
JPS6185370A (ja) ４ｈ‐１，２，４‐トリアゾール誘導体の新製造法、得られる新トリアゾール、それらの薬剤としての使用及びそれらを含む製薬組成物
EP0183584B1 (fr) Nouveaux esters dérivés de l'acide 4-hydroxy 3-quinoléine carboxylique substitué en 2 par une chaîne alpha-hydroxylée, leur préparation, leur application comme médicaments et les compositions les renfermant
DE3880348T2 (de) N-substituierte alpha-mercaptomethylbenzenpropanamid-derivate, ihre herstellung, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen.
FR2462420A1 (fr) Esters o-alcoxycarbonyl-phenyliques d'un acide anthranilique, leur preparation et compositions pharmaceutiques en contenant
FR2482095A2 (fr) Nouveau derive de la taurine, son procede de preparation et son application en therapeutique
CA1189526A (fr) Procede de preparation de nouveaux derives amines de l'acide 4-phenyl 4-oxo 2-butenoique et de leurs sels
CA1106376A (fr) Procede de preparation de nouveaux esters anthraniliques
CA2038199A1 (fr) Derives du 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime, leur procede de preparation et leur application comme medicaments
FR2589468A1 (fr) Nouveaux derives du 2-acylamino ethanethiol 2-substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant